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The map label for this gene is uvrD [H]

Identifier: 110835551

GI number: 110835551

Start: 3036477

End: 3038639

Strand: Reverse

Name: uvrD [H]

Synonym: ABO_2690

Alternate gene names: 110835551

Gene position: 3038639-3036477 (Counterclockwise)

Preceding gene: 110835553

Following gene: 110835550

Centisome position: 97.39

GC content: 58.44

Gene sequence:

>2163_bases
ATGGATGACGTGACTTCCCTTATTGATGGTTTGAACCCGGCCCAGCGCGATGCGGTGGCTGCCGATGATCAACACTTGCT
GGTGCTGGCGGGGGCCGGTTCCGGCAAAACCCGCGTGTTGGTACACCGTATCGCCTGGCAGATTGCCACCGAACAGGCTT
CGCCGTTCGGTATTTTGGCGGTGACCTTTACTAACAAAGCCGCTGCGGAAATGCGCGGGCGTATTGAGCAGCTGCTGGAC
ATGTCTGCCGATGGCATGTGGGTGGGCACTTTTCATGGTATTGCCCATCGCCTGCTGCGCGCCCACTGGCAGGAGGCCGG
TCTCCCCCAAGGCTTCCAGATCATTGATGCGGATGACCAAATCCGGCTGATCAAGCGAGTCAGCAAGGAATTGGGCCTGG
ATGAACAACGCTGGCCAGCCCGTCAGGCCACCTGGTTTATTAATAGTCAGAAAGACGAAGGACTCCGCGCTCGGCATATG
GATACCGGCGGCGACCTGTTCGCGTTGACCATGCAGAAGATCTACTTCGCCTATGAAGAGGCCTGCGAGCGGGGCGGGTT
GGTAGATTTCAACGAAATGCTGCTACGGGTACTGGAGCTGTTCCGCGACAACGACAACCTGCGCGGCCACTACCAGCGTC
GCTTCCGGCACATTTTGGTAGACGAGTTCCAAGATACCAACAGCATCCAGTACGCCTGGTTGCGGTTGCTGGCGGACGAA
AATAATGCGGTCACCATTGTCGGTGACGATGATCAGTCCATTTATGGCTGGCGTGGCGCCAAGATCGAGAACATCCACAA
ATTCAGCCGCGACTTCCCGGATACCCGTACCATTCGCTTGGAGCAGAATTACCGTTCCACCGGCACTATTCTGAAAGCGG
CCAACGCGGTGATCGGCCATAACAGTGACCGCCTAGGCAAGGAACTGTGGACCGAGGGCGGCGATGGCGATTTGATCCGC
CTCTATTCCGGTTTCAATGAAGTGGATGAAGCGCGCTTTATTGCCGGGCGCATGGATAAGCTATTTCAGGAAGGCACCGC
GCGGCGGGAAATGGCGGTGCTGTACCGCTCCAACGCCCAGTCGCGGGTGCTGGAAGAGGCTTTTCTGCAGGCGGGGATTC
CCTACCGTATCTATGGCGGGCAACGCTTCTTCGAGCGGGTGGAAATCAAAAATGCACTGGCCTATCTGCGCCTACTCAGC
CACCGCCATGCGGATGCCGCCTTCGAGCGAGTGGTGAACACACCCACCCGCGGCATTGGCAACAAGACCCTAGAAACCCT
GCGTGAGGTGGCGCGGCAGCGTAACGTGTCCCTGTGGGACGCTGCCCAGGCAGTCGTTAGTGAGCAGTTGCTTACCGCTC
GAGCCATTAATGCGTTGGCGGTGTTCCTGAATCTAATCGCCCAGCTGGAGCAGCAGTGCGATGGGTTGTCGTTGGCGGAA
ACTACCGAGCATGTGATTGAAGCCAGTGGGTTGCTGGAATTTCATGGCAAGGAAAAGGGCGAGAAGGGCCAGCAGCGGCT
GGAAAACCTGCGCGAACTGCTTTCTGCCACCCGGGAATTCGGTGATGAGGATGAGGACTCCGAGCTCGATAGCCTCACCG
CATTTCTGGATCACGCGGCGCTGGAATCCGGGGAGGGCCAGGCTGACGCCCACGAGGACGCGGTGCAGATGATGACCCTG
CACTCGGCCAAGGGGCTGGAATTTCCGGTGGTCTTTATTACCGGCATGGAAGAAGGCTTGTTCCCCCACAAGATGTCCAG
CGAAGAGCCGGGCCGGTTGGCGGAAGAGCGCCGCCTTTGCTACGTGGGCCTGACACGGGCCATGCGCGAGCTGTATCTGA
CCCACGCGGAAAGCCGCCGGTTGTACGGTAACGAAAATTACAATCCACCCAGCCGTTTTCTGCGAGAGATTCCCGCCGAA
ACGCTGGAGGAAGTTCGCGCCCGTGCAGGGTTCAGCCGGCCCATGGGCGGTGCGGCTAAACCCATTCGTGAAACCGAGTC
TAACGGCATCAGCCTGGGTGCTCGGGTGTTACACCCGAAATTCGGGGAAGGTACGATTTTGCAATTTGAAGGGCAGGGGC
CTAATGCGCGCCTACAAATCAATTTCGATGGCGCGGGCACCAAATGGCTGGTTAGCCAATACGCTCGGCTGGAAGTGATA
TAG

Upstream 100 bases:

>100_bases
CCGACTTTCTTGGGAGAGAGGAGGGAAGTATCGGGACAGGGGGAAATTGCCCTCTCCGGCGGGCATCACCGGCAAGGACA
TTCTGCTAAACTTTCGCGCC

Downstream 100 bases:

>100_bases
GGCTGGCGGCTCGCTTGATTCTCGCCCCCCTGATGCCTGACGCTGAAACGAAAGACGGTCTGGCATTGGCATGTAGTGTC
AGGCTGCAAAAATAAACCGA

Product: DNA helicase II

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 720; Mature: 720

Protein sequence:

>720_residues
MDDVTSLIDGLNPAQRDAVAADDQHLLVLAGAGSGKTRVLVHRIAWQIATEQASPFGILAVTFTNKAAAEMRGRIEQLLD
MSADGMWVGTFHGIAHRLLRAHWQEAGLPQGFQIIDADDQIRLIKRVSKELGLDEQRWPARQATWFINSQKDEGLRARHM
DTGGDLFALTMQKIYFAYEEACERGGLVDFNEMLLRVLELFRDNDNLRGHYQRRFRHILVDEFQDTNSIQYAWLRLLADE
NNAVTIVGDDDQSIYGWRGAKIENIHKFSRDFPDTRTIRLEQNYRSTGTILKAANAVIGHNSDRLGKELWTEGGDGDLIR
LYSGFNEVDEARFIAGRMDKLFQEGTARREMAVLYRSNAQSRVLEEAFLQAGIPYRIYGGQRFFERVEIKNALAYLRLLS
HRHADAAFERVVNTPTRGIGNKTLETLREVARQRNVSLWDAAQAVVSEQLLTARAINALAVFLNLIAQLEQQCDGLSLAE
TTEHVIEASGLLEFHGKEKGEKGQQRLENLRELLSATREFGDEDEDSELDSLTAFLDHAALESGEGQADAHEDAVQMMTL
HSAKGLEFPVVFITGMEEGLFPHKMSSEEPGRLAEERRLCYVGLTRAMRELYLTHAESRRLYGNENYNPPSRFLREIPAE
TLEEVRARAGFSRPMGGAAKPIRETESNGISLGARVLHPKFGEGTILQFEGQGPNARLQINFDGAGTKWLVSQYARLEVI

Sequences:

>Translated_720_residues
MDDVTSLIDGLNPAQRDAVAADDQHLLVLAGAGSGKTRVLVHRIAWQIATEQASPFGILAVTFTNKAAAEMRGRIEQLLD
MSADGMWVGTFHGIAHRLLRAHWQEAGLPQGFQIIDADDQIRLIKRVSKELGLDEQRWPARQATWFINSQKDEGLRARHM
DTGGDLFALTMQKIYFAYEEACERGGLVDFNEMLLRVLELFRDNDNLRGHYQRRFRHILVDEFQDTNSIQYAWLRLLADE
NNAVTIVGDDDQSIYGWRGAKIENIHKFSRDFPDTRTIRLEQNYRSTGTILKAANAVIGHNSDRLGKELWTEGGDGDLIR
LYSGFNEVDEARFIAGRMDKLFQEGTARREMAVLYRSNAQSRVLEEAFLQAGIPYRIYGGQRFFERVEIKNALAYLRLLS
HRHADAAFERVVNTPTRGIGNKTLETLREVARQRNVSLWDAAQAVVSEQLLTARAINALAVFLNLIAQLEQQCDGLSLAE
TTEHVIEASGLLEFHGKEKGEKGQQRLENLRELLSATREFGDEDEDSELDSLTAFLDHAALESGEGQADAHEDAVQMMTL
HSAKGLEFPVVFITGMEEGLFPHKMSSEEPGRLAEERRLCYVGLTRAMRELYLTHAESRRLYGNENYNPPSRFLREIPAE
TLEEVRARAGFSRPMGGAAKPIRETESNGISLGARVLHPKFGEGTILQFEGQGPNARLQINFDGAGTKWLVSQYARLEVI
>Mature_720_residues
MDDVTSLIDGLNPAQRDAVAADDQHLLVLAGAGSGKTRVLVHRIAWQIATEQASPFGILAVTFTNKAAAEMRGRIEQLLD
MSADGMWVGTFHGIAHRLLRAHWQEAGLPQGFQIIDADDQIRLIKRVSKELGLDEQRWPARQATWFINSQKDEGLRARHM
DTGGDLFALTMQKIYFAYEEACERGGLVDFNEMLLRVLELFRDNDNLRGHYQRRFRHILVDEFQDTNSIQYAWLRLLADE
NNAVTIVGDDDQSIYGWRGAKIENIHKFSRDFPDTRTIRLEQNYRSTGTILKAANAVIGHNSDRLGKELWTEGGDGDLIR
LYSGFNEVDEARFIAGRMDKLFQEGTARREMAVLYRSNAQSRVLEEAFLQAGIPYRIYGGQRFFERVEIKNALAYLRLLS
HRHADAAFERVVNTPTRGIGNKTLETLREVARQRNVSLWDAAQAVVSEQLLTARAINALAVFLNLIAQLEQQCDGLSLAE
TTEHVIEASGLLEFHGKEKGEKGQQRLENLRELLSATREFGDEDEDSELDSLTAFLDHAALESGEGQADAHEDAVQMMTL
HSAKGLEFPVVFITGMEEGLFPHKMSSEEPGRLAEERRLCYVGLTRAMRELYLTHAESRRLYGNENYNPPSRFLREIPAE
TLEEVRARAGFSRPMGGAAKPIRETESNGISLGARVLHPKFGEGTILQFEGQGPNARLQINFDGAGTKWLVSQYARLEVI

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=720, Percent_Identity=61.3888888888889, Blast_Score=896, Evalue=0.0,
Organism=Escherichia coli, GI48994965, Length=642, Percent_Identity=38.6292834890966, Blast_Score=396, Evalue=1e-111,
Organism=Escherichia coli, GI1787196, Length=387, Percent_Identity=29.9741602067183, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6322369, Length=738, Percent_Identity=27.5067750677507, Blast_Score=187, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6324477, Length=696, Percent_Identity=22.2701149425287, Blast_Score=117, Evalue=6e-27,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 81112; Mature: 81112

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDVTSLIDGLNPAQRDAVAADDQHLLVLAGAGSGKTRVLVHRIAWQIATEQASPFGILA
CCCHHHHHHCCCHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEE
VTFTNKAAAEMRGRIEQLLDMSADGMWVGTFHGIAHRLLRAHWQEAGLPQGFQIIDADDQ
EEECCHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCEEECCCHH
IRLIKRVSKELGLDEQRWPARQATWFINSQKDEGLRARHMDTGGDLFALTMQKIYFAYEE
HHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHH
ACERGGLVDFNEMLLRVLELFRDNDNLRGHYQRRFRHILVDEFQDTNSIQYAWLRLLADE
HHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
NNAVTIVGDDDQSIYGWRGAKIENIHKFSRDFPDTRTIRLEQNYRSTGTILKAANAVIGH
CCEEEEEECCCCCEECCCCCCHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHCC
NSDRLGKELWTEGGDGDLIRLYSGFNEVDEARFIAGRMDKLFQEGTARREMAVLYRSNAQ
CCHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCH
SRVLEEAFLQAGIPYRIYGGQRFFERVEIKNALAYLRLLSHRHADAAFERVVNTPTRGIG
HHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCC
NKTLETLREVARQRNVSLWDAAQAVVSEQLLTARAINALAVFLNLIAQLEQQCDGLSLAE
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
TTEHVIEASGLLEFHGKEKGEKGQQRLENLRELLSATREFGDEDEDSELDSLTAFLDHAA
HHHHHHHHCCHHEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
LESGEGQADAHEDAVQMMTLHSAKGLEFPVVFITGMEEGLFPHKMSSEEPGRLAEERRLC
HCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHCCHH
YVGLTRAMRELYLTHAESRRLYGNENYNPPSRFLREIPAETLEEVRARAGFSRPMGGAAK
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCC
PIRETESNGISLGARVLHPKFGEGTILQFEGQGPNARLQINFDGAGTKWLVSQYARLEVI
CHHHCCCCCCEECHHEECCCCCCCCEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MDDVTSLIDGLNPAQRDAVAADDQHLLVLAGAGSGKTRVLVHRIAWQIATEQASPFGILA
CCCHHHHHHCCCHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEE
VTFTNKAAAEMRGRIEQLLDMSADGMWVGTFHGIAHRLLRAHWQEAGLPQGFQIIDADDQ
EEECCHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCEEECCCHH
IRLIKRVSKELGLDEQRWPARQATWFINSQKDEGLRARHMDTGGDLFALTMQKIYFAYEE
HHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHH
ACERGGLVDFNEMLLRVLELFRDNDNLRGHYQRRFRHILVDEFQDTNSIQYAWLRLLADE
HHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCC
NNAVTIVGDDDQSIYGWRGAKIENIHKFSRDFPDTRTIRLEQNYRSTGTILKAANAVIGH
CCEEEEEECCCCCEECCCCCCHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHCC
NSDRLGKELWTEGGDGDLIRLYSGFNEVDEARFIAGRMDKLFQEGTARREMAVLYRSNAQ
CCHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCH
SRVLEEAFLQAGIPYRIYGGQRFFERVEIKNALAYLRLLSHRHADAAFERVVNTPTRGIG
HHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCC
NKTLETLREVARQRNVSLWDAAQAVVSEQLLTARAINALAVFLNLIAQLEQQCDGLSLAE
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
TTEHVIEASGLLEFHGKEKGEKGQQRLENLRELLSATREFGDEDEDSELDSLTAFLDHAA
HHHHHHHHCCHHEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
LESGEGQADAHEDAVQMMTLHSAKGLEFPVVFITGMEEGLFPHKMSSEEPGRLAEERRLC
HCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHCCHH
YVGLTRAMRELYLTHAESRRLYGNENYNPPSRFLREIPAETLEEVRARAGFSRPMGGAAK
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCC
PIRETESNGISLGARVLHPKFGEGTILQFEGQGPNARLQINFDGAGTKWLVSQYARLEVI
CHHHCCCCCCEECHHEECCCCCCCCEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]