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The map label for this gene is cysK [H]

Identifier: 113474997

GI number: 113474997

Start: 1914921

End: 1915883

Strand: Direct

Name: cysK [H]

Synonym: Tery_1235

Alternate gene names: 113474997

Gene position: 1914921-1915883 (Clockwise)

Preceding gene: 113474996

Following gene: 113475002

Centisome position: 24.71

GC content: 41.33

Gene sequence:

>963_bases
ATGCGTATTGCTCATAATATTACAGAATTAGTAGGTCGCACTCCCCTGGTACAATTAAATTCTATTCCTAAAGCAGAAGG
TTGTTTAGCCAAAATAATAGTAAAGCTAGAAGGAATGAATCCCGCTGCCTCAGTTAAGGATCGTATTGGTGTAAATATGA
TTAATGTAGCGGAGCGCGAAGGTTTGATTAAACCAGGTAAAACAACATTAGTTGAACCAACGTCTGGAAATACAGGTATT
GCTTTGGCAATGGTTGCTGCTGCTAGAGGTTACAAGTTAATTTTGACTATGCCAGAAACAATGAGCATGGAGCGTCGTGT
TATGTTACGAGCTTATGGGGCAGAGTTAGTATTAACTCCAGGTAGTGAAGGTATGAAAGGTGCAATTACCAAAGCACAAG
AAATTGTGGATTTAAGCAGTAATGGATATTATATGTTACAGCAATTTCAGAATCCAGCTAATCCAGAAATTCATAGCAAA
ACTACAGCTCTAGAAATATGGGAAGATACGGATGGAAAGGTAGATATTCTGGTGGCTGGTGTTGGTACTGGTGGGACAGT
TACAGGGGTGGCAGAGACTATTAAGGCAAGAAAGCCTGAATTTCAAGCGATCGCTGTTGAACCTTCTAATAGCCCAGTTT
TGTCTGGGGGAAAACCAGGACCACATAAAATTCAGGGAATAGGAGCTGGTTTTGTGCCAGATGTTTTGGATACGAAGATT
ATTGATGAGGTGATCCAGGTTCCTGATAGTGAGGCGATGGTTTATGGTCGTCGTATAGCAAAGGAAGAAGGTATTTTATC
TGGTATTTCTACGGGAGCTGCTCTTTGTGCGGCGATCGAAGTAGGTAAGCGTCCAGAAAATGATGGTAAGTTAATAGTCA
TGATTCAGCCTAGTTTTGGGGAGCGTTATTTAAGTACTCCATTGTTTCAAGAACTAGGGCCTACTCTCGCTGAAGTCAGG
TAG

Upstream 100 bases:

>100_bases
ATAAAGCTTAATGGTTGAAGTCTGAATTTTTACGTTCTAATAACTGTTTTCTATCATTTATTTGTAGAGTTATAAGTCTA
AGGTTAGAGATAAATATATC

Downstream 100 bases:

>100_bases
ATAATTACGGTTTGCTGAAAAATTATTTTTAAGAAGTAGGAAGTTAGGGGAGTGGTTAGGGACTTTGTATACAATGTATG
TATAGGAGGAAGGTCGAATT

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MRIAHNITELVGRTPLVQLNSIPKAEGCLAKIIVKLEGMNPAASVKDRIGVNMINVAEREGLIKPGKTTLVEPTSGNTGI
ALAMVAAARGYKLILTMPETMSMERRVMLRAYGAELVLTPGSEGMKGAITKAQEIVDLSSNGYYMLQQFQNPANPEIHSK
TTALEIWEDTDGKVDILVAGVGTGGTVTGVAETIKARKPEFQAIAVEPSNSPVLSGGKPGPHKIQGIGAGFVPDVLDTKI
IDEVIQVPDSEAMVYGRRIAKEEGILSGISTGAALCAAIEVGKRPENDGKLIVMIQPSFGERYLSTPLFQELGPTLAEVR

Sequences:

>Translated_320_residues
MRIAHNITELVGRTPLVQLNSIPKAEGCLAKIIVKLEGMNPAASVKDRIGVNMINVAEREGLIKPGKTTLVEPTSGNTGI
ALAMVAAARGYKLILTMPETMSMERRVMLRAYGAELVLTPGSEGMKGAITKAQEIVDLSSNGYYMLQQFQNPANPEIHSK
TTALEIWEDTDGKVDILVAGVGTGGTVTGVAETIKARKPEFQAIAVEPSNSPVLSGGKPGPHKIQGIGAGFVPDVLDTKI
IDEVIQVPDSEAMVYGRRIAKEEGILSGISTGAALCAAIEVGKRPENDGKLIVMIQPSFGERYLSTPLFQELGPTLAEVR
>Mature_320_residues
MRIAHNITELVGRTPLVQLNSIPKAEGCLAKIIVKLEGMNPAASVKDRIGVNMINVAEREGLIKPGKTTLVEPTSGNTGI
ALAMVAAARGYKLILTMPETMSMERRVMLRAYGAELVLTPGSEGMKGAITKAQEIVDLSSNGYYMLQQFQNPANPEIHSK
TTALEIWEDTDGKVDILVAGVGTGGTVTGVAETIKARKPEFQAIAVEPSNSPVLSGGKPGPHKIQGIGAGFVPDVLDTKI
IDEVIQVPDSEAMVYGRRIAKEEGILSGISTGAALCAAIEVGKRPENDGKLIVMIQPSFGERYLSTPLFQELGPTLAEVR

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=315, Percent_Identity=39.0476190476191, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI295821200, Length=315, Percent_Identity=39.0476190476191, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI4557415, Length=315, Percent_Identity=39.0476190476191, Blast_Score=216, Evalue=2e-56,
Organism=Escherichia coli, GI1788754, Length=319, Percent_Identity=57.6802507836991, Blast_Score=321, Evalue=4e-89,
Organism=Escherichia coli, GI2367138, Length=305, Percent_Identity=39.672131147541, Blast_Score=214, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI17535051, Length=312, Percent_Identity=54.8076923076923, Blast_Score=342, Evalue=2e-94,
Organism=Caenorhabditis elegans, GI17562970, Length=304, Percent_Identity=52.6315789473684, Blast_Score=307, Evalue=4e-84,
Organism=Caenorhabditis elegans, GI32566674, Length=296, Percent_Identity=53.7162162162162, Blast_Score=302, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI115535073, Length=310, Percent_Identity=53.2258064516129, Blast_Score=300, Evalue=5e-82,
Organism=Caenorhabditis elegans, GI17561720, Length=317, Percent_Identity=51.4195583596215, Blast_Score=276, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI32566672, Length=216, Percent_Identity=51.3888888888889, Blast_Score=221, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI17534315, Length=319, Percent_Identity=38.871473354232, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI25147552, Length=287, Percent_Identity=39.7212543554007, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17561716, Length=126, Percent_Identity=49.2063492063492, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321594, Length=319, Percent_Identity=38.2445141065831, Blast_Score=201, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6321449, Length=327, Percent_Identity=34.8623853211009, Blast_Score=130, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24643623, Length=312, Percent_Identity=39.7435897435897, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI20129101, Length=312, Percent_Identity=39.7435897435897, Blast_Score=202, Evalue=3e-52,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 33997; Mature: 33997

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIAHNITELVGRTPLVQLNSIPKAEGCLAKIIVKLEGMNPAASVKDRIGVNMINVAERE
CCCHHHHHHHHCCCCEEEECCCCCHHHHHEEHEEEECCCCCHHHHHHHCCCEEEEEHHHC
GLIKPGKTTLVEPTSGNTGIALAMVAAARGYKLILTMPETMSMERRVMLRAYGAELVLTP
CCCCCCCCEEEECCCCCCCHHHHHHHHCCCCEEEEECCHHHCHHHHHHHEECCCEEEECC
GSEGMKGAITKAQEIVDLSSNGYYMLQQFQNPANPEIHSKTTALEIWEDTDGKVDILVAG
CCCCCHHHHHHHHHHEECCCCCEEEEEECCCCCCCCCCCCCEEEEEEECCCCEEEEEEEE
VGTGGTVTGVAETIKARKPEFQAIAVEPSNSPVLSGGKPGPHKIQGIGAGFVPDVLDTKI
CCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCEECCCCCCCCEEEECCCCCCHHHHHHHH
IDEVIQVPDSEAMVYGRRIAKEEGILSGISTGAALCAAIEVGKRPENDGKLIVMIQPSFG
HHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCC
ERYLSTPLFQELGPTLAEVR
CHHHCCHHHHHHCCHHHHCC
>Mature Secondary Structure
MRIAHNITELVGRTPLVQLNSIPKAEGCLAKIIVKLEGMNPAASVKDRIGVNMINVAERE
CCCHHHHHHHHCCCCEEEECCCCCHHHHHEEHEEEECCCCCHHHHHHHCCCEEEEEHHHC
GLIKPGKTTLVEPTSGNTGIALAMVAAARGYKLILTMPETMSMERRVMLRAYGAELVLTP
CCCCCCCCEEEECCCCCCCHHHHHHHHCCCCEEEEECCHHHCHHHHHHHEECCCEEEECC
GSEGMKGAITKAQEIVDLSSNGYYMLQQFQNPANPEIHSKTTALEIWEDTDGKVDILVAG
CCCCCHHHHHHHHHHEECCCCCEEEEEECCCCCCCCCCCCCEEEEEEECCCCEEEEEEEE
VGTGGTVTGVAETIKARKPEFQAIAVEPSNSPVLSGGKPGPHKIQGIGAGFVPDVLDTKI
CCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCEECCCCCCCCEEEECCCCCCHHHHHHHH
IDEVIQVPDSEAMVYGRRIAKEEGILSGISTGAALCAAIEVGKRPENDGKLIVMIQPSFG
HHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCC
ERYLSTPLFQELGPTLAEVR
CHHHCCHHHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]