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The map label for this gene is 113476075

Identifier: 113476075

GI number: 113476075

Start: 3775803

End: 3776918

Strand: Direct

Name: 113476075

Synonym: Tery_2451

Alternate gene names: NA

Gene position: 3775803-3776918 (Clockwise)

Preceding gene: 113476074

Following gene: 113476076

Centisome position: 48.72

GC content: 39.07

Gene sequence:

>1116_bases
ATGAAGAGTACAGCAACTTTAAATAAGACTTTTCTTACAGTCAAAGGCAAACGTTTTCACTATGTTTGGTTGCGGGATAA
TTGCTTATCTCCAAAATCTCGTCATCCAACTTCTTTTCAGAAACTATATGAAATGAAGCATACTTTATGCCCTGAACCAT
TATCTGTAGAAGAGAAAGATGGGGAACTGACTATCATTTGGAACGAAGATCCTCCTCACAAAAGTACATTCTCAATATCT
TGGTTGTTGAGTCACGCTTACGATGACGGAGAGCAGGATAATGAAAATGAAGACTCTGAATCTAATTCTCAGAACCAGGA
ATTTTTATGGGATAAAGCTTGGATAGAAGCAAATATATCAAAGTTGCAGGAAGCTCTTTCATCCAATCCCGAATTGTGGC
TCGAGCAGCTTTTTACTTTCGGATTCACCGTACTCCATAATATACCAGCCAAGGATTTGCAGGCTACAATAGAATCCATT
GGGCCAATTTACAACGGTGACTACGGATTGTTCGCACCATCAAAGACTACAAATGAAGGAAAGGATTTAGCAGAGACTGG
TAATGCGATGAGCTTCCATACTGACTATACTTATTGGCACACTCCACCTTTGCTCACCAGCTTGTATTGTGTAGAAAATA
GTGCTTCTGGTGGGGAGTCGCTGATCGTAGACGGTTTTCGAGTTGTGGATGATTTTCGTCAGCAACATCCGGATTATTTT
CAGATTTTGACTCAAACTCCCATCCAGTTCAAACAGGTGTACACAAAATGGCAATACTTTTATTCCAGAACTCAGCCTAT
ATTAGAATTAGATGAATATGGAAAAGTGACTAGAATCAATTTTGCCAACTCTCACAGCTACACTTGGAAATTACCATTCG
ATCAAATGGAGGAATTTTATGCAGCTTACATAACCTTCTTTCAATATGTAAAAAATCCAGTTTATGAATACTGCTTTAGT
CTAGAACCGGGAGACCTTCTGTTGATGAATGACTCCAGGATTATGCATGGACGGAAAGCTTTTACAGGTAATCGACATCT
GGAAATAGCCTGTGTTTCTTGGGATTTTTTGCAGGCACGGCAGCGCTTTCATCAAAATAAACATCTTTTTATGTAG

Upstream 100 bases:

>100_bases
ATTAAAACCAGGAGATTTACTTCATCAACCCAGTTTCTGCATAAGTTCTGATTAATTTGTATTTTTTGATTTTGAACAAC
TAAAAAAATAGGAGTTTTCC

Downstream 100 bases:

>100_bases
ACTTTCAAAGTTATATAGCAACCCTAATCTCTCCTCCTAGAATGGGTTAGGGTTCTATACCAAGTTTATGGCTAAGGACG
CTATGATTTAATAGTTATAG

Product: taurine catabolism dioxygenase TauD/TfdA

Products: NA

Alternate protein names: Gamma-butyrobetaine hydroxylase; Gamma-BBH; Gamma-butyrobetaine,2-oxoglutarate dioxygenase [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MKSTATLNKTFLTVKGKRFHYVWLRDNCLSPKSRHPTSFQKLYEMKHTLCPEPLSVEEKDGELTIIWNEDPPHKSTFSIS
WLLSHAYDDGEQDNENEDSESNSQNQEFLWDKAWIEANISKLQEALSSNPELWLEQLFTFGFTVLHNIPAKDLQATIESI
GPIYNGDYGLFAPSKTTNEGKDLAETGNAMSFHTDYTYWHTPPLLTSLYCVENSASGGESLIVDGFRVVDDFRQQHPDYF
QILTQTPIQFKQVYTKWQYFYSRTQPILELDEYGKVTRINFANSHSYTWKLPFDQMEEFYAAYITFFQYVKNPVYEYCFS
LEPGDLLLMNDSRIMHGRKAFTGNRHLEIACVSWDFLQARQRFHQNKHLFM

Sequences:

>Translated_371_residues
MKSTATLNKTFLTVKGKRFHYVWLRDNCLSPKSRHPTSFQKLYEMKHTLCPEPLSVEEKDGELTIIWNEDPPHKSTFSIS
WLLSHAYDDGEQDNENEDSESNSQNQEFLWDKAWIEANISKLQEALSSNPELWLEQLFTFGFTVLHNIPAKDLQATIESI
GPIYNGDYGLFAPSKTTNEGKDLAETGNAMSFHTDYTYWHTPPLLTSLYCVENSASGGESLIVDGFRVVDDFRQQHPDYF
QILTQTPIQFKQVYTKWQYFYSRTQPILELDEYGKVTRINFANSHSYTWKLPFDQMEEFYAAYITFFQYVKNPVYEYCFS
LEPGDLLLMNDSRIMHGRKAFTGNRHLEIACVSWDFLQARQRFHQNKHLFM
>Mature_371_residues
MKSTATLNKTFLTVKGKRFHYVWLRDNCLSPKSRHPTSFQKLYEMKHTLCPEPLSVEEKDGELTIIWNEDPPHKSTFSIS
WLLSHAYDDGEQDNENEDSESNSQNQEFLWDKAWIEANISKLQEALSSNPELWLEQLFTFGFTVLHNIPAKDLQATIESI
GPIYNGDYGLFAPSKTTNEGKDLAETGNAMSFHTDYTYWHTPPLLTSLYCVENSASGGESLIVDGFRVVDDFRQQHPDYF
QILTQTPIQFKQVYTKWQYFYSRTQPILELDEYGKVTRINFANSHSYTWKLPFDQMEEFYAAYITFFQYVKNPVYEYCFS
LEPGDLLLMNDSRIMHGRKAFTGNRHLEIACVSWDFLQARQRFHQNKHLFM

Specific function: Catalyzes the formation of L-carnitine from gamma- butyrobetaine [H]

COG id: COG2175

COG function: function code Q; Probable taurine catabolism dioxygenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-BBH/TMLD family [H]

Homologues:

Organism=Homo sapiens, GI4502369, Length=243, Percent_Identity=30.8641975308642, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI8922625, Length=342, Percent_Identity=24.8538011695906, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI296317249, Length=244, Percent_Identity=24.5901639344262, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17534641, Length=385, Percent_Identity=25.4545454545455, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71992672, Length=372, Percent_Identity=25.2688172043011, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI221329931, Length=379, Percent_Identity=24.5382585751979, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI19922166, Length=383, Percent_Identity=26.3707571801567, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24639015, Length=374, Percent_Identity=26.7379679144385, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24648401, Length=349, Percent_Identity=24.6418338108883, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012775
- InterPro:   IPR003819 [H]

Pfam domain/function: PF02668 TauD [H]

EC number: =1.14.11.1 [H]

Molecular weight: Translated: 43437; Mature: 43437

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSTATLNKTFLTVKGKRFHYVWLRDNCLSPKSRHPTSFQKLYEMKHTLCPEPLSVEEKD
CCCCCCCCEEEEEEECCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
GELTIIWNEDPPHKSTFSISWLLSHAYDDGEQDNENEDSESNSQNQEFLWDKAWIEANIS
CCEEEEECCCCCCCCEEEHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
KLQEALSSNPELWLEQLFTFGFTVLHNIPAKDLQATIESIGPIYNGDYGLFAPSKTTNEG
HHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEECCCCCCCCC
KDLAETGNAMSFHTDYTYWHTPPLLTSLYCVENSASGGESLIVDGFRVVDDFRQQHPDYF
CHHHHCCCEEEEECCCCEEECCHHHHHHHEECCCCCCCCEEEECHHHHHHHHHHHCCHHH
QILTQTPIQFKQVYTKWQYFYSRTQPILELDEYGKVTRINFANSHSYTWKLPFDQMEEFY
HHHHCCCHHHHHHHHHHHHHHHCCCCCEEHHCCCCEEEEEECCCCCEEEECCHHHHHHHH
AAYITFFQYVKNPVYEYCFSLEPGDLLLMNDSRIMHGRKAFTGNRHLEIACVSWDFLQAR
HHHHHHHHHHHCHHHHHHHCCCCCCEEEEECCCEECCCCCCCCCCEEEEEEECHHHHHHH
QRFHQNKHLFM
HHHHCCCCCCC
>Mature Secondary Structure
MKSTATLNKTFLTVKGKRFHYVWLRDNCLSPKSRHPTSFQKLYEMKHTLCPEPLSVEEKD
CCCCCCCCEEEEEEECCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
GELTIIWNEDPPHKSTFSISWLLSHAYDDGEQDNENEDSESNSQNQEFLWDKAWIEANIS
CCEEEEECCCCCCCCEEEHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
KLQEALSSNPELWLEQLFTFGFTVLHNIPAKDLQATIESIGPIYNGDYGLFAPSKTTNEG
HHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEECCCCCCCCC
KDLAETGNAMSFHTDYTYWHTPPLLTSLYCVENSASGGESLIVDGFRVVDDFRQQHPDYF
CHHHHCCCEEEEECCCCEEECCHHHHHHHEECCCCCCCCEEEECHHHHHHHHHHHCCHHH
QILTQTPIQFKQVYTKWQYFYSRTQPILELDEYGKVTRINFANSHSYTWKLPFDQMEEFY
HHHHCCCHHHHHHHHHHHHHHHCCCCCEEHHCCCCEEEEEECCCCCEEEECCHHHHHHHH
AAYITFFQYVKNPVYEYCFSLEPGDLLLMNDSRIMHGRKAFTGNRHLEIACVSWDFLQAR
HHHHHHHHHHHCHHHHHHHCCCCCCEEEEECCCEECCCCCCCCCCEEEEEEECHHHHHHH
QRFHQNKHLFM
HHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]