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The map label for this gene is hom [H]

Identifier: 113477955

GI number: 113477955

Start: 7025685

End: 7026989

Strand: Reverse

Name: hom [H]

Synonym: Tery_4567

Alternate gene names: 113477955

Gene position: 7026989-7025685 (Counterclockwise)

Preceding gene: 113477956

Following gene: 113477954

Centisome position: 90.67

GC content: 38.24

Gene sequence:

>1305_bases
GTGGTATTCAAAATCGGTTTGTTGGGATTAGGAACAGTCGGTATAGGGACAGCAAAAATTTTGCTATCCCCACAAGGTCG
TCATCCTTTAATTAATGAATTGGAAATATACCGAGTTGGAGTGCGTGATATATCCAAAACTAGGGATATTAATATATCTC
CAAATATTTTAACAACAGATTTAGAGGCGATAGCTACTGACCCAGATGTAGACATAATAATAGAACTCATCGGTGGGTTA
GAACCAGCAAGAAGTCTAATTCTCAAAGCTATCGAACATGGTAAACATATAGTCACTGCCAACAAAGCTGTCATCTCTCG
TTACGGTCCAGAAATTTTTGATGCAGCTAATAAAAAAAGTGTCTATGTTATGTTAGAAGCATCAGTAGGAGGTGGAATTC
CAGTTATTCAACCCCTCAAAGAATCTCTAACAGTAAATCGCATTCATTCTATTACTGGTATCATCAACGGGACAACTAAC
TACATCCTTACTAAAATGCAAAAAGAGGGAGCAGACTTTGCAGATGTTCTTGCTGATGCTCAAAAGCTGGGTTACGCAGA
GGCAAATCCCACTGCTGATGTGGAAGGGTTAGATGCCAAAGATAAAATCGCCATTCTTGGTTCCCTTGCTTTTAGTGGTT
TCATAAAATTAGAAGACATTTACTGCGAAGGTATTCGTCAAATAACAGCAGCAGATATTACCTACGCTGCTCAACTAAAT
TTCGTAATTAAATTATTAGCGATCGCCAAGCAAGCTCCTAAAAATACTAACTTCACCTCTGATAAACTTCAACTCAGAGT
ACATCCTACCCTCATTCCCAAAACTCATCCCCTTGCCAGTATCAACGATGTTGACAACGCTATCTTCATTGAAGGAGAAC
CCATCGGACAAGTTATGTTTTTTGGTCCTGGTGCCGGTGCTGGTCCAACTGCCAGTGCAGTAGTTTCTGATATTATGAAT
ATTGCGGCTATTCTGCAAACAGAAACCGAACCCATTCCCCATCCATTATTAAGTTGTACTCATCAAAAATATTGTGAAAT
AGTACCCATAAAAGAACTGATCACTAGATTTTATGCTCGTTTCTTAACTCAAGATAAACCAGGAGTAATAGGTAAACTTG
GTAGTTGTTTTGGTAAATATAGTGTTAGTTTAGAATCTGTGGTACAAACAGGAATACATAATCAACTTGCAGAAATAGTT
GTTGTTACCCGTGATGTACGAGAAGGCAACTTCCGGCAAGCATTAGAGGAAATTCAATCATTAGATGTTATTAATAGCAT
TCCCAGTATATTAAGGGTTTTGTAG

Upstream 100 bases:

>100_bases
AGACTATTTTTTTTTATACTTATCTGTTAAACTTAAAAAGTATTCAGCTATAATAGCTGAACTTTGCTCAAAAAAAATTA
TTTAGGAAAGGTTAATAATT

Downstream 100 bases:

>100_bases
AAACAAAAAAATCAGAGAGAAAAACTTAACTTCAAAATAGACTTCTGCGAAAACTAATCTCCAACTTTACAAAAAACCAA
AGGGGGAGAATTAACAGCAA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MVFKIGLLGLGTVGIGTAKILLSPQGRHPLINELEIYRVGVRDISKTRDINISPNILTTDLEAIATDPDVDIIIELIGGL
EPARSLILKAIEHGKHIVTANKAVISRYGPEIFDAANKKSVYVMLEASVGGGIPVIQPLKESLTVNRIHSITGIINGTTN
YILTKMQKEGADFADVLADAQKLGYAEANPTADVEGLDAKDKIAILGSLAFSGFIKLEDIYCEGIRQITAADITYAAQLN
FVIKLLAIAKQAPKNTNFTSDKLQLRVHPTLIPKTHPLASINDVDNAIFIEGEPIGQVMFFGPGAGAGPTASAVVSDIMN
IAAILQTETEPIPHPLLSCTHQKYCEIVPIKELITRFYARFLTQDKPGVIGKLGSCFGKYSVSLESVVQTGIHNQLAEIV
VVTRDVREGNFRQALEEIQSLDVINSIPSILRVL

Sequences:

>Translated_434_residues
MVFKIGLLGLGTVGIGTAKILLSPQGRHPLINELEIYRVGVRDISKTRDINISPNILTTDLEAIATDPDVDIIIELIGGL
EPARSLILKAIEHGKHIVTANKAVISRYGPEIFDAANKKSVYVMLEASVGGGIPVIQPLKESLTVNRIHSITGIINGTTN
YILTKMQKEGADFADVLADAQKLGYAEANPTADVEGLDAKDKIAILGSLAFSGFIKLEDIYCEGIRQITAADITYAAQLN
FVIKLLAIAKQAPKNTNFTSDKLQLRVHPTLIPKTHPLASINDVDNAIFIEGEPIGQVMFFGPGAGAGPTASAVVSDIMN
IAAILQTETEPIPHPLLSCTHQKYCEIVPIKELITRFYARFLTQDKPGVIGKLGSCFGKYSVSLESVVQTGIHNQLAEIV
VVTRDVREGNFRQALEEIQSLDVINSIPSILRVL
>Mature_434_residues
MVFKIGLLGLGTVGIGTAKILLSPQGRHPLINELEIYRVGVRDISKTRDINISPNILTTDLEAIATDPDVDIIIELIGGL
EPARSLILKAIEHGKHIVTANKAVISRYGPEIFDAANKKSVYVMLEASVGGGIPVIQPLKESLTVNRIHSITGIINGTTN
YILTKMQKEGADFADVLADAQKLGYAEANPTADVEGLDAKDKIAILGSLAFSGFIKLEDIYCEGIRQITAADITYAAQLN
FVIKLLAIAKQAPKNTNFTSDKLQLRVHPTLIPKTHPLASINDVDNAIFIEGEPIGQVMFFGPGAGAGPTASAVVSDIMN
IAAILQTETEPIPHPLLSCTHQKYCEIVPIKELITRFYARFLTQDKPGVIGKLGSCFGKYSVSLESVVQTGIHNQLAEIV
VVTRDVREGNFRQALEEIQSLDVINSIPSILRVL

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=261, Percent_Identity=27.2030651340996, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1786183, Length=248, Percent_Identity=27.4193548387097, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322599, Length=134, Percent_Identity=35.0746268656716, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46871; Mature: 46871

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFKIGLLGLGTVGIGTAKILLSPQGRHPLINELEIYRVGVRDISKTRDINISPNILTTD
CEEEEEEEECCCCCCCEEEEEECCCCCCCCCCCEEEEEECHHHHHHCCCCCCCCCEEECC
LEAIATDPDVDIIIELIGGLEPARSLILKAIEHGKHIVTANKAVISRYGPEIFDAANKKS
HHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEECHHHHHHCCCHHHCCCCCCE
VYVMLEASVGGGIPVIQPLKESLTVNRIHSITGIINGTTNYILTKMQKEGADFADVLADA
EEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHCCCCHHHHHHHH
QKLGYAEANPTADVEGLDAKDKIAILGSLAFSGFIKLEDIYCEGIRQITAADITYAAQLN
HHCCCCCCCCCCCCCCCCCCCHHHHEEHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHH
FVIKLLAIAKQAPKNTNFTSDKLQLRVHPTLIPKTHPLASINDVDNAIFIEGEPIGQVMF
HHHHHHHHHHHCCCCCCCCCCEEEEEECCEECCCCCCCCCCCCCCCEEEECCCCCCEEEE
FGPGAGAGPTASAVVSDIMNIAAILQTETEPIPHPLLSCTHQKYCEIVPIKELITRFYAR
ECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCHHHHHCEECHHHHHHHHHHH
FLTQDKPGVIGKLGSCFGKYSVSLESVVQTGIHNQLAEIVVVTRDVREGNFRQALEEIQS
HHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHH
LDVINSIPSILRVL
HHHHHHHHHHHHHC
>Mature Secondary Structure
MVFKIGLLGLGTVGIGTAKILLSPQGRHPLINELEIYRVGVRDISKTRDINISPNILTTD
CEEEEEEEECCCCCCCEEEEEECCCCCCCCCCCEEEEEECHHHHHHCCCCCCCCCEEECC
LEAIATDPDVDIIIELIGGLEPARSLILKAIEHGKHIVTANKAVISRYGPEIFDAANKKS
HHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEECHHHHHHCCCHHHCCCCCCE
VYVMLEASVGGGIPVIQPLKESLTVNRIHSITGIINGTTNYILTKMQKEGADFADVLADA
EEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHCCCCHHHHHHHH
QKLGYAEANPTADVEGLDAKDKIAILGSLAFSGFIKLEDIYCEGIRQITAADITYAAQLN
HHCCCCCCCCCCCCCCCCCCCHHHHEEHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHH
FVIKLLAIAKQAPKNTNFTSDKLQLRVHPTLIPKTHPLASINDVDNAIFIEGEPIGQVMF
HHHHHHHHHHHCCCCCCCCCCEEEEEECCEECCCCCCCCCCCCCCCEEEECCCCCCEEEE
FGPGAGAGPTASAVVSDIMNIAAILQTETEPIPHPLLSCTHQKYCEIVPIKELITRFYAR
ECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCHHHHHCEECHHHHHHHHHHH
FLTQDKPGVIGKLGSCFGKYSVSLESVVQTGIHNQLAEIVVVTRDVREGNFRQALEEIQS
HHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHH
LDVINSIPSILRVL
HHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]