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The map label for this gene is mco [H]

Identifier: 114330050

GI number: 114330050

Start: 15676

End: 17298

Strand: Reverse

Name: mco [H]

Synonym: Neut_0014

Alternate gene names: 114330050

Gene position: 17298-15676 (Counterclockwise)

Preceding gene: 114330052

Following gene: 114330047

Centisome position: 0.65

GC content: 53.17

Gene sequence:

>1623_bases
GTGACAACCAATCATTTAATTAACCGACGCAGCTTTCTGCGTTATGCAGGTTTGGGATCGACTGCATTGCTGCTTGGACT
TCCAGAGCCAAGTACTGCCACCCAGATACACAACAGCTTCGAACCGGATCTTTGGATCGAATTGACGGCCGCACCGAATA
GCGCTGCGCTACGCCCTGGGTTGGCCACTAATGTGTGGTCCTATCGAGCCCGCGTACTCAAGGGAGATCCCGCAAGTGTC
CAGGTGTTGCATGGCAGTTACCTTGGGCCGACCTTACACGTCCAACGCGGACAGAAACTGCGCATCGATTTCTTAAATCA
ACTCGACCAAGCCAGCAACGTACACTGGCACGGTTTGCATGTGCCAGACACCATGGACGGGCATCCACGCTTCGCGATTG
GACCGGGCGAACGTTATCGCTACGAATTTGAAGTGCGCAATCGTGCCGGCACTTATTGGTATCACCCACATCCCCATGGT
CAAACGGGTGAGCAGGTGTACTTTGGGCTCGCTGGCTTACTTCTGGTGAGTGACGATGAGGAACAGGTGCTACAGCTGCC
ACGCGGCGAATATGATGTTCCGATCATCATTCAGGATCGGAGCTTCGATGACAATAACCAATTCCGTTATCTGAGCGGCA
CCGGCCCTGCTGCCGCAGCGAGTAGCGCCTTCGGCGCGCGGCAGGCGTTGGGTGGCATGATGGGTGGTGGAGGAATGATG
TCGGGCGGTATGATGACGTCAATGATGGGGTTCTTTGGTGACACCATTCTGGTGAATGGTCGCTCTGATGCATCACTGGA
AGTTGCTAGGCACCCTTATCGATTGCGTATTCTTAATGGCTCTAATTCGCGGATCTATAAGCTAGCATGGCAGGACGGAC
GGCCGCTCATTGTAATTGGAACGGATGGTGGATTGCTTGAGCGTCCTGTGCATAAGAACTACGTGATGTTGGCTCCCGCT
GAACGTATTGAGTTGTGGGCCGATTTCAGCAACGATGATGTTGGCACAAAAATCACACTCATGAGTCTTGCGTTCGAAGG
GGCGATGAGAGGCATGATGGGGGGCGGCATGGGGCGGATGATGGGCACATCATCGATGGCTGCTGGAGCGCAGTTTCCGA
TGTTTATGATCGAAGTGACGCGCGAGTCGAATGGATCGCTTGAGCTACCCGAGCAGTTGTCCAAAATCACCTGGCTACCA
GTTGAGGATGCCGTCAATCGTACAGCGCCGAGAACATTCCGAATTACGATGGGGCATATGCAATGGGGATTTAACGGACG
CACCTTTGAAATGACGGCCGTGGCGCCCGATGAGCTTGTCAAGCTGAATACCACAGAAGTTTGGGAGTTCGTTAACGATA
GCGGCATGATGGCGATGGCACATCCGATACATGTCCACGATCAGCAGTTTCAAGTGTTGGAGCGGCGTAATGGAAAAGGT
AGCGATGATGTGCGTGATGGTTATGTCGATCAGGGCTGGAAGGACACGGTACTGGTGATGCCAGGTGAGCGCGTGAAACT
TCTGATGCGTTTTAGTGACTATACGGGACTTTATCTCTATCACTGTCACATGCTGGAGCATGAGGACTTTGGGTTAATGC
GTAACTACCGGATAGTGGCGTAG

Upstream 100 bases:

>100_bases
CTACCTCGCCGGTACCTCTTATTGTTTGCACTGAGCCCGACCGGCGAGCTCTTGAGGGTTACTTTCACATTGCGACAAAA
AATGACGTCAGGAGATTACA

Downstream 100 bases:

>100_bases
TGACTACATCGAAGAGGGCATCTTCAATCTAGTGTCTGCATGGTCAAAGATTCTGACCGAAGATGCATGTACGAGAAATA
ATGCCGAAAAATGATGTGGC

Product: twin-arginine translocation pathway signal

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 540; Mature: 539

Protein sequence:

>540_residues
MTTNHLINRRSFLRYAGLGSTALLLGLPEPSTATQIHNSFEPDLWIELTAAPNSAALRPGLATNVWSYRARVLKGDPASV
QVLHGSYLGPTLHVQRGQKLRIDFLNQLDQASNVHWHGLHVPDTMDGHPRFAIGPGERYRYEFEVRNRAGTYWYHPHPHG
QTGEQVYFGLAGLLLVSDDEEQVLQLPRGEYDVPIIIQDRSFDDNNQFRYLSGTGPAAAASSAFGARQALGGMMGGGGMM
SGGMMTSMMGFFGDTILVNGRSDASLEVARHPYRLRILNGSNSRIYKLAWQDGRPLIVIGTDGGLLERPVHKNYVMLAPA
ERIELWADFSNDDVGTKITLMSLAFEGAMRGMMGGGMGRMMGTSSMAAGAQFPMFMIEVTRESNGSLELPEQLSKITWLP
VEDAVNRTAPRTFRITMGHMQWGFNGRTFEMTAVAPDELVKLNTTEVWEFVNDSGMMAMAHPIHVHDQQFQVLERRNGKG
SDDVRDGYVDQGWKDTVLVMPGERVKLLMRFSDYTGLYLYHCHMLEHEDFGLMRNYRIVA

Sequences:

>Translated_540_residues
MTTNHLINRRSFLRYAGLGSTALLLGLPEPSTATQIHNSFEPDLWIELTAAPNSAALRPGLATNVWSYRARVLKGDPASV
QVLHGSYLGPTLHVQRGQKLRIDFLNQLDQASNVHWHGLHVPDTMDGHPRFAIGPGERYRYEFEVRNRAGTYWYHPHPHG
QTGEQVYFGLAGLLLVSDDEEQVLQLPRGEYDVPIIIQDRSFDDNNQFRYLSGTGPAAAASSAFGARQALGGMMGGGGMM
SGGMMTSMMGFFGDTILVNGRSDASLEVARHPYRLRILNGSNSRIYKLAWQDGRPLIVIGTDGGLLERPVHKNYVMLAPA
ERIELWADFSNDDVGTKITLMSLAFEGAMRGMMGGGMGRMMGTSSMAAGAQFPMFMIEVTRESNGSLELPEQLSKITWLP
VEDAVNRTAPRTFRITMGHMQWGFNGRTFEMTAVAPDELVKLNTTEVWEFVNDSGMMAMAHPIHVHDQQFQVLERRNGKG
SDDVRDGYVDQGWKDTVLVMPGERVKLLMRFSDYTGLYLYHCHMLEHEDFGLMRNYRIVA
>Mature_539_residues
TTNHLINRRSFLRYAGLGSTALLLGLPEPSTATQIHNSFEPDLWIELTAAPNSAALRPGLATNVWSYRARVLKGDPASVQ
VLHGSYLGPTLHVQRGQKLRIDFLNQLDQASNVHWHGLHVPDTMDGHPRFAIGPGERYRYEFEVRNRAGTYWYHPHPHGQ
TGEQVYFGLAGLLLVSDDEEQVLQLPRGEYDVPIIIQDRSFDDNNQFRYLSGTGPAAAASSAFGARQALGGMMGGGGMMS
GGMMTSMMGFFGDTILVNGRSDASLEVARHPYRLRILNGSNSRIYKLAWQDGRPLIVIGTDGGLLERPVHKNYVMLAPAE
RIELWADFSNDDVGTKITLMSLAFEGAMRGMMGGGMGRMMGTSSMAAGAQFPMFMIEVTRESNGSLELPEQLSKITWLPV
EDAVNRTAPRTFRITMGHMQWGFNGRTFEMTAVAPDELVKLNTTEVWEFVNDSGMMAMAHPIHVHDQQFQVLERRNGKGS
DDVRDGYVDQGWKDTVLVMPGERVKLLMRFSDYTGLYLYHCHMLEHEDFGLMRNYRIVA

Specific function: May be involved in copper homeostasis and oxidative stress response [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=588, Percent_Identity=29.7619047619048, Blast_Score=208, Evalue=8e-55,
Organism=Escherichia coli, GI1789394, Length=472, Percent_Identity=30.0847457627119, Blast_Score=160, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6323703, Length=532, Percent_Identity=23.3082706766917, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24650186, Length=127, Percent_Identity=33.8582677165354, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI18859919, Length=264, Percent_Identity=26.1363636363636, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR002355
- InterPro:   IPR008972 [H]

Pfam domain/function: PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 60294; Mature: 60162

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTNHLINRRSFLRYAGLGSTALLLGLPEPSTATQIHNSFEPDLWIELTAAPNSAALRPG
CCCCHHHHHHHHHEECCCCCEEEEEECCCCCHHHHHHCCCCCCEEEEEEECCCCCCCCCC
LATNVWSYRARVLKGDPASVQVLHGSYLGPTLHVQRGQKLRIDFLNQLDQASNVHWHGLH
CHHCHHHHEEEEECCCCCEEEEEECCCCCCEEEECCCCEEEHHHHHHHHHHCCCEEEEEE
VPDTMDGHPRFAIGPGERYRYEFEVRNRAGTYWYHPHPHGQTGEQVYFGLAGLLLVSDDE
CCCCCCCCCEEEECCCCCEEEEEEEECCCCCEEECCCCCCCCCCEEEEEEEEEEEEECCH
EQVLQLPRGEYDVPIIIQDRSFDDNNQFRYLSGTGPAAAASSAFGARQALGGMMGGGGMM
HHHHHCCCCCCCCEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCC
SGGMMTSMMGFFGDTILVNGRSDASLEVARHPYRLRILNGSNSRIYKLAWQDGRPLIVIG
CCCHHHHHHHHCCCEEEEECCCCCEEEEECCCEEEEEEECCCCEEEEEEECCCCEEEEEE
TDGGLLERPVHKNYVMLAPAERIELWADFSNDDVGTKITLMSLAFEGAMRGMMGGGMGRM
CCCCCCCCCCCCCEEEEECCCEEEEEECCCCCCCCCEEEEEEHHHHHHHHHHHCCCCHHH
MGTSSMAAGAQFPMFMIEVTRESNGSLELPEQLSKITWLPVEDAVNRTAPRTFRITMGHM
CCCCCCCCCCCCCEEEEEEEECCCCCEECHHHHHHEEEEEHHHHHCCCCCEEEEEEEECE
QWGFNGRTFEMTAVAPDELVKLNTTEVWEFVNDSGMMAMAHPIHVHDQQFQVLERRNGKG
EECCCCCEEEEEEECCHHEEEECCHHHHHHHCCCCCEEEECEEEECCHHHHHHHHCCCCC
SDDVRDGYVDQGWKDTVLVMPGERVKLLMRFSDYTGLYLYHCHMLEHEDFGLMRNYRIVA
CCCCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCEEEEEEEEEECCCCCCCCCCEEEEC
>Mature Secondary Structure 
TTNHLINRRSFLRYAGLGSTALLLGLPEPSTATQIHNSFEPDLWIELTAAPNSAALRPG
CCCHHHHHHHHHEECCCCCEEEEEECCCCCHHHHHHCCCCCCEEEEEEECCCCCCCCCC
LATNVWSYRARVLKGDPASVQVLHGSYLGPTLHVQRGQKLRIDFLNQLDQASNVHWHGLH
CHHCHHHHEEEEECCCCCEEEEEECCCCCCEEEECCCCEEEHHHHHHHHHHCCCEEEEEE
VPDTMDGHPRFAIGPGERYRYEFEVRNRAGTYWYHPHPHGQTGEQVYFGLAGLLLVSDDE
CCCCCCCCCEEEECCCCCEEEEEEEECCCCCEEECCCCCCCCCCEEEEEEEEEEEEECCH
EQVLQLPRGEYDVPIIIQDRSFDDNNQFRYLSGTGPAAAASSAFGARQALGGMMGGGGMM
HHHHHCCCCCCCCEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCC
SGGMMTSMMGFFGDTILVNGRSDASLEVARHPYRLRILNGSNSRIYKLAWQDGRPLIVIG
CCCHHHHHHHHCCCEEEEECCCCCEEEEECCCEEEEEEECCCCEEEEEEECCCCEEEEEE
TDGGLLERPVHKNYVMLAPAERIELWADFSNDDVGTKITLMSLAFEGAMRGMMGGGMGRM
CCCCCCCCCCCCCEEEEECCCEEEEEECCCCCCCCCEEEEEEHHHHHHHHHHHCCCCHHH
MGTSSMAAGAQFPMFMIEVTRESNGSLELPEQLSKITWLPVEDAVNRTAPRTFRITMGHM
CCCCCCCCCCCCCEEEEEEEECCCCCEECHHHHHHEEEEEHHHHHCCCCCEEEEEEEECE
QWGFNGRTFEMTAVAPDELVKLNTTEVWEFVNDSGMMAMAHPIHVHDQQFQVLERRNGKG
EECCCCCEEEEEEECCHHEEEECCHHHHHHHCCCCCEEEECEEEECCHHHHHHHHCCCCC
SDDVRDGYVDQGWKDTVLVMPGERVKLLMRFSDYTGLYLYHCHMLEHEDFGLMRNYRIVA
CCCCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCEEEEEEEEEECCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA