Click here to switch to the map view.

The map label for this gene is rmlA2 [C]

Identifier: 113969254

GI number: 113969254

Start: 1061737

End: 1062405

Strand: Direct

Name: rmlA2 [C]

Synonym: Shewmr4_0910

Alternate gene names: 113969254

Gene position: 1061737-1062405 (Clockwise)

Preceding gene: 113969253

Following gene: 113969255

Centisome position: 22.56

GC content: 52.62

Gene sequence:

>669_bases
ATGAAGGCCATGATCCTAGCCGCAGGTAGGGGAGAGCGTTTACGCCCTTTGACCGACACCCTACCCAAACCTTTAGTGCC
CGTCTTAGGTAAACCGCTGATTGTGTACCATATCGAGAAGTTGGCCGCGGTGGGGATTGTGGATATTGTGATTAATCATG
CTTGGCTCGGGCATAAGCTGGTAGAAACCTTAGGCGATGGTCACGCCTTTGGGGTCAAAATCCAATATAGCGCTGAAGCA
TCGGCCCTCGAAACCGGAGGCGGAATTAAGCAGGCCTTATCTTTGCTGACTGACGGCGACTCGGATGCGCCGTTTTTAGT
GCTCAATGGTGATGTGTTTATCGATGCCTTGCCGACGATTACCCCCTTAGCGGATACTGCTCTGGCGCATTTATGGTTGG
TGCCGAATCCCGAGCAACATCCAAACGGTGACTTTGCCTTGGAACAGGGCCTTGTACGTGAGCAGGGTGAGCAAAAATAC
ACTTTCTCTGGCATGGGTTTATATCGCCCATCATTATTTGATGGCACGCCGGATGATGCCTTTGCCCTTGGGCCTTTGCT
GCGGGCTAAAATGGCCGATGGCTTGATCACCGGGGCACACTTTAATGGACTCTGGTGCGATGTCGGGACGATTGCACGTC
TGCAAGCATTAGAGTCAGCGCTGGCGTAA

Upstream 100 bases:

>100_bases
ACCTTTATCCAGCGCTCACACCATTTTCCGCTTGGGTGCAATCGCGCATAGTGCCTGCGTTTATGGCCAAGGGAAAAGAT
ACTCAGCAGGGAGACAAGCA

Downstream 100 bases:

>100_bases
TGGCAAGGCATATCGCCTTATCGCCTAACGCCTAAGGTTTAGCGCCTTGAGTGAACGGTTTCACTCGCCATGTCGATTGA
CTGAATAAATTATCAAATTG

Product: nucleotidyl transferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MKAMILAAGRGERLRPLTDTLPKPLVPVLGKPLIVYHIEKLAAVGIVDIVINHAWLGHKLVETLGDGHAFGVKIQYSAEA
SALETGGGIKQALSLLTDGDSDAPFLVLNGDVFIDALPTITPLADTALAHLWLVPNPEQHPNGDFALEQGLVREQGEQKY
TFSGMGLYRPSLFDGTPDDAFALGPLLRAKMADGLITGAHFNGLWCDVGTIARLQALESALA

Sequences:

>Translated_222_residues
MKAMILAAGRGERLRPLTDTLPKPLVPVLGKPLIVYHIEKLAAVGIVDIVINHAWLGHKLVETLGDGHAFGVKIQYSAEA
SALETGGGIKQALSLLTDGDSDAPFLVLNGDVFIDALPTITPLADTALAHLWLVPNPEQHPNGDFALEQGLVREQGEQKY
TFSGMGLYRPSLFDGTPDDAFALGPLLRAKMADGLITGAHFNGLWCDVGTIARLQALESALA
>Mature_222_residues
MKAMILAAGRGERLRPLTDTLPKPLVPVLGKPLIVYHIEKLAAVGIVDIVINHAWLGHKLVETLGDGHAFGVKIQYSAEA
SALETGGGIKQALSLLTDGDSDAPFLVLNGDVFIDALPTITPLADTALAHLWLVPNPEQHPNGDFALEQGLVREQGEQKY
TFSGMGLYRPSLFDGTPDDAFALGPLLRAKMADGLITGAHFNGLWCDVGTIARLQALESALA

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=116, Percent_Identity=38.7931034482759, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI11761619, Length=116, Percent_Identity=38.7931034482759, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI31881779, Length=245, Percent_Identity=30.2040816326531, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI45447090, Length=245, Percent_Identity=30.2040816326531, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI133931050, Length=227, Percent_Identity=29.0748898678414, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320148, Length=131, Percent_Identity=42.7480916030534, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21355443, Length=115, Percent_Identity=34.7826086956522, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24644084, Length=115, Percent_Identity=34.7826086956522, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24653912, Length=122, Percent_Identity=38.5245901639344, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 23621; Mature: 23621

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAMILAAGRGERLRPLTDTLPKPLVPVLGKPLIVYHIEKLAAVGIVDIVINHAWLGHKL
CCEEEEECCCCCCCCCHHHHCCCCCHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHH
VETLGDGHAFGVKIQYSAEASALETGGGIKQALSLLTDGDSDAPFLVLNGDVFIDALPTI
HHHHCCCCEEEEEEEECCCCCHHHCCCCHHHHHHHHCCCCCCCCEEEEECCEEEECCCCC
TPLADTALAHLWLVPNPEQHPNGDFALEQGLVREQGEQKYTFSGMGLYRPSLFDGTPDDA
CHHHHHHHHEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCH
FALGPLLRAKMADGLITGAHFNGLWCDVGTIARLQALESALA
HHHHHHHHHHHHCCEEECCCCCCEEECHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKAMILAAGRGERLRPLTDTLPKPLVPVLGKPLIVYHIEKLAAVGIVDIVINHAWLGHKL
CCEEEEECCCCCCCCCHHHHCCCCCHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHH
VETLGDGHAFGVKIQYSAEASALETGGGIKQALSLLTDGDSDAPFLVLNGDVFIDALPTI
HHHHCCCCEEEEEEEECCCCCHHHCCCCHHHHHHHHCCCCCCCCEEEEECCEEEECCCCC
TPLADTALAHLWLVPNPEQHPNGDFALEQGLVREQGEQKYTFSGMGLYRPSLFDGTPDDA
CHHHHHHHHEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCH
FALGPLLRAKMADGLITGAHFNGLWCDVGTIARLQALESALA
HHHHHHHHHHHHCCEEECCCCCCEEECHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA