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The map label for this gene is lysC [H]

Identifier: 113968997

GI number: 113968997

Start: 761028

End: 762383

Strand: Direct

Name: lysC [H]

Synonym: Shewmr4_0653

Alternate gene names: 113968997

Gene position: 761028-762383 (Clockwise)

Preceding gene: 113968996

Following gene: 113968998

Centisome position: 16.17

GC content: 52.95

Gene sequence:

>1356_bases
ATGTCTCTTGTTGTCGCAAAATTTGGTGGTACCTCTGTCGCCGATTACGGTGCAATGAATCGCTGCGCCGATATCGTACT
GGGCAATCCCGATTGCCGTTTAGTGGTGGTTAGCGCCTCCAGTGGCGTGACTAACCTCTTGGTTGAACTCACTCAAGAGT
CGATGAATGACGATGGTCGTTTACAGCGCTTAAAGCAAATAGCCCAAATTCAATACGCTATCTTAGATAAACTGGGTCGC
CCCAACGATGTAGCTGCGGCATTGGATAAGCTGTTAAGTCGTATGGCGGTATTGAGCGAAGCGCTGGCATCCCAACGCAG
CAAGGCCACCATGGATGAGTTATTGTCCCTTGGCGAGCAGTGTTCGTCGGCATTATTTGCGGCGGTATTGCGCGAAAAAG
GCGCCAACTCGAGTGCCTTCGATGTGCGCCGAGTGCTGCGCACCGACAGCCATTTTGGCCGCGCCGAGCCACAGGTTGAG
CAAATTGCCATTCTCTCTCGTGAGCATTTACTGCCGCTGTTATCTGAACAAGTGATTGTGACTCAAGGCTTTATTGGTTC
AGATGAGGCCGGACAAACCACCACACTTGGCCGTGGCGGTAGCGACTATTCTGCGGCACTGTTAGCCGAAGCCTTAAAAG
CCTCTGCGGTTGAGATTTGGACCGATGTGGCCGGGATTTACACGACCGATCCGCGTCTTGCGCCAAACGCCCATCCTATT
GCCGAAATCAGTTTTAACGAAGCCGCCGAAATGGCGACTTTTGGTGCCAAAGTGCTGCACCCTGCGACGATCCTGCCTGC
GGTGCGCCAGCAAATTCAAGTGTTTGTCGGTTCGAGTAAGGAGCCTGAAAAGGGAGGCACTTGGATCCGTCATCAGGTTG
AAGATGCGCCTGTATTTCGTGCGGTTGCGCTGCGCCGCGACCAAACGCTACTCAATTTACACAGCCTGCAAATGTTGCAT
GCTCAGGGCTTCTTGGCTGAAACCTTTGCCACACTGGCAAGGCATAAGATCAGTGTGGATTTGATCACCACTTCAGAAGT
TAACGTATCGCTGACCCTAGATAAAACCGGCTCGGATTCAAGCGGCCAAGGGCTGTTGAGCGAGGCGTTGCTGCAGGAAT
TATCACAGCATTGCCGTGTACGTGTTGAAGATGGTTTAGCACTGGTGGCGATTATCGGTAACCGTATTGCCACCACTGCG
GGCATTTGCCGCCGGGTGTTTGAAGTGCTTGAGCCCCACAATGTGCGTATGATCTGCCAAGGCGCCAGCCCGCATAATTT
GTGCGTATTGGTCGCCGAATCAGAAGCGGCGCAAGTGGTTAAAGCACTGCACGAAAACCTGTTCGAAGGCGCGTAA

Upstream 100 bases:

>100_bases
AGGCTCTTCGAACGAAGTTGGTTCGGAGCGTAATCATGTTAGTTAATCAAGATCTTATCCTAGTTTGTGCCGTGTCTTCT
GCTTCTGCGGAGGTACGATA

Downstream 100 bases:

>100_bases
TATGCAACCGACTGCGTCGTCTTTAACCATTGGGGAGCTTGCCGCAGGGCAAGCACTCACTCTGCCGATTTACCACTTCA
AGCCAAGTGGTCATGTTTCT

Product: aspartate kinase III

Products: NA

Alternate protein names: Aspartate kinase III; AKIII; Lysine-sensitive aspartokinase III [H]

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MSLVVAKFGGTSVADYGAMNRCADIVLGNPDCRLVVVSASSGVTNLLVELTQESMNDDGRLQRLKQIAQIQYAILDKLGR
PNDVAAALDKLLSRMAVLSEALASQRSKATMDELLSLGEQCSSALFAAVLREKGANSSAFDVRRVLRTDSHFGRAEPQVE
QIAILSREHLLPLLSEQVIVTQGFIGSDEAGQTTTLGRGGSDYSAALLAEALKASAVEIWTDVAGIYTTDPRLAPNAHPI
AEISFNEAAEMATFGAKVLHPATILPAVRQQIQVFVGSSKEPEKGGTWIRHQVEDAPVFRAVALRRDQTLLNLHSLQMLH
AQGFLAETFATLARHKISVDLITTSEVNVSLTLDKTGSDSSGQGLLSEALLQELSQHCRVRVEDGLALVAIIGNRIATTA
GICRRVFEVLEPHNVRMICQGASPHNLCVLVAESEAAQVVKALHENLFEGA

Sequences:

>Translated_451_residues
MSLVVAKFGGTSVADYGAMNRCADIVLGNPDCRLVVVSASSGVTNLLVELTQESMNDDGRLQRLKQIAQIQYAILDKLGR
PNDVAAALDKLLSRMAVLSEALASQRSKATMDELLSLGEQCSSALFAAVLREKGANSSAFDVRRVLRTDSHFGRAEPQVE
QIAILSREHLLPLLSEQVIVTQGFIGSDEAGQTTTLGRGGSDYSAALLAEALKASAVEIWTDVAGIYTTDPRLAPNAHPI
AEISFNEAAEMATFGAKVLHPATILPAVRQQIQVFVGSSKEPEKGGTWIRHQVEDAPVFRAVALRRDQTLLNLHSLQMLH
AQGFLAETFATLARHKISVDLITTSEVNVSLTLDKTGSDSSGQGLLSEALLQELSQHCRVRVEDGLALVAIIGNRIATTA
GICRRVFEVLEPHNVRMICQGASPHNLCVLVAESEAAQVVKALHENLFEGA
>Mature_450_residues
SLVVAKFGGTSVADYGAMNRCADIVLGNPDCRLVVVSASSGVTNLLVELTQESMNDDGRLQRLKQIAQIQYAILDKLGRP
NDVAAALDKLLSRMAVLSEALASQRSKATMDELLSLGEQCSSALFAAVLREKGANSSAFDVRRVLRTDSHFGRAEPQVEQ
IAILSREHLLPLLSEQVIVTQGFIGSDEAGQTTTLGRGGSDYSAALLAEALKASAVEIWTDVAGIYTTDPRLAPNAHPIA
EISFNEAAEMATFGAKVLHPATILPAVRQQIQVFVGSSKEPEKGGTWIRHQVEDAPVFRAVALRRDQTLLNLHSLQMLHA
QGFLAETFATLARHKISVDLITTSEVNVSLTLDKTGSDSSGQGLLSEALLQELSQHCRVRVEDGLALVAIIGNRIATTAG
ICRRVFEVLEPHNVRMICQGASPHNLCVLVAESEAAQVVKALHENLFEGA

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790455, Length=447, Percent_Identity=60.8501118568233, Blast_Score=498, Evalue=1e-142,
Organism=Escherichia coli, GI1786183, Length=466, Percent_Identity=30.68669527897, Blast_Score=185, Evalue=4e-48,
Organism=Escherichia coli, GI1790376, Length=461, Percent_Identity=28.1995661605206, Blast_Score=141, Evalue=9e-35,
Organism=Saccharomyces cerevisiae, GI6320893, Length=498, Percent_Identity=28.3132530120482, Blast_Score=160, Evalue=4e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 48429; Mature: 48298

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLVVAKFGGTSVADYGAMNRCADIVLGNPDCRLVVVSASSGVTNLLVELTQESMNDDGR
CCEEEEECCCCCHHHHHHHHHHHHHEECCCCCEEEEEECCCCHHHHHHHHHHHHCCCCHH
LQRLKQIAQIQYAILDKLGRPNDVAAALDKLLSRMAVLSEALASQRSKATMDELLSLGEQ
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CSSALFAAVLREKGANSSAFDVRRVLRTDSHFGRAEPQVEQIAILSREHLLPLLSEQVIV
HHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEE
TQGFIGSDEAGQTTTLGRGGSDYSAALLAEALKASAVEIWTDVAGIYTTDPRLAPNAHPI
EECCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCE
AEISFNEAAEMATFGAKVLHPATILPAVRQQIQVFVGSSKEPEKGGTWIRHQVEDAPVFR
EEECHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCHHHH
AVALRRDQTLLNLHSLQMLHAQGFLAETFATLARHKISVDLITTSEVNVSLTLDKTGSDS
HHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHEEEEEEEEECCEEEEEEEECCCCCC
SGQGLLSEALLQELSQHCRVRVEDGLALVAIIGNRIATTAGICRRVFEVLEPHNVRMICQ
CCCHHHHHHHHHHHHHHCCEEECCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEE
GASPHNLCVLVAESEAAQVVKALHENLFEGA
CCCCCCEEEEEECCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SLVVAKFGGTSVADYGAMNRCADIVLGNPDCRLVVVSASSGVTNLLVELTQESMNDDGR
CEEEEECCCCCHHHHHHHHHHHHHEECCCCCEEEEEECCCCHHHHHHHHHHHHCCCCHH
LQRLKQIAQIQYAILDKLGRPNDVAAALDKLLSRMAVLSEALASQRSKATMDELLSLGEQ
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CSSALFAAVLREKGANSSAFDVRRVLRTDSHFGRAEPQVEQIAILSREHLLPLLSEQVIV
HHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEE
TQGFIGSDEAGQTTTLGRGGSDYSAALLAEALKASAVEIWTDVAGIYTTDPRLAPNAHPI
EECCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCE
AEISFNEAAEMATFGAKVLHPATILPAVRQQIQVFVGSSKEPEKGGTWIRHQVEDAPVFR
EEECHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCHHHH
AVALRRDQTLLNLHSLQMLHAQGFLAETFATLARHKISVDLITTSEVNVSLTLDKTGSDS
HHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHEEEEEEEEECCEEEEEEEECCCCCC
SGQGLLSEALLQELSQHCRVRVEDGLALVAIIGNRIATTAGICRRVFEVLEPHNVRMICQ
CCCHHHHHHHHHHHHHHCCEEECCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEE
GASPHNLCVLVAESEAAQVVKALHENLFEGA
CCCCCCEEEEEECCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3003049; 8265357; 9278503; 6312411 [H]