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The map label for this gene is hemA

Identifier: 113474752

GI number: 113474752

Start: 1496538

End: 1497833

Strand: Direct

Name: hemA

Synonym: Tery_0949

Alternate gene names: 113474752

Gene position: 1496538-1497833 (Clockwise)

Preceding gene: 113474751

Following gene: 113474753

Centisome position: 19.31

GC content: 35.57

Gene sequence:

>1296_bases
ATGAATATTGCAGTAATAGGACTGAGTCACAAAACAGCTCCTGTCGAAGTTCGAGAAAAATTAAGTCTTCCAGAAACAGA
AATACAAAATGCAATTTCTGAATTGTGTAGTGGAACTTATACCCAAGAAGTAGGAATTCTTAGTACCTGTAATCGTTTAG
AAATTTATGTAGTTACTAATGAAATGCAGCCTGGTATTAGGGAAGTAACTCAGTTTCTTTCTGAGTCTAGTAAAATACCT
TTAAATCAGCTTCGTCCTCACTTATTTATGTTACTCCATGAAGATTCTATTATGCACTTAATGCGAGTTGCTTCTGGATT
AGATAGTTTAGTATTAGGTGAAGGGCAAATTTTAGCTCAGGTTAAACAAACTCATAAACTTGGACAAAAATATAAGGGTA
TTGGACGTATTCTTAACCGTTTATTTAAGCAGGCTGTAACTGCTGGAAAAAGGGTACGGACAGAAACAAGCATTGGTACT
GGCGCTGTTTCTGTTAGTTCTGCTGCAGTGGAATTAGCTCAGATGAAATTAGAGGATTTATCTAATTACCAAGTGGCTAT
TGTGGGTGCTGGTAAAATGTCAAAATTACTGGTGCAACATTTATTAGCTAAAGGGGCAAATAAGATATCAATAATTAATC
GTTCTGTGGGACGCGCTCAGGATTTAGCAAATAGTTTTAAAGATGCAAATATAAAAGTTTATTCTATGTTAGAAATGGTT
CAGGTTATTGGTGAATCAGATCTAGTATTTACTAGCACTGCTGCAACTGAACTGATTTTAGATAAAGCCAAATTAGAAAC
AATTTTAGACCCTTTAAAACCTCTAATGTTGGTGGATATTTCTGTACCTCGTAATATTGGTAATGATGTCAGTGAATTGC
CAAATGTTCGTTGTTTTAATGTGGATGATTTAAAGGCGGTTGTTGCTCAAAATAGAGAAAGTCGTCGCCAAATGGCTATG
GAAGCTGAGGTTTTATTAGAGGAAGAGGTAGAAGCTTTTGATGTATGGTGGAAAAGTTTGGAAACTGTTCCGACTATTAA
TTCTTTACGACAAAAAATAGAGACTATTAGAGAACAAGAATTAGAAAAAGCTTTATCTCGTTTAGGTTCAGAATTTGCCG
AAAAACATCAAGAGGTAATTGAGGCTTTAACTAGGGGTATTGTGAATAAAATTTTGCATGATCCGATGGTACAGTTACGA
GCGCAACAGGATATTGAGGCCAGGCGTCATGCAATGGAGACTTTACAACTTTTGTTTAATTTAGAGTCGGAAATGAGTTC
TGGGAAGGTAATTTAG

Upstream 100 bases:

>100_bases
TTATAATCGGTGTCAAAATGATAGAAATTTTTCCTAGTTCATCCTTTAAGGTATGATTTTAATCAAAAAAAAACGAAACA
ATTAACAAAATAAAAATTAT

Downstream 100 bases:

>100_bases
TTAGAGTTTTTGGGTTTTGGTGAATTGGTAATTTTTTTATTTTTTTGTCTATTAGTGTCTTATAAAAAACTATAGTTAGT
AAGTTTCATAATAATAAAAA

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MNIAVIGLSHKTAPVEVREKLSLPETEIQNAISELCSGTYTQEVGILSTCNRLEIYVVTNEMQPGIREVTQFLSESSKIP
LNQLRPHLFMLLHEDSIMHLMRVASGLDSLVLGEGQILAQVKQTHKLGQKYKGIGRILNRLFKQAVTAGKRVRTETSIGT
GAVSVSSAAVELAQMKLEDLSNYQVAIVGAGKMSKLLVQHLLAKGANKISIINRSVGRAQDLANSFKDANIKVYSMLEMV
QVIGESDLVFTSTAATELILDKAKLETILDPLKPLMLVDISVPRNIGNDVSELPNVRCFNVDDLKAVVAQNRESRRQMAM
EAEVLLEEEVEAFDVWWKSLETVPTINSLRQKIETIREQELEKALSRLGSEFAEKHQEVIEALTRGIVNKILHDPMVQLR
AQQDIEARRHAMETLQLLFNLESEMSSGKVI

Sequences:

>Translated_431_residues
MNIAVIGLSHKTAPVEVREKLSLPETEIQNAISELCSGTYTQEVGILSTCNRLEIYVVTNEMQPGIREVTQFLSESSKIP
LNQLRPHLFMLLHEDSIMHLMRVASGLDSLVLGEGQILAQVKQTHKLGQKYKGIGRILNRLFKQAVTAGKRVRTETSIGT
GAVSVSSAAVELAQMKLEDLSNYQVAIVGAGKMSKLLVQHLLAKGANKISIINRSVGRAQDLANSFKDANIKVYSMLEMV
QVIGESDLVFTSTAATELILDKAKLETILDPLKPLMLVDISVPRNIGNDVSELPNVRCFNVDDLKAVVAQNRESRRQMAM
EAEVLLEEEVEAFDVWWKSLETVPTINSLRQKIETIREQELEKALSRLGSEFAEKHQEVIEALTRGIVNKILHDPMVQLR
AQQDIEARRHAMETLQLLFNLESEMSSGKVI
>Mature_431_residues
MNIAVIGLSHKTAPVEVREKLSLPETEIQNAISELCSGTYTQEVGILSTCNRLEIYVVTNEMQPGIREVTQFLSESSKIP
LNQLRPHLFMLLHEDSIMHLMRVASGLDSLVLGEGQILAQVKQTHKLGQKYKGIGRILNRLFKQAVTAGKRVRTETSIGT
GAVSVSSAAVELAQMKLEDLSNYQVAIVGAGKMSKLLVQHLLAKGANKISIINRSVGRAQDLANSFKDANIKVYSMLEMV
QVIGESDLVFTSTAATELILDKAKLETILDPLKPLMLVDISVPRNIGNDVSELPNVRCFNVDDLKAVVAQNRESRRQMAM
EAEVLLEEEVEAFDVWWKSLETVPTINSLRQKIETIREQELEKALSRLGSEFAEKHQEVIEALTRGIVNKILHDPMVQLR
AQQDIEARRHAMETLQLLFNLESEMSSGKVI

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=402, Percent_Identity=35.3233830845771, Blast_Score=227, Evalue=1e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_TRIEI (Q117I4)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_720813.1
- ProteinModelPortal:   Q117I4
- SMR:   Q117I4
- STRING:   Q117I4
- GeneID:   4245688
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_0949
- NMPDR:   fig|203124.1.peg.4140
- eggNOG:   COG0373
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- PhylomeDB:   Q117I4
- ProtClustDB:   PRK00045
- BioCyc:   TERY203124:TERY_0949-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 47969; Mature: 47969

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 109-109 BINDING 120-120

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIAVIGLSHKTAPVEVREKLSLPETEIQNAISELCSGTYTQEVGILSTCNRLEIYVVTN
CCEEEEECCCCCCCHHHHHHCCCCHHHHHHHHHHHHCCCCHHHCCHHHCCCCEEEEEEEC
EMQPGIREVTQFLSESSKIPLNQLRPHLFMLLHEDSIMHLMRVASGLDSLVLGEGQILAQ
CCCCCHHHHHHHHHCCCCCCHHHCCHHHHHHHCHHHHHHHHHHHHCCHHHHHCCHHHHHH
VKQTHKLGQKYKGIGRILNRLFKQAVTAGKRVRTETSIGTGAVSVSSAAVELAQMKLEDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHC
SNYQVAIVGAGKMSKLLVQHLLAKGANKISIINRSVGRAQDLANSFKDANIKVYSMLEMV
CCCEEEEEECCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
QVIGESDLVFTSTAATELILDKAKLETILDPLKPLMLVDISVPRNIGNDVSELPNVRCFN
HHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCHHEEEEECCCCCCCCCHHHCCCCEEEC
VDDLKAVVAQNRESRRQMAMEAEVLLEEEVEAFDVWWKSLETVPTINSLRQKIETIREQE
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LEKALSRLGSEFAEKHQEVIEALTRGIVNKILHDPMVQLRAQQDIEARRHAMETLQLLFN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHH
LESEMSSGKVI
HHHHCCCCCCC
>Mature Secondary Structure
MNIAVIGLSHKTAPVEVREKLSLPETEIQNAISELCSGTYTQEVGILSTCNRLEIYVVTN
CCEEEEECCCCCCCHHHHHHCCCCHHHHHHHHHHHHCCCCHHHCCHHHCCCCEEEEEEEC
EMQPGIREVTQFLSESSKIPLNQLRPHLFMLLHEDSIMHLMRVASGLDSLVLGEGQILAQ
CCCCCHHHHHHHHHCCCCCCHHHCCHHHHHHHCHHHHHHHHHHHHCCHHHHHCCHHHHHH
VKQTHKLGQKYKGIGRILNRLFKQAVTAGKRVRTETSIGTGAVSVSSAAVELAQMKLEDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHC
SNYQVAIVGAGKMSKLLVQHLLAKGANKISIINRSVGRAQDLANSFKDANIKVYSMLEMV
CCCEEEEEECCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
QVIGESDLVFTSTAATELILDKAKLETILDPLKPLMLVDISVPRNIGNDVSELPNVRCFN
HHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCHHEEEEECCCCCCCCCHHHCCCCEEEC
VDDLKAVVAQNRESRRQMAMEAEVLLEEEVEAFDVWWKSLETVPTINSLRQKIETIREQE
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LEKALSRLGSEFAEKHQEVIEALTRGIVNKILHDPMVQLRAQQDIEARRHAMETLQLLFN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHH
LESEMSSGKVI
HHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA