Click here to switch to the map view.

The map label for this gene is proA [H]

Identifier: 113969297

GI number: 113969297

Start: 1115617

End: 1116894

Strand: Direct

Name: proA [H]

Synonym: Shewmr4_0953

Alternate gene names: 113969297

Gene position: 1115617-1116894 (Clockwise)

Preceding gene: 113969296

Following gene: 113969301

Centisome position: 23.7

GC content: 52.82

Gene sequence:

>1278_bases
TTGAGTCAAACTAATCAAGCGCAATATTTACAACAACTGGGCAGTCAGGCTAAACAAGCCAGCTATGCCTTAGCAAATCT
TAGCGCCGCACAGAAAGCGGATTTACTCGAGGCGATTGCCGAGGCCCTGACGCAGAACACTCAGGCGATTCTCGCGGCTA
ACGCCAAAGACGTTGCAGCCGCTAAGGCTGAAGGCTTGAATGATGCAATGATCGATAGACTCTTGCTTAACGAGTCGCGT
CTAGCGGGGATTATCGGTGATATCGGTGATGTGGTGCGTCTTGCCGATCCCGTTGGCGAAGAGTTTGGCAGCCGCGTGTT
GGACAATGGCTTAAGGCTCACGCGCCGCCGTGTTCCACTTGGGGTGATTGGGGTTATCTACGAGGCGCGGCCGAATGTGA
CGGTCGATATTGCTGTGTTGGCACTTAAAACCGGTAACGCGGTGATTTTGCGCGGCGGAAAAGAGACGCTCGAATCTAAC
AAACTGATTAGCGAAGTGATCCGTGGCGCAATTGCAAGCCAAGGTCTGCCAGTCGATGCGGTGCAGCTGATTGATTCTCC
CGATAGAGCCTTAGTCACAGGGCTACTCAAGCTCGACCAATATGTCGATATGATAGTCCCCCGTGGCGGACAAGCCTTAC
AGCGCCTTTGCGCCGAGCAAGCGACGATTCCGGTGATCTTAGGCGGCATTGGGATCTGCCATCTGTATGTCGATAAACAT
GCCGATCTTGAGCGCGCACTCGAGGTGATTGCCAACGCAAAAGTGCAGCGCCCTACGGTATGTAATGCATTAGACACCTT
GCTGGTGGATAACGCGGTTGCCGAGCGTTTTGTGCCGCAAATTGCCGAATACTTACACCGTTTAGGTGTGCGTTTTTCGG
TGTGTGAACAAAGCTATGCGCTGCTCGATGGGCTGGGGTTTGATATTTCCCCGGCAACTGAGCAAAGCTTTGCGACCGAA
TGGTTGTCTTTGGCCTTAGGCATTAAAGTGGTGAATGACATAGATACAGCTATTGCCCATATCCGTACCTATTCCAGTGG
GCACTCGGAGGCGATTCTCACCGATGATATCCATACGGCCACGCATTTTATGAACGAAGTGAATTCGGCTGCTGTGTATG
TGAATGCCAGTACTCGCTTTACCGATGGCGGCCAATTTGGCTTGGGTGCCGAGGTGGCCGTAAGCACACAAAAACTCCAT
GCCCGCGGTCCTATGGGGCTGGAGGCGTTGACCACCTATAAGTGGTTAGCATGGGGCGATTACACCAGCCGTGCTTAG

Upstream 100 bases:

>100_bases
GGGTAAACATTCCGACGAAATCGAGTCAGTGCTCGGTTACGATTATGGTGACGCAATAGTGCACCGCAACGACATGGTCG
TCTTATAAGCGAGGTCTGTT

Downstream 100 bases:

>100_bases
TGAATTAAGTACACTAAAAGTCACCCATTAAAAAAGCCGCAATAGCGGCTTTTTTAATGGGTAAATGGTGCGGTTAATGG
ATAAGCGGAGTGTAAGTGGC

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MSQTNQAQYLQQLGSQAKQASYALANLSAAQKADLLEAIAEALTQNTQAILAANAKDVAAAKAEGLNDAMIDRLLLNESR
LAGIIGDIGDVVRLADPVGEEFGSRVLDNGLRLTRRRVPLGVIGVIYEARPNVTVDIAVLALKTGNAVILRGGKETLESN
KLISEVIRGAIASQGLPVDAVQLIDSPDRALVTGLLKLDQYVDMIVPRGGQALQRLCAEQATIPVILGGIGICHLYVDKH
ADLERALEVIANAKVQRPTVCNALDTLLVDNAVAERFVPQIAEYLHRLGVRFSVCEQSYALLDGLGFDISPATEQSFATE
WLSLALGIKVVNDIDTAIAHIRTYSSGHSEAILTDDIHTATHFMNEVNSAAVYVNASTRFTDGGQFGLGAEVAVSTQKLH
ARGPMGLEALTTYKWLAWGDYTSRA

Sequences:

>Translated_425_residues
MSQTNQAQYLQQLGSQAKQASYALANLSAAQKADLLEAIAEALTQNTQAILAANAKDVAAAKAEGLNDAMIDRLLLNESR
LAGIIGDIGDVVRLADPVGEEFGSRVLDNGLRLTRRRVPLGVIGVIYEARPNVTVDIAVLALKTGNAVILRGGKETLESN
KLISEVIRGAIASQGLPVDAVQLIDSPDRALVTGLLKLDQYVDMIVPRGGQALQRLCAEQATIPVILGGIGICHLYVDKH
ADLERALEVIANAKVQRPTVCNALDTLLVDNAVAERFVPQIAEYLHRLGVRFSVCEQSYALLDGLGFDISPATEQSFATE
WLSLALGIKVVNDIDTAIAHIRTYSSGHSEAILTDDIHTATHFMNEVNSAAVYVNASTRFTDGGQFGLGAEVAVSTQKLH
ARGPMGLEALTTYKWLAWGDYTSRA
>Mature_424_residues
SQTNQAQYLQQLGSQAKQASYALANLSAAQKADLLEAIAEALTQNTQAILAANAKDVAAAKAEGLNDAMIDRLLLNESRL
AGIIGDIGDVVRLADPVGEEFGSRVLDNGLRLTRRRVPLGVIGVIYEARPNVTVDIAVLALKTGNAVILRGGKETLESNK
LISEVIRGAIASQGLPVDAVQLIDSPDRALVTGLLKLDQYVDMIVPRGGQALQRLCAEQATIPVILGGIGICHLYVDKHA
DLERALEVIANAKVQRPTVCNALDTLLVDNAVAERFVPQIAEYLHRLGVRFSVCEQSYALLDGLGFDISPATEQSFATEW
LSLALGIKVVNDIDTAIAHIRTYSSGHSEAILTDDIHTATHFMNEVNSAAVYVNASTRFTDGGQFGLGAEVAVSTQKLHA
RGPMGLEALTTYKWLAWGDYTSRA

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI62912457, Length=413, Percent_Identity=37.2881355932203, Blast_Score=258, Evalue=1e-68,
Organism=Homo sapiens, GI21361368, Length=413, Percent_Identity=37.2881355932203, Blast_Score=258, Evalue=1e-68,
Organism=Escherichia coli, GI1786438, Length=416, Percent_Identity=58.6538461538462, Blast_Score=491, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17569967, Length=415, Percent_Identity=35.9036144578313, Blast_Score=264, Evalue=5e-71,
Organism=Caenorhabditis elegans, GI17569969, Length=415, Percent_Identity=35.9036144578313, Blast_Score=264, Evalue=6e-71,
Organism=Saccharomyces cerevisiae, GI6324899, Length=431, Percent_Identity=38.7470997679814, Blast_Score=288, Evalue=8e-79,
Organism=Drosophila melanogaster, GI21357643, Length=421, Percent_Identity=35.8669833729216, Blast_Score=257, Evalue=1e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 45503; Mature: 45372

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQTNQAQYLQQLGSQAKQASYALANLSAAQKADLLEAIAEALTQNTQAILAANAKDVAA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHH
AKAEGLNDAMIDRLLLNESRLAGIIGDIGDVVRLADPVGEEFGSRVLDNGLRLTRRRVPL
HHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCE
GVIGVIYEARPNVTVDIAVLALKTGNAVILRGGKETLESNKLISEVIRGAIASQGLPVDA
EEEEEEEECCCCCEEEEEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHH
VQLIDSPDRALVTGLLKLDQYVDMIVPRGGQALQRLCAEQATIPVILGGIGICHLYVDKH
HHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEECCCEEEEEEECCC
ADLERALEVIANAKVQRPTVCNALDTLLVDNAVAERFVPQIAEYLHRLGVRFSVCEQSYA
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
LLDGLGFDISPATEQSFATEWLSLALGIKVVNDIDTAIAHIRTYSSGHSEAILTDDIHTA
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHH
THFMNEVNSAAVYVNASTRFTDGGQFGLGAEVAVSTQKLHARGPMGLEALTTYKWLAWGD
HHHHHHCCCEEEEEECCCEECCCCCCCCCCCEEEEHHHHHCCCCCCHHHHHHHHHEEECC
YTSRA
CCCCC
>Mature Secondary Structure 
SQTNQAQYLQQLGSQAKQASYALANLSAAQKADLLEAIAEALTQNTQAILAANAKDVAA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHH
AKAEGLNDAMIDRLLLNESRLAGIIGDIGDVVRLADPVGEEFGSRVLDNGLRLTRRRVPL
HHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCE
GVIGVIYEARPNVTVDIAVLALKTGNAVILRGGKETLESNKLISEVIRGAIASQGLPVDA
EEEEEEEECCCCCEEEEEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHH
VQLIDSPDRALVTGLLKLDQYVDMIVPRGGQALQRLCAEQATIPVILGGIGICHLYVDKH
HHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEECCCEEEEEEECCC
ADLERALEVIANAKVQRPTVCNALDTLLVDNAVAERFVPQIAEYLHRLGVRFSVCEQSYA
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
LLDGLGFDISPATEQSFATEWLSLALGIKVVNDIDTAIAHIRTYSSGHSEAILTDDIHTA
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHH
THFMNEVNSAAVYVNASTRFTDGGQFGLGAEVAVSTQKLHARGPMGLEALTTYKWLAWGD
HHHHHHCCCEEEEEECCCEECCCCCCCCCCCEEEEHHHHHCCCCCCHHHHHHHHHEEECC
YTSRA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]