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The map label for this gene is fkpA [H]

Identifier: 113968834

GI number: 113968834

Start: 562221

End: 563000

Strand: Direct

Name: fkpA [H]

Synonym: Shewmr4_0490

Alternate gene names: 113968834

Gene position: 562221-563000 (Clockwise)

Preceding gene: 113968833

Following gene: 113968835

Centisome position: 11.95

GC content: 48.08

Gene sequence:

>780_bases
ATGAAAATATCTATGCCAACTTCTTTTATCCCAAAAAACCTCACAGTGGCGACCTGCGCTGCATTGTTTGTCTCTATGGC
GAGCTTTGCTGCCCCAACGCTTAAAACCGATGCGGATAAAGCGTCTTACAGCATCGGCGCCTCTGTGGGTAATTACATTT
CTGGCCAGATTTATAACCAAGTCGAACTGGGCGCCGAAGTGAATGTGGACTTAGTGGTGAAGGGCTTTGTGGATGCGCTG
AAAAAACAGCAGCAATTAACCGATGAAGAAGTGCTGACCTATCTTAACCAACGCGCCGAACAGTTAAACCAAGTGAGAAA
GGCTAACGCCGAGAAGCTCGCTGCGGAAAACACTAAGGCAGGTGAAGCATATCTTGCTGAAAATAAGAAGAAATCAGGCG
TAACCGTTACAGAGTCAGGCCTGCAATACGAAGTGTTAACCCAAGGCTCTGGCAATAAACCCAACCCTGAAGATGTGGTC
ACCGTCGAGTACGTTGGCAAGCTTATCGATGGCACCGAGTTTGAAAATACCGTCGGCCGTGAGGAACCCACACGTTTCGC
CCTGATGACAGTCATCCCAGGTTGGGAAGAGGGCTTAAAACTCATGCCTATGGGCTCTAAATACCGTTTTGTTATCCCGG
CAGAGCTGGCCTATGGCAATGAGTTTGTCGGTGAAATCCCACCGCAATCCACCTTAATTTTTGAAATCGAACTGAAAAAT
ATCGAAAAGCCCAGCGAGAAAAAAGAAGCCCGCATGATGGGCATGATGCCTGCCCACTAA

Upstream 100 bases:

>100_bases
ACCATAGTAATCAAATAAATATTTTAATCGGTTATGGGGTTACCCATACGTTTTCGGCTAAAGCACTAAAGCCCAAGGGC
TAAATTGTAGAGAACATAAA

Downstream 100 bases:

>100_bases
GGGCTAAGCATTGGCTTAGGTTCAGTGAGTGATGAACTTGGATAGGCGAGCGTCGAGGTAAGGCATGGCAAGTTTAGGAT
TCAGCATAGCACTTCTGTTA

Product: FKBP-type peptidyl-prolyl isomerase domain-containing protein

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MKISMPTSFIPKNLTVATCAALFVSMASFAAPTLKTDADKASYSIGASVGNYISGQIYNQVELGAEVNVDLVVKGFVDAL
KKQQQLTDEEVLTYLNQRAEQLNQVRKANAEKLAAENTKAGEAYLAENKKKSGVTVTESGLQYEVLTQGSGNKPNPEDVV
TVEYVGKLIDGTEFENTVGREEPTRFALMTVIPGWEEGLKLMPMGSKYRFVIPAELAYGNEFVGEIPPQSTLIFEIELKN
IEKPSEKKEARMMGMMPAH

Sequences:

>Translated_259_residues
MKISMPTSFIPKNLTVATCAALFVSMASFAAPTLKTDADKASYSIGASVGNYISGQIYNQVELGAEVNVDLVVKGFVDAL
KKQQQLTDEEVLTYLNQRAEQLNQVRKANAEKLAAENTKAGEAYLAENKKKSGVTVTESGLQYEVLTQGSGNKPNPEDVV
TVEYVGKLIDGTEFENTVGREEPTRFALMTVIPGWEEGLKLMPMGSKYRFVIPAELAYGNEFVGEIPPQSTLIFEIELKN
IEKPSEKKEARMMGMMPAH
>Mature_259_residues
MKISMPTSFIPKNLTVATCAALFVSMASFAAPTLKTDADKASYSIGASVGNYISGQIYNQVELGAEVNVDLVVKGFVDAL
KKQQQLTDEEVLTYLNQRAEQLNQVRKANAEKLAAENTKAGEAYLAENKKKSGVTVTESGLQYEVLTQGSGNKPNPEDVV
TVEYVGKLIDGTEFENTVGREEPTRFALMTVIPGWEEGLKLMPMGSKYRFVIPAELAYGNEFVGEIPPQSTLIFEIELKN
IEKPSEKKEARMMGMMPAH

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI206725530, Length=97, Percent_Identity=44.3298969072165, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI17149844, Length=97, Percent_Identity=44.3298969072165, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI17149842, Length=97, Percent_Identity=44.3298969072165, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=37.3831775700935, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=37.3831775700935, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI8923659, Length=125, Percent_Identity=36, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI4758380, Length=107, Percent_Identity=34.5794392523364, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1789745, Length=218, Percent_Identity=40.3669724770642, Blast_Score=158, Evalue=3e-40,
Organism=Escherichia coli, GI87082390, Length=213, Percent_Identity=45.5399061032864, Blast_Score=156, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6324194, Length=107, Percent_Identity=37.3831775700935, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320727, Length=94, Percent_Identity=40.4255319148936, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323566, Length=113, Percent_Identity=34.5132743362832, Blast_Score=62, Evalue=8e-11,
Organism=Drosophila melanogaster, GI281363946, Length=102, Percent_Identity=41.1764705882353, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17352457, Length=102, Percent_Identity=41.1764705882353, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24655568, Length=107, Percent_Identity=36.4485981308411, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583150, Length=107, Percent_Identity=35.5140186915888, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 28383; Mature: 28383

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISMPTSFIPKNLTVATCAALFVSMASFAAPTLKTDADKASYSIGASVGNYISGQIYNQ
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHEECCCHHCCHHCCCCHHH
VELGAEVNVDLVVKGFVDALKKQQQLTDEEVLTYLNQRAEQLNQVRKANAEKLAAENTKA
EECCCCCCHHEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCC
GEAYLAENKKKSGVTVTESGLQYEVLTQGSGNKPNPEDVVTVEYVGKLIDGTEFENTVGR
CCHHHHCCCCCCCCEEEECCCEEEEEECCCCCCCCHHHEEEHHHHHHHHCCCCHHHHCCC
EEPTRFALMTVIPGWEEGLKLMPMGSKYRFVIPAELAYGNEFVGEIPPQSTLIFEIELKN
CCCCEEEEEEECCCHHHCCEEEECCCCEEEEEEHHHHCCCCCCCCCCCCCEEEEEEEECC
IEKPSEKKEARMMGMMPAH
CCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MKISMPTSFIPKNLTVATCAALFVSMASFAAPTLKTDADKASYSIGASVGNYISGQIYNQ
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHEECCCHHCCHHCCCCHHH
VELGAEVNVDLVVKGFVDALKKQQQLTDEEVLTYLNQRAEQLNQVRKANAEKLAAENTKA
EECCCCCCHHEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCC
GEAYLAENKKKSGVTVTESGLQYEVLTQGSGNKPNPEDVVTVEYVGKLIDGTEFENTVGR
CCHHHHCCCCCCCCEEEECCCEEEEEECCCCCCCCHHHEEEHHHHHHHHCCCCHHHHCCC
EEPTRFALMTVIPGWEEGLKLMPMGSKYRFVIPAELAYGNEFVGEIPPQSTLIFEIELKN
CCCCEEEEEEECCCHHHCCEEEECCCCEEEEEEHHHHCCCCCCCCCCCCCEEEEEEEECC
IEKPSEKKEARMMGMMPAH
CCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]