Click here to switch to the map view.

The map label for this gene is folP [C]

Identifier: 113474544

GI number: 113474544

Start: 1131311

End: 1132216

Strand: Direct

Name: folP [C]

Synonym: Tery_0697

Alternate gene names: 113474544

Gene position: 1131311-1132216 (Clockwise)

Preceding gene: 113474543

Following gene: 113474545

Centisome position: 14.6

GC content: 33.44

Gene sequence:

>906_bases
ATGCTTACTCTCGCAGAAATCTACGAAATTTATGACAAATATAAAGATGACTACAATACCCAAATAGAAGAGTTCAGTAT
TGGGAATAAAAAATTTAATTTTAATTCTCAAACATCTATTTTAGGAATCATTAATCTTTCTCAAGATTCTTGGTATAAGC
AAACTATTTCTTACACTCCAGAACAAGCAATTCGCCGTGGAAAAGTATTAACACTTCAAGGTGCGGATATTATAGATATT
GGCACTGAGTCTACTGTGAAAACTGCAGCTAGGGTAGACGAGTTGAAACAAACAAGTCAACTTTTGCCTATTCTGAAAAC
TTTCAGTCAAGAAGGTGTGTTAACTTCAGTGGAAACTTATTATCCAGAAGTTGCCAGAGAATGCTTAAAAGCAGGTGCAA
ATGTCATCAACTTTCTGGGAACTGAGCATAGTGAAGAAATGTATCAAGCTGTAGCTGACTTTGATGCAGCAATTATTATT
TGTTATGTAGAAGGAAAACACGCTAGAGATGTAGGGGAATTTGACTTTACTTCAGGTAGAGATATGATAGATGTACTATA
CAATTATTTTGAAAAAGAGATAGAAATAGCAACGAAAATAGGAGTGAAAAAGATTTTTATTGATCCAGCAGTAGGTGTAG
GATACACAAATTTTTACTACCAACACAAAAATGTATCAAATAGAATGAGATATCAAATTGAAACTCTTTTAAATGCTTTT
CGGCTTAGAAAATTAGGCTTTCCTGTTTTTAATCAAATACCTACAGCTTTAGAAATTTTTGGAGAAGAGTTTAGAAGTGC
TCAAGTGTTCACGGCAGTGTTTGCAGCACTAGGAAAAAATGATATGATTAGAACTCATGAAGTTGCTAAAGTTAAAGCTC
TTTTAGAAACTCTGAGTTGCTTGTGA

Upstream 100 bases:

>100_bases
GGGGTTACAGGTTGTAGCAATACTTAGCTATTTTCCTTGACAAAGATTGGGAATTTTAGCCGACTGAAAATTGTTATTGA
TTAAATAAAGGAGTTCAAAA

Downstream 100 bases:

>100_bases
TAGTTTAGATAGAACTTAATATTCAAGACAATGCTAAAAAAAGCACTTGTGACAGGTTCAGGAGTGGGAATAGGTAGGGC
GATCGCTCTTGACTTAGCTG

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MLTLAEIYEIYDKYKDDYNTQIEEFSIGNKKFNFNSQTSILGIINLSQDSWYKQTISYTPEQAIRRGKVLTLQGADIIDI
GTESTVKTAARVDELKQTSQLLPILKTFSQEGVLTSVETYYPEVARECLKAGANVINFLGTEHSEEMYQAVADFDAAIII
CYVEGKHARDVGEFDFTSGRDMIDVLYNYFEKEIEIATKIGVKKIFIDPAVGVGYTNFYYQHKNVSNRMRYQIETLLNAF
RLRKLGFPVFNQIPTALEIFGEEFRSAQVFTAVFAALGKNDMIRTHEVAKVKALLETLSCL

Sequences:

>Translated_301_residues
MLTLAEIYEIYDKYKDDYNTQIEEFSIGNKKFNFNSQTSILGIINLSQDSWYKQTISYTPEQAIRRGKVLTLQGADIIDI
GTESTVKTAARVDELKQTSQLLPILKTFSQEGVLTSVETYYPEVARECLKAGANVINFLGTEHSEEMYQAVADFDAAIII
CYVEGKHARDVGEFDFTSGRDMIDVLYNYFEKEIEIATKIGVKKIFIDPAVGVGYTNFYYQHKNVSNRMRYQIETLLNAF
RLRKLGFPVFNQIPTALEIFGEEFRSAQVFTAVFAALGKNDMIRTHEVAKVKALLETLSCL
>Mature_301_residues
MLTLAEIYEIYDKYKDDYNTQIEEFSIGNKKFNFNSQTSILGIINLSQDSWYKQTISYTPEQAIRRGKVLTLQGADIIDI
GTESTVKTAARVDELKQTSQLLPILKTFSQEGVLTSVETYYPEVARECLKAGANVINFLGTEHSEEMYQAVADFDAAIII
CYVEGKHARDVGEFDFTSGRDMIDVLYNYFEKEIEIATKIGVKKIFIDPAVGVGYTNFYYQHKNVSNRMRYQIETLLNAF
RLRKLGFPVFNQIPTALEIFGEEFRSAQVFTAVFAALGKNDMIRTHEVAKVKALLETLSCL

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=262, Percent_Identity=26.7175572519084, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 34233; Mature: 34233

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS50972 PTERIN_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTLAEIYEIYDKYKDDYNTQIEEFSIGNKKFNFNSQTSILGIINLSQDSWYKQTISYTP
CCHHHHHHHHHHHHCCCCCCCHHHEECCCEEECCCCCCEEEEEEECCCCHHHHHHHCCCH
EQAIRRGKVLTLQGADIIDIGTESTVKTAARVDELKQTSQLLPILKTFSQEGVLTSVETY
HHHHHCCCEEEECCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
YPEVARECLKAGANVINFLGTEHSEEMYQAVADFDAAIIICYVEGKHARDVGEFDFTSGR
HHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCC
DMIDVLYNYFEKEIEIATKIGVKKIFIDPAVGVGYTNFYYQHKNVSNRMRYQIETLLNAF
HHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHEEECCCHHHHHHHHHHHHHHHH
RLRKLGFPVFNQIPTALEIFGEEFRSAQVFTAVFAALGKNDMIRTHEVAKVKALLETLSC
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHC
L
C
>Mature Secondary Structure
MLTLAEIYEIYDKYKDDYNTQIEEFSIGNKKFNFNSQTSILGIINLSQDSWYKQTISYTP
CCHHHHHHHHHHHHCCCCCCCHHHEECCCEEECCCCCCEEEEEEECCCCHHHHHHHCCCH
EQAIRRGKVLTLQGADIIDIGTESTVKTAARVDELKQTSQLLPILKTFSQEGVLTSVETY
HHHHHCCCEEEECCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
YPEVARECLKAGANVINFLGTEHSEEMYQAVADFDAAIIICYVEGKHARDVGEFDFTSGR
HHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCC
DMIDVLYNYFEKEIEIATKIGVKKIFIDPAVGVGYTNFYYQHKNVSNRMRYQIETLLNAF
HHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHEEECCCHHHHHHHHHHHHHHHH
RLRKLGFPVFNQIPTALEIFGEEFRSAQVFTAVFAALGKNDMIRTHEVAKVKALLETLSC
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHC
L
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8396545 [H]