Click here to switch to the map view.

The map label for this gene is rmlA1 [H]

Identifier: 113969680

GI number: 113969680

Start: 1551247

End: 1552185

Strand: Direct

Name: rmlA1 [H]

Synonym: Shewmr4_1338

Alternate gene names: 113969680

Gene position: 1551247-1552185 (Clockwise)

Preceding gene: 113969679

Following gene: 113969681

Centisome position: 32.96

GC content: 44.62

Gene sequence:

>939_bases
ATGTTACAATCATCCCTTCACTTTGACTCACTAATCCTTGATATATCAATGAGAAAAGGCATTTTATTGGCTGGCGGGAC
CGGTTCTCGCCTATATCCGATGACACAGGTTGTATGTAAGCAGTTATTGCCTATTTACGATAAACCAATGATTTATTATC
CACTTGTGACCTTAATGCAGGCTGGCATAAAAGAGATTTTAATTATCTGTACACGCAGTGATTTGCCTCTTTTTCAGGCA
TTGCTTGGTGATGGTCACCGTTGGGGCATTCAGCTTGAATATGCGGTACAGCCTTCTCCAAAGGGATTAGCCGAAGCACT
TATTATCGGAGAGGCTTTTTTGGCGGGAGAGGCCTGTGCGTTGATTCTGGGCGATAACTTATTTTATGGGCAGCAACTGA
GCACAAACTTGCATAGAGCTTATCTACTCGAAGTGGGGGCGACCGTTTTTGGCTACCATGTGGCTAATCCGAATGCCTAC
GGCGTTGTCGAGTTTGATAAGAGAGGAAGGGCGATTTCAATCGAAGAGAAACCCCGAGTTGCGCGTTCTTCCTATGCTAT
TCCTGGATTGTATTTCTTTGATAACAGGGCTAGTGAATGGGCTAAAAAAGTGATGCCTTCGGCGCGGGGCGAGTTGGAGA
TCGTTGATCTAATCAATCAATATCTTCTGTTGGGGGAATTGCAGGTAGAAATAATGGGGCGGGGCACTGCTTGGCTCGAT
ACGGGAACGCCGGATGCGATGGCTGAAGCAACACAATTTATTGCTGCTATAGAAAAACGCCAAGGGTTGAAAGTGAACTG
TCCTGAAGAGGTTGCTTTTCATTCTGGTTGGATAGATGCTGCGCAGCTTACTGCTTTAGCACAACCTTTGCTTAAAAGCG
GTTATGGTGAGTATCTTTTAGGATTATTAAATAAGCAGGTGTTTAATGAAGTGCATTGA

Upstream 100 bases:

>100_bases
GTTGAAATACAGATCCCTGAGAAATGACCTAAGCACATTGTTTAGGCGGTAATACGGCCTTGTTTGAGACCTCGCGCCAT
TCAGCTTTATCGGCATTTAT

Downstream 100 bases:

>100_bases
AACCGAGCTTGCAGAAGTATTGGTGTTCGAACCGCAAGTATTTGGTGATGAACGCGGTTTTTTTATGGAAACATTTCGGC
AGTCGTATTTCACTGAATGT

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MLQSSLHFDSLILDISMRKGILLAGGTGSRLYPMTQVVCKQLLPIYDKPMIYYPLVTLMQAGIKEILIICTRSDLPLFQA
LLGDGHRWGIQLEYAVQPSPKGLAEALIIGEAFLAGEACALILGDNLFYGQQLSTNLHRAYLLEVGATVFGYHVANPNAY
GVVEFDKRGRAISIEEKPRVARSSYAIPGLYFFDNRASEWAKKVMPSARGELEIVDLINQYLLLGELQVEIMGRGTAWLD
TGTPDAMAEATQFIAAIEKRQGLKVNCPEEVAFHSGWIDAAQLTALAQPLLKSGYGEYLLGLLNKQVFNEVH

Sequences:

>Translated_312_residues
MLQSSLHFDSLILDISMRKGILLAGGTGSRLYPMTQVVCKQLLPIYDKPMIYYPLVTLMQAGIKEILIICTRSDLPLFQA
LLGDGHRWGIQLEYAVQPSPKGLAEALIIGEAFLAGEACALILGDNLFYGQQLSTNLHRAYLLEVGATVFGYHVANPNAY
GVVEFDKRGRAISIEEKPRVARSSYAIPGLYFFDNRASEWAKKVMPSARGELEIVDLINQYLLLGELQVEIMGRGTAWLD
TGTPDAMAEATQFIAAIEKRQGLKVNCPEEVAFHSGWIDAAQLTALAQPLLKSGYGEYLLGLLNKQVFNEVH
>Mature_312_residues
MLQSSLHFDSLILDISMRKGILLAGGTGSRLYPMTQVVCKQLLPIYDKPMIYYPLVTLMQAGIKEILIICTRSDLPLFQA
LLGDGHRWGIQLEYAVQPSPKGLAEALIIGEAFLAGEACALILGDNLFYGQQLSTNLHRAYLLEVGATVFGYHVANPNAY
GVVEFDKRGRAISIEEKPRVARSSYAIPGLYFFDNRASEWAKKVMPSARGELEIVDLINQYLLLGELQVEIMGRGTAWLD
TGTPDAMAEATQFIAAIEKRQGLKVNCPEEVAFHSGWIDAAQLTALAQPLLKSGYGEYLLGLLNKQVFNEVH

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788351, Length=285, Percent_Identity=62.4561403508772, Blast_Score=373, Evalue=1e-105,
Organism=Escherichia coli, GI1790224, Length=288, Percent_Identity=57.9861111111111, Blast_Score=342, Evalue=2e-95,
Organism=Caenorhabditis elegans, GI133931050, Length=182, Percent_Identity=27.4725274725275, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320148, Length=286, Percent_Identity=22.3776223776224, Blast_Score=66, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21355443, Length=252, Percent_Identity=23.8095238095238, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24644084, Length=252, Percent_Identity=23.8095238095238, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 34421; Mature: 34421

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQSSLHFDSLILDISMRKGILLAGGTGSRLYPMTQVVCKQLLPIYDKPMIYYPLVTLMQ
CCCCCCCHHHHEEEEECCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
AGIKEILIICTRSDLPLFQALLGDGHRWGIQLEYAVQPSPKGLAEALIIGEAFLAGEACA
HCHHHEEEEEECCCCHHHHHHHCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCEEE
LILGDNLFYGQQLSTNLHRAYLLEVGATVFGYHVANPNAYGVVEFDKRGRAISIEEKPRV
EEEECCEEECCHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEEECCCCCEEEECCCCCH
ARSSYAIPGLYFFDNRASEWAKKVMPSARGELEIVDLINQYLLLGELQVEIMGRGTAWLD
HHCCCCCCCEEEECCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHEEEEEEEECCEEEEC
TGTPDAMAEATQFIAAIEKRQGLKVNCPEEVAFHSGWIDAAQLTALAQPLLKSGYGEYLL
CCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHH
GLLNKQVFNEVH
HHHHHHHHHHCC
>Mature Secondary Structure
MLQSSLHFDSLILDISMRKGILLAGGTGSRLYPMTQVVCKQLLPIYDKPMIYYPLVTLMQ
CCCCCCCHHHHEEEEECCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
AGIKEILIICTRSDLPLFQALLGDGHRWGIQLEYAVQPSPKGLAEALIIGEAFLAGEACA
HCHHHEEEEEECCCCHHHHHHHCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHCCCEEE
LILGDNLFYGQQLSTNLHRAYLLEVGATVFGYHVANPNAYGVVEFDKRGRAISIEEKPRV
EEEECCEEECCHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEEECCCCCEEEECCCCCH
ARSSYAIPGLYFFDNRASEWAKKVMPSARGELEIVDLINQYLLLGELQVEIMGRGTAWLD
HHCCCCCCCEEEECCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHEEEEEEEECCEEEEC
TGTPDAMAEATQFIAAIEKRQGLKVNCPEEVAFHSGWIDAAQLTALAQPLLKSGYGEYLL
CCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHH
GLLNKQVFNEVH
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]