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The map label for this gene is ilvA [H]

Identifier: 113968709

GI number: 113968709

Start: 390978

End: 392651

Strand: Direct

Name: ilvA [H]

Synonym: Shewmr4_0365

Alternate gene names: 113968709

Gene position: 390978-392651 (Clockwise)

Preceding gene: 113968708

Following gene: 113968710

Centisome position: 8.31

GC content: 53.88

Gene sequence:

>1674_bases
ATGTTATCTCTCGCATCGTCGCAAACGGAGCAGGCTGAGGCCCAGTCCTCTCAAGTTCAATCCTCTCAAGTTCAGTCCGA
TAAGGCGCAATCGGGCACTTCTGCCTTAGAAAAGAGTCAGCTTGCGCAAAGCTACCTGCAAAAAATCCTGCTGTCGTCGG
TTTATGACGTTGCGAAAGTGACCCCACTCTCGAGCCTGAATAAACTCTCGGCGCGTTTGGGCTGCCAAGTATTTTTAAAG
CGTGAGGATATGCAGCCTGTGCATTCCTTCAAGCTGCGTGGCGCCTATAACCGTATCGCCCAGTTAAGCCAAGCCGAATG
TCAACGCGGCGTAGTGTGCGCCTCGGCGGGTAACCATGCTCAAGGCGTGGCCATGTCAGCGGCCAGTCGTGGTGTGGATG
CTGTGATTGTGATGCCCGAAACTACGCCAGATATTAAAGTCGATGCGGTGCGCCGCTTGGGTGGCAACGTGGTGTTGCAC
GGCCAAGCCTTCGATCAGGCCAATGGCTTTGCGATGGAGATGGCCGAGCAGGAGGGGCGGGTGTATATCGCCCCCTTCGA
TGACGAAGCCGTTATCGCAGGCCAAGGCACTATCGCCCAAGAAATGCTGCAACAGCAGCGCGACCTTGAAGTGGTATTTG
TACCCGTGGGCGGCGGTGGCTTAATTGCTGGGATTGCTGCCTATTACAAAGCGGTGATGCCACAGGTCAAAATTGTTGGG
GTGGAGCCTGAAGATGCGGCCTGCTTAAAAGCGGCGATGGAGGCGGGCGAGCCTGTCACACTCCCGCAGGTCGGCTTGTT
TGCCGATGGAGTCGCGGTTAAACGTATCGGCACCGAGCCATTTCGCCTAGCTAAGTGGTTTGTGGATGAAGTGGTGACGG
TAACGTCCGACGAGATCTGCGCCGCCGTTAAAGATATTTTTGAGGATACCCGCGCCATTGCCGAACCTGCAGGTGCTTTA
TCCCTTGCTGGGCTTAAAAAATATGTCAGCACCAATGCTACGGGCGAGAGTGGCAAGGGTGAGAAAGTCGCGGCGATTTT
AAGTGGCGCGAATGTGAACTTCCACAGCCTACGTTATGTGTCGGAGCGTTGCGAGTTGGGTGAGCAAAAAGAAGCCGTGC
TGGCGGTTAAAGTGCCCGAGCGTCCCGGCAGCTTCCTGCGTTTTTGTGAGTTGCTCGAAAAGCGGGTGATGACCGAATTT
AACTATCGTTTTAGCAGCCGCGATATGGCGGTGGTGTTTGCGGGTATTCGTTTGACCAAAGGCCATGGCGAATTAGAGCA
GATCATCAATACCTTAGAAGATAATGGCTTCGAGGTGCAGGACTTATCCGGTGACGAAACCGCGAAATTACATGTGCGCT
ATATGGTCGGTGGTCATCCGCCAGAGCCGTTAGAGGAGCGCCTATTTAGCTTCGAGTTTCCCGAGCATCCGGGGGCGCTG
CTGAAGTTTTTAACTACCCTGCAGAGCAAGTGGAATATCAGTTTATTCCATTACCGTAATCACGGCGCGGCCTTTGGGCG
AGTGCTGGCGGGGTTTGAAGTCCCCGAGGGCGATGCCTTGCCGTTTCAGCAGTTTTTAACTGAGCTGGGATTTGTCTATC
AAGAAGAGACGCAAAGCCCTGCTTATCAGCTGTTTTTGAATGCCGGAAAAGGGAAAAAGAGCCTGCCTTTGTAG

Upstream 100 bases:

>100_bases
CGTCAGCGTTATGTGTCGATGGCGCTCAAAGCCTACGCCATGCTTGCCACCAGTGCCGATAAGGGCGCGGTGCGCGATCG
CAGTAAGTTGGAGGACTGAT

Downstream 100 bases:

>100_bases
TCGCTTTGCTTTAGGTTACAACTTAGGCTAAAGGAGGGGCGCACAGGCGCCCCTTTTTGTGGTAGTTTGGTTTAACAAGT
TAAGAGTGAATGCTCTAGTC

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 557; Mature: 557

Protein sequence:

>557_residues
MLSLASSQTEQAEAQSSQVQSSQVQSDKAQSGTSALEKSQLAQSYLQKILLSSVYDVAKVTPLSSLNKLSARLGCQVFLK
REDMQPVHSFKLRGAYNRIAQLSQAECQRGVVCASAGNHAQGVAMSAASRGVDAVIVMPETTPDIKVDAVRRLGGNVVLH
GQAFDQANGFAMEMAEQEGRVYIAPFDDEAVIAGQGTIAQEMLQQQRDLEVVFVPVGGGGLIAGIAAYYKAVMPQVKIVG
VEPEDAACLKAAMEAGEPVTLPQVGLFADGVAVKRIGTEPFRLAKWFVDEVVTVTSDEICAAVKDIFEDTRAIAEPAGAL
SLAGLKKYVSTNATGESGKGEKVAAILSGANVNFHSLRYVSERCELGEQKEAVLAVKVPERPGSFLRFCELLEKRVMTEF
NYRFSSRDMAVVFAGIRLTKGHGELEQIINTLEDNGFEVQDLSGDETAKLHVRYMVGGHPPEPLEERLFSFEFPEHPGAL
LKFLTTLQSKWNISLFHYRNHGAAFGRVLAGFEVPEGDALPFQQFLTELGFVYQEETQSPAYQLFLNAGKGKKSLPL

Sequences:

>Translated_557_residues
MLSLASSQTEQAEAQSSQVQSSQVQSDKAQSGTSALEKSQLAQSYLQKILLSSVYDVAKVTPLSSLNKLSARLGCQVFLK
REDMQPVHSFKLRGAYNRIAQLSQAECQRGVVCASAGNHAQGVAMSAASRGVDAVIVMPETTPDIKVDAVRRLGGNVVLH
GQAFDQANGFAMEMAEQEGRVYIAPFDDEAVIAGQGTIAQEMLQQQRDLEVVFVPVGGGGLIAGIAAYYKAVMPQVKIVG
VEPEDAACLKAAMEAGEPVTLPQVGLFADGVAVKRIGTEPFRLAKWFVDEVVTVTSDEICAAVKDIFEDTRAIAEPAGAL
SLAGLKKYVSTNATGESGKGEKVAAILSGANVNFHSLRYVSERCELGEQKEAVLAVKVPERPGSFLRFCELLEKRVMTEF
NYRFSSRDMAVVFAGIRLTKGHGELEQIINTLEDNGFEVQDLSGDETAKLHVRYMVGGHPPEPLEERLFSFEFPEHPGAL
LKFLTTLQSKWNISLFHYRNHGAAFGRVLAGFEVPEGDALPFQQFLTELGFVYQEETQSPAYQLFLNAGKGKKSLPL
>Mature_557_residues
MLSLASSQTEQAEAQSSQVQSSQVQSDKAQSGTSALEKSQLAQSYLQKILLSSVYDVAKVTPLSSLNKLSARLGCQVFLK
REDMQPVHSFKLRGAYNRIAQLSQAECQRGVVCASAGNHAQGVAMSAASRGVDAVIVMPETTPDIKVDAVRRLGGNVVLH
GQAFDQANGFAMEMAEQEGRVYIAPFDDEAVIAGQGTIAQEMLQQQRDLEVVFVPVGGGGLIAGIAAYYKAVMPQVKIVG
VEPEDAACLKAAMEAGEPVTLPQVGLFADGVAVKRIGTEPFRLAKWFVDEVVTVTSDEICAAVKDIFEDTRAIAEPAGAL
SLAGLKKYVSTNATGESGKGEKVAAILSGANVNFHSLRYVSERCELGEQKEAVLAVKVPERPGSFLRFCELLEKRVMTEF
NYRFSSRDMAVVFAGIRLTKGHGELEQIINTLEDNGFEVQDLSGDETAKLHVRYMVGGHPPEPLEERLFSFEFPEHPGAL
LKFLTTLQSKWNISLFHYRNHGAAFGRVLAGFEVPEGDALPFQQFLTELGFVYQEETQSPAYQLFLNAGKGKKSLPL

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia. Deaminates L-threonine, but also L-serine to a lesser extent [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=340, Percent_Identity=32.6470588235294, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI19923959, Length=308, Percent_Identity=30.8441558441558, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI33469958, Length=310, Percent_Identity=28.0645161290323, Blast_Score=99, Evalue=7e-21,
Organism=Escherichia coli, GI1790207, Length=503, Percent_Identity=60.0397614314115, Blast_Score=603, Evalue=1e-174,
Organism=Escherichia coli, GI1789505, Length=306, Percent_Identity=38.2352941176471, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI1789235, Length=257, Percent_Identity=25.6809338521401, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI2367138, Length=206, Percent_Identity=27.6699029126214, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71991565, Length=327, Percent_Identity=35.1681957186544, Blast_Score=164, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17537387, Length=328, Percent_Identity=31.4024390243902, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17508781, Length=255, Percent_Identity=29.8039215686275, Blast_Score=118, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6320930, Length=513, Percent_Identity=51.0721247563353, Blast_Score=481, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6322631, Length=303, Percent_Identity=35.973597359736, Blast_Score=166, Evalue=8e-42,
Organism=Saccharomyces cerevisiae, GI6319788, Length=297, Percent_Identity=25.5892255892256, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21355833, Length=319, Percent_Identity=34.1692789968652, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24645328, Length=255, Percent_Identity=34.5098039215686, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24643623, Length=207, Percent_Identity=28.5024154589372, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI20129101, Length=207, Percent_Identity=28.5024154589372, Blast_Score=75, Evalue=9e-14,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 60417; Mature: 60417

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSLASSQTEQAEAQSSQVQSSQVQSDKAQSGTSALEKSQLAQSYLQKILLSSVYDVAKV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TPLSSLNKLSARLGCQVFLKREDMQPVHSFKLRGAYNRIAQLSQAECQRGVVCASAGNHA
CCHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCC
QGVAMSAASRGVDAVIVMPETTPDIKVDAVRRLGGNVVLHGQAFDQANGFAMEMAEQEGR
CCHHHHHHCCCCCEEEEECCCCCCCHHHHHHHCCCCEEEECCCCCCCCCCEEEHHHHCCC
VYIAPFDDEAVIAGQGTIAQEMLQQQRDLEVVFVPVGGGGLIAGIAAYYKAVMPQVKIVG
EEEEECCCCEEEECCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEEE
VEPEDAACLKAAMEAGEPVTLPQVGLFADGVAVKRIGTEPFRLAKWFVDEVVTVTSDEIC
ECCCHHHHHHHHHHCCCCCCCCCCCHHCCCEEEECCCCCHHHHHHHHHHHHHHCCCHHHH
AAVKDIFEDTRAIAEPAGALSLAGLKKYVSTNATGESGKGEKVAAILSGANVNFHSLRYV
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCHHHHHHH
SERCELGEQKEAVLAVKVPERPGSFLRFCELLEKRVMTEFNYRFSSRDMAVVFAGIRLTK
HHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEC
GHGELEQIINTLEDNGFEVQDLSGDETAKLHVRYMVGGHPPEPLEERLFSFEFPEHPGAL
CCCHHHHHHHHHHCCCEEEEECCCCCEEEEEEEEEECCCCCCHHHHHHHCCCCCCCCHHH
LKFLTTLQSKWNISLFHYRNHGAAFGRVLAGFEVPEGDALPFQQFLTELGFVYQEETQSP
HHHHHHHHCCCCEEEEEEECCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHCCCCC
AYQLFLNAGKGKKSLPL
EEEEEEECCCCCCCCCC
>Mature Secondary Structure
MLSLASSQTEQAEAQSSQVQSSQVQSDKAQSGTSALEKSQLAQSYLQKILLSSVYDVAKV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TPLSSLNKLSARLGCQVFLKREDMQPVHSFKLRGAYNRIAQLSQAECQRGVVCASAGNHA
CCHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCC
QGVAMSAASRGVDAVIVMPETTPDIKVDAVRRLGGNVVLHGQAFDQANGFAMEMAEQEGR
CCHHHHHHCCCCCEEEEECCCCCCCHHHHHHHCCCCEEEECCCCCCCCCCEEEHHHHCCC
VYIAPFDDEAVIAGQGTIAQEMLQQQRDLEVVFVPVGGGGLIAGIAAYYKAVMPQVKIVG
EEEEECCCCEEEECCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCEEEEE
VEPEDAACLKAAMEAGEPVTLPQVGLFADGVAVKRIGTEPFRLAKWFVDEVVTVTSDEIC
ECCCHHHHHHHHHHCCCCCCCCCCCHHCCCEEEECCCCCHHHHHHHHHHHHHHCCCHHHH
AAVKDIFEDTRAIAEPAGALSLAGLKKYVSTNATGESGKGEKVAAILSGANVNFHSLRYV
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCHHHHHHH
SERCELGEQKEAVLAVKVPERPGSFLRFCELLEKRVMTEFNYRFSSRDMAVVFAGIRLTK
HHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEC
GHGELEQIINTLEDNGFEVQDLSGDETAKLHVRYMVGGHPPEPLEERLFSFEFPEHPGAL
CCCHHHHHHHHHHCCCEEEEECCCCCEEEEEEEEEECCCCCCHHHHHHHCCCCCCCCHHH
LKFLTTLQSKWNISLFHYRNHGAAFGRVLAGFEVPEGDALPFQQFLTELGFVYQEETQSP
HHHHHHHHCCCCEEEEEEECCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHCCCCC
AYQLFLNAGKGKKSLPL
EEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3315862; 3550695; 1379743; 9278503; 3003115; 2473940; 9562556 [H]