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The map label for this gene is ytfL [H]

Identifier: 113968703

GI number: 113968703

Start: 382594

End: 383910

Strand: Direct

Name: ytfL [H]

Synonym: Shewmr4_0359

Alternate gene names: 113968703

Gene position: 382594-383910 (Clockwise)

Preceding gene: 113968701

Following gene: 113968705

Centisome position: 8.13

GC content: 47.38

Gene sequence:

>1317_bases
ATGAGTCTCTTAGATAACGTGATGATTATATTGTGCTTAATTGCCGCGAGTTGTTTCTTTTCCATGTCAGAAATTGCTTT
GGCCGCATCACGGAAAATCCGTTTACGTCAGTTAGCCGATGAAGGTGATGCCAGAGCTGAAAAGGTACTGCATTTACAGT
CGTATCCCGGCAGCTTTTTTACTGTGGTGCAAATTGGTCTGAATGCCGTGGCCATCATGGGCGGTATTGTGGGTGAATCT
GCATTTCGTCCGTATTTTTATCAATTCCTTTCACCTTGGTTAGCCGATCCCTGGTTGGGTCAGGTGAGCTTTTTGATGTC
GTTTTTACTCGTTACCAGTGCCTTTATTTTGGTGGCCGATTTAATGCCTAAGCGTATTGCGATGGCGATGCCTGAGCAAG
TTGCCTTGGCTGTCGTTGGCCCTATGAGTTTCTGCATCGCGATCCTTCGTCCATTGGTGTGGTTTTTCAATGGCATGGCT
AGCGCGATTTTTAAGTTGCTGCAAATCCCCACGGCTAGAAATGATGAAATTACTTCCGATGATATTTACGCGGTAATGAA
CGCGGGGGCAGAAGCCGGTGTACTCGATAGGGGAGAGCAACAGATGATGGAGAACGTGTTTGAAATGCAAACCGTTTCAG
TCACTTCTGCTATGACGGCCCGTGAGAGCTTAGTGTATTTCCTGCTGCAAGACAGCGAGGAGGATATCAAACGTAAGATT
GCCGAAGATCCTCACACTAAGTTTTTAGTCTGTGATGGCCAATTGGATATGGTCAAAGGTTTTGTAGATGCGAAGGAGCT
GCTGATCCGTGTGATTAACGGCGAGAACATCACCTTAAAGGACAACAGTCTTGTGCATACCTCTTTGATTATTCCCGATA
CCTTAAGCCTGTCCGAGGCGATGGAATACTTCAAAAATAGCCGCGCCGATTTCGCCGTGGTGATGAATGAATACGCCCTA
GTTGTGGGGATTGTCACCACCAACGATCTGCAACGGGCAGTGATGGGGGCTTGGTCGCTACACGAGAGCGAAGAGCAGAT
TATCGCCCGTGATGGTAATTCTTGGTTAGTCGATGGGGTCACGCCCATTACCGATGTGATGCGCGCCTTCGATATTGAAG
AGTTCCCCCACAGTCAAAATTATGAAACCATCGCCGGCTTTATGATGTACATGCTGCGTAAGATCCCCAAGCGCACCGAC
TTTGTTAACTATGCCGGTTACAAGTTTGAAGTGGTGGATATCGACGCCTACAAGGTCGACCAATTGCTGGTAACTCGTAT
CGATGGCAACGATAAGTTGATGTCTCCAGATACCTAA

Upstream 100 bases:

>100_bases
CACAGGCTAGAGCCGCTTTATTGGGAAAAATTCAACTGATCCGCGAAAATCACTGCGCGGGTTGGTGCAAGTAAGTCTAG
TGTGAAACAAAAGGTGTTAC

Downstream 100 bases:

>100_bases
TCTTATCAACATCATAAAAAACGGGACTCAGTCCCGTTTTTTATATCGCTACTAAAATTTAGATCGCTTCTAAAAACGCA
TTCACTATCGGATCGTCCAA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MSLLDNVMIILCLIAASCFFSMSEIALAASRKIRLRQLADEGDARAEKVLHLQSYPGSFFTVVQIGLNAVAIMGGIVGES
AFRPYFYQFLSPWLADPWLGQVSFLMSFLLVTSAFILVADLMPKRIAMAMPEQVALAVVGPMSFCIAILRPLVWFFNGMA
SAIFKLLQIPTARNDEITSDDIYAVMNAGAEAGVLDRGEQQMMENVFEMQTVSVTSAMTARESLVYFLLQDSEEDIKRKI
AEDPHTKFLVCDGQLDMVKGFVDAKELLIRVINGENITLKDNSLVHTSLIIPDTLSLSEAMEYFKNSRADFAVVMNEYAL
VVGIVTTNDLQRAVMGAWSLHESEEQIIARDGNSWLVDGVTPITDVMRAFDIEEFPHSQNYETIAGFMMYMLRKIPKRTD
FVNYAGYKFEVVDIDAYKVDQLLVTRIDGNDKLMSPDT

Sequences:

>Translated_438_residues
MSLLDNVMIILCLIAASCFFSMSEIALAASRKIRLRQLADEGDARAEKVLHLQSYPGSFFTVVQIGLNAVAIMGGIVGES
AFRPYFYQFLSPWLADPWLGQVSFLMSFLLVTSAFILVADLMPKRIAMAMPEQVALAVVGPMSFCIAILRPLVWFFNGMA
SAIFKLLQIPTARNDEITSDDIYAVMNAGAEAGVLDRGEQQMMENVFEMQTVSVTSAMTARESLVYFLLQDSEEDIKRKI
AEDPHTKFLVCDGQLDMVKGFVDAKELLIRVINGENITLKDNSLVHTSLIIPDTLSLSEAMEYFKNSRADFAVVMNEYAL
VVGIVTTNDLQRAVMGAWSLHESEEQIIARDGNSWLVDGVTPITDVMRAFDIEEFPHSQNYETIAGFMMYMLRKIPKRTD
FVNYAGYKFEVVDIDAYKVDQLLVTRIDGNDKLMSPDT
>Mature_437_residues
SLLDNVMIILCLIAASCFFSMSEIALAASRKIRLRQLADEGDARAEKVLHLQSYPGSFFTVVQIGLNAVAIMGGIVGESA
FRPYFYQFLSPWLADPWLGQVSFLMSFLLVTSAFILVADLMPKRIAMAMPEQVALAVVGPMSFCIAILRPLVWFFNGMAS
AIFKLLQIPTARNDEITSDDIYAVMNAGAEAGVLDRGEQQMMENVFEMQTVSVTSAMTARESLVYFLLQDSEEDIKRKIA
EDPHTKFLVCDGQLDMVKGFVDAKELLIRVINGENITLKDNSLVHTSLIIPDTLSLSEAMEYFKNSRADFAVVMNEYALV
VGIVTTNDLQRAVMGAWSLHESEEQIIARDGNSWLVDGVTPITDVMRAFDIEEFPHSQNYETIAGFMMYMLRKIPKRTDF
VNYAGYKFEVVDIDAYKVDQLLVTRIDGNDKLMSPDT

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=384, Percent_Identity=26.8229166666667, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI1790664, Length=434, Percent_Identity=58.294930875576, Blast_Score=540, Evalue=1e-155,
Organism=Escherichia coli, GI87082033, Length=264, Percent_Identity=30.6818181818182, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI145693175, Length=422, Percent_Identity=23.2227488151659, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1788119, Length=234, Percent_Identity=26.4957264957265, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI1786879, Length=250, Percent_Identity=22, Blast_Score=72, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21 [H]

EC number: NA

Molecular weight: Translated: 48977; Mature: 48846

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLDNVMIILCLIAASCFFSMSEIALAASRKIRLRQLADEGDARAEKVLHLQSYPGSFF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHH
TVVQIGLNAVAIMGGIVGESAFRPYFYQFLSPWLADPWLGQVSFLMSFLLVTSAFILVAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
LMPKRIAMAMPEQVALAVVGPMSFCIAILRPLVWFFNGMASAIFKLLQIPTARNDEITSD
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
DIYAVMNAGAEAGVLDRGEQQMMENVFEMQTVSVTSAMTARESLVYFLLQDSEEDIKRKI
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHH
AEDPHTKFLVCDGQLDMVKGFVDAKELLIRVINGENITLKDNSLVHTSLIIPDTLSLSEA
HCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEEECCCCCCHHHH
MEYFKNSRADFAVVMNEYALVVGIVTTNDLQRAVMGAWSLHESEEQIIARDGNSWLVDGV
HHHHHCCCCCEEHHHHCCEEEEEEEECHHHHHHHHHHHHCCCCCHHHEEECCCCEEECCC
TPITDVMRAFDIEEFPHSQNYETIAGFMMYMLRKIPKRTDFVNYAGYKFEVVDIDAYKVD
CHHHHHHHHHCHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCEEEEEEECCHHHHC
QLLVTRIDGNDKLMSPDT
EEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
SLLDNVMIILCLIAASCFFSMSEIALAASRKIRLRQLADEGDARAEKVLHLQSYPGSFF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHH
TVVQIGLNAVAIMGGIVGESAFRPYFYQFLSPWLADPWLGQVSFLMSFLLVTSAFILVAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
LMPKRIAMAMPEQVALAVVGPMSFCIAILRPLVWFFNGMASAIFKLLQIPTARNDEITSD
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
DIYAVMNAGAEAGVLDRGEQQMMENVFEMQTVSVTSAMTARESLVYFLLQDSEEDIKRKI
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHH
AEDPHTKFLVCDGQLDMVKGFVDAKELLIRVINGENITLKDNSLVHTSLIIPDTLSLSEA
HCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEEECCCCCCHHHH
MEYFKNSRADFAVVMNEYALVVGIVTTNDLQRAVMGAWSLHESEEQIIARDGNSWLVDGV
HHHHHCCCCCEEHHHHCCEEEEEEEECHHHHHHHHHHHHCCCCCHHHEEECCCCEEECCC
TPITDVMRAFDIEEFPHSQNYETIAGFMMYMLRKIPKRTDFVNYAGYKFEVVDIDAYKVD
CHHHHHHHHHCHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCEEEEEEECCHHHHC
QLLVTRIDGNDKLMSPDT
EEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]