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The map label for this gene is ltaE [H]

Identifier: 113969551

GI number: 113969551

Start: 1407109

End: 1408122

Strand: Direct

Name: ltaE [H]

Synonym: Shewmr4_1207

Alternate gene names: 113969551

Gene position: 1407109-1408122 (Clockwise)

Preceding gene: 113969547

Following gene: 113969552

Centisome position: 29.9

GC content: 51.78

Gene sequence:

>1014_bases
ATGATAGATTTACGCAGTGATACCGTGACCCAGCCAACAGAGGCGATGCGCTTAGCCATGTCGAGGGCTGAAGTAGGTGA
TGATGTTTATGGTGATGATCCGACCGTCAACAGCTTGCAAGATATGGCCGCCGAGATGTTTGGCTTTGAGAGTGCGCTGT
TTACCGCATCTGGCACTCAGGCCAATTTGCTCGCGCTGATGGCACATTGTGAACGTGGAGATGAATATCTGTGCGGCCAG
CAGGCCCATAACTATAAATTCGAGGGCGGTGGTGCGGCGGTACTCGGGAGCATTCAGCCGCAACCGCTGACCAATCAGCT
GGATGGCACCATTGCCCTGACCGATATTGAAGCGGCGATTAAACCCGATGATATTCACTTCGCGCGCACGCGCTTATTGA
GCCTAGAAAACACTATCGGTGGCAAGGTATTACCCCAATCCTATCTTGCTAATGCGCAGGCGCTGGCATTTCAGCGTGGT
TTAAAAATTCACTTAGATGGCGCTCGGGTTGCTAATGCCGCCGTGGCCCAGGGGATTGGGATTGCCGATATTGCGGGGCA
TTTTGATTCTGTCTCCATCTGTTTATCCAAGGGGTTGTGTGCGCCTGTTGGCTCACTGCTCCTAGGTGATGAGCGCCTAA
TTAAAAAGGCCACGCGCTGGCGTAAAATGCTGGGCGGCGGTATGCGCCAGGCGGGGATATTAGCGGCTGCGGGTAAATTA
GCCCTCACCGAACAAGTTGAGCGATTAGGGGAAGATCATGAGAATGCTGCGTATTTTGCTCAGCAATTAAGTTTGTTGAG
TGAGTTTGAAATCGATTTGGCCGCCGTACAAACCAATATGGTGTTTGCAAACCTCGCGCCCCATGTCGATGAGCAAGCCC
TAGCGAAACGTTGCTGTGAGGCGGGGATCCTCATCAGCCCTAGCCGTACTCTGCGCTTTGTGACCCATAAAGATGTCTCG
CGTCAGGACATTGATAAAGTGCTGCAAGTGTTTAAATTACATTTGCAGGTATAA

Upstream 100 bases:

>100_bases
CAGATATAAAGGCAAACTATACAAATTTTTCCTTTGAGGCTAGAGTCGCACTAGCGCTCTATATCAGCGTTGGGGATAGG
CAGAAGAAGTCGAGGACAAG

Downstream 100 bases:

>100_bases
TCGGCGTGACGCCCAAGTGAAAGCTTGGGCTTTTTTATACCTCTGGCTTGCAATATCGCGGATTTAAAATCAAAAGTCGA
ATTGTGAGCCAGATGATAGG

Product: L-threonine aldolase

Products: NA

Alternate protein names: Low-specificity L-TA [H]

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MIDLRSDTVTQPTEAMRLAMSRAEVGDDVYGDDPTVNSLQDMAAEMFGFESALFTASGTQANLLALMAHCERGDEYLCGQ
QAHNYKFEGGGAAVLGSIQPQPLTNQLDGTIALTDIEAAIKPDDIHFARTRLLSLENTIGGKVLPQSYLANAQALAFQRG
LKIHLDGARVANAAVAQGIGIADIAGHFDSVSICLSKGLCAPVGSLLLGDERLIKKATRWRKMLGGGMRQAGILAAAGKL
ALTEQVERLGEDHENAAYFAQQLSLLSEFEIDLAAVQTNMVFANLAPHVDEQALAKRCCEAGILISPSRTLRFVTHKDVS
RQDIDKVLQVFKLHLQV

Sequences:

>Translated_337_residues
MIDLRSDTVTQPTEAMRLAMSRAEVGDDVYGDDPTVNSLQDMAAEMFGFESALFTASGTQANLLALMAHCERGDEYLCGQ
QAHNYKFEGGGAAVLGSIQPQPLTNQLDGTIALTDIEAAIKPDDIHFARTRLLSLENTIGGKVLPQSYLANAQALAFQRG
LKIHLDGARVANAAVAQGIGIADIAGHFDSVSICLSKGLCAPVGSLLLGDERLIKKATRWRKMLGGGMRQAGILAAAGKL
ALTEQVERLGEDHENAAYFAQQLSLLSEFEIDLAAVQTNMVFANLAPHVDEQALAKRCCEAGILISPSRTLRFVTHKDVS
RQDIDKVLQVFKLHLQV
>Mature_337_residues
MIDLRSDTVTQPTEAMRLAMSRAEVGDDVYGDDPTVNSLQDMAAEMFGFESALFTASGTQANLLALMAHCERGDEYLCGQ
QAHNYKFEGGGAAVLGSIQPQPLTNQLDGTIALTDIEAAIKPDDIHFARTRLLSLENTIGGKVLPQSYLANAQALAFQRG
LKIHLDGARVANAAVAQGIGIADIAGHFDSVSICLSKGLCAPVGSLLLGDERLIKKATRWRKMLGGGMRQAGILAAAGKL
ALTEQVERLGEDHENAAYFAQQLSLLSEFEIDLAAVQTNMVFANLAPHVDEQALAKRCCEAGILISPSRTLRFVTHKDVS
RQDIDKVLQVFKLHLQV

Specific function: Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. L-threo-phenylserine and L- erythro-phenylserine are also good substrates [H]

COG id: COG2008

COG function: function code E; Threonine aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1787095, Length=335, Percent_Identity=56.7164179104478, Blast_Score=369, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI193206522, Length=345, Percent_Identity=42.6086956521739, Blast_Score=247, Evalue=5e-66,
Organism=Caenorhabditis elegans, GI193206520, Length=345, Percent_Identity=42.6086956521739, Blast_Score=247, Evalue=7e-66,
Organism=Caenorhabditis elegans, GI193206524, Length=345, Percent_Identity=42.6086956521739, Blast_Score=247, Evalue=7e-66,
Organism=Saccharomyces cerevisiae, GI6320789, Length=335, Percent_Identity=38.2089552238806, Blast_Score=195, Evalue=9e-51,
Organism=Drosophila melanogaster, GI21355439, Length=298, Percent_Identity=47.6510067114094, Blast_Score=257, Evalue=6e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001597
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01212 Beta_elim_lyase [H]

EC number: =4.1.2.5 [H]

Molecular weight: Translated: 36271; Mature: 36271

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDLRSDTVTQPTEAMRLAMSRAEVGDDVYGDDPTVNSLQDMAAEMFGFESALFTASGTQ
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCHHHHHEECCCCH
ANLLALMAHCERGDEYLCGQQAHNYKFEGGGAAVLGSIQPQPLTNQLDGTIALTDIEAAI
HHHHHHHHHHHCCCCCCCCCCCCCEEECCCCEEEECCCCCCCCCCCCCCEEEEEEEHHHC
KPDDIHFARTRLLSLENTIGGKVLPQSYLANAQALAFQRGLKIHLDGARVANAAVAQGIG
CCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHCCCEEEECCHHHHHHHHHCCCC
IADIAGHFDSVSICLSKGLCAPVGSLLLGDERLIKKATRWRKMLGGGMRQAGILAAAGKL
HHHHHCCHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHH
ALTEQVERLGEDHENAAYFAQQLSLLSEFEIDLAAVQTNMVFANLAPHVDEQALAKRCCE
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHH
AGILISPSRTLRFVTHKDVSRQDIDKVLQVFKLHLQV
CCEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIDLRSDTVTQPTEAMRLAMSRAEVGDDVYGDDPTVNSLQDMAAEMFGFESALFTASGTQ
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCHHHHHEECCCCH
ANLLALMAHCERGDEYLCGQQAHNYKFEGGGAAVLGSIQPQPLTNQLDGTIALTDIEAAI
HHHHHHHHHHHCCCCCCCCCCCCCEEECCCCEEEECCCCCCCCCCCCCCEEEEEEEHHHC
KPDDIHFARTRLLSLENTIGGKVLPQSYLANAQALAFQRGLKIHLDGARVANAAVAQGIG
CCCCHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHHCCCEEEECCHHHHHHHHHCCCC
IADIAGHFDSVSICLSKGLCAPVGSLLLGDERLIKKATRWRKMLGGGMRQAGILAAAGKL
HHHHHCCHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCHH
ALTEQVERLGEDHENAAYFAQQLSLLSEFEIDLAAVQTNMVFANLAPHVDEQALAKRCCE
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHH
AGILISPSRTLRFVTHKDVSRQDIDKVLQVFKLHLQV
CCEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]