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The map label for this gene is gltP [H]

Identifier: 113968986

GI number: 113968986

Start: 747496

End: 748746

Strand: Direct

Name: gltP [H]

Synonym: Shewmr4_0642

Alternate gene names: 113968986

Gene position: 747496-748746 (Clockwise)

Preceding gene: 113968985

Following gene: 113968994

Centisome position: 15.88

GC content: 50.52

Gene sequence:

>1251_bases
ATGATTAAATCACTTTCGACACGGATCTTTATCGGTCTGTTTGCGGGACTTATTCTCGGCACCTTAGTGCAATATTTTCT
AAACGATATTGGCTTCTTTTCTGGCAATTTAGTCGAACTGGCTGGCGGCGTCGGCACTATGTTCGTCAATATGATCATGA
TGTTGGTCGTACCGCTGGTGTTTGTCAGTATCGTTTGCGGCGTGTGTGAGCTGCAGGACTTAAAAAGCTTTGGGCGCCTT
GGCGGCAAAACCTTCGGCTTTTACATCGTTAATACCGTGGTCGCTATCTCAACCGCCCTATTAGTCGTATTACTGCTCGA
CCCAGGTAAAGGCGTCGATATGAGCAGCACTGATGGGGTGGCGATTACCGCGACTGAACTTCCCAGCTTAATGGCGCTGC
TGATTGATATAGTGCCGCGCAACCCAGTGGCGGCTTTTATGTCGGGCAATATGCTGCAAGTGATCTTTATGGCACTGATG
CTGGGCGGGGTGATCAAATCCCTCGGCGAGCATGTGGCTGGCGCGGTACAAGGTTTTCAAACCGCCAATAAAATCATGAT
GAAACTGATTTCTGTGGTGATGAGCCTTGCGCCTTATGGTGTGTTTGCGCTGATGTTTAAGTTAGGCGCTACCTTAGATG
CGGCAGTATTTATGAGTGTGCTCGAATACGTCATGATCATTCTGGCGCTGCTATTACTGTGGATTTTTGTGGTCTATCCA
TTGGCAGTGGGTTTCTTCACACCGATTTCGGCCAAGAGCTTTCGCGAGAAAACCCAAGAGCAAGTGCTGTTTTCCCTGTC
TACCGCCAGCTCTAATGCCACGATTCCTGTGACCATGCGCACCCTAACGGAAAAGCTTGGGGTTAATCGCGCCGTGGCAG
GTTTTGGTGTGCCGCTTGGGGCGACCATGAACATGGGCGGCGTGGCGATTTATATCACGATTGCGATTTTCTTTGTCGCC
AATGCCTTCGGTATGCCAATCACCAGCGAGCAATTGCCATCGCTGCTGTTTAGTATCTTTTTATTATCTGTTGGCGCGGG
TGGTGTGCCCGGTGGCGGCATGGTGATGATTGGGGTATTAATCCATCAAATGGGCTTGCCGATTGAAGCCTTTGCGATTG
TGGCCGCACTGGACCGCATCATCGACATGGTGCTGACCTCCTGCAACGTGGTGGGGGATACGGCGGTGTTGACCATAGTC
GACCAAACCGAAAAGACCCATCAAGTCGAGCTAGTCGATAGCGAGTCTTAA

Upstream 100 bases:

>100_bases
CATGTTTCACTATCCCCGCCTGAACCGAAAAGGGAATGGCGATTTTGCTCATCAAGGAAGATGAATAATAAAAGATGAGC
TATTTGGGGAAACCATAAGC

Downstream 100 bases:

>100_bases
ATCGCATGTCCCGTCCTAAGATAGGTTGACAGTTTTTAGGCCAGCTCCAGTAGCTGGCCTTTTCTATTGTGCACCTGATT
AGGGGAGTCCATATTCAAAC

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MIKSLSTRIFIGLFAGLILGTLVQYFLNDIGFFSGNLVELAGGVGTMFVNMIMMLVVPLVFVSIVCGVCELQDLKSFGRL
GGKTFGFYIVNTVVAISTALLVVLLLDPGKGVDMSSTDGVAITATELPSLMALLIDIVPRNPVAAFMSGNMLQVIFMALM
LGGVIKSLGEHVAGAVQGFQTANKIMMKLISVVMSLAPYGVFALMFKLGATLDAAVFMSVLEYVMIILALLLLWIFVVYP
LAVGFFTPISAKSFREKTQEQVLFSLSTASSNATIPVTMRTLTEKLGVNRAVAGFGVPLGATMNMGGVAIYITIAIFFVA
NAFGMPITSEQLPSLLFSIFLLSVGAGGVPGGGMVMIGVLIHQMGLPIEAFAIVAALDRIIDMVLTSCNVVGDTAVLTIV
DQTEKTHQVELVDSES

Sequences:

>Translated_416_residues
MIKSLSTRIFIGLFAGLILGTLVQYFLNDIGFFSGNLVELAGGVGTMFVNMIMMLVVPLVFVSIVCGVCELQDLKSFGRL
GGKTFGFYIVNTVVAISTALLVVLLLDPGKGVDMSSTDGVAITATELPSLMALLIDIVPRNPVAAFMSGNMLQVIFMALM
LGGVIKSLGEHVAGAVQGFQTANKIMMKLISVVMSLAPYGVFALMFKLGATLDAAVFMSVLEYVMIILALLLLWIFVVYP
LAVGFFTPISAKSFREKTQEQVLFSLSTASSNATIPVTMRTLTEKLGVNRAVAGFGVPLGATMNMGGVAIYITIAIFFVA
NAFGMPITSEQLPSLLFSIFLLSVGAGGVPGGGMVMIGVLIHQMGLPIEAFAIVAALDRIIDMVLTSCNVVGDTAVLTIV
DQTEKTHQVELVDSES
>Mature_416_residues
MIKSLSTRIFIGLFAGLILGTLVQYFLNDIGFFSGNLVELAGGVGTMFVNMIMMLVVPLVFVSIVCGVCELQDLKSFGRL
GGKTFGFYIVNTVVAISTALLVVLLLDPGKGVDMSSTDGVAITATELPSLMALLIDIVPRNPVAAFMSGNMLQVIFMALM
LGGVIKSLGEHVAGAVQGFQTANKIMMKLISVVMSLAPYGVFALMFKLGATLDAAVFMSVLEYVMIILALLLLWIFVVYP
LAVGFFTPISAKSFREKTQEQVLFSLSTASSNATIPVTMRTLTEKLGVNRAVAGFGVPLGATMNMGGVAIYITIAIFFVA
NAFGMPITSEQLPSLLFSIFLLSVGAGGVPGGGMVMIGVLIHQMGLPIEAFAIVAALDRIIDMVLTSCNVVGDTAVLTIV
DQTEKTHQVELVDSES

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI40254478, Length=471, Percent_Identity=26.7515923566879, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI169790839, Length=426, Percent_Identity=25.5868544600939, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI21314632, Length=426, Percent_Identity=26.5258215962441, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI194239697, Length=444, Percent_Identity=24.7747747747748, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4827012, Length=239, Percent_Identity=30.1255230125523, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI5032093, Length=399, Percent_Identity=26.5664160401003, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI66773030, Length=270, Percent_Identity=30, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI223468566, Length=283, Percent_Identity=27.5618374558304, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI223468564, Length=274, Percent_Identity=27.3722627737226, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI262359914, Length=364, Percent_Identity=25.5494505494505, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI301601644, Length=122, Percent_Identity=36.0655737704918, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1790514, Length=419, Percent_Identity=30.0715990453461, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1789947, Length=423, Percent_Identity=27.4231678486998, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1788024, Length=394, Percent_Identity=29.1878172588832, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1789473, Length=403, Percent_Identity=28.0397022332506, Blast_Score=95, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI71983106, Length=427, Percent_Identity=28.3372365339578, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI71983099, Length=427, Percent_Identity=28.3372365339578, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17537407, Length=415, Percent_Identity=26.5060240963855, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI193206505, Length=430, Percent_Identity=25.3488372093023, Blast_Score=131, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI193206654, Length=449, Percent_Identity=26.7260579064588, Blast_Score=131, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI71996953, Length=427, Percent_Identity=26.463700234192, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17541374, Length=403, Percent_Identity=24.8138957816377, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24583025, Length=445, Percent_Identity=24.9438202247191, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17137668, Length=445, Percent_Identity=24.9438202247191, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24583023, Length=445, Percent_Identity=24.9438202247191, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI281360481, Length=453, Percent_Identity=22.9580573951435, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI281360483, Length=453, Percent_Identity=22.9580573951435, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI17137666, Length=453, Percent_Identity=22.9580573951435, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 44027; Mature: 44027

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
6.0 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
6.0 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCEEEEECCCC
>Mature Secondary Structure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HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]