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The map label for this gene is hemK [C]

Identifier: 113475328

GI number: 113475328

Start: 2505939

End: 2506844

Strand: Direct

Name: hemK [C]

Synonym: Tery_1642

Alternate gene names: 113475328

Gene position: 2505939-2506844 (Clockwise)

Preceding gene: 113475327

Following gene: 113475329

Centisome position: 32.33

GC content: 42.27

Gene sequence:

>906_bases
ATGAATTTTCCTTTTAGGTGGCTGGTTTCAGGTAATGAACTCTGGGAATGGTATTGTCAAACTAAGGCTTGTGCTTTGAG
GGCAGGTATATCTGTTGCTGAGGTTGATTTATTCTTAGAGGAGTTTGCTAGTCTCAATAGATTAACCCTGCGTTTGGAGT
CTTTTAAAGATTGGCCTAATGTTTCAATGGAGCTTTCTTTAGTTGAGTTGGATAGTCTTTGGCGCCGACGTTTGGAAGAT
AGGGTTCCGCTTCAATATTTAACTGGGGTTACTTATTGGCGGAATTTTTCTTTGAGGGTTGGTTCTGGAGTTTTGATACC
TAGACCGGAAACAGAGCTTTTAATTGATCTGGTTTTGGTTGCTACTAATTCGGTTTTGGAGCTTGGGCACGGAAATTGGG
TGGATATGGGAACTGGTAGTGGAGCGATCGCTTGTGGTTTAGCAGATATATTGACAGATGCTTCTATTTATGGTATAGAT
TGCAGTCCAGTAGCTTTGGCAATTGCTAGACAAAATGCTGTTAGCCTAGGTTATGGTGATCGAATCAATTTCTATGAAGG
CTCTTGGTGGCAACCACTGGAACATTTGCGTGGCCAGGTGAGTGGGATGGTGGCGAATCCTCCTTATATTCCTAGTGATA
TGGTTTCTACTCTGGAACCAGAGGTCAGGAAACATGAGCCTCATTTGGCCCTTGATGGTGGTGTTGATGGTCTAGATTGT
ATTAGGTTTTTAGTTGAAACTGCTCCACTATATTTGGTTTCTGGTGGTGTTTGGTTGGTGGAAATGATGGCTGGGCAAAG
TGAGGAAGTCGCTAAAATTTTGTATGATCATGGTTCTTATTGTCAGGTTGAGATTTTCGGTGATTTGGAGGGGGTTGATC
GCTTTGCTATGGCTTATTTAAAGTAG

Upstream 100 bases:

>100_bases
GGAAAAAATTATTTTTATTCCTCCACGGGAGTCTTTGGAGTTTGTACAACAGTTGAGAGAATCTGATAATAAATAAGTTG
AGATTCTGAGTGATTGATAG

Downstream 100 bases:

>100_bases
CAAAAGTAGCAAATATTATTTTTCTTAAGCTTAAAAAATTTGCGTCAAAAAATTGGGTTTGAAGTCTTGCCTATAAGTGG
GCGACTTTTAAATAAGGTTT

Product: HemK family modification methylase

Products: NA

Alternate protein names: M.Ssp6803HemKP [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MNFPFRWLVSGNELWEWYCQTKACALRAGISVAEVDLFLEEFASLNRLTLRLESFKDWPNVSMELSLVELDSLWRRRLED
RVPLQYLTGVTYWRNFSLRVGSGVLIPRPETELLIDLVLVATNSVLELGHGNWVDMGTGSGAIACGLADILTDASIYGID
CSPVALAIARQNAVSLGYGDRINFYEGSWWQPLEHLRGQVSGMVANPPYIPSDMVSTLEPEVRKHEPHLALDGGVDGLDC
IRFLVETAPLYLVSGGVWLVEMMAGQSEEVAKILYDHGSYCQVEIFGDLEGVDRFAMAYLK

Sequences:

>Translated_301_residues
MNFPFRWLVSGNELWEWYCQTKACALRAGISVAEVDLFLEEFASLNRLTLRLESFKDWPNVSMELSLVELDSLWRRRLED
RVPLQYLTGVTYWRNFSLRVGSGVLIPRPETELLIDLVLVATNSVLELGHGNWVDMGTGSGAIACGLADILTDASIYGID
CSPVALAIARQNAVSLGYGDRINFYEGSWWQPLEHLRGQVSGMVANPPYIPSDMVSTLEPEVRKHEPHLALDGGVDGLDC
IRFLVETAPLYLVSGGVWLVEMMAGQSEEVAKILYDHGSYCQVEIFGDLEGVDRFAMAYLK
>Mature_301_residues
MNFPFRWLVSGNELWEWYCQTKACALRAGISVAEVDLFLEEFASLNRLTLRLESFKDWPNVSMELSLVELDSLWRRRLED
RVPLQYLTGVTYWRNFSLRVGSGVLIPRPETELLIDLVLVATNSVLELGHGNWVDMGTGSGAIACGLADILTDASIYGID
CSPVALAIARQNAVSLGYGDRINFYEGSWWQPLEHLRGQVSGMVANPPYIPSDMVSTLEPEVRKHEPHLALDGGVDGLDC
IRFLVETAPLYLVSGGVWLVEMMAGQSEEVAKILYDHGSYCQVEIFGDLEGVDRFAMAYLK

Specific function: Probable protein methyltransferase. May methylate a Gln residue in target proteins [H]

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hemK family [H]

Homologues:

Organism=Homo sapiens, GI7705409, Length=251, Percent_Identity=33.4661354581673, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1787463, Length=227, Percent_Identity=34.8017621145374, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI87082085, Length=187, Percent_Identity=33.1550802139037, Blast_Score=90, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24582226, Length=184, Percent_Identity=31.5217391304348, Blast_Score=88, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004556
- InterPro:   IPR019874
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: 2.1.1.-

Molecular weight: Translated: 33627; Mature: 33627

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFPFRWLVSGNELWEWYCQTKACALRAGISVAEVDLFLEEFASLNRLTLRLESFKDWPN
CCCCEEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEEEHHCCCCCC
VSMELSLVELDSLWRRRLEDRVPLQYLTGVTYWRNFSLRVGSGVLIPRPETELLIDLVLV
CEEEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEECCEEEECCCCHHHHHHHHHH
ATNSVLELGHGNWVDMGTGSGAIACGLADILTDASIYGIDCSPVALAIARQNAVSLGYGD
HHCCCEECCCCCEEECCCCCCHHHHHHHHHHCCCEEEECCCCHHHHEEECCCCEEECCCC
RINFYEGSWWQPLEHLRGQVSGMVANPPYIPSDMVSTLEPEVRKHEPHLALDGGVDGLDC
EECCCCCCCCCHHHHHHHHHCCEECCCCCCCHHHHHHCCCHHHHCCCCEEECCCCCHHHH
IRFLVETAPLYLVSGGVWLVEMMAGQSEEVAKILYDHGSYCQVEIFGDLEGVDRFAMAYL
HHHHHHCCCEEEEECCHHHHHHHCCCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHC
K
C
>Mature Secondary Structure
MNFPFRWLVSGNELWEWYCQTKACALRAGISVAEVDLFLEEFASLNRLTLRLESFKDWPN
CCCCEEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEEEHHCCCCCC
VSMELSLVELDSLWRRRLEDRVPLQYLTGVTYWRNFSLRVGSGVLIPRPETELLIDLVLV
CEEEEEEEHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEECCEEEECCCCHHHHHHHHHH
ATNSVLELGHGNWVDMGTGSGAIACGLADILTDASIYGIDCSPVALAIARQNAVSLGYGD
HHCCCEECCCCCEEECCCCCCHHHHHHHHHHCCCEEEECCCCHHHHEEECCCCEEECCCC
RINFYEGSWWQPLEHLRGQVSGMVANPPYIPSDMVSTLEPEVRKHEPHLALDGGVDGLDC
EECCCCCCCCCHHHHHHHHHCCEECCCCCCCHHHHHHCCCHHHHCCCCEEECCCCCHHHH
IRFLVETAPLYLVSGGVWLVEMMAGQSEEVAKILYDHGSYCQVEIFGDLEGVDRFAMAYL
HHHHHHCCCEEEEECCHHHHHHHCCCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]