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The map label for this gene is lysC [H]

Identifier: 113474005

GI number: 113474005

Start: 119376

End: 121190

Strand: Direct

Name: lysC [H]

Synonym: Tery_0087

Alternate gene names: 113474005

Gene position: 119376-121190 (Clockwise)

Preceding gene: 113474004

Following gene: 113474007

Centisome position: 1.54

GC content: 43.86

Gene sequence:

>1815_bases
ATGCTAATAGTCCAAAAATACGGTGGCACATCAGTAGGGTCTGTGGAAAGGATTAAAGCCGTGGCCCAACGTATTGCTAA
AACAGCTAGCGATCGCTCAGTAGTAGTAGTCGTATCAGCGATGGGAAAAACCACAGATACCCTAGTCAAACTAGCAAACG
ACATCTCCCCCAACCCCTGTCGCCGAGAAATGGATATGTTACTATCTACAGGAGAACAAGTTACTATCGCTCTAGTGAGT
ATGGCCTTACAAGAGTTGGGAGTACCAGCTATTTCCCTCACTGGAGCCCAGGTAGGAATAGTCACAGAAGCTCAACATTC
CCGGGCTCGTATTTTACATATTCAAACCGAACGGATAGAAGAACATCTGCAACTGGGAGAGGTTGTAGTTGTTGCAGGTT
TCCAAGGTATTAGTCAGACTCGCCATCAGGAAATCACAACATTAGGTAGAGGTGGTTCAGATACTTCCGCAGTTGCTTTA
GCTGCAGCACTCCAAGCACAAAGGTGTGAAATATATACAGACGTACCCGGAATTTTAACAACTGATCCCCGCATAGTACC
TGAAGCACAGTTAATGTCAGAAATTACCTGTGATGAAATGTTGGAGTTGGCAAGCTTAGGAGCAAAAGTGCTACATCCTA
GGGCTGTTGAAATTGCTCGAAATTATGGAATGCCATTAGTAGTCTTATCAAGTTGGAGCGATGCACCAGGTACCCGTGTA
GTTTCAGCAATACCCAAACGTCCTGCCTTGCAAGATTTAGAATTAACTAAACCTGTAGACGCCGTAGAATATGATACTAA
CCAAGCTGGAATTTCTATGCTGCGCCTTCCGGATCGCCCTGGTGTGGCAGCCCAATTATTTTCTGGTATTGCTCTACAAA
ATATAGATGTAGATTTGATTATTCAATCTATTCACGAAAGCAATACTAATGATATTGCGTTTACCGTCAGTAAAGATGTA
TTGAAACAAGCAGCAGCAGTTGCAGATGCTATGCTGCCGGCTTTAGGAAAAAATGCTCACCCCAGTTTGGGGGAACCAGA
AGTTAAAACAGAAGAGCGACCTATTGCCAAAGTTAGTCTTGTGGGTGCGGGAATGATCGGGCGACCAGAAGTAGCAGCCA
AAATGTTTGAAGCTCTGGCAGCAGCAGGAGTCAATATAATAATGATTTCCACTTCGGAGGTTAAGGTCAGTTGTGTAGTA
GATGCAGAAGACTGTAAAAAAACAGTTAATTCTTTGTGTCAAGCATTTGATGTGGATGTTGCAGATATTTCCAGTAGCTC
TACTGCTGGTGAGTCGGAAGAAGTGCCCCCACCAGTGCGAGGGGTGGCTTTGGATATAAAGCAAGCAAGACTGGCAGTGC
GTCAAGTTCCGGATCATCCAGGAATGGCAGCCAAGATATTTGGTTTGTTGGCGCAGCAGAATATTAGTGTAGATATGATT
ATTCAATCTCAACGCTGCCACAGTGTGGATGGAGTTTTGACTCGTGATATTGCTTTTACTGTATCTCAACCAGAGGGAGA
AACTGCATATCAAATTTTGGCAAATACAGCGGCTGACTTTGGTTGGGGAGAAGTGGTATTGGAGAGTAGTATCGCGAAAG
TGAGTGTAGTTGGCTCCGGAATGATTTCTCATCCAGGGGTAGCAGCACAGATGTTTGAGGCGTTGGCAGCAAGTCAAATC
AATATTTTGATGATTACCACTTCGGAAATTAAAATTAGTTGTGTGGTAGAAGAGGAGGATGGTGTGAAGGCATTGCAAGC
TATTCATAAAGCTTTTTGTTTGTCTGCTAATGAGGTAGTTAAAGTTCCAGCTTAA

Upstream 100 bases:

>100_bases
AGCTAACTTTAGCTCCATAGTTAATCGAGTTAAAAAATTTGAACACAAGAATTTAAAATTAATACAATTTATCTGTTAAA
AATCTAATTCTTAAATCAAT

Downstream 100 bases:

>100_bases
GGGTTCTATAAGGTACAAAAATCATAGTCTAACCTCTGTGGTGCGGCCATCTTACCCGCCACATAGGGACTTTATTTGAG
CAGGGTATTTGTCTAATCTT

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase 2; Aspartokinase II [H]

Number of amino acids: Translated: 604; Mature: 604

Protein sequence:

>604_residues
MLIVQKYGGTSVGSVERIKAVAQRIAKTASDRSVVVVVSAMGKTTDTLVKLANDISPNPCRREMDMLLSTGEQVTIALVS
MALQELGVPAISLTGAQVGIVTEAQHSRARILHIQTERIEEHLQLGEVVVVAGFQGISQTRHQEITTLGRGGSDTSAVAL
AAALQAQRCEIYTDVPGILTTDPRIVPEAQLMSEITCDEMLELASLGAKVLHPRAVEIARNYGMPLVVLSSWSDAPGTRV
VSAIPKRPALQDLELTKPVDAVEYDTNQAGISMLRLPDRPGVAAQLFSGIALQNIDVDLIIQSIHESNTNDIAFTVSKDV
LKQAAAVADAMLPALGKNAHPSLGEPEVKTEERPIAKVSLVGAGMIGRPEVAAKMFEALAAAGVNIIMISTSEVKVSCVV
DAEDCKKTVNSLCQAFDVDVADISSSSTAGESEEVPPPVRGVALDIKQARLAVRQVPDHPGMAAKIFGLLAQQNISVDMI
IQSQRCHSVDGVLTRDIAFTVSQPEGETAYQILANTAADFGWGEVVLESSIAKVSVVGSGMISHPGVAAQMFEALAASQI
NILMITTSEIKISCVVEEEDGVKALQAIHKAFCLSANEVVKVPA

Sequences:

>Translated_604_residues
MLIVQKYGGTSVGSVERIKAVAQRIAKTASDRSVVVVVSAMGKTTDTLVKLANDISPNPCRREMDMLLSTGEQVTIALVS
MALQELGVPAISLTGAQVGIVTEAQHSRARILHIQTERIEEHLQLGEVVVVAGFQGISQTRHQEITTLGRGGSDTSAVAL
AAALQAQRCEIYTDVPGILTTDPRIVPEAQLMSEITCDEMLELASLGAKVLHPRAVEIARNYGMPLVVLSSWSDAPGTRV
VSAIPKRPALQDLELTKPVDAVEYDTNQAGISMLRLPDRPGVAAQLFSGIALQNIDVDLIIQSIHESNTNDIAFTVSKDV
LKQAAAVADAMLPALGKNAHPSLGEPEVKTEERPIAKVSLVGAGMIGRPEVAAKMFEALAAAGVNIIMISTSEVKVSCVV
DAEDCKKTVNSLCQAFDVDVADISSSSTAGESEEVPPPVRGVALDIKQARLAVRQVPDHPGMAAKIFGLLAQQNISVDMI
IQSQRCHSVDGVLTRDIAFTVSQPEGETAYQILANTAADFGWGEVVLESSIAKVSVVGSGMISHPGVAAQMFEALAASQI
NILMITTSEIKISCVVEEEDGVKALQAIHKAFCLSANEVVKVPA
>Mature_604_residues
MLIVQKYGGTSVGSVERIKAVAQRIAKTASDRSVVVVVSAMGKTTDTLVKLANDISPNPCRREMDMLLSTGEQVTIALVS
MALQELGVPAISLTGAQVGIVTEAQHSRARILHIQTERIEEHLQLGEVVVVAGFQGISQTRHQEITTLGRGGSDTSAVAL
AAALQAQRCEIYTDVPGILTTDPRIVPEAQLMSEITCDEMLELASLGAKVLHPRAVEIARNYGMPLVVLSSWSDAPGTRV
VSAIPKRPALQDLELTKPVDAVEYDTNQAGISMLRLPDRPGVAAQLFSGIALQNIDVDLIIQSIHESNTNDIAFTVSKDV
LKQAAAVADAMLPALGKNAHPSLGEPEVKTEERPIAKVSLVGAGMIGRPEVAAKMFEALAAAGVNIIMISTSEVKVSCVV
DAEDCKKTVNSLCQAFDVDVADISSSSTAGESEEVPPPVRGVALDIKQARLAVRQVPDHPGMAAKIFGLLAQQNISVDMI
IQSQRCHSVDGVLTRDIAFTVSQPEGETAYQILANTAADFGWGEVVLESSIAKVSVVGSGMISHPGVAAQMFEALAASQI
NILMITTSEIKISCVVEEEDGVKALQAIHKAFCLSANEVVKVPA

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=300, Percent_Identity=35, Blast_Score=129, Evalue=6e-31,
Organism=Escherichia coli, GI1790455, Length=472, Percent_Identity=28.6016949152542, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1790376, Length=295, Percent_Identity=26.4406779661017, Blast_Score=69, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6320893, Length=374, Percent_Identity=26.2032085561497, Blast_Score=85, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 63887; Mature: 63887

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIVQKYGGTSVGSVERIKAVAQRIAKTASDRSVVVVVSAMGKTTDTLVKLANDISPNPC
CEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCHH
RREMDMLLSTGEQVTIALVSMALQELGVPAISLTGAQVGIVTEAQHSRARILHIQTERIE
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEECCCEEEEEECCCCCCEEEEEEEHHHHH
EHLQLGEVVVVAGFQGISQTRHQEITTLGRGGSDTSAVALAAALQAQRCEIYTDVPGILT
HHHHHCCEEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCEEEECCCCCEE
TDPRIVPEAQLMSEITCDEMLELASLGAKVLHPRAVEIARNYGMPLVVLSSWSDAPGTRV
CCCCCCCHHHHHHHCCHHHHHHHHHCCHHHCCCHHHHHHHHCCCCEEEEECCCCCCCCHH
VSAIPKRPALQDLELTKPVDAVEYDTNQAGISMLRLPDRPGVAAQLFSGIALQNIDVDLI
HHHCCCCCCCCCCCCCCCCCHHCCCCCCCCEEEEECCCCCCHHHHHHCCCEEECCCHHHH
IQSIHESNTNDIAFTVSKDVLKQAAAVADAMLPALGKNAHPSLGEPEVKTEERPIAKVSL
HHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEE
VGAGMIGRPEVAAKMFEALAAAGVNIIMISTSEVKVSCVVDAEDCKKTVNSLCQAFDVDV
ECCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCEEEEEEEEHHHHHHHHHHHHHHHCCCH
ADISSSSTAGESEEVPPPVRGVALDIKQARLAVRQVPDHPGMAAKIFGLLAQQNISVDMI
HHCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEE
IQSQRCHSVDGVLTRDIAFTVSQPEGETAYQILANTAADFGWGEVVLESSIAKVSVVGSG
EECCCCCCCCCEEEEEEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHCCCCEEEEECCC
MISHPGVAAQMFEALAASQINILMITTSEIKISCVVEEEDGVKALQAIHKAFCLSANEVV
CCCCCCHHHHHHHHHHHCCEEEEEEEECCEEEEEEEECCCCHHHHHHHHHHHHCCCCCEE
KVPA
ECCC
>Mature Secondary Structure
MLIVQKYGGTSVGSVERIKAVAQRIAKTASDRSVVVVVSAMGKTTDTLVKLANDISPNPC
CEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCHH
RREMDMLLSTGEQVTIALVSMALQELGVPAISLTGAQVGIVTEAQHSRARILHIQTERIE
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEECCCEEEEEECCCCCCEEEEEEEHHHHH
EHLQLGEVVVVAGFQGISQTRHQEITTLGRGGSDTSAVALAAALQAQRCEIYTDVPGILT
HHHHHCCEEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCEEEECCCCCEE
TDPRIVPEAQLMSEITCDEMLELASLGAKVLHPRAVEIARNYGMPLVVLSSWSDAPGTRV
CCCCCCCHHHHHHHCCHHHHHHHHHCCHHHCCCHHHHHHHHCCCCEEEEECCCCCCCCHH
VSAIPKRPALQDLELTKPVDAVEYDTNQAGISMLRLPDRPGVAAQLFSGIALQNIDVDLI
HHHCCCCCCCCCCCCCCCCCHHCCCCCCCCEEEEECCCCCCHHHHHHCCCEEECCCHHHH
IQSIHESNTNDIAFTVSKDVLKQAAAVADAMLPALGKNAHPSLGEPEVKTEERPIAKVSL
HHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEE
VGAGMIGRPEVAAKMFEALAAAGVNIIMISTSEVKVSCVVDAEDCKKTVNSLCQAFDVDV
ECCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCEEEEEEEEHHHHHHHHHHHHHHHCCCH
ADISSSSTAGESEEVPPPVRGVALDIKQARLAVRQVPDHPGMAAKIFGLLAQQNISVDMI
HHCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEE
IQSQRCHSVDGVLTRDIAFTVSQPEGETAYQILANTAADFGWGEVVLESSIAKVSVVGSG
EECCCCCCCCCEEEEEEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHCCCCEEEEECCC
MISHPGVAAQMFEALAASQINILMITTSEIKISCVVEEEDGVKALQAIHKAFCLSANEVV
CCCCCCHHHHHHHHHHHCCEEEEEEEECCEEEEEEEECCCCHHHHHHHHHHHHCCCCCEE
KVPA
ECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1444390 [H]