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The map label for this gene is argH [H]

Identifier: 113474583

GI number: 113474583

Start: 1195939

End: 1197330

Strand: Direct

Name: argH [H]

Synonym: Tery_0740

Alternate gene names: 113474583

Gene position: 1195939-1197330 (Clockwise)

Preceding gene: 113474582

Following gene: 113474586

Centisome position: 15.43

GC content: 34.99

Gene sequence:

>1392_bases
ATGAAGCAAGATAGACAAACATGGAGCCAAAGATTTGAAAAAGCACTGCATCCTATGATAGCTAGATTTAATGCTAGTAT
TAGCTTTGATATTGAATTGATTGAGCATGATATAAATGGCTCAGTAGCTCATACAAAAATGTTAGCTAAAACAGGTATTA
TCTCCGCTGAAGAAGGAGAAAAATTATTGACAGGTTTAGAACAAATTCGTCAAGAATATATAACCGGAAATTTTCATATA
GTTGAAGATGCTGAAGACGTTCACTTTGCTGTCGAAAAAAGACTGATAGAAATCACTGGAGATGTAGGCAAAAAACTACA
TACAGCTAGGTCTAGAAATGACCAAGTAGGAACTGATACTAGGCTTTATTTACGAGAAAAAATTGAACAAATTCGGTTTT
TATTGATCAAATTTCAAAAAGTTATATTAGAATTAGCTGAGTCTAATATTGAAACTTTAATCCCTGGTTATACTCACTTA
CAAAGAGCGCAACCTTTGAGTTTAGCTCATCATCTTTTGGCTTATTTTCATAAGGCGGAAAGAGATTGGGAAAGGCTAGG
AGATGTTTATCGTCGAGTTAATATTTCTCCCCTTGGTTGTGGTGCTTTAGCTGGTACAACTTTTCCTATTGATAGACACT
ATACTGCTGAGTTATTAGGGTTTGAAAAACCTTATGCTAATAGTTTAGATGGCGTAAGTGACAGAGATTTTGCTATTGAA
TTTCTTTGCGCAGCTAGTATAATTATGGTGCATTTAAGTCGTTTGGCTGAAGAAATAATTGTGTGGTCATCTGAAGAATT
TAGGTTTGTAACTTTAACTGATGTTTGTTCCACAGGCTCGAGTATTATGCCTCAAAAAAAGAATCCTGATGTACCAGAGT
TAGTTAGGGGAAAAACAGGTCGAGTATTTGGTCATTTACAAAGTATGTTAGTGGTGATGAAGGGTCTGCCACTAGCATAT
AATAAAGACTTGCAAGAAGATAAAGAAGGTTTGTTTGATAGTATTAAAACTGTTAAAAGTTGTCTGGAGGCAATGACAAT
TTTATTGGAGGAAGGTTTGGAATTTAACAGTGATCGCCTAACAGAAGCAGTAGCAGAAGATTTTTCTAATGCTACAGATG
TGGCAGATTATTTAGCAGCTCGTGGTGTACCATTTCGAGAAGCTTATAATTTAGTAGGTAAGGTTGTGAAAACTTGTATT
TCTGGTGGTAAATTACTGAAAGATTTAACTATAAAAGAATGGAAGGAATTACATCCTGTTTTTGCAAGTGACATTTATGA
AGCGATAACCCCTTACCAAGTAGTGTCTGCACGCAATAGCTATGGTGGAACTGGTTTTAAACAAGTAAAAACAGAAATTG
ACGTTGCCAAGCAAAAATTGGCAGAAAAATAA

Upstream 100 bases:

>100_bases
AATATTTAGTTGTTCTGATAATTGGTTAGATAGTTAAAAGTATTTAACCATAATTACTCGCTATTAATAATTTTATTAAA
TAGGAAAAAAAATCAGTAAA

Downstream 100 bases:

>100_bases
ATAAATTTGGCTTCAAGCCTCACCCATAAGTGGGCTACCTTTGAGTTGTTTTTTTTGAATAAATACGGATATTATTATTG
ATACTATGAGTGCTAACAAT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MKQDRQTWSQRFEKALHPMIARFNASISFDIELIEHDINGSVAHTKMLAKTGIISAEEGEKLLTGLEQIRQEYITGNFHI
VEDAEDVHFAVEKRLIEITGDVGKKLHTARSRNDQVGTDTRLYLREKIEQIRFLLIKFQKVILELAESNIETLIPGYTHL
QRAQPLSLAHHLLAYFHKAERDWERLGDVYRRVNISPLGCGALAGTTFPIDRHYTAELLGFEKPYANSLDGVSDRDFAIE
FLCAASIIMVHLSRLAEEIIVWSSEEFRFVTLTDVCSTGSSIMPQKKNPDVPELVRGKTGRVFGHLQSMLVVMKGLPLAY
NKDLQEDKEGLFDSIKTVKSCLEAMTILLEEGLEFNSDRLTEAVAEDFSNATDVADYLAARGVPFREAYNLVGKVVKTCI
SGGKLLKDLTIKEWKELHPVFASDIYEAITPYQVVSARNSYGGTGFKQVKTEIDVAKQKLAEK

Sequences:

>Translated_463_residues
MKQDRQTWSQRFEKALHPMIARFNASISFDIELIEHDINGSVAHTKMLAKTGIISAEEGEKLLTGLEQIRQEYITGNFHI
VEDAEDVHFAVEKRLIEITGDVGKKLHTARSRNDQVGTDTRLYLREKIEQIRFLLIKFQKVILELAESNIETLIPGYTHL
QRAQPLSLAHHLLAYFHKAERDWERLGDVYRRVNISPLGCGALAGTTFPIDRHYTAELLGFEKPYANSLDGVSDRDFAIE
FLCAASIIMVHLSRLAEEIIVWSSEEFRFVTLTDVCSTGSSIMPQKKNPDVPELVRGKTGRVFGHLQSMLVVMKGLPLAY
NKDLQEDKEGLFDSIKTVKSCLEAMTILLEEGLEFNSDRLTEAVAEDFSNATDVADYLAARGVPFREAYNLVGKVVKTCI
SGGKLLKDLTIKEWKELHPVFASDIYEAITPYQVVSARNSYGGTGFKQVKTEIDVAKQKLAEK
>Mature_463_residues
MKQDRQTWSQRFEKALHPMIARFNASISFDIELIEHDINGSVAHTKMLAKTGIISAEEGEKLLTGLEQIRQEYITGNFHI
VEDAEDVHFAVEKRLIEITGDVGKKLHTARSRNDQVGTDTRLYLREKIEQIRFLLIKFQKVILELAESNIETLIPGYTHL
QRAQPLSLAHHLLAYFHKAERDWERLGDVYRRVNISPLGCGALAGTTFPIDRHYTAELLGFEKPYANSLDGVSDRDFAIE
FLCAASIIMVHLSRLAEEIIVWSSEEFRFVTLTDVCSTGSSIMPQKKNPDVPELVRGKTGRVFGHLQSMLVVMKGLPLAY
NKDLQEDKEGLFDSIKTVKSCLEAMTILLEEGLEFNSDRLTEAVAEDFSNATDVADYLAARGVPFREAYNLVGKVVKTCI
SGGKLLKDLTIKEWKELHPVFASDIYEAITPYQVVSARNSYGGTGFKQVKTEIDVAKQKLAEK

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=446, Percent_Identity=41.7040358744395, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI68303542, Length=446, Percent_Identity=41.7040358744395, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI68303549, Length=446, Percent_Identity=39.237668161435, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI68303547, Length=446, Percent_Identity=39.237668161435, Blast_Score=331, Evalue=1e-90,
Organism=Escherichia coli, GI1790398, Length=455, Percent_Identity=46.3736263736264, Blast_Score=414, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6321806, Length=462, Percent_Identity=41.1255411255411, Blast_Score=355, Evalue=6e-99,
Organism=Drosophila melanogaster, GI221473854, Length=453, Percent_Identity=38.8520971302428, Blast_Score=336, Evalue=2e-92,
Organism=Drosophila melanogaster, GI78706858, Length=453, Percent_Identity=38.8520971302428, Blast_Score=336, Evalue=2e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 52195; Mature: 52195

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00163 FUMARATE_LYASES ; PS00636 DNAJ_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQDRQTWSQRFEKALHPMIARFNASISFDIELIEHDINGSVAHTKMLAKTGIISAEEGE
CCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHHHHHHHHCCCCCCCHH
KLLTGLEQIRQEYITGNFHIVEDAEDVHFAVEKRLIEITGDVGKKLHTARSRNDQVGTDT
HHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
RLYLREKIEQIRFLLIKFQKVILELAESNIETLIPGYTHLQRAQPLSLAHHLLAYFHKAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHH
RDWERLGDVYRRVNISPLGCGALAGTTFPIDRHYTAELLGFEKPYANSLDGVSDRDFAIE
HHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHH
FLCAASIIMVHLSRLAEEIIVWSSEEFRFVTLTDVCSTGSSIMPQKKNPDVPELVRGKTG
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHCCCCCCCCCCCCCCCHHHHCCCCC
RVFGHLQSMLVVMKGLPLAYNKDLQEDKEGLFDSIKTVKSCLEAMTILLEEGLEFNSDRL
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
TEAVAEDFSNATDVADYLAARGVPFREAYNLVGKVVKTCISGGKLLKDLTIKEWKELHPV
HHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
FASDIYEAITPYQVVSARNSYGGTGFKQVKTEIDVAKQKLAEK
HHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKQDRQTWSQRFEKALHPMIARFNASISFDIELIEHDINGSVAHTKMLAKTGIISAEEGE
CCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHHHHHHHHCCCCCCCHH
KLLTGLEQIRQEYITGNFHIVEDAEDVHFAVEKRLIEITGDVGKKLHTARSRNDQVGTDT
HHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
RLYLREKIEQIRFLLIKFQKVILELAESNIETLIPGYTHLQRAQPLSLAHHLLAYFHKAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHH
RDWERLGDVYRRVNISPLGCGALAGTTFPIDRHYTAELLGFEKPYANSLDGVSDRDFAIE
HHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHH
FLCAASIIMVHLSRLAEEIIVWSSEEFRFVTLTDVCSTGSSIMPQKKNPDVPELVRGKTG
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHCCCCCCCCCCCCCCCHHHHCCCCC
RVFGHLQSMLVVMKGLPLAYNKDLQEDKEGLFDSIKTVKSCLEAMTILLEEGLEFNSDRL
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
TEAVAEDFSNATDVADYLAARGVPFREAYNLVGKVVKTCISGGKLLKDLTIKEWKELHPV
HHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
FASDIYEAITPYQVVSARNSYGGTGFKQVKTEIDVAKQKLAEK
HHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA