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The map label for this gene is mprA [H]

Identifier: 113474731

GI number: 113474731

Start: 1455460

End: 1456596

Strand: Reverse

Name: mprA [H]

Synonym: Tery_0921

Alternate gene names: 113474731

Gene position: 1456596-1455460 (Counterclockwise)

Preceding gene: 113474733

Following gene: 113474728

Centisome position: 18.79

GC content: 34.83

Gene sequence:

>1137_bases
ATGATATATAAAATTTTGGTTATTGATGATGATACTACAGTTCAGGAATTGCTTAGAAGAGTTCTAGGCAAACAGGGTTA
TACTGTCACAGTAGCAAGTAACGGTGAAGAAGGTTTTAAACAAGCCCAACTCCTACAACCTGCTTTAATTATCTGTGACT
GGATCATGCCGCGGCTCACAGGAATAGAAGTATGCCGTAAGGTTAAAGCTAGTTCTGATTTGTCCACTACTTTCTTCATT
TTGTTAACTTCTTTAGGAAGTGTTCAAGATTTAGTTAAAGGTCTTGATGCTGGTGCTGATGACTTTATTTCCAAACCTAT
AAACATCAATGAAATGAAGGCTAGGGTCAGAGCTGGACTCCGACTACATCAGCTTTCTCAAGACTTGCAGACCCAAAAGC
AACTACTAGAAGCAGAATTAGCTGAGGCTGCGAACTATGTGTCTTCTCTTCTACCAGCATCTGTAACAGAACCAGTAAAA
GTTGAATCTCAGTTTATTCCTTGTCGCAAGTTAGGAGGAGACTGCTTTGATTATTATTGGTTAGATGAAAATTACTTAGC
TGTATATTTATTAGATGTCGCAGGTCATGGTTTACGAGCTGCACTTCCTTCAGTTTCAGTTTTGAATTTGTTGAGGTCAA
AGGCCATACCTAACTTAGATTACTATAAACCTAGTGATGTACTTAGAGCTTTAAATAATACTTACCAAATAACCTCTCAA
AATGATAAATACTTTACTATTTGGTATGGTGTATATAATCTCTCTGAAAGTCAATTAGTTTATGCAAGTGCTGGTCATCC
CCCAGCTATTTTGATCTCTGGTGATAGTCACCTTGCTCAAGTAAGTAAATTGAGAACTCCTGGAATGCCTATTGGTATGT
TTCCAGAGGCTACTTATATAGATGATTCTTGCATAGTAGAAAAGTCTAGCTCTCTATATATATTTAGTGATGGTGTTTAC
GAAATTTATTTATCTGACGGAGAAATTTGGGGAATAGATAATTTTATTAATCTAATTTTAGAATATTATAGATATGGTTA
TTGCGATATAAACAAAATATTAGACTATATACAAAAGCTAAATTGTAGTGATGTATTTAGTGATGATTTTTCTTTGCTAA
AACTTATCTTTAGTTAG

Upstream 100 bases:

>100_bases
AATTTATGTAAATAATTAACATTATAAATTCCAGCTGCTGGTCTACTTACTTTTATGTCATCTTTAGCCGAAACAGTGAA
TTAATTGTTTAACTAAGTCC

Downstream 100 bases:

>100_bases
ACTGCCTATGTATCTTGAAATTATTTGAGTATTAAGGATAAAATGAATTACAATTCAGGAAAAGTAAGTATTCAGGTGAG
ATTCATCACACTTTGGCCAA

Product: response regulator receiver modulated serine phosphatase

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MIYKILVIDDDTTVQELLRRVLGKQGYTVTVASNGEEGFKQAQLLQPALIICDWIMPRLTGIEVCRKVKASSDLSTTFFI
LLTSLGSVQDLVKGLDAGADDFISKPININEMKARVRAGLRLHQLSQDLQTQKQLLEAELAEAANYVSSLLPASVTEPVK
VESQFIPCRKLGGDCFDYYWLDENYLAVYLLDVAGHGLRAALPSVSVLNLLRSKAIPNLDYYKPSDVLRALNNTYQITSQ
NDKYFTIWYGVYNLSESQLVYASAGHPPAILISGDSHLAQVSKLRTPGMPIGMFPEATYIDDSCIVEKSSSLYIFSDGVY
EIYLSDGEIWGIDNFINLILEYYRYGYCDINKILDYIQKLNCSDVFSDDFSLLKLIFS

Sequences:

>Translated_378_residues
MIYKILVIDDDTTVQELLRRVLGKQGYTVTVASNGEEGFKQAQLLQPALIICDWIMPRLTGIEVCRKVKASSDLSTTFFI
LLTSLGSVQDLVKGLDAGADDFISKPININEMKARVRAGLRLHQLSQDLQTQKQLLEAELAEAANYVSSLLPASVTEPVK
VESQFIPCRKLGGDCFDYYWLDENYLAVYLLDVAGHGLRAALPSVSVLNLLRSKAIPNLDYYKPSDVLRALNNTYQITSQ
NDKYFTIWYGVYNLSESQLVYASAGHPPAILISGDSHLAQVSKLRTPGMPIGMFPEATYIDDSCIVEKSSSLYIFSDGVY
EIYLSDGEIWGIDNFINLILEYYRYGYCDINKILDYIQKLNCSDVFSDDFSLLKLIFS
>Mature_378_residues
MIYKILVIDDDTTVQELLRRVLGKQGYTVTVASNGEEGFKQAQLLQPALIICDWIMPRLTGIEVCRKVKASSDLSTTFFI
LLTSLGSVQDLVKGLDAGADDFISKPININEMKARVRAGLRLHQLSQDLQTQKQLLEAELAEAANYVSSLLPASVTEPVK
VESQFIPCRKLGGDCFDYYWLDENYLAVYLLDVAGHGLRAALPSVSVLNLLRSKAIPNLDYYKPSDVLRALNNTYQITSQ
NDKYFTIWYGVYNLSESQLVYASAGHPPAILISGDSHLAQVSKLRTPGMPIGMFPEATYIDDSCIVEKSSSLYIFSDGVY
EIYLSDGEIWGIDNFINLILEYYRYGYCDINKILDYIQKLNCSDVFSDDFSLLKLIFS

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG2208

COG function: function code TK; Serine phosphatase RsbU, regulator of sigma subunit

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=214, Percent_Identity=27.5700934579439, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1789809, Length=119, Percent_Identity=37.8151260504202, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI87082012, Length=121, Percent_Identity=38.0165289256198, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1786784, Length=118, Percent_Identity=35.5932203389831, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786911, Length=122, Percent_Identity=34.4262295081967, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI2367329, Length=130, Percent_Identity=36.1538461538462, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787487, Length=308, Percent_Identity=25.6493506493506, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1788394, Length=129, Percent_Identity=31.0077519379845, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788550, Length=135, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790552, Length=124, Percent_Identity=30.6451612903226, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1787229, Length=135, Percent_Identity=29.6296296296296, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1790860, Length=117, Percent_Identity=30.7692307692308, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 42371; Mature: 42371

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYKILVIDDDTTVQELLRRVLGKQGYTVTVASNGEEGFKQAQLLQPALIICDWIMPRLT
CEEEEEEECCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
GIEVCRKVKASSDLSTTFFILLTSLGSVQDLVKGLDAGADDFISKPININEMKARVRAGL
HHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCHHHHCCCCCHHHHHHHHHHCH
RLHQLSQDLQTQKQLLEAELAEAANYVSSLLPASVTEPVKVESQFIPCRKLGGDCFDYYW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCCEEEEEE
LDENYLAVYLLDVAGHGLRAALPSVSVLNLLRSKAIPNLDYYKPSDVLRALNNTYQITSQ
ECCCEEEEEEEECCCCCHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCEEEEEC
NDKYFTIWYGVYNLSESQLVYASAGHPPAILISGDSHLAQVSKLRTPGMPIGMFPEATYI
CCCEEEEEEEEEECCCCCEEEEECCCCCEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCC
DDSCIVEKSSSLYIFSDGVYEIYLSDGEIWGIDNFINLILEYYRYGYCDINKILDYIQKL
CCHHEEECCCCEEEEECCEEEEEECCCCEECHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
NCSDVFSDDFSLLKLIFS
CCCHHCCCCHHHHHHHCC
>Mature Secondary Structure
MIYKILVIDDDTTVQELLRRVLGKQGYTVTVASNGEEGFKQAQLLQPALIICDWIMPRLT
CEEEEEEECCCHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
GIEVCRKVKASSDLSTTFFILLTSLGSVQDLVKGLDAGADDFISKPININEMKARVRAGL
HHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCHHHHCCCCCHHHHHHHHHHCH
RLHQLSQDLQTQKQLLEAELAEAANYVSSLLPASVTEPVKVESQFIPCRKLGGDCFDYYW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCCEEEEEE
LDENYLAVYLLDVAGHGLRAALPSVSVLNLLRSKAIPNLDYYKPSDVLRALNNTYQITSQ
ECCCEEEEEEEECCCCCHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCEEEEEC
NDKYFTIWYGVYNLSESQLVYASAGHPPAILISGDSHLAQVSKLRTPGMPIGMFPEATYI
CCCEEEEEEEEEECCCCCEEEEECCCCCEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCC
DDSCIVEKSSSLYIFSDGVYEIYLSDGEIWGIDNFINLILEYYRYGYCDINKILDYIQKL
CCHHEEECCCCEEEEECCEEEEEECCCCEECHHHHHHHHHHHHHCCCCCHHHHHHHHHHC
NCSDVFSDDFSLLKLIFS
CCCHHCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA