Click here to switch to the map view.

The map label for this gene is aroE [H]

Identifier: 113968383

GI number: 113968383

Start: 40394

End: 41272

Strand: Direct

Name: aroE [H]

Synonym: Shewmr4_0037

Alternate gene names: 113968383

Gene position: 40394-41272 (Clockwise)

Preceding gene: 113968381

Following gene: 113968384

Centisome position: 0.86

GC content: 52.79

Gene sequence:

>879_bases
ATGACAGATATGCCTTCAGTAACTACGCCAGCGCTTGATCGATATGCCGTGTTCGGTAACCCGATAGGTCACAGTAAATC
GCCCATTATTCATGGACAGTTTGCGTCCCTTACTCTGCAGCCTTTGAGTTATGAAGCGATTCTGGCGCCCATCGATGGTT
TTGAAGCGAGTTTACGAGCATTTTTTCAGGCGGGAGGAAAGGGCGCGAATGTGACAGTGCCCTTTAAAGAACAAGCCTTT
GCCCTCTGCGACAGCCTTAGTGCCGAAGCGACACTGGCGGGTGCGGTTAATACCTTAAGCTTGCTGGCCGATGGCACTCT
TTATGGTGATAACACCGATGGTTTAGGGCTGGTGGCCGATCTTCTTCGCCATCTCGGCAGTTTGCAGCATAAGCGGGTGC
TCTTGGTCGGGGCTGGCGGCGCGGCGCGCGGCTGTATCTTGCCATTGCTTAAGGCTGAAGTGGGTCAACTGGTCATCACT
AACCGAACTCAAAGTAAGGCGCAGGCCTTAGTGGAGATATTTAGCCAAGTACAACAAGGGCGCTACAGCGATAAACTCCA
AGCGATGTCGATGCCAGAGTTGTCGGGGGAGTTCGATTTAGTGATTAACTCGACCTCAGCGAGTCTCGCGGGAGAGCTAC
CGCCACTACCACAGTCCATCATCGGCAATAAAACGGCTTGCTACGATATGATGTATGGCGCAAAACCAACGGCATTTAAT
CAATGGGCTGTGCAACAGGGCGCAGCGCAAGTGATTGATGGACTAGGTATGCTTGTCGGTCAGGCGGCAAAGAGTTTTGC
GCTCTGGCGTGGCGTCGAGCCAGATACCTCAGGAGTGCTTAAATTGCTCAGGGACAAACTACAGGCCGACGCGCAATAG

Upstream 100 bases:

>100_bases
GCTAAAGTCAGGTACAACAACTTAGGCTCGCCATTAGGCTGTGCTACCGCCTAAAAGCACGCTAGACTGCAAGCCATTCA
CAGCCAATAGAATCCCGCAG

Downstream 100 bases:

>100_bases
AGGCTCAAGAGGAAGATAAGATGAATCAGAGTATTTTATTCCCCGATCTGCAACATTGGGATGAAACCCAAAAGCACATT
TGCTTTATTGCCCAGCAGCA

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MTDMPSVTTPALDRYAVFGNPIGHSKSPIIHGQFASLTLQPLSYEAILAPIDGFEASLRAFFQAGGKGANVTVPFKEQAF
ALCDSLSAEATLAGAVNTLSLLADGTLYGDNTDGLGLVADLLRHLGSLQHKRVLLVGAGGAARGCILPLLKAEVGQLVIT
NRTQSKAQALVEIFSQVQQGRYSDKLQAMSMPELSGEFDLVINSTSASLAGELPPLPQSIIGNKTACYDMMYGAKPTAFN
QWAVQQGAAQVIDGLGMLVGQAAKSFALWRGVEPDTSGVLKLLRDKLQADAQ

Sequences:

>Translated_292_residues
MTDMPSVTTPALDRYAVFGNPIGHSKSPIIHGQFASLTLQPLSYEAILAPIDGFEASLRAFFQAGGKGANVTVPFKEQAF
ALCDSLSAEATLAGAVNTLSLLADGTLYGDNTDGLGLVADLLRHLGSLQHKRVLLVGAGGAARGCILPLLKAEVGQLVIT
NRTQSKAQALVEIFSQVQQGRYSDKLQAMSMPELSGEFDLVINSTSASLAGELPPLPQSIIGNKTACYDMMYGAKPTAFN
QWAVQQGAAQVIDGLGMLVGQAAKSFALWRGVEPDTSGVLKLLRDKLQADAQ
>Mature_291_residues
TDMPSVTTPALDRYAVFGNPIGHSKSPIIHGQFASLTLQPLSYEAILAPIDGFEASLRAFFQAGGKGANVTVPFKEQAFA
LCDSLSAEATLAGAVNTLSLLADGTLYGDNTDGLGLVADLLRHLGSLQHKRVLLVGAGGAARGCILPLLKAEVGQLVITN
RTQSKAQALVEIFSQVQQGRYSDKLQAMSMPELSGEFDLVINSTSASLAGELPPLPQSIIGNKTACYDMMYGAKPTAFNQ
WAVQQGAAQVIDGLGMLVGQAAKSFALWRGVEPDTSGVLKLLRDKLQADAQ

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1789675, Length=279, Percent_Identity=52.3297491039427, Blast_Score=274, Evalue=5e-75,
Organism=Escherichia coli, GI1787983, Length=281, Percent_Identity=26.3345195729537, Blast_Score=79, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6320332, Length=167, Percent_Identity=34.7305389221557, Blast_Score=80, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 30747; Mature: 30615

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDMPSVTTPALDRYAVFGNPIGHSKSPIIHGQFASLTLQPLSYEAILAPIDGFEASLRA
CCCCCCCCCCCHHHHHEECCCCCCCCCCEEECCHHEEEECCCCCEEEEECCCCHHHHHHH
FFQAGGKGANVTVPFKEQAFALCDSLSAEATLAGAVNTLSLLADGTLYGDNTDGLGLVAD
HHHCCCCCCEEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEECCCCCCHHHHHH
LLRHLGSLQHKRVLLVGAGGAARGCILPLLKAEVGQLVITNRTQSKAQALVEIFSQVQQG
HHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHCC
RYSDKLQAMSMPELSGEFDLVINSTSASLAGELPPLPQSIIGNKTACYDMMYGAKPTAFN
CCHHHHHHHCCCCCCCCEEEEEECCCCHHCCCCCCCCHHHHCCCHHHHHHHHCCCCCCCH
QWAVQQGAAQVIDGLGMLVGQAAKSFALWRGVEPDTSGVLKLLRDKLQADAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TDMPSVTTPALDRYAVFGNPIGHSKSPIIHGQFASLTLQPLSYEAILAPIDGFEASLRA
CCCCCCCCCCHHHHHEECCCCCCCCCCEEECCHHEEEECCCCCEEEEECCCCHHHHHHH
FFQAGGKGANVTVPFKEQAFALCDSLSAEATLAGAVNTLSLLADGTLYGDNTDGLGLVAD
HHHCCCCCCEEEECCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEECCCCCCHHHHHH
LLRHLGSLQHKRVLLVGAGGAARGCILPLLKAEVGQLVITNRTQSKAQALVEIFSQVQQG
HHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHCC
RYSDKLQAMSMPELSGEFDLVINSTSASLAGELPPLPQSIIGNKTACYDMMYGAKPTAFN
CCHHHHHHHCCCCCCCCEEEEEECCCCHHCCCCCCCCHHHHCCCHHHHHHHHCCCCCCCH
QWAVQQGAAQVIDGLGMLVGQAAKSFALWRGVEPDTSGVLKLLRDKLQADAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA