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The map label for this gene is cobW [H]

Identifier: 113474814

GI number: 113474814

Start: 1602686

End: 1603732

Strand: Direct

Name: cobW [H]

Synonym: Tery_1027

Alternate gene names: 113474814

Gene position: 1602686-1603732 (Clockwise)

Preceding gene: 113474813

Following gene: 113474818

Centisome position: 20.68

GC content: 35.43

Gene sequence:

>1047_bases
ATGAGTGCTAAAATTCCAGTTACTGTAATTACGGGTTTTCTCGGTAGTGGTAAAACTACGACAATTCGCCATTTATTAAA
AAATAATAAAGGTCGTCGCATTGCTGTTTTAGTGAATGAATTTGGTGAAGTTGGTATAGATGGAGATTTATTACGTTCTT
GTCAAGTTTATGATGAGGAAGGTATTATTAATAATATTGTTGAACTAAATAATGGTTGTCTTTGCTGTACTGTGCAAGAG
GAATTTTTTCCGACTATGCAAGAACTATTAAAACGTCGAGAAAAAATTGATTCTATTTTAATTGAAACTTCTGGGTTAGC
TTTACCAAAACCTTTGGTACAAGCATTTCGTTGGCCTCAAATTAAGACTTCTGCTACGGTGGATGGAGTTGTTACTGTTG
TTGATTGTGAAGCTGTGGCAAATGGTAGTTTGGTTGGAGATATTGATGCTTTGAAAGCTCAACGTCAAGCTGACCCAAAT
TTGGATCATGAAACCCCTATTGAGGAATTATTTGAAGATCAGTTAGCTTGTGCTGATCTGGTTTTATTAACTAAGGTTGA
TATGGTGGATGAAGCTACTTCTGATAAAGTACAAAATTGGTTGAGGGAGCATTTGCCTAAAACTGTGAAAATAGTTCCTT
GTATTGGAGGTGAAATTAATCCAGATTTATTGTTGGGTTTTAATGCTGTAGTTGAAGATAATTTAGATTCTCGTCCTAGT
CACCATGATACTCAAGAAGAACATGAACATGATGATGAAATTAATTCTGTACATTTAATTTTGGATGAAGAGTTTGAACC
CCAAGGGTTAGTTGAAAAGTTGAACGGTTTAGTGACAAATTCTGAAATATATCGGATTAAAGGTTTTGTGGCAGTGCCAA
ATAAGTCTATGCGTCTGGTTTTGCAGGGGGTGGGTTCACGCTTTGATTTTTTCTATGACCGTCTCTGGCAAAAACAGGAG
ACTAGGCAAACTAAGTTAGTTTTAATTGGTCGTTCTCTACAAAGAGAAAAAATTTACTCCGAGCTGGTTTCTAATTTCTC
TAATTAA

Upstream 100 bases:

>100_bases
CTAATCCCTAAAAAGTTAACTTTTTGATTTCTTGTTTTTTCTCTCTTTTCTTGACTTATTAATTTTTTCAAATAACTTTC
AATAAATTACTAATAAAATT

Downstream 100 bases:

>100_bases
ATGAAATGTTTTCTATTCTTTTTTTGGAGAGATTGGATATTTCATATTAGTGATTTTTTTCTATTTTAACTTTTTTTTGT
TGAATAAAAAATCTAGTTTA

Product: cobalamin biosynthesis protein CobW

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MSAKIPVTVITGFLGSGKTTTIRHLLKNNKGRRIAVLVNEFGEVGIDGDLLRSCQVYDEEGIINNIVELNNGCLCCTVQE
EFFPTMQELLKRREKIDSILIETSGLALPKPLVQAFRWPQIKTSATVDGVVTVVDCEAVANGSLVGDIDALKAQRQADPN
LDHETPIEELFEDQLACADLVLLTKVDMVDEATSDKVQNWLREHLPKTVKIVPCIGGEINPDLLLGFNAVVEDNLDSRPS
HHDTQEEHEHDDEINSVHLILDEEFEPQGLVEKLNGLVTNSEIYRIKGFVAVPNKSMRLVLQGVGSRFDFFYDRLWQKQE
TRQTKLVLIGRSLQREKIYSELVSNFSN

Sequences:

>Translated_348_residues
MSAKIPVTVITGFLGSGKTTTIRHLLKNNKGRRIAVLVNEFGEVGIDGDLLRSCQVYDEEGIINNIVELNNGCLCCTVQE
EFFPTMQELLKRREKIDSILIETSGLALPKPLVQAFRWPQIKTSATVDGVVTVVDCEAVANGSLVGDIDALKAQRQADPN
LDHETPIEELFEDQLACADLVLLTKVDMVDEATSDKVQNWLREHLPKTVKIVPCIGGEINPDLLLGFNAVVEDNLDSRPS
HHDTQEEHEHDDEINSVHLILDEEFEPQGLVEKLNGLVTNSEIYRIKGFVAVPNKSMRLVLQGVGSRFDFFYDRLWQKQE
TRQTKLVLIGRSLQREKIYSELVSNFSN
>Mature_347_residues
SAKIPVTVITGFLGSGKTTTIRHLLKNNKGRRIAVLVNEFGEVGIDGDLLRSCQVYDEEGIINNIVELNNGCLCCTVQEE
FFPTMQELLKRREKIDSILIETSGLALPKPLVQAFRWPQIKTSATVDGVVTVVDCEAVANGSLVGDIDALKAQRQADPNL
DHETPIEELFEDQLACADLVLLTKVDMVDEATSDKVQNWLREHLPKTVKIVPCIGGEINPDLLLGFNAVVEDNLDSRPSH
HDTQEEHEHDDEINSVHLILDEEFEPQGLVEKLNGLVTNSEIYRIKGFVAVPNKSMRLVLQGVGSRFDFFYDRLWQKQET
RQTKLVLIGRSLQREKIYSELVSNFSN

Specific function: Might be involved in cobalt reduction leading to cobalt(I) corrinoids [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=358, Percent_Identity=28.4916201117318, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI126722884, Length=357, Percent_Identity=28.5714285714286, Blast_Score=131, Evalue=8e-31,
Organism=Homo sapiens, GI223941779, Length=357, Percent_Identity=28.8515406162465, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI148727351, Length=357, Percent_Identity=28.5714285714286, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI146231952, Length=357, Percent_Identity=28.5714285714286, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI223941776, Length=345, Percent_Identity=27.2463768115942, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI119120938, Length=137, Percent_Identity=38.6861313868613, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI87082430, Length=354, Percent_Identity=29.0960451977401, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1788499, Length=197, Percent_Identity=32.994923857868, Blast_Score=93, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324356, Length=370, Percent_Identity=27.027027027027, Blast_Score=119, Evalue=8e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012824
- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 39033; Mature: 38902

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAKIPVTVITGFLGSGKTTTIRHLLKNNKGRRIAVLVNEFGEVGIDGDLLRSCQVYDEE
CCCCCCHHEEEECCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCC
GIINNIVELNNGCLCCTVQEEFFPTMQELLKRREKIDSILIETSGLALPKPLVQAFRWPQ
CHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHCCCC
IKTSATVDGVVTVVDCEAVANGSLVGDIDALKAQRQADPNLDHETPIEELFEDQLACADL
CCCCCCCCCEEEEEEEHHHCCCCEEECHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
VLLTKVDMVDEATSDKVQNWLREHLPKTVKIVPCIGGEINPDLLLGFNAVVEDNLDSRPS
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHEEECHHHHHCCCCCCCC
HHDTQEEHEHDDEINSVHLILDEEFEPQGLVEKLNGLVTNSEIYRIKGFVAVPNKSMRLV
CCCCHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCEEEEEEEEEECCCHHHHHH
LQGVGSRFDFFYDRLWQKQETRQTKLVLIGRSLQREKIYSELVSNFSN
HHHCCCHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SAKIPVTVITGFLGSGKTTTIRHLLKNNKGRRIAVLVNEFGEVGIDGDLLRSCQVYDEE
CCCCCHHEEEECCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCC
GIINNIVELNNGCLCCTVQEEFFPTMQELLKRREKIDSILIETSGLALPKPLVQAFRWPQ
CHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHCCCC
IKTSATVDGVVTVVDCEAVANGSLVGDIDALKAQRQADPNLDHETPIEELFEDQLACADL
CCCCCCCCCEEEEEEEHHHCCCCEEECHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
VLLTKVDMVDEATSDKVQNWLREHLPKTVKIVPCIGGEINPDLLLGFNAVVEDNLDSRPS
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHEEECHHHHHCCCCCCCC
HHDTQEEHEHDDEINSVHLILDEEFEPQGLVEKLNGLVTNSEIYRIKGFVAVPNKSMRLV
CCCCHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCEEEEEEEEEECCCHHHHHH
LQGVGSRFDFFYDRLWQKQETRQTKLVLIGRSLQREKIYSELVSNFSN
HHHCCCHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]