Click here to switch to the map view.

The map label for this gene is nadC [H]

Identifier: 113477756

GI number: 113477756

Start: 6710540

End: 6711412

Strand: Reverse

Name: nadC [H]

Synonym: Tery_4352

Alternate gene names: 113477756

Gene position: 6711412-6710540 (Counterclockwise)

Preceding gene: 113477757

Following gene: 113477755

Centisome position: 86.6

GC content: 41.35

Gene sequence:

>873_bases
ATGAAAGGGGTCATACCTCCAAAAATAATATTAGATAATTTATTAAAAGATTGGTTGCTAGAAGATATTGGTCGCGGCGA
TCGCACAACTTCTGGCCTTTTACTAGAAGATGAGGTAATTGTAGGAACAGGCCATTGGTTAATAAAGGAGCCTGGGGTTA
TTGCAGGTTTGCCTATAGCCGCTAGGGTATTTGAACTTCTAGACCAGCAGGTAAACTTTTTACCTACTGTTGCTGAGGGA
GAATGGTGTGAGAAGGGAACTGTAGTTGCTAAGTTGGATGGGTCTTTAGATAGTTTACTGACTGGGGAAAGGGTGGCTTT
AAATTTGGGGATGCGTCTGAGTGGGATAGCAACTATGACTCGTAAATATGTGGAGAAAATTGCTGGTCTGCCAGTACAGT
TGGTTGATACTCGGAAAACAACCCCTGGTCTGAGAATTTTGGAAAAGTATGCTACTCAAGTTGGTGGGGCGAAAAATCAT
CGGATGGGTTTGGATGATGGGGTGATGATTAAAGATAATCATATTGCTGCTGCTGGAGGTATTGGGGAAGCGATCGCTAA
GGTGAGAGAAAGGATACCTTATCCTTTGACTATTGAGGTGGAGACGGAAACATTGGTGGAGGTTGAGAGGGCTTTGGAGC
ATCAAGCGGATATTATTATGCTTGATAATATGTCTGTTGAAGTGATGGAGCAAGCGGTTAAAATGATTCGGCAAAATAAT
AGTCGGATTAAAATTGAAGCCTCGGGAAATATTACCCTGGAAACTATTAGAAATGTTGCGGAAACCGGAGTTGATTATAT
TTCGACTAGTGCTCCTATTACTCGGTCAACTTGGTTAGATTTAAGTATGAAAATAACAAAAGCGGTTTCATAA

Upstream 100 bases:

>100_bases
TAATCTTAAAGTAGTAGAGATATGGGGAATGTACAAGATGGTTATTATTGATTGTACTGGAAAAAAATTTTTTGTTTGAT
TTTCGCAAATAGGGAAAACT

Downstream 100 bases:

>100_bases
GTGTTTCATTTCTAGGTAAAAAATATGAATTAATGTTGAGGATGTTGTATACAAGGTCCTTATGGTCGCAGTGGGAGAAT
CTCACAACAGCTATAAAGGT

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MKGVIPPKIILDNLLKDWLLEDIGRGDRTTSGLLLEDEVIVGTGHWLIKEPGVIAGLPIAARVFELLDQQVNFLPTVAEG
EWCEKGTVVAKLDGSLDSLLTGERVALNLGMRLSGIATMTRKYVEKIAGLPVQLVDTRKTTPGLRILEKYATQVGGAKNH
RMGLDDGVMIKDNHIAAAGGIGEAIAKVRERIPYPLTIEVETETLVEVERALEHQADIIMLDNMSVEVMEQAVKMIRQNN
SRIKIEASGNITLETIRNVAETGVDYISTSAPITRSTWLDLSMKITKAVS

Sequences:

>Translated_290_residues
MKGVIPPKIILDNLLKDWLLEDIGRGDRTTSGLLLEDEVIVGTGHWLIKEPGVIAGLPIAARVFELLDQQVNFLPTVAEG
EWCEKGTVVAKLDGSLDSLLTGERVALNLGMRLSGIATMTRKYVEKIAGLPVQLVDTRKTTPGLRILEKYATQVGGAKNH
RMGLDDGVMIKDNHIAAAGGIGEAIAKVRERIPYPLTIEVETETLVEVERALEHQADIIMLDNMSVEVMEQAVKMIRQNN
SRIKIEASGNITLETIRNVAETGVDYISTSAPITRSTWLDLSMKITKAVS
>Mature_290_residues
MKGVIPPKIILDNLLKDWLLEDIGRGDRTTSGLLLEDEVIVGTGHWLIKEPGVIAGLPIAARVFELLDQQVNFLPTVAEG
EWCEKGTVVAKLDGSLDSLLTGERVALNLGMRLSGIATMTRKYVEKIAGLPVQLVDTRKTTPGLRILEKYATQVGGAKNH
RMGLDDGVMIKDNHIAAAGGIGEAIAKVRERIPYPLTIEVETETLVEVERALEHQADIIMLDNMSVEVMEQAVKMIRQNN
SRIKIEASGNITLETIRNVAETGVDYISTSAPITRSTWLDLSMKITKAVS

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=287, Percent_Identity=36.9337979094077, Blast_Score=154, Evalue=1e-37,
Organism=Escherichia coli, GI1786299, Length=240, Percent_Identity=43.75, Blast_Score=160, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6321162, Length=280, Percent_Identity=34.2857142857143, Blast_Score=141, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31715; Mature: 31715

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGVIPPKIILDNLLKDWLLEDIGRGDRTTSGLLLEDEVIVGTGHWLIKEPGVIAGLPIA
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCEEEECCCEEEECCCEEECCCHH
ARVFELLDQQVNFLPTVAEGEWCEKGTVVAKLDGSLDSLLTGERVALNLGMRLSGIATMT
HHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCHHHHHCCCEEEEECCCHHHHHHHHH
RKYVEKIAGLPVQLVDTRKTTPGLRILEKYATQVGGAKNHRMGLDDGVMIKDNHIAAAGG
HHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCEEECCC
IGEAIAKVRERIPYPLTIEVETETLVEVERALEHQADIIMLDNMSVEVMEQAVKMIRQNN
HHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCC
SRIKIEASGNITLETIRNVAETGVDYISTSAPITRSTWLDLSMKITKAVS
CEEEEEECCCEEHHHHHHHHHCCHHHHCCCCCCCHHHHHHHEEEEHHHCC
>Mature Secondary Structure
MKGVIPPKIILDNLLKDWLLEDIGRGDRTTSGLLLEDEVIVGTGHWLIKEPGVIAGLPIA
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCEEEECCCEEEECCCEEECCCHH
ARVFELLDQQVNFLPTVAEGEWCEKGTVVAKLDGSLDSLLTGERVALNLGMRLSGIATMT
HHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCHHHHHCCCEEEEECCCHHHHHHHHH
RKYVEKIAGLPVQLVDTRKTTPGLRILEKYATQVGGAKNHRMGLDDGVMIKDNHIAAAGG
HHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCEEECCC
IGEAIAKVRERIPYPLTIEVETETLVEVERALEHQADIIMLDNMSVEVMEQAVKMIRQNN
HHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCC
SRIKIEASGNITLETIRNVAETGVDYISTSAPITRSTWLDLSMKITKAVS
CEEEEEECCCEEHHHHHHHHHCCHHHHCCCCCCCHHHHHHHEEEEHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]