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The map label for this gene is hemE

Identifier: 113475390

GI number: 113475390

Start: 2607210

End: 2608274

Strand: Direct

Name: hemE

Synonym: Tery_1714

Alternate gene names: 113475390

Gene position: 2607210-2608274 (Clockwise)

Preceding gene: 113475389

Following gene: 113475391

Centisome position: 33.64

GC content: 39.72

Gene sequence:

>1065_bases
ATGGCCCAATTAAGCCAAGTACCCTATTTATTACGAGCAACTCGGGGTGAATTATTAGATCGTCCACCTGTATGGATGAT
GAGACAGGCAGGTCGCTACATGAAAGCTTATCGAGACTTACGAGAGAAATATCCCTCATTTCGCGAGCGTTCTGAAAACA
CAGATATTGCTGTGGAAATATCCCTGCAACCTTTCCACGCTTTTAAGCCAGATGGAGTAATTTTATTCTCAGACATCCTG
ACTCCACTCCCAGCAATAGGCATTGATTTTGATATCATCGAAAGCAAAGGACCAATTATTGACCCCCCTATTCGCACTGA
AGCTCAAATTGACAAGCTTCATCCCATCGAACCAGAAGAGTCTCTACCTTTTATTAGGGAAATTTTACAAACTCTCAGAA
GAGAAGTTAAGAACGAGGCAGCAGTTTTAGGTTTTATTGGGGCTCCTTGGACTTTAGCTGCTTACGCCATAGAAGGTAAG
AGTTGTAAAGATTATACCAATATCAAAAAAATGGCTTTTTGTCAACCAGAAATGTTACATAAATTTCTAGGAAAGCTGGC
AGAAGCGATCGCCGTTTATGCTCGTTATCAGATAAACAGTGGAGCACAAGTCATCCAAATGTTTGATTCTTGGGCAGGTC
AACTTAGTCCTCAAGACTATGAAACTTTCGCTTTGCCCTATCAAAAATTAGTGGTGCAGGAAGTTAAAAAGACCCATCCT
AATACACCTTTTATTCTATATATAAATGGTAGTGCCGGATTATTAGAGAGAATGCCCCAGACTGGTGTTGATATAGTGAG
TGTGGACTGGAGTGTAGACATAGCCGAAGCTAGACAACGCCTTGGTAATAATATTTGTGTACAAGGAAATATAGACCCCG
GTGTACTGTTTGGTTCTCAAGAATTTATCAAATCTCGCATACTAGAAACTATTCGCAAAGCTGGCAACCGAGGTCATATA
TTAAATTTAGGACATGGTGTTTTGAAAGAAACTCCTGAAGAGAATGTAGAGTTCTTCTTTAAAACAGCAAAAGAAATAAG
TAGTTTACTAGCATTAACCGCTTAA

Upstream 100 bases:

>100_bases
TTCCACAAGCGTCATGTCCCTGTAAACTTACAATTCAGGACAATTAAATTGACCTAACCAGTTAAAATCAAAGATTTTAG
AAGCAAAAGGTAAAGCAAAT

Downstream 100 bases:

>100_bases
GTTTAGTTAGGGTAAATTTGAGATTTCCATGATTTTTTCAGGGGTTAGTTATAACCTAGCCCTAAATTTATTAGTAAGCA
TTCAACCGAATGCTTACCAT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MAQLSQVPYLLRATRGELLDRPPVWMMRQAGRYMKAYRDLREKYPSFRERSENTDIAVEISLQPFHAFKPDGVILFSDIL
TPLPAIGIDFDIIESKGPIIDPPIRTEAQIDKLHPIEPEESLPFIREILQTLRREVKNEAAVLGFIGAPWTLAAYAIEGK
SCKDYTNIKKMAFCQPEMLHKFLGKLAEAIAVYARYQINSGAQVIQMFDSWAGQLSPQDYETFALPYQKLVVQEVKKTHP
NTPFILYINGSAGLLERMPQTGVDIVSVDWSVDIAEARQRLGNNICVQGNIDPGVLFGSQEFIKSRILETIRKAGNRGHI
LNLGHGVLKETPEENVEFFFKTAKEISSLLALTA

Sequences:

>Translated_354_residues
MAQLSQVPYLLRATRGELLDRPPVWMMRQAGRYMKAYRDLREKYPSFRERSENTDIAVEISLQPFHAFKPDGVILFSDIL
TPLPAIGIDFDIIESKGPIIDPPIRTEAQIDKLHPIEPEESLPFIREILQTLRREVKNEAAVLGFIGAPWTLAAYAIEGK
SCKDYTNIKKMAFCQPEMLHKFLGKLAEAIAVYARYQINSGAQVIQMFDSWAGQLSPQDYETFALPYQKLVVQEVKKTHP
NTPFILYINGSAGLLERMPQTGVDIVSVDWSVDIAEARQRLGNNICVQGNIDPGVLFGSQEFIKSRILETIRKAGNRGHI
LNLGHGVLKETPEENVEFFFKTAKEISSLLALTA
>Mature_353_residues
AQLSQVPYLLRATRGELLDRPPVWMMRQAGRYMKAYRDLREKYPSFRERSENTDIAVEISLQPFHAFKPDGVILFSDILT
PLPAIGIDFDIIESKGPIIDPPIRTEAQIDKLHPIEPEESLPFIREILQTLRREVKNEAAVLGFIGAPWTLAAYAIEGKS
CKDYTNIKKMAFCQPEMLHKFLGKLAEAIAVYARYQINSGAQVIQMFDSWAGQLSPQDYETFALPYQKLVVQEVKKTHPN
TPFILYINGSAGLLERMPQTGVDIVSVDWSVDIAEARQRLGNNICVQGNIDPGVLFGSQEFIKSRILETIRKAGNRGHIL
NLGHGVLKETPEENVEFFFKTAKEISSLLALTA

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=349, Percent_Identity=33.5243553008596, Blast_Score=211, Evalue=9e-55,
Organism=Escherichia coli, GI2367337, Length=350, Percent_Identity=38.2857142857143, Blast_Score=274, Evalue=7e-75,
Organism=Saccharomyces cerevisiae, GI6320252, Length=351, Percent_Identity=32.7635327635328, Blast_Score=217, Evalue=2e-57,
Organism=Drosophila melanogaster, GI19921920, Length=341, Percent_Identity=34.3108504398827, Blast_Score=223, Evalue=1e-58,
Organism=Drosophila melanogaster, GI221330099, Length=341, Percent_Identity=34.6041055718475, Blast_Score=223, Evalue=2e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_TRIEI (Q114U6)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_721451.1
- ProteinModelPortal:   Q114U6
- SMR:   Q114U6
- STRING:   Q114U6
- GeneID:   4243313
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_1714
- NMPDR:   fig|203124.1.peg.530
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- PhylomeDB:   Q114U6
- ProtClustDB:   PRK00115
- BioCyc:   TERY203124:TERY_1714-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 39919; Mature: 39787

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 78-78 BINDING 155-155 BINDING 210-210 BINDING 325-325

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQLSQVPYLLRATRGELLDRPPVWMMRQAGRYMKAYRDLREKYPSFRERSENTDIAVEI
CCCHHHCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCEEEEE
SLQPFHAFKPDGVILFSDILTPLPAIGIDFDIIESKGPIIDPPIRTEAQIDKLHPIEPEE
EECCCCCCCCCCEEEHHHHHCCCCCCCCCCEEECCCCCCCCCCCCCCCHHHCCCCCCCCC
SLPFIREILQTLRREVKNEAAVLGFIGAPWTLAAYAIEGKSCKDYTNIKKMAFCQPEMLH
CCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHEEEEECCCCCCHHHHHHHHHCCCHHHHH
KFLGKLAEAIAVYARYQINSGAQVIQMFDSWAGQLSPQDYETFALPYQKLVVQEVKKTHP
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCC
NTPFILYINGSAGLLERMPQTGVDIVSVDWSVDIAEARQRLGNNICVQGNIDPGVLFGSQ
CCCEEEEECCCCHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCEEEECCCCCCEEECCH
EFIKSRILETIRKAGNRGHILNLGHGVLKETPEENVEFFFKTAKEISSLLALTA
HHHHHHHHHHHHHCCCCCCEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AQLSQVPYLLRATRGELLDRPPVWMMRQAGRYMKAYRDLREKYPSFRERSENTDIAVEI
CCHHHCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCEEEEE
SLQPFHAFKPDGVILFSDILTPLPAIGIDFDIIESKGPIIDPPIRTEAQIDKLHPIEPEE
EECCCCCCCCCCEEEHHHHHCCCCCCCCCCEEECCCCCCCCCCCCCCCHHHCCCCCCCCC
SLPFIREILQTLRREVKNEAAVLGFIGAPWTLAAYAIEGKSCKDYTNIKKMAFCQPEMLH
CCHHHHHHHHHHHHHHCCCCEEEEECCCCHHHEEEEECCCCCCHHHHHHHHHCCCHHHHH
KFLGKLAEAIAVYARYQINSGAQVIQMFDSWAGQLSPQDYETFALPYQKLVVQEVKKTHP
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCC
NTPFILYINGSAGLLERMPQTGVDIVSVDWSVDIAEARQRLGNNICVQGNIDPGVLFGSQ
CCCEEEEECCCCHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCEEEECCCCCCEEECCH
EFIKSRILETIRKAGNRGHILNLGHGVLKETPEENVEFFFKTAKEISSLLALTA
HHHHHHHHHHHHHCCCCCCEEECCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA