| Definition | Shewanella sp. MR-4 chromosome, complete genome. |
|---|---|
| Accession | NC_008321 |
| Length | 4,706,287 |
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The map label for this gene is ada [H]
Identifier: 113969709
GI number: 113969709
Start: 1594653
End: 1596281
Strand: Direct
Name: ada [H]
Synonym: Shewmr4_1367
Alternate gene names: 113969709
Gene position: 1594653-1596281 (Clockwise)
Preceding gene: 113969707
Following gene: 113969710
Centisome position: 33.88
GC content: 50.95
Gene sequence:
>1629_bases ATGAAGCAGATAACCGTGAGCCTAAAGCCAAGTTTCAAACCGCCATTAGTGCAAACATCAAGTGACTTGCAGGATTGCCA AATATCCGCCGGGATTTGCCATGAAGCGCGCATGAGTCGCGATCCGCGTTTTGATGGTAAGTTCTTTGTGGGCGTGTTAA GTACGGGGATTTATTGCCGAACAGTATGCCCAGCAGTGGCGCCGAAGGAAGAAAATGTTCGTTATTTTGACTCGGCCATT AAAGCTGCGCAGGCGGGACTTAGACCTTGCCTGCGTTGCCGCCCCGATAGCGCCCCTGGTTCTAATCCTTGGAAAGGTAC TAACACTACCTTAGACAGAGCGATAGGCTTGATTGAAGCTGGCACCTTATCTGGCGAACAAGCATTAACGGTTGAGGCCT TGGCAGATAAACTGGGGATCAGCAGCCGTTATTTAAATAAATTATTTACCGCAGGATTTGGCACATCACCAAAGCAATTT GCCCTCTATCGTCAGTTATTGTTCGCAAAACAGTTATTGCATCAAACGCAGTTGCCCATCACTCAGGTCGCCCTTGCCGC AGGTTTTAACAGTATTCGTCGTTTCAACGAGGCGTTTCAGCAGGCATTGCAATTAACGCCTACGCAGTTACGAAAATCGA GCCAGAAGTCGACGACGAAAATAGACGACGGGGAGAGTGTCGAACTCGTTTGTTCGCAGGAGATGCCAGCGCATAGCTTG AGTCTGTATCAGTACTACCGGCCGCCACTCGATTGGTCGGCGCAATTAGCCTTTTATCGCCTGCGCGCCGTCGCTGGCAT GGAATGGTTTAGTGAAACAGAAGACTCTCACGCCCATGGGGCGATTGACCAAGATACGCCACTTGAGTATGGCCGCACTC TGCAACTTGAGGATATCCGCGCTGTGGTGCATATCGTCCATGAGGCGTCTTTGCATCGCTTTAAAATCACGCTGACGTTA ACGCCCGACTCGCCCTTATCGGGTCTACAAAAGCTCATCACCCAAGTGCGGCGCATTTTAGATCTCGATGCCGACATGCA GCAGATTGAACACAATTTAGAGCACTTGACCGATCTTAAACTCAGTAGCAAATCCGGGCTTAGGATCCCGGGCGCTGGCA CTGTGTTTGAGGCGGGTTGCCGAGCGGTCTTAGGCCAGCAGGTGAGCGTAGTGCAGGCCACTAAATTACTGAATATATTG GTCGAAGCCTATGGCGAGCGCTTTAGTTTAAACGGGCGGGAATATCGACTATTCCCCACGCCGCAGGCGATTCGTGAGGC GAGTCTCGATGAGCTTAAAATGCCCGGTGCGCGCAAATTGGCGCTCAATGCGCTTGCGGCGTTTATCTGTGAGCAGCCCG AAGCCTCAGTCGATGAGTGGATTGGGGTAAAAGGCATCGGCCCTTGGACCATTGCCTATGCCAAACTGCGAGGACTTGGC GATCCGAATATCTTCTTGCACACGGATTTAATTGTTAAAAAACAATTGTTAGCCAGTGTTGCCGCGCAAAAAGGCGTGGA TATTGAAGCGGTAAAGCAGCTGGATTATACAACGCTTGCACAGCGGGTGAGCGCGGATATCGCCCCTTGGGGGAGTTATT TAACTTTCCAGCTGTGGTCCAATGCATAA
Upstream 100 bases:
>100_bases ACGTGATGATCCAGTTCCGTTTTCCGCGAGTGTGCTAGCATAGGGTGACGTACAGTAACCGACAAGTACAAAATTGTGAA TAAGATTGTCGGATAACTCA
Downstream 100 bases:
>100_bases GACATTTCAGGCCACTCGTTATGGATCCAGTACCTAGGCTCCATATGAGAGCCACTAATAGAAACATTATTTGAAACACA GTACGAAAACATAGTACGAA
Product: transcriptional regulator Ada / DNA-3-methyladenine glycosylase II / DNA-O6-methylguanine--protein-cysteine S-methyltransferase
Products: NA
Alternate protein names: Regulatory protein of adaptative response; Methylated-DNA--protein-cysteine methyltransferase; O-6-methylguanine-DNA alkyltransferase [H]
Number of amino acids: Translated: 542; Mature: 542
Protein sequence:
>542_residues MKQITVSLKPSFKPPLVQTSSDLQDCQISAGICHEARMSRDPRFDGKFFVGVLSTGIYCRTVCPAVAPKEENVRYFDSAI KAAQAGLRPCLRCRPDSAPGSNPWKGTNTTLDRAIGLIEAGTLSGEQALTVEALADKLGISSRYLNKLFTAGFGTSPKQF ALYRQLLFAKQLLHQTQLPITQVALAAGFNSIRRFNEAFQQALQLTPTQLRKSSQKSTTKIDDGESVELVCSQEMPAHSL SLYQYYRPPLDWSAQLAFYRLRAVAGMEWFSETEDSHAHGAIDQDTPLEYGRTLQLEDIRAVVHIVHEASLHRFKITLTL TPDSPLSGLQKLITQVRRILDLDADMQQIEHNLEHLTDLKLSSKSGLRIPGAGTVFEAGCRAVLGQQVSVVQATKLLNIL VEAYGERFSLNGREYRLFPTPQAIREASLDELKMPGARKLALNALAAFICEQPEASVDEWIGVKGIGPWTIAYAKLRGLG DPNIFLHTDLIVKKQLLASVAAQKGVDIEAVKQLDYTTLAQRVSADIAPWGSYLTFQLWSNA
Sequences:
>Translated_542_residues MKQITVSLKPSFKPPLVQTSSDLQDCQISAGICHEARMSRDPRFDGKFFVGVLSTGIYCRTVCPAVAPKEENVRYFDSAI KAAQAGLRPCLRCRPDSAPGSNPWKGTNTTLDRAIGLIEAGTLSGEQALTVEALADKLGISSRYLNKLFTAGFGTSPKQF ALYRQLLFAKQLLHQTQLPITQVALAAGFNSIRRFNEAFQQALQLTPTQLRKSSQKSTTKIDDGESVELVCSQEMPAHSL SLYQYYRPPLDWSAQLAFYRLRAVAGMEWFSETEDSHAHGAIDQDTPLEYGRTLQLEDIRAVVHIVHEASLHRFKITLTL TPDSPLSGLQKLITQVRRILDLDADMQQIEHNLEHLTDLKLSSKSGLRIPGAGTVFEAGCRAVLGQQVSVVQATKLLNIL VEAYGERFSLNGREYRLFPTPQAIREASLDELKMPGARKLALNALAAFICEQPEASVDEWIGVKGIGPWTIAYAKLRGLG DPNIFLHTDLIVKKQLLASVAAQKGVDIEAVKQLDYTTLAQRVSADIAPWGSYLTFQLWSNA >Mature_542_residues MKQITVSLKPSFKPPLVQTSSDLQDCQISAGICHEARMSRDPRFDGKFFVGVLSTGIYCRTVCPAVAPKEENVRYFDSAI KAAQAGLRPCLRCRPDSAPGSNPWKGTNTTLDRAIGLIEAGTLSGEQALTVEALADKLGISSRYLNKLFTAGFGTSPKQF ALYRQLLFAKQLLHQTQLPITQVALAAGFNSIRRFNEAFQQALQLTPTQLRKSSQKSTTKIDDGESVELVCSQEMPAHSL SLYQYYRPPLDWSAQLAFYRLRAVAGMEWFSETEDSHAHGAIDQDTPLEYGRTLQLEDIRAVVHIVHEASLHRFKITLTL TPDSPLSGLQKLITQVRRILDLDADMQQIEHNLEHLTDLKLSSKSGLRIPGAGTVFEAGCRAVLGQQVSVVQATKLLNIL VEAYGERFSLNGREYRLFPTPQAIREASLDELKMPGARKLALNALAAFICEQPEASVDEWIGVKGIGPWTIAYAKLRGLG DPNIFLHTDLIVKKQLLASVAAQKGVDIEAVKQLDYTTLAQRVSADIAPWGSYLTFQLWSNA
Specific function: The methylated ADA protein acts as a positive regulator of its own synthesis, as well as that of other proteins. The transcription-activating function of the ADA protein resides in its N-terminus [H]
COG id: COG2169
COG function: function code F; Adenosine deaminase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]
Homologues:
Organism=Escherichia coli, GI1788383, Length=310, Percent_Identity=30, Blast_Score=110, Evalue=2e-25, Organism=Escherichia coli, GI1788542, Length=181, Percent_Identity=32.5966850828729, Blast_Score=89, Evalue=6e-19,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR004026 - InterPro: IPR010316 - InterPro: IPR011257 - InterPro: IPR003265 - InterPro: IPR003583 - InterPro: IPR009057 - InterPro: IPR012287 - InterPro: IPR018062 - InterPro: IPR018060 - InterPro: IPR023170 - InterPro: IPR012294 [H]
Pfam domain/function: PF02805 Ada_Zn_binding; PF06029 AlkA_N; PF00730 HhH-GPD [H]
EC number: =2.1.1.63 [H]
Molecular weight: Translated: 59870; Mature: 59870
Theoretical pI: Translated: 8.15; Mature: 8.15
Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS01124 HTH_ARAC_FAMILY_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.7 %Cys (Translated Protein) 1.1 %Met (Translated Protein) 2.8 %Cys+Met (Translated Protein) 1.7 %Cys (Mature Protein) 1.1 %Met (Mature Protein) 2.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKQITVSLKPSFKPPLVQTSSDLQDCQISAGICHEARMSRDPRFDGKFFVGVLSTGIYCR CCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCHHHHHCCCCCCCCCCEEHHHHHCCHHHH TVCPAVAPKEENVRYFDSAIKAAQAGLRPCLRCRPDSAPGSNPWKGTNTTLDRAIGLIEA HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCC GTLSGEQALTVEALADKLGISSRYLNKLFTAGFGTSPKQFALYRQLLFAKQLLHQTQLPI CCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCH TQVALAAGFNSIRRFNEAFQQALQLTPTQLRKSSQKSTTKIDDGESVELVCSQEMPAHSL HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHH SLYQYYRPPLDWSAQLAFYRLRAVAGMEWFSETEDSHAHGAIDQDTPLEYGRTLQLEDIR HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEHHHHH AVVHIVHEASLHRFKITLTLTPDSPLSGLQKLITQVRRILDLDADMQQIEHNLEHLTDLK HHHHHHHHHCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC LSSKSGLRIPGAGTVFEAGCRAVLGQQVSVVQATKLLNILVEAYGERFSLNGREYRLFPT CCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEECCCCEEEECCC PQAIREASLDELKMPGARKLALNALAAFICEQPEASVDEWIGVKGIGPWTIAYAKLRGLG HHHHHHCCHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHCCC DPNIFLHTDLIVKKQLLASVAAQKGVDIEAVKQLDYTTLAQRVSADIAPWGSYLTFQLWS CCCEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEC NA CC >Mature Secondary Structure MKQITVSLKPSFKPPLVQTSSDLQDCQISAGICHEARMSRDPRFDGKFFVGVLSTGIYCR CCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCHHHHHCCCCCCCCCCEEHHHHHCCHHHH TVCPAVAPKEENVRYFDSAIKAAQAGLRPCLRCRPDSAPGSNPWKGTNTTLDRAIGLIEA HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCC GTLSGEQALTVEALADKLGISSRYLNKLFTAGFGTSPKQFALYRQLLFAKQLLHQTQLPI CCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCH TQVALAAGFNSIRRFNEAFQQALQLTPTQLRKSSQKSTTKIDDGESVELVCSQEMPAHSL HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHH SLYQYYRPPLDWSAQLAFYRLRAVAGMEWFSETEDSHAHGAIDQDTPLEYGRTLQLEDIR HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEHHHHH AVVHIVHEASLHRFKITLTLTPDSPLSGLQKLITQVRRILDLDADMQQIEHNLEHLTDLK HHHHHHHHHCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCC LSSKSGLRIPGAGTVFEAGCRAVLGQQVSVVQATKLLNILVEAYGERFSLNGREYRLFPT CCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEECCCCEEEECCC PQAIREASLDELKMPGARKLALNALAAFICEQPEASVDEWIGVKGIGPWTIAYAKLRGLG HHHHHHCCHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHCCC DPNIFLHTDLIVKKQLLASVAAQKGVDIEAVKQLDYTTLAQRVSADIAPWGSYLTFQLWS CCCEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEC NA CC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9634230; 12218036 [H]