Click here to switch to the map view.

The map label for this gene is kbl [C]

Identifier: 113475636

GI number: 113475636

Start: 3062275

End: 3063909

Strand: Direct

Name: kbl [C]

Synonym: Tery_1973

Alternate gene names: 113475636

Gene position: 3062275-3063909 (Clockwise)

Preceding gene: 113475635

Following gene: 113475656

Centisome position: 39.51

GC content: 38.1

Gene sequence:

>1635_bases
ATGAAATTGTTGAACCAGCTTGTGAATGAGCAAGACAAACAACATCTGTCCTTAGAGATGACTGATCGAGACCCTGCTTT
GCAAGTCCCACAATTATCTCCAGTCAGAAAAAATATTAAGTCCTGGTTGATATCCCAATTGGCCGAACGGCTTGAAATTG
AGACCGATCAAATAGATATTCAGCGGGATTTTACTGATTATGGTCTTAACTCAATTGAAGTGGTCAATCTTTCTGGAGAA
TTAGAAAATCTTCTGGGTCGGCGACTTCCTCCTACTCTTTTGTTGGATTATCCTACTATTGAGTCTTTGGCTGAATATTT
AGTAGAAGATACTTCGGAGGATACTGGGCCAAATGTTCACAAAAAATTAGAAGATGAGGTTGAGGTCTCAACTTCTAATC
CAACTACGGAAACTGAAGAAATTCCTTTAGAATATTATAGGTTTGACCTCTATCCAGAATATCTACAACTGCAAAAGCAA
TTGGCAGATATTAATTCTACTGGCATTAGTAGTCCTTTCTTTATACCTCAAGAACGGGTTAATAATAATACTACGGTTAT
TGGTGGTAGAAAACTGGTGAATTATGCTACCTATAATTATTTGGGTATGTGTGGTGACCCTTTTGTCTCTAACGCTGCAA
AGGAAGCTATTAATCGTTATGGTACTTCTGTTTCTGCTAGTAGGTTATTATCAGGAGAAAAGCCTTTACATCAGGAGTTA
GAAAGAGAAATTGCTGATTTTATTGGTGTAGAAGATAGTATTCTTTATGTTGGAGGTCATGCTACTAATGTAACTACTAT
TAGTCATTTATTTGGGCAAAATGATTTAATTCTCCATGACTCTTTAAGTCACAATAGCATTTTCCAAGGTTGTTTATTAT
CGGGGGCAACTATTATTGCTTTTCCTCATAATGACTGGGAAGCTTTGGAGAAGTTACTGCGCGATCGCCGTCATCGTTAT
AAGCGGGTACTTATTGCTATAGAAGGTGTATATAGTACAGATGGTGATATTCCAGAGTTACCAAAGTTTATTGAGATTAA
AAAACATTACAAAGCTTTTCTGATGGTGGATGAGGCTCATTCTATTGGTACTATTGGTAAACATGGTCGTGGAATTAGTG
AGTATTTTGGGATTAACCCTAATGATGTTGACCTATGGATGGGTACTCTGAGTAAGTCTTTTGCTAGTTGCGGTGGTTAT
ATTGCTGGTACTAAAGCGTTAGTGGAATATCTTAAGTATACTTCTCCAGGGTTTGTTTATAGTGTGGGCATTTCTCCACC
AGATACGGCGTCGGTCTTAGCTGCTATTCGGTTGTTGAAGAAGGAACCCGAAAGGGTGGCAAAACTACAGGAAATGTCTC
GACTATTTTTGCAGTCTGCTCGTGAGCGGGGGCTTAATACTGGTATGAGTAAAGATTCTCCGGTTATACCTATTATTGTA
GGTGAATCTATTAAGTCTGTAATGTTGTCCCAAAGTTTGTTTAAGCGAGGGATTAATGTTCCGTTTATGTTTTACCCGTC
TGTACCACAAAATGCGGCCAGATTACGCTTTTTTATTACTTGTAATCATACAGAGGAGCAAATTCTTTTTACTATAGATG
CTCTGGCGGAAGAGCTGAGTTTAATGGGTGTTTAA

Upstream 100 bases:

>100_bases
TTCTCAAGTGACTTTTTAACCCTAATTGTGTGCCATTGCCTATAAGCTACTGGAAAAAAACTGAGTGATAAGTAATTTTA
ATGTGGTGCAGGAGTGAACA

Downstream 100 bases:

>100_bases
TAAGTAGCTGATGGTTAATAGCTAATTATATTCTTGATAGAATTGATTATTAGCTATTAGCTATTCTGAAAATTGAAAGT
CATTAGGGCTTATAGAGGTT

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 544; Mature: 544

Protein sequence:

>544_residues
MKLLNQLVNEQDKQHLSLEMTDRDPALQVPQLSPVRKNIKSWLISQLAERLEIETDQIDIQRDFTDYGLNSIEVVNLSGE
LENLLGRRLPPTLLLDYPTIESLAEYLVEDTSEDTGPNVHKKLEDEVEVSTSNPTTETEEIPLEYYRFDLYPEYLQLQKQ
LADINSTGISSPFFIPQERVNNNTTVIGGRKLVNYATYNYLGMCGDPFVSNAAKEAINRYGTSVSASRLLSGEKPLHQEL
EREIADFIGVEDSILYVGGHATNVTTISHLFGQNDLILHDSLSHNSIFQGCLLSGATIIAFPHNDWEALEKLLRDRRHRY
KRVLIAIEGVYSTDGDIPELPKFIEIKKHYKAFLMVDEAHSIGTIGKHGRGISEYFGINPNDVDLWMGTLSKSFASCGGY
IAGTKALVEYLKYTSPGFVYSVGISPPDTASVLAAIRLLKKEPERVAKLQEMSRLFLQSARERGLNTGMSKDSPVIPIIV
GESIKSVMLSQSLFKRGINVPFMFYPSVPQNAARLRFFITCNHTEEQILFTIDALAEELSLMGV

Sequences:

>Translated_544_residues
MKLLNQLVNEQDKQHLSLEMTDRDPALQVPQLSPVRKNIKSWLISQLAERLEIETDQIDIQRDFTDYGLNSIEVVNLSGE
LENLLGRRLPPTLLLDYPTIESLAEYLVEDTSEDTGPNVHKKLEDEVEVSTSNPTTETEEIPLEYYRFDLYPEYLQLQKQ
LADINSTGISSPFFIPQERVNNNTTVIGGRKLVNYATYNYLGMCGDPFVSNAAKEAINRYGTSVSASRLLSGEKPLHQEL
EREIADFIGVEDSILYVGGHATNVTTISHLFGQNDLILHDSLSHNSIFQGCLLSGATIIAFPHNDWEALEKLLRDRRHRY
KRVLIAIEGVYSTDGDIPELPKFIEIKKHYKAFLMVDEAHSIGTIGKHGRGISEYFGINPNDVDLWMGTLSKSFASCGGY
IAGTKALVEYLKYTSPGFVYSVGISPPDTASVLAAIRLLKKEPERVAKLQEMSRLFLQSARERGLNTGMSKDSPVIPIIV
GESIKSVMLSQSLFKRGINVPFMFYPSVPQNAARLRFFITCNHTEEQILFTIDALAEELSLMGV
>Mature_544_residues
MKLLNQLVNEQDKQHLSLEMTDRDPALQVPQLSPVRKNIKSWLISQLAERLEIETDQIDIQRDFTDYGLNSIEVVNLSGE
LENLLGRRLPPTLLLDYPTIESLAEYLVEDTSEDTGPNVHKKLEDEVEVSTSNPTTETEEIPLEYYRFDLYPEYLQLQKQ
LADINSTGISSPFFIPQERVNNNTTVIGGRKLVNYATYNYLGMCGDPFVSNAAKEAINRYGTSVSASRLLSGEKPLHQEL
EREIADFIGVEDSILYVGGHATNVTTISHLFGQNDLILHDSLSHNSIFQGCLLSGATIIAFPHNDWEALEKLLRDRRHRY
KRVLIAIEGVYSTDGDIPELPKFIEIKKHYKAFLMVDEAHSIGTIGKHGRGISEYFGINPNDVDLWMGTLSKSFASCGGY
IAGTKALVEYLKYTSPGFVYSVGISPPDTASVLAAIRLLKKEPERVAKLQEMSRLFLQSARERGLNTGMSKDSPVIPIIV
GESIKSVMLSQSLFKRGINVPFMFYPSVPQNAARLRFFITCNHTEEQILFTIDALAEELSLMGV

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI119220554, Length=393, Percent_Identity=37.6590330788804, Blast_Score=258, Evalue=8e-69,
Organism=Homo sapiens, GI4758668, Length=370, Percent_Identity=38.6486486486486, Blast_Score=258, Evalue=1e-68,
Organism=Homo sapiens, GI7657118, Length=372, Percent_Identity=31.1827956989247, Blast_Score=169, Evalue=6e-42,
Organism=Homo sapiens, GI5454084, Length=279, Percent_Identity=30.8243727598566, Blast_Score=169, Evalue=9e-42,
Organism=Homo sapiens, GI284448556, Length=356, Percent_Identity=30.8988764044944, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI83977442, Length=351, Percent_Identity=31.0541310541311, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI83977440, Length=351, Percent_Identity=31.0541310541311, Blast_Score=162, Evalue=9e-40,
Organism=Homo sapiens, GI83977444, Length=351, Percent_Identity=31.0541310541311, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI4502025, Length=356, Percent_Identity=29.4943820224719, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI40316939, Length=356, Percent_Identity=29.4943820224719, Blast_Score=147, Evalue=2e-35,
Organism=Escherichia coli, GI1790046, Length=393, Percent_Identity=32.0610687022901, Blast_Score=213, Evalue=3e-56,
Organism=Escherichia coli, GI1786993, Length=341, Percent_Identity=27.8592375366569, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI32566772, Length=362, Percent_Identity=38.6740331491713, Blast_Score=266, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI17560912, Length=368, Percent_Identity=36.6847826086957, Blast_Score=249, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI17560914, Length=368, Percent_Identity=36.6847826086957, Blast_Score=248, Evalue=5e-66,
Organism=Caenorhabditis elegans, GI71994529, Length=388, Percent_Identity=32.2164948453608, Blast_Score=194, Evalue=9e-50,
Organism=Caenorhabditis elegans, GI71982625, Length=276, Percent_Identity=34.0579710144928, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71982617, Length=276, Percent_Identity=34.0579710144928, Blast_Score=170, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6320267, Length=392, Percent_Identity=32.3979591836735, Blast_Score=221, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6320438, Length=379, Percent_Identity=28.2321899736148, Blast_Score=144, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6323954, Length=272, Percent_Identity=27.2058823529412, Blast_Score=127, Evalue=5e-30,
Organism=Drosophila melanogaster, GI17136286, Length=370, Percent_Identity=35.1351351351351, Blast_Score=235, Evalue=6e-62,
Organism=Drosophila melanogaster, GI24662918, Length=383, Percent_Identity=31.5926892950392, Blast_Score=199, Evalue=6e-51,
Organism=Drosophila melanogaster, GI24653280, Length=294, Percent_Identity=31.2925170068027, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24653276, Length=294, Percent_Identity=31.2925170068027, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24653278, Length=294, Percent_Identity=31.2925170068027, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI17137420, Length=341, Percent_Identity=30.2052785923754, Blast_Score=153, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 61027; Mature: 61027

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS50075 ACP_DOMAIN ; PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLNQLVNEQDKQHLSLEMTDRDPALQVPQLSPVRKNIKSWLISQLAERLEIETDQIDI
CCHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEE
QRDFTDYGLNSIEVVNLSGELENLLGRRLPPTLLLDYPTIESLAEYLVEDTSEDTGPNVH
EECHHHCCCCCEEEEECCHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHCCCCCCCCCHH
KKLEDEVEVSTSNPTTETEEIPLEYYRFDLYPEYLQLQKQLADINSTGISSPFFIPQERV
HHCCCCEEECCCCCCCCCCCCCHHHHEECCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHC
NNNTTVIGGRKLVNYATYNYLGMCGDPFVSNAAKEAINRYGTSVSASRLLSGEKPLHQEL
CCCCEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHH
EREIADFIGVEDSILYVGGHATNVTTISHLFGQNDLILHDSLSHNSIFQGCLLSGATIIA
HHHHHHHHCCCCCEEEECCCCCCHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCEEEE
FPHNDWEALEKLLRDRRHRYKRVLIAIEGVYSTDGDIPELPKFIEIKKHYKAFLMVDEAH
ECCCCHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCHHHHHHHHHHEEEEEEECCC
SIGTIGKHGRGISEYFGINPNDVDLWMGTLSKSFASCGGYIAGTKALVEYLKYTSPGFVY
CCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEE
SVGISPPDTASVLAAIRLLKKEPERVAKLQEMSRLFLQSARERGLNTGMSKDSPVIPIIV
EECCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEE
GESIKSVMLSQSLFKRGINVPFMFYPSVPQNAARLRFFITCNHTEEQILFTIDALAEELS
CCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHH
LMGV
HCCC
>Mature Secondary Structure
MKLLNQLVNEQDKQHLSLEMTDRDPALQVPQLSPVRKNIKSWLISQLAERLEIETDQIDI
CCHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEE
QRDFTDYGLNSIEVVNLSGELENLLGRRLPPTLLLDYPTIESLAEYLVEDTSEDTGPNVH
EECHHHCCCCCEEEEECCHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHCCCCCCCCCHH
KKLEDEVEVSTSNPTTETEEIPLEYYRFDLYPEYLQLQKQLADINSTGISSPFFIPQERV
HHCCCCEEECCCCCCCCCCCCCHHHHEECCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHC
NNNTTVIGGRKLVNYATYNYLGMCGDPFVSNAAKEAINRYGTSVSASRLLSGEKPLHQEL
CCCCEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHH
EREIADFIGVEDSILYVGGHATNVTTISHLFGQNDLILHDSLSHNSIFQGCLLSGATIIA
HHHHHHHHCCCCCEEEECCCCCCHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCEEEE
FPHNDWEALEKLLRDRRHRYKRVLIAIEGVYSTDGDIPELPKFIEIKKHYKAFLMVDEAH
ECCCCHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCHHHHHHHHHHEEEEEEECCC
SIGTIGKHGRGISEYFGINPNDVDLWMGTLSKSFASCGGYIAGTKALVEYLKYTSPGFVY
CCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEE
SVGISPPDTASVLAAIRLLKKEPERVAKLQEMSRLFLQSARERGLNTGMSKDSPVIPIIV
EECCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEE
GESIKSVMLSQSLFKRGINVPFMFYPSVPQNAARLRFFITCNHTEEQILFTIDALAEELS
CCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHH
LMGV
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA