Click here to switch to the map view.

The map label for this gene is purH

Identifier: 113474902

GI number: 113474902

Start: 1782421

End: 1783974

Strand: Reverse

Name: purH

Synonym: Tery_1128

Alternate gene names: 113474902

Gene position: 1783974-1782421 (Counterclockwise)

Preceding gene: 113474903

Following gene: 113474901

Centisome position: 23.02

GC content: 35.01

Gene sequence:

>1554_bases
ATGAAACGTTTAGCATTACTTAGTACATCTGATAAAACAGGTCTGATTGATTTAGCAAAAAGTCTAGTTACAGAATTTGA
CTATGAAATAATTAGTAGTGGCGGTACTGCTAAAACTCTCAAAGATGCTGGAATTTATGTTACTAAGGTATCTGACTATA
CGGGATTTCCAGAAATTTTAGGAGGTAGAGTTAAAACATTACATCCTCGCATTCATGGGGGTATTTTAGCAAGAAAAGAT
TTGCCTCAAGATGTTGAAGAACTAAATGCTAATAATATTCGACCTATTGACTTAGTTGTTGTTAATTTATACCCCTTTGA
AGAAACAATTTCTAAACCAGAAGTTACTCTGGCAGAAGCAATTGAAAAAATTGATATTGGCGGACCTGCAATGTTAAGAG
CATCAGCTAAAAATTTTGCTCATCTGACAGTTTTATGCAACCATTTTCAATACAATTCTTATTTAGAAGAGTTAAGAAAA
AATGCCGGGGAAGTATCCTTAGAATTTCGTCAAAAATGTGCATTAGCAGGATTTAAACATACCGCAACTTACGACCAGGC
GATCGCTACTTATTTACAGGAGCAACAAACAACTTCTGAGTCGGAAAAATCAGAAAAAGAAATATTTTTTCTCTCTGGCA
AAAAAATTAAAACTTTGCGTTATGGAGAAAACCCTCATCAATATGCAACTTGGTATCAAAGAGGAATTAATGCTAGTGGT
TGGGGTGCAAGTAAAATTATTCAAGGTAAAGAATTAAGCTATAATAATTTAGTAGATTTAGAAGCAGCAAGACGGATTAT
TATAGAATTTTCTGATGCTCCGACTGTAGCAATTCTTAAACATACAAATCCTTGTGGAGTTGCAGTTGATGAAACTATTT
TGGCAGCTTATGAAAGAGCTTTTGCCGGAGATTCAGTTTCAGCTTTTGGAGGAATTGTTGCTTTAAATAAATCTATTGAT
GCAGCAACTGCTAAGGCAATGACTAAGACCTTTTTGGAATGTGTAGTTGCTCCTGGATGTGAACCTGAAGCGGAGAAAAT
TTTTAAATCTAAATCTAAATTAAGAGTCTTAATTTCACCATATTTCAAACAGAGTGAACCGGAAACTATAAAAGTAATTT
CTGGGGGTTTTTTAGTACAAGATACTGATGATACGATAGATAATTATAGTGATTGGAAAATCGTTACAGAAAAACAACCA
ACTACTGAACAAATAGAAGAATTAATGTTTGCTTGGAAGGTGGTGAAGCACGTTAAGTCTAATGCAATTGTTGTGACAAA
AAATCGAGCTACTGTTGGTATTGGTGCGGGTCAAATGAATAGAGTCGGGGCAGTAAAAATAGCTTTGGAACAAGCAGGGG
AAAAAGCTATTGGAGGTGTATTAGCTAGTGACGCTTTTTTCCCTTTTGATGATTCCGTAAAAACAGCAGCAGCAGCAGGA
GTAACTGCAATTATTCAACCAGGTGGTAGTCTGAAAGATAAAGATTCTATTGCTGCAGCAAATGAATTAGGTTTGATAAT
GATACTCACCGGAATTCGTCACTTTTTACATTAG

Upstream 100 bases:

>100_bases
ATCTGACAAAAATATTAAAAGAATCTGCATAGTTTCAATATCTTAATTTTCAATTATTAAAATATAGACTATCAGTTCTC
GAAGTTAGGATTTAAAACTA

Downstream 100 bases:

>100_bases
AAAAAGCCGGATAAGTTATCAGTTTTTAGTTCTCTGTTTTTAGTGATAATTTACATAATATGCATTACCTTTAACTCCAG
AAGTGACAAAATTAAATTGA

Product: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase

Products: NA

Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase

Number of amino acids: Translated: 517; Mature: 517

Protein sequence:

>517_residues
MKRLALLSTSDKTGLIDLAKSLVTEFDYEIISSGGTAKTLKDAGIYVTKVSDYTGFPEILGGRVKTLHPRIHGGILARKD
LPQDVEELNANNIRPIDLVVVNLYPFEETISKPEVTLAEAIEKIDIGGPAMLRASAKNFAHLTVLCNHFQYNSYLEELRK
NAGEVSLEFRQKCALAGFKHTATYDQAIATYLQEQQTTSESEKSEKEIFFLSGKKIKTLRYGENPHQYATWYQRGINASG
WGASKIIQGKELSYNNLVDLEAARRIIIEFSDAPTVAILKHTNPCGVAVDETILAAYERAFAGDSVSAFGGIVALNKSID
AATAKAMTKTFLECVVAPGCEPEAEKIFKSKSKLRVLISPYFKQSEPETIKVISGGFLVQDTDDTIDNYSDWKIVTEKQP
TTEQIEELMFAWKVVKHVKSNAIVVTKNRATVGIGAGQMNRVGAVKIALEQAGEKAIGGVLASDAFFPFDDSVKTAAAAG
VTAIIQPGGSLKDKDSIAAANELGLIMILTGIRHFLH

Sequences:

>Translated_517_residues
MKRLALLSTSDKTGLIDLAKSLVTEFDYEIISSGGTAKTLKDAGIYVTKVSDYTGFPEILGGRVKTLHPRIHGGILARKD
LPQDVEELNANNIRPIDLVVVNLYPFEETISKPEVTLAEAIEKIDIGGPAMLRASAKNFAHLTVLCNHFQYNSYLEELRK
NAGEVSLEFRQKCALAGFKHTATYDQAIATYLQEQQTTSESEKSEKEIFFLSGKKIKTLRYGENPHQYATWYQRGINASG
WGASKIIQGKELSYNNLVDLEAARRIIIEFSDAPTVAILKHTNPCGVAVDETILAAYERAFAGDSVSAFGGIVALNKSID
AATAKAMTKTFLECVVAPGCEPEAEKIFKSKSKLRVLISPYFKQSEPETIKVISGGFLVQDTDDTIDNYSDWKIVTEKQP
TTEQIEELMFAWKVVKHVKSNAIVVTKNRATVGIGAGQMNRVGAVKIALEQAGEKAIGGVLASDAFFPFDDSVKTAAAAG
VTAIIQPGGSLKDKDSIAAANELGLIMILTGIRHFLH
>Mature_517_residues
MKRLALLSTSDKTGLIDLAKSLVTEFDYEIISSGGTAKTLKDAGIYVTKVSDYTGFPEILGGRVKTLHPRIHGGILARKD
LPQDVEELNANNIRPIDLVVVNLYPFEETISKPEVTLAEAIEKIDIGGPAMLRASAKNFAHLTVLCNHFQYNSYLEELRK
NAGEVSLEFRQKCALAGFKHTATYDQAIATYLQEQQTTSESEKSEKEIFFLSGKKIKTLRYGENPHQYATWYQRGINASG
WGASKIIQGKELSYNNLVDLEAARRIIIEFSDAPTVAILKHTNPCGVAVDETILAAYERAFAGDSVSAFGGIVALNKSID
AATAKAMTKTFLECVVAPGCEPEAEKIFKSKSKLRVLISPYFKQSEPETIKVISGGFLVQDTDDTIDNYSDWKIVTEKQP
TTEQIEELMFAWKVVKHVKSNAIVVTKNRATVGIGAGQMNRVGAVKIALEQAGEKAIGGVLASDAFFPFDDSVKTAAAAG
VTAIIQPGGSLKDKDSIAAANELGLIMILTGIRHFLH

Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]

COG id: COG0138

COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purH family

Homologues:

Organism=Homo sapiens, GI20127454, Length=483, Percent_Identity=36.4389233954451, Blast_Score=265, Evalue=7e-71,
Organism=Escherichia coli, GI1790439, Length=526, Percent_Identity=45.0570342205323, Blast_Score=450, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI71985564, Length=526, Percent_Identity=33.4600760456274, Blast_Score=244, Evalue=9e-65,
Organism=Caenorhabditis elegans, GI71985574, Length=350, Percent_Identity=25.4285714285714, Blast_Score=86, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323768, Length=476, Percent_Identity=38.0252100840336, Blast_Score=285, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6323056, Length=473, Percent_Identity=39.9577167019027, Blast_Score=281, Evalue=2e-76,
Organism=Drosophila melanogaster, GI24649832, Length=485, Percent_Identity=37.9381443298969, Blast_Score=276, Evalue=3e-74,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR9_TRIEI (Q116T4)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_720963.1
- ProteinModelPortal:   Q116T4
- SMR:   Q116T4
- STRING:   Q116T4
- GeneID:   4242860
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_1128
- NMPDR:   fig|203124.1.peg.3445
- eggNOG:   COG0138
- HOGENOM:   HBG498048
- OMA:   ASDGFFP
- PhylomeDB:   Q116T4
- ProtClustDB:   PRK00881
- BioCyc:   TERY203124:TERY_1128-MONOMER
- HAMAP:   MF_00139
- InterPro:   IPR002695
- InterPro:   IPR013982
- InterPro:   IPR016193
- InterPro:   IPR011607
- Gene3D:   G3DSA:3.40.50.1380
- PANTHER:   PTHR11692
- PIRSF:   PIRSF000414
- SMART:   SM00798
- SMART:   SM00851
- TIGRFAMs:   TIGR00355

Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS; SSF53927 Cytidine_deaminase-like; SSF52335 MGS-like_dom

EC number: =2.1.2.3; =3.5.4.10

Molecular weight: Translated: 56371; Mature: 56371

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLALLSTSDKTGLIDLAKSLVTEFDYEIISSGGTAKTLKDAGIYVTKVSDYTGFPEIL
CCCEEEEECCCCCCHHHHHHHHHHHHCHHHHCCCCCEEEHHCCCEEEEEECCCCCCHHHH
GGRVKTLHPRIHGGILARKDLPQDVEELNANNIRPIDLVVVNLYPFEETISKPEVTLAEA
CCCEEEECCHHHCCEEECCCCCHHHHHCCCCCCCEEEEEEEEEECCHHHCCCCCHHHHHH
IEKIDIGGPAMLRASAKNFAHLTVLCNHFQYNSYLEELRKNAGEVSLEFRQKCALAGFKH
HHHCCCCCCHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCCCCC
TATYDQAIATYLQEQQTTSESEKSEKEIFFLSGKKIKTLRYGENPHQYATWYQRGINASG
CCHHHHHHHHHHHHHHHCCHHHCCCCEEEEECCCEEEEEECCCCCHHHHHHHHHCCCCCC
WGASKIIQGKELSYNNLVDLEAARRIIIEFSDAPTVAILKHTNPCGVAVDETILAAYERA
CCHHHEECCCCCCCCCEEEHHHCCEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHH
FAGDSVSAFGGIVALNKSIDAATAKAMTKTFLECVVAPGCEPEAEKIFKSKSKLRVLISP
HCCCCHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEEH
YFKQSEPETIKVISGGFLVQDTDDTIDNYSDWKIVTEKQPTTEQIEELMFAWKVVKHVKS
HCCCCCCCEEEEEECCEEEECCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCC
NAIVVTKNRATVGIGAGQMNRVGAVKIALEQAGEKAIGGVLASDAFFPFDDSVKTAAAAG
CEEEEEECCEEEEECCCCCCCCCCEEEEHHHCCCHHHCCHHHCCCCCCCCCCHHHHHHCC
VTAIIQPGGSLKDKDSIAAANELGLIMILTGIRHFLH
EEEEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHC
>Mature Secondary Structure
MKRLALLSTSDKTGLIDLAKSLVTEFDYEIISSGGTAKTLKDAGIYVTKVSDYTGFPEIL
CCCEEEEECCCCCCHHHHHHHHHHHHCHHHHCCCCCEEEHHCCCEEEEEECCCCCCHHHH
GGRVKTLHPRIHGGILARKDLPQDVEELNANNIRPIDLVVVNLYPFEETISKPEVTLAEA
CCCEEEECCHHHCCEEECCCCCHHHHHCCCCCCCEEEEEEEEEECCHHHCCCCCHHHHHH
IEKIDIGGPAMLRASAKNFAHLTVLCNHFQYNSYLEELRKNAGEVSLEFRQKCALAGFKH
HHHCCCCCCHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHCCCCC
TATYDQAIATYLQEQQTTSESEKSEKEIFFLSGKKIKTLRYGENPHQYATWYQRGINASG
CCHHHHHHHHHHHHHHHCCHHHCCCCEEEEECCCEEEEEECCCCCHHHHHHHHHCCCCCC
WGASKIIQGKELSYNNLVDLEAARRIIIEFSDAPTVAILKHTNPCGVAVDETILAAYERA
CCHHHEECCCCCCCCCEEEHHHCCEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHH
FAGDSVSAFGGIVALNKSIDAATAKAMTKTFLECVVAPGCEPEAEKIFKSKSKLRVLISP
HCCCCHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEEH
YFKQSEPETIKVISGGFLVQDTDDTIDNYSDWKIVTEKQPTTEQIEELMFAWKVVKHVKS
HCCCCCCCEEEEEECCEEEECCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCC
NAIVVTKNRATVGIGAGQMNRVGAVKIALEQAGEKAIGGVLASDAFFPFDDSVKTAAAAG
CEEEEEECCEEEEECCCCCCCCCCEEEEHHHCCCHHHCCHHHCCCCCCCCCCHHHHHHCC
VTAIIQPGGSLKDKDSIAAANELGLIMILTGIRHFLH
EEEEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA