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The map label for this gene is tuaD [H]

Identifier: 113475903

GI number: 113475903

Start: 3520677

End: 3522032

Strand: Direct

Name: tuaD [H]

Synonym: Tery_2263

Alternate gene names: 113475903

Gene position: 3520677-3522032 (Clockwise)

Preceding gene: 113475902

Following gene: 113475904

Centisome position: 45.43

GC content: 39.9

Gene sequence:

>1356_bases
ATGAAAGTTTCTATGATTGGTACGGGATATGTAGGTCTAGTGTCTGGGGTTTGCTTTGCCGAAAAGGGGCATTCGGTTAT
TTGTGTAGATATTGACCAAGATAAGGTCGATTCTATTAATCAGGGCATTCCCCCAATATATGAGAAGGGTTTGCAGGAGT
TGTTGCAAAAAAATATTGGTGATGGCTTACAAGCTGTCACCGACTTGGGACAGGCAGTACAAGAAACTGAAATTTCTATG
ATTGCTGTTGGCACTCCTTTTGATGGTAAGGAAATTGACTTGGGTTATATCAAGCAGGTTTCTCAGCAAATAGGGGAAGC
TTTAAGGAATAAAAATTCTTATCATTTGGTCGTTATCAAAAGTACGGTAGTACCAGGTACTACTGAAAATGTGGTGTTAC
CAATATTAGAGGAAACTTCTGGCAAAAAAGCAGGGGTGGATTTTGGTCTGGGGATGAATCCTGAATTTTTGAGGGAAGGG
GAAGCTATTGAGGATTTTATGTTTCTTGATAGGATTATTTTAGGTGGAATTGATGCTAAAAGTATTAGCTTACTGGAGCT
TTTATACCAAGTTTTCGAGGGCATAGAAAAGCTAACTACAAATTGCACTACGGCAGAAATGATTAAGTACACTGCTAATT
CACTTTTGGCTACTATGATTTCGTTTTCTAATGAAATAGGTAATCTCTGTAGTGCTGTTGGTGGTGTAGATGTGGTTGAG
GTGATGCAAGGAGTTCATTTGGATAAACGCTTTAGCCCAATTACGGCTAGTGGCGATCGCATTACTCCTGCTTTTCTGAG
CTACTTACAAGCAGGTTGTGGTTTTGGTGGTAGTTGCTTTCCTAAAGATATAAAAGCTTTAACTGCTTATGGCAGTAAAC
TGGGAAACCAGATGGAAATTCTGGAGGCTGCGATTAGAGTGAATGTTGCTCAACCTCAGAAAGTTTTGGATTTGTTGAAA
AAGCATTTTCCTTCGACTGAGGGGGTAAAGGTAAGTGTTTTGGGTCTAGCTTTTAAACCTGGGACTGATGATATCCGAGA
GTCTCCGGCGATTCCTATCATTGAATCTCTCTTAAGTCAAGGTGCGATAGTTAAGACTTACGATCCATTTGCTCAAAAGG
AGGCTCAAAAGTATTTTTGTGAAAATGAATTGCTGTTTTGTGATGATTTAACTGATGCTTTAGATGCTGTAGAGGCAGTA
ATAATAGTCACTTGCTGGTCTGAGTTTGAGGCTCTCCCACGGCTATTAGCTGGTAAGGATAATCCACCAGTTGTGGTTGA
TGGCAGAAGAATGTTGGGTAAACAGAGTGTTTCTATCTATGAAGGAATAGGTTGGTCCTCCAAATCAAAGTATTGA

Upstream 100 bases:

>100_bases
TAGAAATGATTTGGGATACAATCCTGGTATTTCTCTTGATGAAGGGCTAAAAAGATCGCTGATATGGTATCAAGATAATT
CAGAAGCAGCGGAGGCATAA

Downstream 100 bases:

>100_bases
AAACATGACACAAACAATTTTAGTTACTGGGGCTACAGGATTTGTGGGAAGTCATTTGGTTAGGCAACTCCTGAATAAAG
GCAATCGAGTTATTATTCTC

Product: GDP-mannose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH; Teichuronic acid biosynthesis protein tuaD [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MKVSMIGTGYVGLVSGVCFAEKGHSVICVDIDQDKVDSINQGIPPIYEKGLQELLQKNIGDGLQAVTDLGQAVQETEISM
IAVGTPFDGKEIDLGYIKQVSQQIGEALRNKNSYHLVVIKSTVVPGTTENVVLPILEETSGKKAGVDFGLGMNPEFLREG
EAIEDFMFLDRIILGGIDAKSISLLELLYQVFEGIEKLTTNCTTAEMIKYTANSLLATMISFSNEIGNLCSAVGGVDVVE
VMQGVHLDKRFSPITASGDRITPAFLSYLQAGCGFGGSCFPKDIKALTAYGSKLGNQMEILEAAIRVNVAQPQKVLDLLK
KHFPSTEGVKVSVLGLAFKPGTDDIRESPAIPIIESLLSQGAIVKTYDPFAQKEAQKYFCENELLFCDDLTDALDAVEAV
IIVTCWSEFEALPRLLAGKDNPPVVVDGRRMLGKQSVSIYEGIGWSSKSKY

Sequences:

>Translated_451_residues
MKVSMIGTGYVGLVSGVCFAEKGHSVICVDIDQDKVDSINQGIPPIYEKGLQELLQKNIGDGLQAVTDLGQAVQETEISM
IAVGTPFDGKEIDLGYIKQVSQQIGEALRNKNSYHLVVIKSTVVPGTTENVVLPILEETSGKKAGVDFGLGMNPEFLREG
EAIEDFMFLDRIILGGIDAKSISLLELLYQVFEGIEKLTTNCTTAEMIKYTANSLLATMISFSNEIGNLCSAVGGVDVVE
VMQGVHLDKRFSPITASGDRITPAFLSYLQAGCGFGGSCFPKDIKALTAYGSKLGNQMEILEAAIRVNVAQPQKVLDLLK
KHFPSTEGVKVSVLGLAFKPGTDDIRESPAIPIIESLLSQGAIVKTYDPFAQKEAQKYFCENELLFCDDLTDALDAVEAV
IIVTCWSEFEALPRLLAGKDNPPVVVDGRRMLGKQSVSIYEGIGWSSKSKY
>Mature_451_residues
MKVSMIGTGYVGLVSGVCFAEKGHSVICVDIDQDKVDSINQGIPPIYEKGLQELLQKNIGDGLQAVTDLGQAVQETEISM
IAVGTPFDGKEIDLGYIKQVSQQIGEALRNKNSYHLVVIKSTVVPGTTENVVLPILEETSGKKAGVDFGLGMNPEFLREG
EAIEDFMFLDRIILGGIDAKSISLLELLYQVFEGIEKLTTNCTTAEMIKYTANSLLATMISFSNEIGNLCSAVGGVDVVE
VMQGVHLDKRFSPITASGDRITPAFLSYLQAGCGFGGSCFPKDIKALTAYGSKLGNQMEILEAAIRVNVAQPQKVLDLLK
KHFPSTEGVKVSVLGLAFKPGTDDIRESPAIPIIESLLSQGAIVKTYDPFAQKEAQKYFCENELLFCDDLTDALDAVEAV
IIVTCWSEFEALPRLLAGKDNPPVVVDGRRMLGKQSVSIYEGIGWSSKSKY

Specific function: Catalyzes the conversion of UDP-glucose into UDP- glucuronate, one of the precursors of teichuronic acid [H]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=464, Percent_Identity=31.25, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI296040438, Length=366, Percent_Identity=31.9672131147541, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI296040443, Length=458, Percent_Identity=28.1659388646288, Blast_Score=139, Evalue=5e-33,
Organism=Escherichia coli, GI48994968, Length=376, Percent_Identity=31.3829787234043, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI1788340, Length=379, Percent_Identity=28.7598944591029, Blast_Score=135, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17560350, Length=465, Percent_Identity=29.4623655913978, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI17136908, Length=482, Percent_Identity=30.9128630705394, Blast_Score=186, Evalue=3e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 48768; Mature: 48768

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVSMIGTGYVGLVSGVCFAEKGHSVICVDIDQDKVDSINQGIPPIYEKGLQELLQKNIG
CEEEEECCCHHHHHHHHHEECCCCEEEEEECCCHHHHHHHCCCCHHHHHHHHHHHHHHHC
DGLQAVTDLGQAVQETEISMIAVGTPFDGKEIDLGYIKQVSQQIGEALRNKNSYHLVVIK
CHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEE
STVVPGTTENVVLPILEETSGKKAGVDFGLGMNPEFLREGEAIEDFMFLDRIILGGIDAK
EEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCHH
SISLLELLYQVFEGIEKLTTNCTTAEMIKYTANSLLATMISFSNEIGNLCSAVGGVDVVE
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
VMQGVHLDKRFSPITASGDRITPAFLSYLQAGCGFGGSCFPKDIKALTAYGSKLGNQMEI
HHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHH
LEAAIRVNVAQPQKVLDLLKKHFPSTEGVKVSVLGLAFKPGTDDIRESPAIPIIESLLSQ
HHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCHHHCCCCCHHHHHHHHC
GAIVKTYDPFAQKEAQKYFCENELLFCDDLTDALDAVEAVIIVTCWSEFEALPRLLAGKD
CCEEEECCHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NPPVVVDGRRMLGKQSVSIYEGIGWSSKSKY
CCCEEECCHHHHCCCCCHHHHCCCCCCCCCC
>Mature Secondary Structure
MKVSMIGTGYVGLVSGVCFAEKGHSVICVDIDQDKVDSINQGIPPIYEKGLQELLQKNIG
CEEEEECCCHHHHHHHHHEECCCCEEEEEECCCHHHHHHHCCCCHHHHHHHHHHHHHHHC
DGLQAVTDLGQAVQETEISMIAVGTPFDGKEIDLGYIKQVSQQIGEALRNKNSYHLVVIK
CHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEE
STVVPGTTENVVLPILEETSGKKAGVDFGLGMNPEFLREGEAIEDFMFLDRIILGGIDAK
EEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCHH
SISLLELLYQVFEGIEKLTTNCTTAEMIKYTANSLLATMISFSNEIGNLCSAVGGVDVVE
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
VMQGVHLDKRFSPITASGDRITPAFLSYLQAGCGFGGSCFPKDIKALTAYGSKLGNQMEI
HHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHH
LEAAIRVNVAQPQKVLDLLKKHFPSTEGVKVSVLGLAFKPGTDDIRESPAIPIIESLLSQ
HHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCHHHCCCCCHHHHHHHHC
GAIVKTYDPFAQKEAQKYFCENELLFCDDLTDALDAVEAVIIVTCWSEFEALPRLLAGKD
CCEEEECCHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NPPVVVDGRRMLGKQSVSIYEGIGWSSKSKY
CCCEEECCHHHHCCCCCHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10048024; 9384377; 10376820 [H]