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The map label for this gene is proA

Identifier: 113475915

GI number: 113475915

Start: 3542138

End: 3543433

Strand: Direct

Name: proA

Synonym: Tery_2275

Alternate gene names: 113475915

Gene position: 3542138-3543433 (Clockwise)

Preceding gene: 113475905

Following gene: 113475916

Centisome position: 45.7

GC content: 39.04

Gene sequence:

>1296_bases
ATGGTTACAGAAGTTTCTTTGATTGAAATAGCTAAAACCACCCGCCAAGCAGCACAAAAATCAGCAGTGTTATCCACAGA
AGCCAAAAATCAAGCTATTGAAGCAGTTGCCCAGGCATTAGAAAAAGCTACACCAAAAATTATTACAGCAAACCAACTTG
ACTGTCGAATAGCTGAAACTGATGGAATTGCCAAACCCCTATACAATAGATTGAAAATGGATGAGGCTAAACTCAACAGT
GCGATCGAAGGTTTACGTAACGTTGCTACTCTTAGGGATCCTATAGGTGTAGTACAAATACATCGAGAACTCGATGCAGG
ATTAATTCTCAAGCGTATTACTTGTCCCCTGGGTGTTATTGGTGTCGTGTTTGAAGCCCGCCCAGATGCTGTAATTCAAA
TTTCAGCTTTGGCAATTAAATCAGGAAATGGCGTCATTCTTAAAGGGGGTAAAGAAGCAACTAATTCATGTCTTGAGTTA
GTGACAGCAATTCGCCAAGGTTTATCTACAACTTCTGTTAACCCTGATGGGGTACAGTTATTAACTACCCGGGAAGAAAC
TCTGGAGTTATTGAAGTTAGATGAATATGTGGATTTAATTATTCCCAGAGGTTCTAATTCCTTTGTGAAATTTGTTCAAG
AAAATACCCAAATTCCAGTTTTAGGTCATGCTGAAGGAATTTGTCATGTCTATGTAGATAAATTTGCAGATATTCAAAAA
GCAGTAAAAATTACTATTGATGCCAAAACTCAATATCCTGCTGCTTGTAATGCTGCCGAAACTTTGTTGGTACATACTGA
TGTTGCTGCCAAGTTTCTCTCAGAAGTTTTCCCAGAACTAGAAAAACGTCAGGTTGAGTTACGGGGTGATAGAGCTACTC
AGCAAATTTTATCATCAGTTAAGGAAGCGACAGATCTAGACTGGGCAACAGAATACAGTGATCTAGTTTTATCAGTTAAA
GTAGTAGATAGTTTAGACTCAGCGATCGCTCATATCAATAATTATGGTTCCGGACACACAGATGCTATCATAACTGAGGA
TGGAAAAGCTGCGGAGATATTCCTCGCACAAATAGGTTCTGCTGGGGTATTCCATAACTGCTCAACTAGATTTTCTGACG
GTTTCCGTTATGGTTTTGGCGCTGAAGTCGGAATTAGTACACAGAAAATGCCACCAAGAGGTCCAGTAGGTTTAGAAGGA
TTAGTCACTTATAAATATCAAATTGTTGGTGATGGTCATATTGCTGCCACTTATTCTGGTGAAAATGCTAAACCATTTAC
TCACCAAGATTTTTGA

Upstream 100 bases:

>100_bases
TCACACTTGGTCTAAAAGCCTAGTTGAAAATATAATTAATAATAATTAGCAAAAAATGATACAGTAGGAAAATAATTATT
AAAATTTTGCCGAAAGTAAA

Downstream 100 bases:

>100_bases
CGCAGAAATAAAGGCCTTGGTCAATTTAGCTATGATTTTCCTGCTTAGGGGTTAAGGAGCATTGACTTAATCAAAGAATA
ACTATATAAGTAGAGACGTT

Product: glutamate-5-semialdehyde dehydrogenase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MVTEVSLIEIAKTTRQAAQKSAVLSTEAKNQAIEAVAQALEKATPKIITANQLDCRIAETDGIAKPLYNRLKMDEAKLNS
AIEGLRNVATLRDPIGVVQIHRELDAGLILKRITCPLGVIGVVFEARPDAVIQISALAIKSGNGVILKGGKEATNSCLEL
VTAIRQGLSTTSVNPDGVQLLTTREETLELLKLDEYVDLIIPRGSNSFVKFVQENTQIPVLGHAEGICHVYVDKFADIQK
AVKITIDAKTQYPAACNAAETLLVHTDVAAKFLSEVFPELEKRQVELRGDRATQQILSSVKEATDLDWATEYSDLVLSVK
VVDSLDSAIAHINNYGSGHTDAIITEDGKAAEIFLAQIGSAGVFHNCSTRFSDGFRYGFGAEVGISTQKMPPRGPVGLEG
LVTYKYQIVGDGHIAATYSGENAKPFTHQDF

Sequences:

>Translated_431_residues
MVTEVSLIEIAKTTRQAAQKSAVLSTEAKNQAIEAVAQALEKATPKIITANQLDCRIAETDGIAKPLYNRLKMDEAKLNS
AIEGLRNVATLRDPIGVVQIHRELDAGLILKRITCPLGVIGVVFEARPDAVIQISALAIKSGNGVILKGGKEATNSCLEL
VTAIRQGLSTTSVNPDGVQLLTTREETLELLKLDEYVDLIIPRGSNSFVKFVQENTQIPVLGHAEGICHVYVDKFADIQK
AVKITIDAKTQYPAACNAAETLLVHTDVAAKFLSEVFPELEKRQVELRGDRATQQILSSVKEATDLDWATEYSDLVLSVK
VVDSLDSAIAHINNYGSGHTDAIITEDGKAAEIFLAQIGSAGVFHNCSTRFSDGFRYGFGAEVGISTQKMPPRGPVGLEG
LVTYKYQIVGDGHIAATYSGENAKPFTHQDF
>Mature_431_residues
MVTEVSLIEIAKTTRQAAQKSAVLSTEAKNQAIEAVAQALEKATPKIITANQLDCRIAETDGIAKPLYNRLKMDEAKLNS
AIEGLRNVATLRDPIGVVQIHRELDAGLILKRITCPLGVIGVVFEARPDAVIQISALAIKSGNGVILKGGKEATNSCLEL
VTAIRQGLSTTSVNPDGVQLLTTREETLELLKLDEYVDLIIPRGSNSFVKFVQENTQIPVLGHAEGICHVYVDKFADIQK
AVKITIDAKTQYPAACNAAETLLVHTDVAAKFLSEVFPELEKRQVELRGDRATQQILSSVKEATDLDWATEYSDLVLSVK
VVDSLDSAIAHINNYGSGHTDAIITEDGKAAEIFLAQIGSAGVFHNCSTRFSDGFRYGFGAEVGISTQKMPPRGPVGLEG
LVTYKYQIVGDGHIAATYSGENAKPFTHQDF

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI21361368, Length=423, Percent_Identity=43.7352245862884, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI62912457, Length=423, Percent_Identity=43.7352245862884, Blast_Score=333, Evalue=2e-91,
Organism=Escherichia coli, GI1786438, Length=416, Percent_Identity=39.4230769230769, Blast_Score=301, Evalue=7e-83,
Organism=Caenorhabditis elegans, GI17569967, Length=428, Percent_Identity=41.3551401869159, Blast_Score=322, Evalue=3e-88,
Organism=Caenorhabditis elegans, GI17569969, Length=428, Percent_Identity=41.3551401869159, Blast_Score=322, Evalue=3e-88,
Organism=Saccharomyces cerevisiae, GI6324899, Length=451, Percent_Identity=44.1241685144124, Blast_Score=358, Evalue=1e-100,
Organism=Drosophila melanogaster, GI21357643, Length=424, Percent_Identity=42.9245283018868, Blast_Score=336, Evalue=2e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_TRIEI (Q112S1)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_721976.1
- ProteinModelPortal:   Q112S1
- SMR:   Q112S1
- STRING:   Q112S1
- GeneID:   4243270
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_2275
- NMPDR:   fig|203124.1.peg.1488
- eggNOG:   COG0014
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- PhylomeDB:   Q112S1
- BioCyc:   TERY203124:TERY_2275-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 46530; Mature: 46530

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTEVSLIEIAKTTRQAAQKSAVLSTEAKNQAIEAVAQALEKATPKIITANQLDCRIAET
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEECC
DGIAKPLYNRLKMDEAKLNSAIEGLRNVATLRDPIGVVQIHRELDAGLILKRITCPLGVI
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHCCHHHH
GVVFEARPDAVIQISALAIKSGNGVILKGGKEATNSCLELVTAIRQGLSTTSVNPDGVQL
HHEEECCCCCEEEEEEEEEECCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
LTTREETLELLKLDEYVDLIIPRGSNSFVKFVQENTQIPVLGHAEGICHVYVDKFADIQK
EECHHHHHHHHHHHCCEEEEEECCCCHHHHHHHCCCCCEEEECCCCEEEHHHHHHHHHHE
AVKITIDAKTQYPAACNAAETLLVHTDVAAKFLSEVFPELEKRQVELRGDRATQQILSSV
EEEEEEECCCCCCCCCCCHHEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
KEATDLDWATEYSDLVLSVKVVDSLDSAIAHINNYGSGHTDAIITEDGKAAEIFLAQIGS
HHHCCCCHHHCHHHHEEEEHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHEEHHCC
AGVFHNCSTRFSDGFRYGFGAEVGISTQKMPPRGPVGLEGLVTYKYQIVGDGHIAATYSG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCEEEEEECC
ENAKPFTHQDF
CCCCCCCCCCC
>Mature Secondary Structure
MVTEVSLIEIAKTTRQAAQKSAVLSTEAKNQAIEAVAQALEKATPKIITANQLDCRIAET
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEECC
DGIAKPLYNRLKMDEAKLNSAIEGLRNVATLRDPIGVVQIHRELDAGLILKRITCPLGVI
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCHHHHHHHHHCCHHHH
GVVFEARPDAVIQISALAIKSGNGVILKGGKEATNSCLELVTAIRQGLSTTSVNPDGVQL
HHEEECCCCCEEEEEEEEEECCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
LTTREETLELLKLDEYVDLIIPRGSNSFVKFVQENTQIPVLGHAEGICHVYVDKFADIQK
EECHHHHHHHHHHHCCEEEEEECCCCHHHHHHHCCCCCEEEECCCCEEEHHHHHHHHHHE
AVKITIDAKTQYPAACNAAETLLVHTDVAAKFLSEVFPELEKRQVELRGDRATQQILSSV
EEEEEEECCCCCCCCCCCHHEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
KEATDLDWATEYSDLVLSVKVVDSLDSAIAHINNYGSGHTDAIITEDGKAAEIFLAQIGS
HHHCCCCHHHCHHHHEEEEHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHEEHHCC
AGVFHNCSTRFSDGFRYGFGAEVGISTQKMPPRGPVGLEGLVTYKYQIVGDGHIAATYSG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCEEEEEECC
ENAKPFTHQDF
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA