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The map label for this gene is gnd [H]

Identifier: 113475502

GI number: 113475502

Start: 2802722

End: 2804143

Strand: Direct

Name: gnd [H]

Synonym: Tery_1834

Alternate gene names: 113475502

Gene position: 2802722-2804143 (Clockwise)

Preceding gene: 113475500

Following gene: 113475503

Centisome position: 36.16

GC content: 41.56

Gene sequence:

>1422_bases
ATGGGACAGCAAAAATTTGGTGTTATCGGTCTAGCTGTAATGGGTGAAAACCTAGCTCTCAATGTAGAACGCAACGGATT
CCCCATTTCTGTATATAACCGCAGTGACGATAAAACTAAGAAATTTATGGCAGAACGGGCACAAGGAAAAAACGTCCACG
CTGCTTATAGTTTAGAAGATTTTGTTCAATCCCTAGAAAGACCCCGCAGAATCCTAGTAATGGTAAAAGCAGGAAATCCA
GTCGATAAGGTTGTTGAACAACTTAAACCTCTGTTAGATAAAGGTGACATGATCATTGACGGTGGTAACTCTCTCTATGA
AGATACAGAACGCCGTACTAAGGATTTAGAATCCACTGGATTAGGTTTCATGGGAATGGGAGTTAGTGGTGGAGAAGAAG
GTGCCTTATGGGGTCCTAGTTTAATGCCGGGTGGTACAGAGGCTTCTTACAAAGAATTAGAAGCTATTTTAACTAAAATA
GCTGCTCAAGTTGATGATGGTCCTTGTGTCGACTACGTTGGTCCTGGAGGTGCTGGTCACTATGTGAAAATGGTACACAA
CGGCATTGAGTATGGCGATATGCAGTTAATTGCTGAAGCTTATGACTTGCTGAAAAATGCTGTAGGAGTTAGCAACGAAC
AACTCCATGAAATTTTTGCTGAGTGGAATAAAACTCCAGAGTTGGAATCTTTCTTAATTGAAATTACAGCTGATATCTTT
ACTAAGAAAGATACTGAGACTAGCAATCATTTAGTTGACATGATTGTTGATTCTGCTGGACAGAAGGGTACAGGCAGATG
GACGGTGATTAATGCTTTAGAATTGGGTGTTGCTGTTCCTACTATTACGGCGGCTGTTAATGCTCGTATCATGTCTGGTA
TTAAGGAGGAGCGTGTTGGTGCTGCTAAGGAATTAACTGGTCCGAGTGGTCAGTATGAAGGTGATAAGCAAGCTATGATT
AATAAGGTGCGGGATGCCTTGTATTGTTCTAAGATTTGTTCTTATGCTCAAGGTATGGCTTTGTTGGCTCAGGCGTCTCG
ACAGTTTGATTATAAGCTGAATTTGGGTGAGTGTGCGCGAATTTGGAAAGGTGGTTGTATTATTCGGGCTGGGTTTTTGA
ATAAGATTAAGAAGGCTTTTGATGAAAATCCTGCTCTACCTAATTTATTGTTAGCTCCAGAGTTTAAGCAGACTATTCTT
GATCGCCAGAATGCTTGGCGGGAAGTTGTTGCTTTAGCTGGTAAGTTAGGACTGCCTGTTCCTGCTTTTAGTGCTTCTCT
AGATTATTTTGATAGTTATCGTCGGGTAACTTTGCCTCAAAACTTGACTCAGGCTCAACGGGATTATTTCGGCGCTCACA
CTTATGAGCGTATTGATAAGTCTCGTGGTCAGTTCTTCCATACTGAGTGGCCTACTAAGTAA

Upstream 100 bases:

>100_bases
AAAAACTTTTTCTACAAAAAGTACACAAAAAACACTTGTAATCTAAAAACGGTGATAAAAATTTAATTAGAGAACTTAAT
ACTCACAAAAGTAAAAAACT

Downstream 100 bases:

>100_bases
TTTAGGACTACCCGCAAACCGAAACTAGAAACCTGGTTTTTCAGAGATGTCTATTGTTAAAACATAAGATTTTTTGTGAA
AACTGGGTTTCTTTGGGTAA

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MGQQKFGVIGLAVMGENLALNVERNGFPISVYNRSDDKTKKFMAERAQGKNVHAAYSLEDFVQSLERPRRILVMVKAGNP
VDKVVEQLKPLLDKGDMIIDGGNSLYEDTERRTKDLESTGLGFMGMGVSGGEEGALWGPSLMPGGTEASYKELEAILTKI
AAQVDDGPCVDYVGPGGAGHYVKMVHNGIEYGDMQLIAEAYDLLKNAVGVSNEQLHEIFAEWNKTPELESFLIEITADIF
TKKDTETSNHLVDMIVDSAGQKGTGRWTVINALELGVAVPTITAAVNARIMSGIKEERVGAAKELTGPSGQYEGDKQAMI
NKVRDALYCSKICSYAQGMALLAQASRQFDYKLNLGECARIWKGGCIIRAGFLNKIKKAFDENPALPNLLLAPEFKQTIL
DRQNAWREVVALAGKLGLPVPAFSASLDYFDSYRRVTLPQNLTQAQRDYFGAHTYERIDKSRGQFFHTEWPTK

Sequences:

>Translated_473_residues
MGQQKFGVIGLAVMGENLALNVERNGFPISVYNRSDDKTKKFMAERAQGKNVHAAYSLEDFVQSLERPRRILVMVKAGNP
VDKVVEQLKPLLDKGDMIIDGGNSLYEDTERRTKDLESTGLGFMGMGVSGGEEGALWGPSLMPGGTEASYKELEAILTKI
AAQVDDGPCVDYVGPGGAGHYVKMVHNGIEYGDMQLIAEAYDLLKNAVGVSNEQLHEIFAEWNKTPELESFLIEITADIF
TKKDTETSNHLVDMIVDSAGQKGTGRWTVINALELGVAVPTITAAVNARIMSGIKEERVGAAKELTGPSGQYEGDKQAMI
NKVRDALYCSKICSYAQGMALLAQASRQFDYKLNLGECARIWKGGCIIRAGFLNKIKKAFDENPALPNLLLAPEFKQTIL
DRQNAWREVVALAGKLGLPVPAFSASLDYFDSYRRVTLPQNLTQAQRDYFGAHTYERIDKSRGQFFHTEWPTK
>Mature_472_residues
GQQKFGVIGLAVMGENLALNVERNGFPISVYNRSDDKTKKFMAERAQGKNVHAAYSLEDFVQSLERPRRILVMVKAGNPV
DKVVEQLKPLLDKGDMIIDGGNSLYEDTERRTKDLESTGLGFMGMGVSGGEEGALWGPSLMPGGTEASYKELEAILTKIA
AQVDDGPCVDYVGPGGAGHYVKMVHNGIEYGDMQLIAEAYDLLKNAVGVSNEQLHEIFAEWNKTPELESFLIEITADIFT
KKDTETSNHLVDMIVDSAGQKGTGRWTVINALELGVAVPTITAAVNARIMSGIKEERVGAAKELTGPSGQYEGDKQAMIN
KVRDALYCSKICSYAQGMALLAQASRQFDYKLNLGECARIWKGGCIIRAGFLNKIKKAFDENPALPNLLLAPEFKQTILD
RQNAWREVVALAGKLGLPVPAFSASLDYFDSYRRVTLPQNLTQAQRDYFGAHTYERIDKSRGQFFHTEWPTK

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=472, Percent_Identity=53.8135593220339, Blast_Score=492, Evalue=1e-139,
Organism=Escherichia coli, GI1788341, Length=471, Percent_Identity=57.9617834394904, Blast_Score=550, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI17542558, Length=473, Percent_Identity=51.3742071881607, Blast_Score=487, Evalue=1e-138,
Organism=Saccharomyces cerevisiae, GI6321695, Length=453, Percent_Identity=50.3311258278146, Blast_Score=468, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6321977, Length=452, Percent_Identity=51.1061946902655, Blast_Score=457, Evalue=1e-129,
Organism=Drosophila melanogaster, GI24639279, Length=470, Percent_Identity=52.1276595744681, Blast_Score=464, Evalue=1e-131,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 52076; Mature: 51945

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQQKFGVIGLAVMGENLALNVERNGFPISVYNRSDDKTKKFMAERAQGKNVHAAYSLED
CCCCCCCEEEEEEECCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEECHHH
FVQSLERPRRILVMVKAGNPVDKVVEQLKPLLDKGDMIIDGGNSLYEDTERRTKDLESTG
HHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHCC
LGFMGMGVSGGEEGALWGPSLMPGGTEASYKELEAILTKIAAQVDDGPCVDYVGPGGAGH
CCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCH
YVKMVHNGIEYGDMQLIAEAYDLLKNAVGVSNEQLHEIFAEWNKTPELESFLIEITADIF
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
TKKDTETSNHLVDMIVDSAGQKGTGRWTVINALELGVAVPTITAAVNARIMSGIKEERVG
HCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AAKELTGPSGQYEGDKQAMINKVRDALYCSKICSYAQGMALLAQASRQFDYKLNLGECAR
CHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHHHHH
IWKGGCIIRAGFLNKIKKAFDENPALPNLLLAPEFKQTILDRQNAWREVVALAGKLGLPV
HHCCCCEEEHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCC
PAFSASLDYFDSYRRVTLPQNLTQAQRDYFGAHTYERIDKSRGQFFHTEWPTK
CHHHHHHHHHHCCCEECCCHHHHHHHHHHHCHHHHHHHHHHCCCEECCCCCCC
>Mature Secondary Structure 
GQQKFGVIGLAVMGENLALNVERNGFPISVYNRSDDKTKKFMAERAQGKNVHAAYSLED
CCCCCCEEEEEEECCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEECHHH
FVQSLERPRRILVMVKAGNPVDKVVEQLKPLLDKGDMIIDGGNSLYEDTERRTKDLESTG
HHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHCC
LGFMGMGVSGGEEGALWGPSLMPGGTEASYKELEAILTKIAAQVDDGPCVDYVGPGGAGH
CCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCH
YVKMVHNGIEYGDMQLIAEAYDLLKNAVGVSNEQLHEIFAEWNKTPELESFLIEITADIF
HHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
TKKDTETSNHLVDMIVDSAGQKGTGRWTVINALELGVAVPTITAAVNARIMSGIKEERVG
HCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
AAKELTGPSGQYEGDKQAMINKVRDALYCSKICSYAQGMALLAQASRQFDYKLNLGECAR
CHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHHHHH
IWKGGCIIRAGFLNKIKKAFDENPALPNLLLAPEFKQTILDRQNAWREVVALAGKLGLPV
HHCCCCEEEHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCC
PAFSASLDYFDSYRRVTLPQNLTQAQRDYFGAHTYERIDKSRGQFFHTEWPTK
CHHHHHHHHHHCCCEECCCHHHHHHHHHHHCHHHHHHHHHHCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]