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The map label for this gene is ndk

Identifier: 113474915

GI number: 113474915

Start: 1798046

End: 1798495

Strand: Reverse

Name: ndk

Synonym: Tery_1141

Alternate gene names: 113474915

Gene position: 1798495-1798046 (Counterclockwise)

Preceding gene: 113474917

Following gene: 113474913

Centisome position: 23.21

GC content: 38.22

Gene sequence:

>450_bases
TTGGAACGCACCTTTATAGCGATTAAACCGGATGGTGTCCAAAGAGGACTTGTAGGCCAGATTATCAGTCGCTTTGAAAC
AAAAGGTTTTACCCTAGTAGGTCTTAAAATCATGACGGTAACTAAGGAACTTGCTGAAAAACACTATGATGTTCACAAAG
AAAGACCATTTTTTTCAAGTTTAATAGAATTTATTAAATCTGGTCCTTTAGTAGCAATGGTTTGGGAAGGTGAAGGAGTT
GTAGCGTCTGCGAGAAAAATTATTGGGGCAACTAATCCTTTGACCGCTGAACCTGGTACAATTCGCGGTGACTATGGAAT
TAGTCTTGGCCGTAATCTAATACATGGTTCTGATGCTATTGAGACAGCTCAGACCGAAATTAATCTTTGGTTTAAAGAAG
AAGAGTTAGTATCATGGAAACCTACTTTAACTTCCTGGATTGTAGAATAA

Upstream 100 bases:

>100_bases
TATAAAAGTTATCAAAAAAATTATAATACTGTAGCCTAAACTATAATTTACTTTGTATTGTAGAGTACTACTGTAGAATA
AATTTTTGAGGAGTATCAGT

Downstream 100 bases:

>100_bases
AATAGTTAAAATTGTTCTGACTTGAAATATCTATTAGTTAGCTCCCTAATTTAAAGGGCTAACTATCTTTCTGGGAAGTA
GAGAATAGAAAAAAAGGAAA

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MERTFIAIKPDGVQRGLVGQIISRFETKGFTLVGLKIMTVTKELAEKHYDVHKERPFFSSLIEFIKSGPLVAMVWEGEGV
VASARKIIGATNPLTAEPGTIRGDYGISLGRNLIHGSDAIETAQTEINLWFKEEELVSWKPTLTSWIVE

Sequences:

>Translated_149_residues
MERTFIAIKPDGVQRGLVGQIISRFETKGFTLVGLKIMTVTKELAEKHYDVHKERPFFSSLIEFIKSGPLVAMVWEGEGV
VASARKIIGATNPLTAEPGTIRGDYGISLGRNLIHGSDAIETAQTEINLWFKEEELVSWKPTLTSWIVE
>Mature_149_residues
MERTFIAIKPDGVQRGLVGQIISRFETKGFTLVGLKIMTVTKELAEKHYDVHKERPFFSSLIEFIKSGPLVAMVWEGEGV
VASARKIIGATNPLTAEPGTIRGDYGISLGRNLIHGSDAIETAQTEINLWFKEEELVSWKPTLTSWIVE

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI4557797, Length=149, Percent_Identity=59.0604026845638, Blast_Score=193, Evalue=5e-50,
Organism=Homo sapiens, GI38045913, Length=149, Percent_Identity=59.0604026845638, Blast_Score=193, Evalue=5e-50,
Organism=Homo sapiens, GI66392203, Length=149, Percent_Identity=57.0469798657718, Blast_Score=190, Evalue=4e-49,
Organism=Homo sapiens, GI66392227, Length=149, Percent_Identity=57.0469798657718, Blast_Score=190, Evalue=4e-49,
Organism=Homo sapiens, GI66392205, Length=149, Percent_Identity=57.0469798657718, Blast_Score=190, Evalue=4e-49,
Organism=Homo sapiens, GI4505409, Length=149, Percent_Identity=57.0469798657718, Blast_Score=190, Evalue=4e-49,
Organism=Homo sapiens, GI66392192, Length=149, Percent_Identity=57.0469798657718, Blast_Score=190, Evalue=4e-49,
Organism=Homo sapiens, GI37693993, Length=148, Percent_Identity=55.4054054054054, Blast_Score=187, Evalue=2e-48,
Organism=Homo sapiens, GI4826862, Length=138, Percent_Identity=53.6231884057971, Blast_Score=169, Evalue=8e-43,
Organism=Homo sapiens, GI7019465, Length=134, Percent_Identity=35.0746268656716, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI37574614, Length=134, Percent_Identity=35.0746268656716, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI5031951, Length=148, Percent_Identity=29.7297297297297, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI4505413, Length=137, Percent_Identity=32.1167883211679, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI148839372, Length=140, Percent_Identity=31.4285714285714, Blast_Score=67, Evalue=7e-12,
Organism=Escherichia coli, GI1788866, Length=137, Percent_Identity=46.7153284671533, Blast_Score=133, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17506807, Length=149, Percent_Identity=58.3892617449664, Blast_Score=188, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI17507605, Length=98, Percent_Identity=39.7959183673469, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322783, Length=148, Percent_Identity=59.4594594594595, Blast_Score=199, Evalue=2e-52,
Organism=Drosophila melanogaster, GI45549037, Length=148, Percent_Identity=60.8108108108108, Blast_Score=196, Evalue=7e-51,
Organism=Drosophila melanogaster, GI18860097, Length=136, Percent_Identity=36.0294117647059, Blast_Score=89, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_TRIEI (Q116S1)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_720976.1
- ProteinModelPortal:   Q116S1
- SMR:   Q116S1
- STRING:   Q116S1
- GeneID:   4244411
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_1141
- NMPDR:   fig|203124.1.peg.3458
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- PhylomeDB:   Q116S1
- ProtClustDB:   PRK00668
- BioCyc:   TERY203124:TERY_1141-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 16587; Mature: 16587

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 115-115 BINDING 9-9 BINDING 57-57 BINDING 85-85 BINDING 91-91 BINDING 102-102 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERTFIAIKPDGVQRGLVGQIISRFETKGFTLVGLKIMTVTKELAEKHYDVHKERPFFSS
CCCEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCHHHH
LIEFIKSGPLVAMVWEGEGVVASARKIIGATNPLTAEPGTIRGDYGISLGRNLIHGSDAI
HHHHHHCCCEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCEECCCCHHHCCCEECCCCHH
ETAQTEINLWFKEEELVSWKPTLTSWIVE
HHHHHEEEEEEECCCCEECCCCHHHHHCC
>Mature Secondary Structure
MERTFIAIKPDGVQRGLVGQIISRFETKGFTLVGLKIMTVTKELAEKHYDVHKERPFFSS
CCCEEEEECCCCCCCCHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCHHHH
LIEFIKSGPLVAMVWEGEGVVASARKIIGATNPLTAEPGTIRGDYGISLGRNLIHGSDAI
HHHHHHCCCEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCEECCCCHHHCCCEECCCCHH
ETAQTEINLWFKEEELVSWKPTLTSWIVE
HHHHHEEEEEEECCCCEECCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA