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The map label for this gene is hemF [H]

Identifier: 113968381

GI number: 113968381

Start: 38845

End: 39753

Strand: Direct

Name: hemF [H]

Synonym: Shewmr4_0035

Alternate gene names: 113968381

Gene position: 38845-39753 (Clockwise)

Preceding gene: 113968380

Following gene: 113968383

Centisome position: 0.83

GC content: 49.83

Gene sequence:

>909_bases
ATGAGCGTGCCAGATGCGACAGTGGTAAAAGCATTTTTACTCGATCTACAGAATCGAATTTGTGCGGGTCTTGAGCAGTT
GGATGGGCAAGCAAGCTTTGCGGCCGATTCATGGACACGCACCGAAGGCGGTGGCGGTACCAGTCGTGTTTTAACCCAAG
GTGCGGTATTCGAGCAAGCTGGGGTGAACTTTTCCCATGTAACAGGTGCGGCCATGCCTGCATCGGCAACGGCTCATCGC
CCAGAATTGGCGGGGCGTAGTTTTGAGGCCATGGGCGTTTCTTTAGTGATTCACCCTAAAAACCCTTATATTCCAACTAC
CCATGCTAACGTGCGTTTCTTTATTGCCCATAAAGACGGTGCGGATCCCGTTTGGTGGTTTGGTGGTGGTTTTGACTTAA
CGCCTTACTATCCTTTCGAAGAAGATGTGCGCGAGTGGCATCAAACCGCTAAAAATCTGTGTCTGCCCTTTGGCGACGAC
ATATATCCTAAATATAAGAAGTGGTGTGATGAGTATTTCTTCCTGCCACATCGTAATGAAACCCGCGGCGTGGGCGGACT
GTTTTTCGATGACTTGAATCAAGCTGGCTTCGATAAGAGTTTCGATTTTATGCAAGCGGTGGGGAATGGCTTCTTAACCG
CTTATGCGCCGATTGTTGAGCGCCGTAAAGAGACGCCTTATGGCGAACGTGAGCGTGAGTTCCAGTTATATCGTCGCGGC
CGTTATGTTGAGTTCAATCTGGTATACGACAGAGGTACCTTGTTCGGCCTGCAAACTGGTGGTCGCACTGAGTCCATTTT
GATGTCAATGCCGCCATTGGTACGCTGGCAATATGCTTATACGCCAGAGGCGGGTAGCCCAGAGGCAGATCTATACGATA
ACTACCTCAAACCTCGAGATTGGGTATAA

Upstream 100 bases:

>100_bases
TAGGCGAACAGCGTCAACCCTCCACCATTATTGATGCCCGCAGCGGTAAGATATTACGTAACGGACAATAACTGATTTAT
AACGCAAAGGATAAAAGCAG

Downstream 100 bases:

>100_bases
GCACGCTAACACGAGTTGCGTAATCAGTACGTTACTGATTACGCATATGATCTGCCAGAGTTGAAATCGCCTCATAGATA
GCGGCGCGATGCTCTGGCTT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MSVPDATVVKAFLLDLQNRICAGLEQLDGQASFAADSWTRTEGGGGTSRVLTQGAVFEQAGVNFSHVTGAAMPASATAHR
PELAGRSFEAMGVSLVIHPKNPYIPTTHANVRFFIAHKDGADPVWWFGGGFDLTPYYPFEEDVREWHQTAKNLCLPFGDD
IYPKYKKWCDEYFFLPHRNETRGVGGLFFDDLNQAGFDKSFDFMQAVGNGFLTAYAPIVERRKETPYGEREREFQLYRRG
RYVEFNLVYDRGTLFGLQTGGRTESILMSMPPLVRWQYAYTPEAGSPEADLYDNYLKPRDWV

Sequences:

>Translated_302_residues
MSVPDATVVKAFLLDLQNRICAGLEQLDGQASFAADSWTRTEGGGGTSRVLTQGAVFEQAGVNFSHVTGAAMPASATAHR
PELAGRSFEAMGVSLVIHPKNPYIPTTHANVRFFIAHKDGADPVWWFGGGFDLTPYYPFEEDVREWHQTAKNLCLPFGDD
IYPKYKKWCDEYFFLPHRNETRGVGGLFFDDLNQAGFDKSFDFMQAVGNGFLTAYAPIVERRKETPYGEREREFQLYRRG
RYVEFNLVYDRGTLFGLQTGGRTESILMSMPPLVRWQYAYTPEAGSPEADLYDNYLKPRDWV
>Mature_301_residues
SVPDATVVKAFLLDLQNRICAGLEQLDGQASFAADSWTRTEGGGGTSRVLTQGAVFEQAGVNFSHVTGAAMPASATAHRP
ELAGRSFEAMGVSLVIHPKNPYIPTTHANVRFFIAHKDGADPVWWFGGGFDLTPYYPFEEDVREWHQTAKNLCLPFGDDI
YPKYKKWCDEYFFLPHRNETRGVGGLFFDDLNQAGFDKSFDFMQAVGNGFLTAYAPIVERRKETPYGEREREFQLYRRGR
YVEFNLVYDRGTLFGLQTGGRTESILMSMPPLVRWQYAYTPEAGSPEADLYDNYLKPRDWV

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=304, Percent_Identity=47.0394736842105, Blast_Score=287, Evalue=6e-78,
Organism=Escherichia coli, GI1788777, Length=299, Percent_Identity=75.5852842809365, Blast_Score=471, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6320249, Length=320, Percent_Identity=45.625, Blast_Score=276, Evalue=4e-75,
Organism=Drosophila melanogaster, GI17864388, Length=302, Percent_Identity=46.3576158940397, Blast_Score=286, Evalue=9e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 34151; Mature: 34019

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVPDATVVKAFLLDLQNRICAGLEQLDGQASFAADSWTRTEGGGGTSRVLTQGAVFEQA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHH
GVNFSHVTGAAMPASATAHRPELAGRSFEAMGVSLVIHPKNPYIPTTHANVRFFIAHKDG
CCCHHHHCCCCCCCCCCCCCCHHCCCCEECCCEEEEEECCCCCCCCCCCCEEEEEEECCC
ADPVWWFGGGFDLTPYYPFEEDVREWHQTAKNLCLPFGDDIYPKYKKWCDEYFFLPHRNE
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHEECCCCCC
TRGVGGLFFDDLNQAGFDKSFDFMQAVGNGFLTAYAPIVERRKETPYGEREREFQLYRRG
CCCCCCHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCC
RYVEFNLVYDRGTLFGLQTGGRTESILMSMPPLVRWQYAYTPEAGSPEADLYDNYLKPRD
CEEEEEEEEECCEEEEECCCCCCHHHHHCCCCCCEEEEEECCCCCCCCHHHHHCCCCCCC
WV
CC
>Mature Secondary Structure 
SVPDATVVKAFLLDLQNRICAGLEQLDGQASFAADSWTRTEGGGGTSRVLTQGAVFEQA
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHH
GVNFSHVTGAAMPASATAHRPELAGRSFEAMGVSLVIHPKNPYIPTTHANVRFFIAHKDG
CCCHHHHCCCCCCCCCCCCCCHHCCCCEECCCEEEEEECCCCCCCCCCCCEEEEEEECCC
ADPVWWFGGGFDLTPYYPFEEDVREWHQTAKNLCLPFGDDIYPKYKKWCDEYFFLPHRNE
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHEECCCCCC
TRGVGGLFFDDLNQAGFDKSFDFMQAVGNGFLTAYAPIVERRKETPYGEREREFQLYRRG
CCCCCCHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCC
RYVEFNLVYDRGTLFGLQTGGRTESILMSMPPLVRWQYAYTPEAGSPEADLYDNYLKPRD
CEEEEEEEEECCEEEEECCCCCCHHHHHCCCCCCEEEEEECCCCCCCCHHHHHCCCCCCC
WV
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA