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The map label for this gene is sppA [H]

Identifier: 113475281

GI number: 113475281

Start: 2430333

End: 2432159

Strand: Direct

Name: sppA [H]

Synonym: Tery_1590

Alternate gene names: 113475281

Gene position: 2430333-2432159 (Clockwise)

Preceding gene: 113475280

Following gene: 113475284

Centisome position: 31.36

GC content: 37.88

Gene sequence:

>1827_bases
ATGAAAGACTTTTTCAAATACACCTTTGCCAGCCTAATTGGCAGCATACTAGGAATTACTTTAATAATCGGTGTCGGATT
TGGCGGATTAATATTTTTTGTCGTTTCCATAGCCAGTCAAACCAAAGATCTAGGTCCACAAGTTGAAGACAAATCAATCT
TAGTTTTCGACCTTGCTACAAGTATTACAGATAGTCGACCCATTTCCTCAACTGGGGAAGCACTCCAAGAAGCCCTATCT
AGCGACCAAGCTACAACCATAACCCTCCGAAAAGCAATTAATACTCTCAATGCTGCTGCCAAAGATAAAAAAATAATCGG
CATTTACATTAAAGGTAGTAATGCTCCAGGGGTAACAGGACTAGCAAACCTACAAGAAATAAGACAAGCACTTCAACGGT
TCCGAGAAACAGGCAAAACTATTATTGCTTATGATATGGACTGGACAGAAAGAGAATATTACCTAAGTTCAGTAGCAGAT
GAAATTGCAATTAATCCTTTGGGTGTTTTAGAGTTCAATGGTTTAAGTTCTGAAACTATGTTCTTGAGTGGTGCATTAGA
TAAATTTGGTATCGGGGTTCAGGTAACAAAAGTTGGTAAATATAAATCTGCCACTGAACCTTTTCTCCGAGAAAAAATGA
GTCCGGAGAACCGACAGCAAACTCTTCAATTGTTACAAGATATTTGGGGTCAATATCTGCAAACAGTTGCTACAAGTCGA
AAGTCTACAACAGAGCAGTTACAGGCGATCGCTGATAATCAGGGAATTTTGATGGCGAATAATGCTTTACAGAGTAAGTT
AGTAGATAGAGTTGTCTACTACGATGAAGTTCTGAAAAAACTTAAAGAACTAACAGGTATTGAAGAGGACGATAAAAGTT
TCACACAAATTAGTCTGAACAACTATAGCAAAGTACCAAGAGTTGCAAAAACTCTTAGTAAGAATATTAAAAGCAACAAT
AAAATTGCTGTAGTCTACGCTCAAGGAGAAGTAGTTAATGGTAGTGGTACTTCTAGACAAATAGGGGGCGATCGCCTAGC
AAAGAAATTACGACAACTACGACTTGATGAAAAAGTGAAAGCTGTGGTTTTACGAGTTAATAGTCCAGGGGGGAGTGCTT
CAGCATCTGAAGTTATTAGTAGGGAAGTAAAACTTATGAGTGAGGAAAAACCTGTAATTGTATCTATGGGTAATATAGCT
GCTTCTGGAGGGTATTGGATTTCTATGAATGCAGATCGGATCGTTGCTGAAGTCAATACTATTACAGGTTCTATAGGAGT
TTTTGGTGTGTTGTTCAATATTCAAGAAATAGCTAATCAAAATGGAATTACTTGGGATGTGGTTAAAATTGGTAAGTTTG
CAGATTTGAATACTACTTCTCGCCCTAAGACTGAAGATGAGTTAGTTTTGATTCAAAAGATGGTAGATTCAATTTACGAG
CGGTTTATTAAAAATGTAGCGACAGCCCGTAATTTAGCACCCGAAAAAGTAGAGGAAATTGCTCAAGGTCGAGTTTGGTC
TGGTGCCAACGCTCAAAAGTTAGGTTTAGTTGATGAAATTGGTGGGATAGAAACTGCTATTAAAGTTGCTGCAGAAAAAG
CTGAACTGGGAGATAGTTGGAAAATTGAGGAGTATCCTAAGTCTCGTAGTTTGGAGCAACAGATTTTTCGTAGTCTTTCT
GGTATGGAAGTTGATATACCTACTATGCCTTTAGATCCGTTAGCGACAGAATTTAAAAAGTTGCAAGAGGAGTTAGCTAG
TTTGAGAGCGATGAATGATCCTTATGGGGTTTATACTCGTTTGCCGTTCAACTTGAGAATAGATTAA

Upstream 100 bases:

>100_bases
ACAGTTCACTACAGTTTCAAACTTAGCAAATTCAAATAGTAGGTGATAATTAACTAATACCAAATAATTAACTTCCTAAA
AAGGAACTCCCACTAGAAAC

Downstream 100 bases:

>100_bases
TTTAGGAGTCATAACTCATAGTTCATCTATTTCTAAAACCTAAAATTTTATAAGTCTTCCCAAATCTTTTTTGAGATGAG
AATTAAGGGATATGAGCAAA

Product: signal peptide peptidase A

Products: NA

Alternate protein names: Endopeptidase IV; Protease IV homolog; Signal peptide peptidase [H]

Number of amino acids: Translated: 608; Mature: 608

Protein sequence:

>608_residues
MKDFFKYTFASLIGSILGITLIIGVGFGGLIFFVVSIASQTKDLGPQVEDKSILVFDLATSITDSRPISSTGEALQEALS
SDQATTITLRKAINTLNAAAKDKKIIGIYIKGSNAPGVTGLANLQEIRQALQRFRETGKTIIAYDMDWTEREYYLSSVAD
EIAINPLGVLEFNGLSSETMFLSGALDKFGIGVQVTKVGKYKSATEPFLREKMSPENRQQTLQLLQDIWGQYLQTVATSR
KSTTEQLQAIADNQGILMANNALQSKLVDRVVYYDEVLKKLKELTGIEEDDKSFTQISLNNYSKVPRVAKTLSKNIKSNN
KIAVVYAQGEVVNGSGTSRQIGGDRLAKKLRQLRLDEKVKAVVLRVNSPGGSASASEVISREVKLMSEEKPVIVSMGNIA
ASGGYWISMNADRIVAEVNTITGSIGVFGVLFNIQEIANQNGITWDVVKIGKFADLNTTSRPKTEDELVLIQKMVDSIYE
RFIKNVATARNLAPEKVEEIAQGRVWSGANAQKLGLVDEIGGIETAIKVAAEKAELGDSWKIEEYPKSRSLEQQIFRSLS
GMEVDIPTMPLDPLATEFKKLQEELASLRAMNDPYGVYTRLPFNLRID

Sequences:

>Translated_608_residues
MKDFFKYTFASLIGSILGITLIIGVGFGGLIFFVVSIASQTKDLGPQVEDKSILVFDLATSITDSRPISSTGEALQEALS
SDQATTITLRKAINTLNAAAKDKKIIGIYIKGSNAPGVTGLANLQEIRQALQRFRETGKTIIAYDMDWTEREYYLSSVAD
EIAINPLGVLEFNGLSSETMFLSGALDKFGIGVQVTKVGKYKSATEPFLREKMSPENRQQTLQLLQDIWGQYLQTVATSR
KSTTEQLQAIADNQGILMANNALQSKLVDRVVYYDEVLKKLKELTGIEEDDKSFTQISLNNYSKVPRVAKTLSKNIKSNN
KIAVVYAQGEVVNGSGTSRQIGGDRLAKKLRQLRLDEKVKAVVLRVNSPGGSASASEVISREVKLMSEEKPVIVSMGNIA
ASGGYWISMNADRIVAEVNTITGSIGVFGVLFNIQEIANQNGITWDVVKIGKFADLNTTSRPKTEDELVLIQKMVDSIYE
RFIKNVATARNLAPEKVEEIAQGRVWSGANAQKLGLVDEIGGIETAIKVAAEKAELGDSWKIEEYPKSRSLEQQIFRSLS
GMEVDIPTMPLDPLATEFKKLQEELASLRAMNDPYGVYTRLPFNLRID
>Mature_608_residues
MKDFFKYTFASLIGSILGITLIIGVGFGGLIFFVVSIASQTKDLGPQVEDKSILVFDLATSITDSRPISSTGEALQEALS
SDQATTITLRKAINTLNAAAKDKKIIGIYIKGSNAPGVTGLANLQEIRQALQRFRETGKTIIAYDMDWTEREYYLSSVAD
EIAINPLGVLEFNGLSSETMFLSGALDKFGIGVQVTKVGKYKSATEPFLREKMSPENRQQTLQLLQDIWGQYLQTVATSR
KSTTEQLQAIADNQGILMANNALQSKLVDRVVYYDEVLKKLKELTGIEEDDKSFTQISLNNYSKVPRVAKTLSKNIKSNN
KIAVVYAQGEVVNGSGTSRQIGGDRLAKKLRQLRLDEKVKAVVLRVNSPGGSASASEVISREVKLMSEEKPVIVSMGNIA
ASGGYWISMNADRIVAEVNTITGSIGVFGVLFNIQEIANQNGITWDVVKIGKFADLNTTSRPKTEDELVLIQKMVDSIYE
RFIKNVATARNLAPEKVEEIAQGRVWSGANAQKLGLVDEIGGIETAIKVAAEKAELGDSWKIEEYPKSRSLEQQIFRSLS
GMEVDIPTMPLDPLATEFKKLQEELASLRAMNDPYGVYTRLPFNLRID

Specific function: Digestion of the cleaved signal peptides. This activity is necessary to maintain proper secretion of mature proteins across the membrane [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=620, Percent_Identity=35, Blast_Score=326, Evalue=2e-90,
Organism=Escherichia coli, GI1787527, Length=160, Percent_Identity=29.375, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004634
- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 66824; Mature: 66824

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDFFKYTFASLIGSILGITLIIGVGFGGLIFFVVSIASQTKDLGPQVEDKSILVFDLAT
CCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHH
SITDSRPISSTGEALQEALSSDQATTITLRKAINTLNAAAKDKKIIGIYIKGSNAPGVTG
HCCCCCCCCHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCH
LANLQEIRQALQRFRETGKTIIAYDMDWTEREYYLSSVADEIAINPLGVLEFNGLSSETM
HHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCE
FLSGALDKFGIGVQVTKVGKYKSATEPFLREKMSPENRQQTLQLLQDIWGQYLQTVATSR
EEECCHHHHCCCEEEEECCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCC
KSTTEQLQAIADNQGILMANNALQSKLVDRVVYYDEVLKKLKELTGIEEDDKSFTQISLN
CHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECC
NYSKVPRVAKTLSKNIKSNNKIAVVYAQGEVVNGSGTSRQIGGDRLAKKLRQLRLDEKVK
CCHHHHHHHHHHHHHCCCCCCEEEEEECCEEECCCCCCCCCCHHHHHHHHHHHHHCCCEE
AVVLRVNSPGGSASASEVISREVKLMSEEKPVIVSMGNIAASGGYWISMNADRIVAEVNT
EEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEECCEEECCCEEEEECCCCEEHHHHH
ITGSIGVFGVLFNIQEIANQNGITWDVVKIGKFADLNTTSRPKTEDELVLIQKMVDSIYE
HHCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
RFIKNVATARNLAPEKVEEIAQGRVWSGANAQKLGLVDEIGGIETAIKVAAEKAELGDSW
HHHHHHHHHHCCCHHHHHHHHCCCEECCCCCCCCCCHHHHCCHHHHHHHHHHHHHCCCCC
KIEEYPKSRSLEQQIFRSLSGMEVDIPTMPLDPLATEFKKLQEELASLRAMNDPYGVYTR
CCCCCCCCCCHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEE
LPFNLRID
CCEEEECC
>Mature Secondary Structure
MKDFFKYTFASLIGSILGITLIIGVGFGGLIFFVVSIASQTKDLGPQVEDKSILVFDLAT
CCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEHH
SITDSRPISSTGEALQEALSSDQATTITLRKAINTLNAAAKDKKIIGIYIKGSNAPGVTG
HCCCCCCCCHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCH
LANLQEIRQALQRFRETGKTIIAYDMDWTEREYYLSSVADEIAINPLGVLEFNGLSSETM
HHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCE
FLSGALDKFGIGVQVTKVGKYKSATEPFLREKMSPENRQQTLQLLQDIWGQYLQTVATSR
EEECCHHHHCCCEEEEECCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCC
KSTTEQLQAIADNQGILMANNALQSKLVDRVVYYDEVLKKLKELTGIEEDDKSFTQISLN
CHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECC
NYSKVPRVAKTLSKNIKSNNKIAVVYAQGEVVNGSGTSRQIGGDRLAKKLRQLRLDEKVK
CCHHHHHHHHHHHHHCCCCCCEEEEEECCEEECCCCCCCCCCHHHHHHHHHHHHHCCCEE
AVVLRVNSPGGSASASEVISREVKLMSEEKPVIVSMGNIAASGGYWISMNADRIVAEVNT
EEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEECCEEECCCEEEEECCCCEEHHHHH
ITGSIGVFGVLFNIQEIANQNGITWDVVKIGKFADLNTTSRPKTEDELVLIQKMVDSIYE
HHCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
RFIKNVATARNLAPEKVEEIAQGRVWSGANAQKLGLVDEIGGIETAIKVAAEKAELGDSW
HHHHHHHHHHCCCHHHHHHHHCCCEECCCCCCCCCCHHHHCCHHHHHHHHHHHHHCCCCC
KIEEYPKSRSLEQQIFRSLSGMEVDIPTMPLDPLATEFKKLQEELASLRAMNDPYGVYTR
CCCCCCCCCCHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEE
LPFNLRID
CCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]