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The map label for this gene is hisB

Identifier: 113475686

GI number: 113475686

Start: 3155435

End: 3156076

Strand: Direct

Name: hisB

Synonym: Tery_2028

Alternate gene names: 113475686

Gene position: 3155435-3156076 (Clockwise)

Preceding gene: 113475685

Following gene: 113475688

Centisome position: 40.71

GC content: 41.9

Gene sequence:

>642_bases
ATGCAGATAAGCGATCGCCTTTCTTCATCTACTGCACCAATACTGAATTTGCCTGTTAGACGTGCTTCTGTGAAACGAAA
AACTGGAGAAACTGATGTGACTGTTAATCTTAATCTTGATGGTGTGGGTAATTGTCAGGCTAATACTGGTATTCCTTTTT
TGGATCATATGTTGCATCAAATTTCTTCTCATGGACTGATTGATTTGGATGTCCAGGCTGTGGGGGATATTGAAATTGAT
GACCATCATACTAATGAGGATGTGGGCATTACTTTAGGCCAGGCTTTAAAGCAGGCCTTGGGCGATCGAAAGGGTATTGT
CCGTTTTGGTCATTTTTTGGCTCCTTTGGATGAGGCTTTGGTTGAAGTGGCCTTAGATTTTTCTGGTCGTCCACATTTAA
GTTATGGTTTGGAAATGCCAACTCAACGGGTGGGAAATTATGATACTCAGTTAGTACGGGAATTTTTTGTGGCCCTGGCC
AATAATAGTTTGATGACTTTGCATATTCGGCAGTTGGGAGGAATTAATTCTCATCATATTATTGAGGCAGGGTTTAAAGC
TTTTGCTCGTTCTCTACGGATGGCTACGGAAATTGACCCCAGGCGAGTTGGGGAAATTCCTAGTTCCAAAGGAGTTTTGT
AG

Upstream 100 bases:

>100_bases
CTTACTTGGCTTAGTTTAACAATAATGAATAAACAGGCTGTAAAACTGTGCTACTGAAAAAGTAAAATTTAAAATTTATA
TCTATATTTATATATTTATT

Downstream 100 bases:

>100_bases
TTAGTTATCAGTTTTTGACTTTAGCGATCGCCTATGAGAAATTATTTTATACCAATTTCCTAAAGTCCGACTACACATAA
TGCTTCAAGAATAAAATCAT

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MQISDRLSSSTAPILNLPVRRASVKRKTGETDVTVNLNLDGVGNCQANTGIPFLDHMLHQISSHGLIDLDVQAVGDIEID
DHHTNEDVGITLGQALKQALGDRKGIVRFGHFLAPLDEALVEVALDFSGRPHLSYGLEMPTQRVGNYDTQLVREFFVALA
NNSLMTLHIRQLGGINSHHIIEAGFKAFARSLRMATEIDPRRVGEIPSSKGVL

Sequences:

>Translated_213_residues
MQISDRLSSSTAPILNLPVRRASVKRKTGETDVTVNLNLDGVGNCQANTGIPFLDHMLHQISSHGLIDLDVQAVGDIEID
DHHTNEDVGITLGQALKQALGDRKGIVRFGHFLAPLDEALVEVALDFSGRPHLSYGLEMPTQRVGNYDTQLVREFFVALA
NNSLMTLHIRQLGGINSHHIIEAGFKAFARSLRMATEIDPRRVGEIPSSKGVL
>Mature_213_residues
MQISDRLSSSTAPILNLPVRRASVKRKTGETDVTVNLNLDGVGNCQANTGIPFLDHMLHQISSHGLIDLDVQAVGDIEID
DHHTNEDVGITLGQALKQALGDRKGIVRFGHFLAPLDEALVEVALDFSGRPHLSYGLEMPTQRVGNYDTQLVREFFVALA
NNSLMTLHIRQLGGINSHHIIEAGFKAFARSLRMATEIDPRRVGEIPSSKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=194, Percent_Identity=48.9690721649485, Blast_Score=183, Evalue=8e-48,
Organism=Saccharomyces cerevisiae, GI6324776, Length=218, Percent_Identity=39.4495412844037, Blast_Score=153, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_TRIEI (Q93DQ9)

Other databases:

- EMBL:   AF382392
- EMBL:   CP000393
- RefSeq:   YP_721747.1
- ProteinModelPortal:   Q93DQ9
- SMR:   Q93DQ9
- STRING:   Q93DQ9
- GeneID:   4243632
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_2028
- NMPDR:   fig|203124.1.peg.5429
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- PhylomeDB:   Q93DQ9
- ProtClustDB:   PRK00951
- BioCyc:   TERY203124:TERY_2028-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 23291; Mature: 23291

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQISDRLSSSTAPILNLPVRRASVKRKTGETDVTVNLNLDGVGNCQANTGIPFLDHMLHQ
CCCHHHHCCCCCCEEECCHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHH
ISSHGLIDLDVQAVGDIEIDDHHTNEDVGITLGQALKQALGDRKGIVRFGHFLAPLDEAL
HHCCCEEEEEEEEECCEEECCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
VEVALDFSGRPHLSYGLEMPTQRVGNYDTQLVREFFVALANNSLMTLHIRQLGGINSHHI
HHHHHCCCCCCCCEECCCCCHHHHCCHHHHHHHHHHHHHHCCCEEEEEEHHHCCCCCCHH
IEAGFKAFARSLRMATEIDPRRVGEIPSSKGVL
HHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCC
>Mature Secondary Structure
MQISDRLSSSTAPILNLPVRRASVKRKTGETDVTVNLNLDGVGNCQANTGIPFLDHMLHQ
CCCHHHHCCCCCCEEECCHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHH
ISSHGLIDLDVQAVGDIEIDDHHTNEDVGITLGQALKQALGDRKGIVRFGHFLAPLDEAL
HHCCCEEEEEEEEECCEEECCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
VEVALDFSGRPHLSYGLEMPTQRVGNYDTQLVREFFVALANNSLMTLHIRQLGGINSHHI
HHHHHCCCCCCCCEECCCCCHHHHCCHHHHHHHHHHHHHHCCCEEEEEEHHHCCCCCCHH
IEAGFKAFARSLRMATEIDPRRVGEIPSSKGVL
HHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA