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The map label for this gene is ilvD [H]

Identifier: 113968708

GI number: 113968708

Start: 389117

End: 390976

Strand: Direct

Name: ilvD [H]

Synonym: Shewmr4_0364

Alternate gene names: 113968708

Gene position: 389117-390976 (Clockwise)

Preceding gene: 113968707

Following gene: 113968709

Centisome position: 8.27

GC content: 55.7

Gene sequence:

>1860_bases
ATGCCAAAGTTACGTTCAGCAACCAGTACCGAAGGCCGCAATATGGCGGGTGCCCGTGCGCTATGGCGCGCCACAGGGGT
GAAAGACAATGATTTTGGTAAGCCGATTATTGCGATTGCCAACTCCTTTACTCAGTTTGTCCCTGGCCATGTGCACTTAA
AAGATATGGGCTCTCTGGTGGCGGGCGCCATCGAAGAAGCAGGCGGTATTGCCAAAGAATTCAACACCATCGCTGTGGAT
GATGGTATCGCCATGGGCCACGGTGGCATGCTCTACAGTCTGCCTTCGCGGGAGCTTATCGCCGATAGCGTCGAGTATAT
GGTCAATGCCCACTGCGCTGATGCGCTGGTTTGTATCTCTAACTGCGACAAAATCACCCCCGGCATGTTGATGGCGGCGC
TGCGCCTCAATATCCCCGTGGTGTTTGTGTCGGGCGGGCCGATGGAGGCGGGTAAAACCAAACTGTCGGACAAGCTTATC
AAACTCGATTTAGTCGATGCCATGGTGGCGGCGGCAGACTCGAGTGTGAGCGATGAAGATAGCGCTAAAATCGAACGTAG
TGCTTGCCCTACATGTGGTTCCTGTTCGGGCATGTTTACCGCTAACTCGATGAACTGTTTAACCGAAGCTTTAGGTCTGT
CGCTGCCGGGCAACGGCTCCATGCTCGCGACCCATGCCGATCGCCGCGAACTGTTTTTAGAAGCGGGCCGCCGCGTAATG
GCGCTAACCAAACGTTACTACGAAAAAGATGATGCCTCGGCACTGCCGCGCAACATCGCCAGCTTTAAAGCCTTTGAGAA
CGCCATGGCGCTGGATATCGCCATGGGCGGTTCGTCTAATACTGTGTTGCACTTATTGGCTGCGGCGCAGGAGGCAGACG
TGGCATTTACTATGGACGATATCGACCGTATGTCGCGCCAAGTGCCGCATCTGTGTAAGGTGGCGCCGTCGACCGCTAAA
TACCATATGGAAGATGTGCACCGCGCCGGTGGTGTGATGGGCATCTTAGGCGAACTCGACCGCGCCGGACTGCTGCATAC
CGATGTGCCACACGTCGCCGCCGATGCGGGCGGCAATCTCAAGTCGGTGCTCGCAAAGTACGATGTCATGCAAACCCAAG
ATGACAACGTAAAACAATTTTTTATGGCTGGACCTGCGGGCATTCCTACCACTAAAGCCTTTAGCCAAGACTGCCGCTGG
CCATCGCTGGACGATGACAGGCGTGAAGGTTGTATCCGTAGCCGCGAATTTGCCTTCAGCCAAGAGGGCGGTTTGGCCGT
GTTATCGGGCAATCTGGCCGACAATGGCTGTATCGTTAAAACTGCCGGTGTGGATGAGTCTAACCTGACCTTTACTGGCA
GCGCTCGGGTGTACGAAAGCCAAGATGACGCAGTCGCTGGCATCTTAGGTGGCGAAGTGGTGGCGGGTGATGTGGTGGTG
ATTCGTTACGAAGGGCCAAAAGGCGGCCCAGGTATGCAAGAAATGTTGTACCCCACCAGTTACTTAAAATCCCGTGGCTT
AGGCAAGGCCTGCGCGCTGATCACCGACGGCCGTTTCTCTGGTGGAACTTCCGGTTTATCCATCGGCCATGTATCGCCTG
AAGCGGCGGCGGGCGGCACTATTGCCTTGATTGAAAACGGCGATCGGATCGAAATCGATATTCCTAAGCGCAGTATCAAG
CTTGCGGTGAGTGATGCTGAATTGGCTGCGCGCCGTGAAACCATGCTCGCCCGTGGGCCAATGGCGTGGAAACCGCTTTC
GCGTCAGCGTTATGTGTCGATGGCGCTCAAAGCCTACGCCATGCTTGCCACCAGTGCCGATAAGGGCGCGGTGCGCGATC
GCAGTAAGTTGGAGGACTGA

Upstream 100 bases:

>100_bases
CAACAAAAAGTACACGCATAAGCATCCAGTGGCTGCGGTATTAGCACTGCAGCAACGCCCTAAGGGCACGATTTTCGATT
TGAGATAAGGGATAGAGTCA

Downstream 100 bases:

>100_bases
TATGTTATCTCTCGCATCGTCGCAAACGGAGCAGGCTGAGGCCCAGTCCTCTCAAGTTCAATCCTCTCAAGTTCAGTCCG
ATAAGGCGCAATCGGGCACT

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 619; Mature: 618

Protein sequence:

>619_residues
MPKLRSATSTEGRNMAGARALWRATGVKDNDFGKPIIAIANSFTQFVPGHVHLKDMGSLVAGAIEEAGGIAKEFNTIAVD
DGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADALVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLSDKLI
KLDLVDAMVAAADSSVSDEDSAKIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRRELFLEAGRRVM
ALTKRYYEKDDASALPRNIASFKAFENAMALDIAMGGSSNTVLHLLAAAQEADVAFTMDDIDRMSRQVPHLCKVAPSTAK
YHMEDVHRAGGVMGILGELDRAGLLHTDVPHVAADAGGNLKSVLAKYDVMQTQDDNVKQFFMAGPAGIPTTKAFSQDCRW
PSLDDDRREGCIRSREFAFSQEGGLAVLSGNLADNGCIVKTAGVDESNLTFTGSARVYESQDDAVAGILGGEVVAGDVVV
IRYEGPKGGPGMQEMLYPTSYLKSRGLGKACALITDGRFSGGTSGLSIGHVSPEAAAGGTIALIENGDRIEIDIPKRSIK
LAVSDAELAARRETMLARGPMAWKPLSRQRYVSMALKAYAMLATSADKGAVRDRSKLED

Sequences:

>Translated_619_residues
MPKLRSATSTEGRNMAGARALWRATGVKDNDFGKPIIAIANSFTQFVPGHVHLKDMGSLVAGAIEEAGGIAKEFNTIAVD
DGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADALVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLSDKLI
KLDLVDAMVAAADSSVSDEDSAKIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRRELFLEAGRRVM
ALTKRYYEKDDASALPRNIASFKAFENAMALDIAMGGSSNTVLHLLAAAQEADVAFTMDDIDRMSRQVPHLCKVAPSTAK
YHMEDVHRAGGVMGILGELDRAGLLHTDVPHVAADAGGNLKSVLAKYDVMQTQDDNVKQFFMAGPAGIPTTKAFSQDCRW
PSLDDDRREGCIRSREFAFSQEGGLAVLSGNLADNGCIVKTAGVDESNLTFTGSARVYESQDDAVAGILGGEVVAGDVVV
IRYEGPKGGPGMQEMLYPTSYLKSRGLGKACALITDGRFSGGTSGLSIGHVSPEAAAGGTIALIENGDRIEIDIPKRSIK
LAVSDAELAARRETMLARGPMAWKPLSRQRYVSMALKAYAMLATSADKGAVRDRSKLED
>Mature_618_residues
PKLRSATSTEGRNMAGARALWRATGVKDNDFGKPIIAIANSFTQFVPGHVHLKDMGSLVAGAIEEAGGIAKEFNTIAVDD
GIAMGHGGMLYSLPSRELIADSVEYMVNAHCADALVCISNCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLSDKLIK
LDLVDAMVAAADSSVSDEDSAKIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRRELFLEAGRRVMA
LTKRYYEKDDASALPRNIASFKAFENAMALDIAMGGSSNTVLHLLAAAQEADVAFTMDDIDRMSRQVPHLCKVAPSTAKY
HMEDVHRAGGVMGILGELDRAGLLHTDVPHVAADAGGNLKSVLAKYDVMQTQDDNVKQFFMAGPAGIPTTKAFSQDCRWP
SLDDDRREGCIRSREFAFSQEGGLAVLSGNLADNGCIVKTAGVDESNLTFTGSARVYESQDDAVAGILGGEVVAGDVVVI
RYEGPKGGPGMQEMLYPTSYLKSRGLGKACALITDGRFSGGTSGLSIGHVSPEAAAGGTIALIENGDRIEIDIPKRSIKL
AVSDAELAARRETMLARGPMAWKPLSRQRYVSMALKAYAMLATSADKGAVRDRSKLED

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=617, Percent_Identity=79.902755267423, Blast_Score=1017, Evalue=0.0,
Organism=Escherichia coli, GI1788157, Length=541, Percent_Identity=31.2384473197782, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI2367371, Length=513, Percent_Identity=31.1890838206628, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1786464, Length=537, Percent_Identity=29.7951582867784, Blast_Score=166, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6322476, Length=611, Percent_Identity=36.8248772504092, Blast_Score=341, Evalue=2e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 65531; Mature: 65399

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKLRSATSTEGRNMAGARALWRATGVKDNDFGKPIIAIANSFTQFVPGHVHLKDMGSLV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHH
AGAIEEAGGIAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADALVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLSDKLIKLDLVDAMVAAADSSVSDED
CCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHEEHHHHHHHHHHCCCCCCCCH
SAKIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRRELFLEAGRRVM
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHCCHHH
ALTKRYYEKDDASALPRNIASFKAFENAMALDIAMGGSSNTVLHLLAAAQEADVAFTMDD
HHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCCEEEEHHH
IDRMSRQVPHLCKVAPSTAKYHMEDVHRAGGVMGILGELDRAGLLHTDVPHVAADAGGNL
HHHHHHHCCHHHHCCCCHHHHHHHHHHHHCCCEEHHHHHCCCCCEECCCCCHHHCCCCCH
KSVLAKYDVMQTQDDNVKQFFMAGPAGIPTTKAFSQDCRWPSLDDDRREGCIRSREFAFS
HHHHHHHHHHCCCCCCHHHHEEECCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHCCCC
QEGGLAVLSGNLADNGCIVKTAGVDESNLTFTGSARVYESQDDAVAGILGGEVVAGDVVV
CCCCEEEEECCCCCCCEEEEECCCCCCCEEEECCCEEEECCCCCEEEEECCCEEECCEEE
IRYEGPKGGPGMQEMLYPTSYLKSRGLGKACALITDGRFSGGTSGLSIGHVSPEAAAGGT
EEECCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCE
IALIENGDRIEIDIPKRSIKLAVSDAELAARRETMLARGPMAWKPLSRQRYVSMALKAYA
EEEEECCCEEEEECCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
MLATSADKGAVRDRSKLED
HHHCCCCCCCCCCHHHCCC
>Mature Secondary Structure 
PKLRSATSTEGRNMAGARALWRATGVKDNDFGKPIIAIANSFTQFVPGHVHLKDMGSLV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHH
AGAIEEAGGIAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADALVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAALRLNIPVVFVSGGPMEAGKTKLSDKLIKLDLVDAMVAAADSSVSDED
CCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHEEHHHHHHHHHHCCCCCCCCH
SAKIERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSMLATHADRRELFLEAGRRVM
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHCCHHH
ALTKRYYEKDDASALPRNIASFKAFENAMALDIAMGGSSNTVLHLLAAAQEADVAFTMDD
HHHHHHHCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHCCCCEEEEHHH
IDRMSRQVPHLCKVAPSTAKYHMEDVHRAGGVMGILGELDRAGLLHTDVPHVAADAGGNL
HHHHHHHCCHHHHCCCCHHHHHHHHHHHHCCCEEHHHHHCCCCCEECCCCCHHHCCCCCH
KSVLAKYDVMQTQDDNVKQFFMAGPAGIPTTKAFSQDCRWPSLDDDRREGCIRSREFAFS
HHHHHHHHHHCCCCCCHHHHEEECCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHCCCC
QEGGLAVLSGNLADNGCIVKTAGVDESNLTFTGSARVYESQDDAVAGILGGEVVAGDVVV
CCCCEEEEECCCCCCCEEEEECCCCCCCEEEECCCEEEECCCCCEEEEECCCEEECCEEE
IRYEGPKGGPGMQEMLYPTSYLKSRGLGKACALITDGRFSGGTSGLSIGHVSPEAAAGGT
EEECCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCE
IALIENGDRIEIDIPKRSIKLAVSDAELAARRETMLARGPMAWKPLSRQRYVSMALKAYA
EEEEECCCEEEEECCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
MLATSADKGAVRDRSKLED
HHHCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA