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The map label for this gene is fhs [H]

Identifier: 113968905

GI number: 113968905

Start: 643936

End: 645648

Strand: Direct

Name: fhs [H]

Synonym: Shewmr4_0561

Alternate gene names: 113968905

Gene position: 643936-645648 (Clockwise)

Preceding gene: 113968903

Following gene: 113968907

Centisome position: 13.68

GC content: 53.36

Gene sequence:

>1713_bases
ATGCTAACCGATATGGATATTTCGCGCCGTGCGCCCCTAAAAGATATCGCAGTGCTTGGCGCCGAGTTTGGGTTATTGCC
CGATGAGATGCAGCTATTTGGCAAGACAAAAGCCAAGGTCGATTTACGTGTGCAGCAGCGCTTAGCAGAGCAGCAACAGG
GTAAGCTGATCATTGTCACCGCCGTGACACCAACGCCCCACGGCGAAGGCAAAACCGTCACCACCATTGGCTTAACCCAA
TCCCTCAAAGCGCTTGGTAACAAGGTGTGCGCCTGTATTCGCCAGCCCAGTATGGGCCCGGTATTTGGGGTGAAAGGTGG
TGCAGCTGGTGGCGGTTACGCCCAAGTGGTGCCCATGCAGGAGCTGAATCTGCATCTAACGGGTGATATTCATGCCGTCA
GCAATGCCCATAATCTTGGCGCGGCGGCGATAGCCTCTCGGCTATATCATGAAACACGTTTAGGTAAGGCCGAATTTGAG
CTGCAGTCTGGGCAGAATTACCTAGATATAGCGCCTAATGGCATCCGTTGGCACAGGGTGGTCGACCATAACGATCGCTG
CTTACGTGAAATTGAAGTTGGGCTGGGTGAAAATAATGGCCCAGCTTACACCTCTGGCTTTGATATTACCGCTGCCTCTG
AGTTAATGGCGATTCTGGCGCTCAGTCGTAATCTGGCGGATATGCGCGCGCGTATTGGCAAGCTTGTGCTGGCAGTCAAT
CGTCAAGGTGCGGCTATTAGCGCGGAAGACCTTGGGGTTGCCGGCGCGATGACGGCGATCATGGCGGATGCGGTAAAACC
CACCTTGATGCAGACTTTAAACGGTGCGCCTTGTCTTATTCACGCAGGGCCATTTGCGAATATTGCCCATGGCAACTCGT
CGGTGATTGCCGACGATATCGCCTTAAAGCTGGCCGATTTTGTGGTGACGGAAGGCGGTTTTGGCTCCGATATGGGGTTT
GAGAAATTTTGTAATATCAAGGCGCGCCAGTCGGGATTAACCCCGAGCGCTGCGGTGTTAGTGACTACCTTAAAGGCATT
GAAGGCCAATAGCGGCTTAACGTCGGATGCGGATATCAATGCGCCCGACCAAGCCCGTCTCGAGGCGGGATTTGCCAACT
TAAACTGGCATATCAACAATGTGGCGCGTTACGGTATTCCCGTTGTGGTGGCTATTAATCGCTTTGCAACCGATACGGAT
GCCGAGCTTAACTGGTTGATTGAAGCCGTTGCGGGCACTGCCGCCTTTGGCTGCGAGCTTAGCGAGGCTTTCAGCCAAGG
TGAGGCGGGGGCATTGGCCTTGGCGCAAACCGTCATGCGCGCCTGTGAGCAGCCAAGCGAGTTTACCCTGCTATATCCCG
ATGACATGGCGCTTGAGGCGAAATTATCGACCTTAGCTGAAGTCGGCTATGGCGCTGCAGGGGTGAGTTTATCCGAGGCG
GCTAAGCTCCAATTACAAGAACTCAGTGCCCTTGGTTACGCCGATTTACCCGTCTGCATGGCAAAAACACCCTTATCCAT
TAGCCATGACCCTCAACTTAAAGGCGTACCGCAGGGTTTTATCGTGCCAGTGCGCGAGTTAGTGTTAAATGCTGGAGCCG
GATTTATTACCGCGCTGGTGGGGAATGTGATGACTATGCCAGGGCTTGGATTAGTTCCTGGCTATTTAAAGATTGATATC
GGCGCAGATGGCGAGATTACTGGCTTAGGTTAA

Upstream 100 bases:

>100_bases
ATCAGCCGTTGCTGATACTTACCGATTTTGCATACCTATTTTGTATTTCCTGCTCGCATGCCTAGCGTGGATACCAAAAT
ACCCAAGGGAGAGATGACCC

Downstream 100 bases:

>100_bases
TCGATTAACAGTTTGAATATCATGAAAAAGGCGCAATCTAGGATTGCGCCTTTTGTTTACTTCTCGCCTTGGCGAAGCGT
TATTTACTGGTTTGGTAAAT

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS [H]

Number of amino acids: Translated: 570; Mature: 570

Protein sequence:

>570_residues
MLTDMDISRRAPLKDIAVLGAEFGLLPDEMQLFGKTKAKVDLRVQQRLAEQQQGKLIIVTAVTPTPHGEGKTVTTIGLTQ
SLKALGNKVCACIRQPSMGPVFGVKGGAAGGGYAQVVPMQELNLHLTGDIHAVSNAHNLGAAAIASRLYHETRLGKAEFE
LQSGQNYLDIAPNGIRWHRVVDHNDRCLREIEVGLGENNGPAYTSGFDITAASELMAILALSRNLADMRARIGKLVLAVN
RQGAAISAEDLGVAGAMTAIMADAVKPTLMQTLNGAPCLIHAGPFANIAHGNSSVIADDIALKLADFVVTEGGFGSDMGF
EKFCNIKARQSGLTPSAAVLVTTLKALKANSGLTSDADINAPDQARLEAGFANLNWHINNVARYGIPVVVAINRFATDTD
AELNWLIEAVAGTAAFGCELSEAFSQGEAGALALAQTVMRACEQPSEFTLLYPDDMALEAKLSTLAEVGYGAAGVSLSEA
AKLQLQELSALGYADLPVCMAKTPLSISHDPQLKGVPQGFIVPVRELVLNAGAGFITALVGNVMTMPGLGLVPGYLKIDI
GADGEITGLG

Sequences:

>Translated_570_residues
MLTDMDISRRAPLKDIAVLGAEFGLLPDEMQLFGKTKAKVDLRVQQRLAEQQQGKLIIVTAVTPTPHGEGKTVTTIGLTQ
SLKALGNKVCACIRQPSMGPVFGVKGGAAGGGYAQVVPMQELNLHLTGDIHAVSNAHNLGAAAIASRLYHETRLGKAEFE
LQSGQNYLDIAPNGIRWHRVVDHNDRCLREIEVGLGENNGPAYTSGFDITAASELMAILALSRNLADMRARIGKLVLAVN
RQGAAISAEDLGVAGAMTAIMADAVKPTLMQTLNGAPCLIHAGPFANIAHGNSSVIADDIALKLADFVVTEGGFGSDMGF
EKFCNIKARQSGLTPSAAVLVTTLKALKANSGLTSDADINAPDQARLEAGFANLNWHINNVARYGIPVVVAINRFATDTD
AELNWLIEAVAGTAAFGCELSEAFSQGEAGALALAQTVMRACEQPSEFTLLYPDDMALEAKLSTLAEVGYGAAGVSLSEA
AKLQLQELSALGYADLPVCMAKTPLSISHDPQLKGVPQGFIVPVRELVLNAGAGFITALVGNVMTMPGLGLVPGYLKIDI
GADGEITGLG
>Mature_570_residues
MLTDMDISRRAPLKDIAVLGAEFGLLPDEMQLFGKTKAKVDLRVQQRLAEQQQGKLIIVTAVTPTPHGEGKTVTTIGLTQ
SLKALGNKVCACIRQPSMGPVFGVKGGAAGGGYAQVVPMQELNLHLTGDIHAVSNAHNLGAAAIASRLYHETRLGKAEFE
LQSGQNYLDIAPNGIRWHRVVDHNDRCLREIEVGLGENNGPAYTSGFDITAASELMAILALSRNLADMRARIGKLVLAVN
RQGAAISAEDLGVAGAMTAIMADAVKPTLMQTLNGAPCLIHAGPFANIAHGNSSVIADDIALKLADFVVTEGGFGSDMGF
EKFCNIKARQSGLTPSAAVLVTTLKALKANSGLTSDADINAPDQARLEAGFANLNWHINNVARYGIPVVVAINRFATDTD
AELNWLIEAVAGTAAFGCELSEAFSQGEAGALALAQTVMRACEQPSEFTLLYPDDMALEAKLSTLAEVGYGAAGVSLSEA
AKLQLQELSALGYADLPVCMAKTPLSISHDPQLKGVPQGFIVPVRELVLNAGAGFITALVGNVMTMPGLGLVPGYLKIDI
GADGEITGLG

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family [H]

Homologues:

Organism=Homo sapiens, GI222136639, Length=617, Percent_Identity=48.6223662884927, Blast_Score=509, Evalue=1e-144,
Organism=Homo sapiens, GI36796743, Length=612, Percent_Identity=46.4052287581699, Blast_Score=485, Evalue=1e-137,
Organism=Homo sapiens, GI310124614, Length=81, Percent_Identity=44.4444444444444, Blast_Score=81, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17568737, Length=620, Percent_Identity=48.0645161290323, Blast_Score=517, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI17568739, Length=620, Percent_Identity=48.0645161290323, Blast_Score=517, Evalue=1e-147,
Organism=Saccharomyces cerevisiae, GI6321643, Length=626, Percent_Identity=45.3674121405751, Blast_Score=478, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6319558, Length=629, Percent_Identity=42.7662957074722, Blast_Score=463, Evalue=1e-131,
Organism=Drosophila melanogaster, GI62472483, Length=618, Percent_Identity=44.4983818770227, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI45551871, Length=618, Percent_Identity=44.4983818770227, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24645718, Length=618, Percent_Identity=44.4983818770227, Blast_Score=467, Evalue=1e-132,
Organism=Drosophila melanogaster, GI17137370, Length=618, Percent_Identity=44.4983818770227, Blast_Score=467, Evalue=1e-132,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000559
- InterPro:   IPR020628 [H]

Pfam domain/function: PF01268 FTHFS [H]

EC number: =6.3.4.3 [H]

Molecular weight: Translated: 59683; Mature: 59683

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00721 FTHFS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTDMDISRRAPLKDIAVLGAEFGLLPDEMQLFGKTKAKVDLRVQQRLAEQQQGKLIIVT
CCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCEEHHHHHHHHHHHHCCCEEEEE
AVTPTPHGEGKTVTTIGLTQSLKALGNKVCACIRQPSMGPVFGVKGGAAGGGYAQVVPMQ
EECCCCCCCCCEEEEECHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCEEEEEHH
ELNLHLTGDIHAVSNAHNLGAAAIASRLYHETRLGKAEFELQSGQNYLDIAPNGIRWHRV
HCCEEEECCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCEEEECCCCEEEEEE
VDHNDRCLREIEVGLGENNGPAYTSGFDITAASELMAILALSRNLADMRARIGKLVLAVN
ECCCHHHHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHEEEEEE
RQGAAISAEDLGVAGAMTAIMADAVKPTLMQTLNGAPCLIHAGPFANIAHGNSSVIADDI
CCCCEECHHHCCHHHHHHHHHHHHCCHHHHHHCCCCCEEEECCCCCEECCCCCCEEHHHH
ALKLADFVVTEGGFGSDMGFEKFCNIKARQSGLTPSAAVLVTTLKALKANSGLTSDADIN
HHHHHHHHEECCCCCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCC
APDQARLEAGFANLNWHINNVARYGIPVVVAINRFATDTDAELNWLIEAVAGTAAFGCEL
CCCHHHHHCCCEEEEEEEECHHHHCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCH
SEAFSQGEAGALALAQTVMRACEQPSEFTLLYPDDMALEAKLSTLAEVGYGAAGVSLSEA
HHHHCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCHHHH
AKLQLQELSALGYADLPVCMAKTPLSISHDPQLKGVPQGFIVPVRELVLNAGAGFITALV
HHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHH
GNVMTMPGLGLVPGYLKIDIGADGEITGLG
HHHHHCCCCCCCCCEEEEEECCCCCEECCC
>Mature Secondary Structure
MLTDMDISRRAPLKDIAVLGAEFGLLPDEMQLFGKTKAKVDLRVQQRLAEQQQGKLIIVT
CCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCEEHHHHHHHHHHHHCCCEEEEE
AVTPTPHGEGKTVTTIGLTQSLKALGNKVCACIRQPSMGPVFGVKGGAAGGGYAQVVPMQ
EECCCCCCCCCEEEEECHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCEEEEEHH
ELNLHLTGDIHAVSNAHNLGAAAIASRLYHETRLGKAEFELQSGQNYLDIAPNGIRWHRV
HCCEEEECCEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCEEEECCCCEEEEEE
VDHNDRCLREIEVGLGENNGPAYTSGFDITAASELMAILALSRNLADMRARIGKLVLAVN
ECCCHHHHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHEEEEEE
RQGAAISAEDLGVAGAMTAIMADAVKPTLMQTLNGAPCLIHAGPFANIAHGNSSVIADDI
CCCCEECHHHCCHHHHHHHHHHHHCCHHHHHHCCCCCEEEECCCCCEECCCCCCEEHHHH
ALKLADFVVTEGGFGSDMGFEKFCNIKARQSGLTPSAAVLVTTLKALKANSGLTSDADIN
HHHHHHHHEECCCCCCCCCHHHHCCCHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCC
APDQARLEAGFANLNWHINNVARYGIPVVVAINRFATDTDAELNWLIEAVAGTAAFGCEL
CCCHHHHHCCCEEEEEEEECHHHHCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCH
SEAFSQGEAGALALAQTVMRACEQPSEFTLLYPDDMALEAKLSTLAEVGYGAAGVSLSEA
HHHHCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCHHHH
AKLQLQELSALGYADLPVCMAKTPLSISHDPQLKGVPQGFIVPVRELVLNAGAGFITALV
HHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHH
GNVMTMPGLGLVPGYLKIDIGADGEITGLG
HHHHHCCCCCCCCCEEEEEECCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]