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The map label for this gene is apt

Identifier: 113474306

GI number: 113474306

Start: 685183

End: 685695

Strand: Reverse

Name: apt

Synonym: Tery_0435

Alternate gene names: 113474306

Gene position: 685695-685183 (Counterclockwise)

Preceding gene: 113474308

Following gene: 113474305

Centisome position: 8.85

GC content: 36.45

Gene sequence:

>513_bases
ATGGAACTAAAAAATTTAATCCGCGAAATCCCAAATTTCCCTAAATCTGGAATTATATTCCGAGATATTACTACTCTTTT
AAGCAATACAGATGGTCTACATTACACTATTGACATTTTGACAGAAAAATGCTTAGAATTTAAACCAGACTATGTAGTAG
GCATCGAATCCAGAGGGTTTATTTTTGGTATGCCTTTAGCTTATCAGTTGAATGTAGGCTTTATTCCAGTTCGCAAACCC
GGAAAGCTACCCGCAGAAGTTTACTCAGTTTCTTATGATTTAGAGTATGGCCAAGACAGTCTAGAGGTACACCAAGATGC
AATGCCAGCAGGTAGTAGAGTTTTAGTAATTGACGATCTGCTGGCAACGGGTGGAACTGCAGGAGCTACAACTCAATTAA
TTGAAAAAGCAAAGTGTAATTTAGTGGGTTTTGCTTTTGTTATTGAGTTAAAGGAATTAGGTGGCCGTGAAAAATTACCA
AAAGTGCCAATTATTAGTTTAATTGAATACTAG

Upstream 100 bases:

>100_bases
GATTTTAATAAGTATTTAGTATCTGAATAGTATTAAGCAACTACAATTGGTTGCTACAAATCTAATATATTTTCAATTTT
GACTTTTGACTTGAACAACA

Downstream 100 bases:

>100_bases
ACATTTTAGTAAGCAGTAAATTTTGCAATAGGGAGGGTTGACCCTCACTTTATCCTTGGTATGAATGGATATTCCTATCA
ATTATCAATCTTTGGTAGAA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MELKNLIREIPNFPKSGIIFRDITTLLSNTDGLHYTIDILTEKCLEFKPDYVVGIESRGFIFGMPLAYQLNVGFIPVRKP
GKLPAEVYSVSYDLEYGQDSLEVHQDAMPAGSRVLVIDDLLATGGTAGATTQLIEKAKCNLVGFAFVIELKELGGREKLP
KVPIISLIEY

Sequences:

>Translated_170_residues
MELKNLIREIPNFPKSGIIFRDITTLLSNTDGLHYTIDILTEKCLEFKPDYVVGIESRGFIFGMPLAYQLNVGFIPVRKP
GKLPAEVYSVSYDLEYGQDSLEVHQDAMPAGSRVLVIDDLLATGGTAGATTQLIEKAKCNLVGFAFVIELKELGGREKLP
KVPIISLIEY
>Mature_170_residues
MELKNLIREIPNFPKSGIIFRDITTLLSNTDGLHYTIDILTEKCLEFKPDYVVGIESRGFIFGMPLAYQLNVGFIPVRKP
GKLPAEVYSVSYDLEYGQDSLEVHQDAMPAGSRVLVIDDLLATGGTAGATTQLIEKAKCNLVGFAFVIELKELGGREKLP
KVPIISLIEY

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=171, Percent_Identity=40.9356725146199, Blast_Score=140, Evalue=7e-34,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=42.4, Blast_Score=108, Evalue=3e-24,
Organism=Escherichia coli, GI1786675, Length=164, Percent_Identity=51.8292682926829, Blast_Score=166, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17509087, Length=172, Percent_Identity=45.3488372093023, Blast_Score=133, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6323619, Length=171, Percent_Identity=46.1988304093567, Blast_Score=140, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6320649, Length=172, Percent_Identity=37.7906976744186, Blast_Score=99, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17136334, Length=170, Percent_Identity=44.7058823529412, Blast_Score=132, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_TRIEI (Q119D0)

Other databases:

- EMBL:   CP000393
- RefSeq:   YP_720367.1
- ProteinModelPortal:   Q119D0
- SMR:   Q119D0
- STRING:   Q119D0
- GeneID:   4242213
- GenomeReviews:   CP000393_GR
- KEGG:   ter:Tery_0435
- NMPDR:   fig|203124.1.peg.1797
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- PhylomeDB:   Q119D0
- ProtClustDB:   PRK02304
- BioCyc:   TERY203124:TERY_0435-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 18806; Mature: 18806

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELKNLIREIPNFPKSGIIFRDITTLLSNTDGLHYTIDILTEKCLEFKPDYVVGIESRGF
CCHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCCEEEEECCCCE
IFGMPLAYQLNVGFIPVRKPGKLPAEVYSVSYDLEYGQDSLEVHQDAMPAGSRVLVIDDL
EEECCEEEEECCCEEECCCCCCCCHHHEEEEEECCCCCCHHHHHHHCCCCCCEEEEEECH
LATGGTAGATTQLIEKAKCNLVGFAFVIELKELGGREKLPKVPIISLIEY
HHCCCCCCHHHHHHHHHCCCEEEHHHEEEHHHCCCCCCCCCCCHHHEECC
>Mature Secondary Structure
MELKNLIREIPNFPKSGIIFRDITTLLSNTDGLHYTIDILTEKCLEFKPDYVVGIESRGF
CCHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCCEEEEECCCCE
IFGMPLAYQLNVGFIPVRKPGKLPAEVYSVSYDLEYGQDSLEVHQDAMPAGSRVLVIDDL
EEECCEEEEECCCEEECCCCCCCCHHHEEEEEECCCCCCHHHHHHHCCCCCCEEEEEECH
LATGGTAGATTQLIEKAKCNLVGFAFVIELKELGGREKLPKVPIISLIEY
HHCCCCCCHHHHHHHHHCCCEEEHHHEEEHHHCCCCCCCCCCCHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA