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The map label for this gene is trpC [H]

Identifier: 114330164

GI number: 114330164

Start: 132021

End: 132941

Strand: Reverse

Name: trpC [H]

Synonym: Neut_0133

Alternate gene names: 114330164

Gene position: 132941-132021 (Counterclockwise)

Preceding gene: 114330165

Following gene: 114330163

Centisome position: 5.0

GC content: 48.75

Gene sequence:

>921_bases
ATGTCAGATATTCTTGATCGCATCCTCGCCGTAAAAAAGCAGGAGATTTCAGCTACCCAAACACAAAAATCACTGGATAA
AATTCATGACGAAGCACGGGCAGTACCCGCTCCACGTGATTTTCTCCAGGCCATACGCAGCCGGATTAATCAAAACCACG
CTGCTGTCATTGCAGAGATCAAACGGGCCAGCCCAAGCAAGGGCTTATTGCGCGGACAAACAGAGTCACAAAATGTTTCT
GGATCAGGACATGTGGGAAATTTATCCGGGCGGAATCCGATCCTGGAAGATTTTATCCCGACAGACATTGCAGCCAGTTA
CGCCAGAAACGGGGCGGCCTGTCTATCCGTGCTGACGGATGAGCAGTTCTTCATGGGCAATGCTGATTTTTTACGGCAGG
CACGCGCTGCTTGTGATTTACCGGTGCTGCGCAAGGATTTTATGTTAGACGAATATCAGGTCTACGAAGCGCGTGCCATG
GGTGCCGATTGTATTCTGCTGATCGTTGCAGCCTTTTTTTCACCCATTTTTCAACATGATTCCGCTATCAATCAAGGTGA
CAGTGCACTCGAACGGATGCACAAACTGGAAACCATTGCACAGGAACTGGGCATGGCCGTACTGGTGGAAGTGCATAACG
CAGATGAGCTTGATCTCGCATTACAATTGTCCACACCATTGATCGGAATCAACAACCGTAATCTGAAAACGTTTGAAACC
ACACTGGATACGACCTTGCAGCTGGTCAAACATATCCCGTCCGGACGAATTATCGTTACCGAAAGTGGCATTCGTACACC
AGCTGATGTAGAAATGATGCTATCTCATTGCATCCACACTTTTCTGATCGGGGAAACCTTCATGCGCGCACCGGACCCTG
GTGTTGCGCTGGCAAACCTGTTCACAACAAATCTGGCGTAA

Upstream 100 bases:

>100_bases
GTGGAAATTGCCCGTGACAAGCTGGCCAGTGGTGCTGCCAAAGAAAAAATGCTGGCATTAATCAAATTCTCCAATCAGTT
AACCCATTAATTAGTTTTGC

Downstream 100 bases:

>100_bases
ACTGCGCCGCACCTGCCGACCGGATAAGCATCTTCCCGATCGGGATGAAATAATTATGTTATCAACATCAACTAAAAGGA
GATCTTCATGAACTTTAAAA

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MSDILDRILAVKKQEISATQTQKSLDKIHDEARAVPAPRDFLQAIRSRINQNHAAVIAEIKRASPSKGLLRGQTESQNVS
GSGHVGNLSGRNPILEDFIPTDIAASYARNGAACLSVLTDEQFFMGNADFLRQARAACDLPVLRKDFMLDEYQVYEARAM
GADCILLIVAAFFSPIFQHDSAINQGDSALERMHKLETIAQELGMAVLVEVHNADELDLALQLSTPLIGINNRNLKTFET
TLDTTLQLVKHIPSGRIIVTESGIRTPADVEMMLSHCIHTFLIGETFMRAPDPGVALANLFTTNLA

Sequences:

>Translated_306_residues
MSDILDRILAVKKQEISATQTQKSLDKIHDEARAVPAPRDFLQAIRSRINQNHAAVIAEIKRASPSKGLLRGQTESQNVS
GSGHVGNLSGRNPILEDFIPTDIAASYARNGAACLSVLTDEQFFMGNADFLRQARAACDLPVLRKDFMLDEYQVYEARAM
GADCILLIVAAFFSPIFQHDSAINQGDSALERMHKLETIAQELGMAVLVEVHNADELDLALQLSTPLIGINNRNLKTFET
TLDTTLQLVKHIPSGRIIVTESGIRTPADVEMMLSHCIHTFLIGETFMRAPDPGVALANLFTTNLA
>Mature_305_residues
SDILDRILAVKKQEISATQTQKSLDKIHDEARAVPAPRDFLQAIRSRINQNHAAVIAEIKRASPSKGLLRGQTESQNVSG
SGHVGNLSGRNPILEDFIPTDIAASYARNGAACLSVLTDEQFFMGNADFLRQARAACDLPVLRKDFMLDEYQVYEARAMG
ADCILLIVAAFFSPIFQHDSAINQGDSALERMHKLETIAQELGMAVLVEVHNADELDLALQLSTPLIGINNRNLKTFETT
LDTTLQLVKHIPSGRIIVTESGIRTPADVEMMLSHCIHTFLIGETFMRAPDPGVALANLFTTNLA

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=292, Percent_Identity=32.1917808219178, Blast_Score=132, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6322638, Length=304, Percent_Identity=32.5657894736842, Blast_Score=143, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 33548; Mature: 33417

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDILDRILAVKKQEISATQTQKSLDKIHDEARAVPAPRDFLQAIRSRINQNHAAVIAEI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHH
KRASPSKGLLRGQTESQNVSGSGHVGNLSGRNPILEDFIPTDIAASYARNGAACLSVLTD
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHCCHHHHHHHHHC
EQFFMGNADFLRQARAACDLPVLRKDFMLDEYQVYEARAMGADCILLIVAAFFSPIFQHD
CHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
SAINQGDSALERMHKLETIAQELGMAVLVEVHNADELDLALQLSTPLIGINNRNLKTFET
CCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCEEECCCCCCHHHHH
TLDTTLQLVKHIPSGRIIVTESGIRTPADVEMMLSHCIHTFLIGETFMRAPDPGVALANL
HHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
FTTNLA
HHHCCC
>Mature Secondary Structure 
SDILDRILAVKKQEISATQTQKSLDKIHDEARAVPAPRDFLQAIRSRINQNHAAVIAEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHH
KRASPSKGLLRGQTESQNVSGSGHVGNLSGRNPILEDFIPTDIAASYARNGAACLSVLTD
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHCCHHHHHHHHHC
EQFFMGNADFLRQARAACDLPVLRKDFMLDEYQVYEARAMGADCILLIVAAFFSPIFQHD
CHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCC
SAINQGDSALERMHKLETIAQELGMAVLVEVHNADELDLALQLSTPLIGINNRNLKTFET
CCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCEEECCCCCCHHHHH
TLDTTLQLVKHIPSGRIIVTESGIRTPADVEMMLSHCIHTFLIGETFMRAPDPGVALANL
HHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
FTTNLA
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA