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The map label for this gene is mvaB [H]

Identifier: 110835526

GI number: 110835526

Start: 3012622

End: 3013674

Strand: Direct

Name: mvaB [H]

Synonym: ABO_2665

Alternate gene names: 110835526

Gene position: 3012622-3013674 (Clockwise)

Preceding gene: 110835522

Following gene: 110835531

Centisome position: 96.55

GC content: 58.97

Gene sequence:

>1053_bases
ATGACTGTCGGACAACGCGCGTGGAAAAGACACGCTCGACTGGCCGTTTGTTCTACTCGCTCCCTGAGGTGCACATCCGC
AACGCTGATGGCACACTTGCAGCCCCCTTTCGGCACGACGGTATTTACCATGACAGACCAGGCAATCATCAACGAGGTGG
GGCTGCGCGACGGCCTACAAAATCAACCTGTAACCGTAGACACCGCCACCAAGGCAAAACTGGCCCAGTTACTGGTCGAT
GCGGGCATGCGCTATTTGGAACCGGTCAGCTTTGTCAGCCCCAAGGCAATCCCACAGATGGCCGACGCCGCTGCGTTAAC
TCCGCTGCTGCCACAAGGTAACGATCTACATTACACCGCCCTGATACCCAACTTAAAAGGTTATCAGCTGGCCCGCGATG
CGGGTTACCCCACCGTGGGGCTCGTGCTATCCACTACCGACTCCTTCAACGAACGCAACCTACGCATGAGCCTAGAGCAG
GCAGCGCAAAGCTGTGAAGCGATTATTGCCGCCGCCAAAGCCGACGGCATCGCCACCCGGACCTATATTTCCGGCGCCTT
TGCCTGCCCCTACGACGGCCCAGTGCCAGTAACCCTGCCCCAGAAACTCAGCGAGCGCATGTTTGCTGCCGGTTCCGACG
AGGTGGCCATTGCCGATACCATTGGTGCGGGCAACCCACAACAGATGAAAGACATCATGGCGCCTTTGATTCAAGAGTTC
GGCGCCGAAAAATTCTATGTCCACCTGCACGACACTCGCGGGCTAGCCGCCGCCATGGCTTGGGCAGCGGCAGACCTAGG
GGTAAGGCGGTTTGACGCTTCCATCGGCGGGCTGGGCGGCTGCCCATTTGCACCCGGCGCTACCGGTAACATGGCCACGG
AAGATCTGGTGTACTTGCTGGAAAGCGCCGGGCTGAAAACCGGCATTGATGTGCAGGGCTTGCGCGAAGCGGTGGCTCTG
GCAGCCGAAGCAACCCAACGACCATTAGGCGGGCGCATTCTGGGATGGATCGAATCTCAGGAGAAGCAGGGCAAAACAGC
CTGCATAGGATAA

Upstream 100 bases:

>100_bases
AGCAGCGACAGCAGAAAAATGATCAGATCCATCTCTTCATTGCTCCGTTGTTATTGTGCCAACGCTAGGGCAGCGTGACC
GAAGATACCATGTCGCTAGT

Downstream 100 bases:

>100_bases
CAACAAGCGACAACGCGATTAACGCTTGTTTCGCGTTGATCCAATGACGCCGCACTCATACTCTGAGCGCAGCGTCATTC
ATAGAAACCCATTCACCTCT

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MTVGQRAWKRHARLAVCSTRSLRCTSATLMAHLQPPFGTTVFTMTDQAIINEVGLRDGLQNQPVTVDTATKAKLAQLLVD
AGMRYLEPVSFVSPKAIPQMADAAALTPLLPQGNDLHYTALIPNLKGYQLARDAGYPTVGLVLSTTDSFNERNLRMSLEQ
AAQSCEAIIAAAKADGIATRTYISGAFACPYDGPVPVTLPQKLSERMFAAGSDEVAIADTIGAGNPQQMKDIMAPLIQEF
GAEKFYVHLHDTRGLAAAMAWAAADLGVRRFDASIGGLGGCPFAPGATGNMATEDLVYLLESAGLKTGIDVQGLREAVAL
AAEATQRPLGGRILGWIESQEKQGKTACIG

Sequences:

>Translated_350_residues
MTVGQRAWKRHARLAVCSTRSLRCTSATLMAHLQPPFGTTVFTMTDQAIINEVGLRDGLQNQPVTVDTATKAKLAQLLVD
AGMRYLEPVSFVSPKAIPQMADAAALTPLLPQGNDLHYTALIPNLKGYQLARDAGYPTVGLVLSTTDSFNERNLRMSLEQ
AAQSCEAIIAAAKADGIATRTYISGAFACPYDGPVPVTLPQKLSERMFAAGSDEVAIADTIGAGNPQQMKDIMAPLIQEF
GAEKFYVHLHDTRGLAAAMAWAAADLGVRRFDASIGGLGGCPFAPGATGNMATEDLVYLLESAGLKTGIDVQGLREAVAL
AAEATQRPLGGRILGWIESQEKQGKTACIG
>Mature_349_residues
TVGQRAWKRHARLAVCSTRSLRCTSATLMAHLQPPFGTTVFTMTDQAIINEVGLRDGLQNQPVTVDTATKAKLAQLLVDA
GMRYLEPVSFVSPKAIPQMADAAALTPLLPQGNDLHYTALIPNLKGYQLARDAGYPTVGLVLSTTDSFNERNLRMSLEQA
AQSCEAIIAAAKADGIATRTYISGAFACPYDGPVPVTLPQKLSERMFAAGSDEVAIADTIGAGNPQQMKDIMAPLIQEFG
AEKFYVHLHDTRGLAAAMAWAAADLGVRRFDASIGGLGGCPFAPGATGNMATEDLVYLLESAGLKTGIDVQGLREAVALA
AEATQRPLGGRILGWIESQEKQGKTACIG

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=304, Percent_Identity=38.1578947368421, Blast_Score=228, Evalue=8e-60,
Organism=Homo sapiens, GI109150427, Length=287, Percent_Identity=36.2369337979094, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI109150422, Length=287, Percent_Identity=36.2369337979094, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI260654708, Length=131, Percent_Identity=41.9847328244275, Blast_Score=119, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17510563, Length=283, Percent_Identity=34.2756183745583, Blast_Score=182, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6320071, Length=226, Percent_Identity=26.9911504424779, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320019, Length=226, Percent_Identity=26.9911504424779, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24582381, Length=276, Percent_Identity=38.4057971014493, Blast_Score=207, Evalue=9e-54,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 37061; Mature: 36930

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00815 AIPM_HOMOCIT_SYNTH_1 ; PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVGQRAWKRHARLAVCSTRSLRCTSATLMAHLQPPFGTTVFTMTDQAIINEVGLRDGLQ
CCCCHHHHHHHCEEEEECCCCCCHHHHHHHHCCCCCCCCEEEEECHHHHHHHHHHHCCCC
NQPVTVDTATKAKLAQLLVDAGMRYLEPVSFVSPKAIPQMADAAALTPLLPQGNDLHYTA
CCCEEEECHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHCCCCCCCCCEEEEE
LIPNLKGYQLARDAGYPTVGLVLSTTDSFNERNLRMSLEQAAQSCEAIIAAAKADGIATR
ECCCCCCCEEHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEH
TYISGAFACPYDGPVPVTLPQKLSERMFAAGSDEVAIADTIGAGNPQQMKDIMAPLIQEF
HHHCCEEECCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHH
GAEKFYVHLHDTRGLAAAMAWAAADLGVRRFDASIGGLGGCPFAPGATGNMATEDLVYLL
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
ESAGLKTGIDVQGLREAVALAAEATQRPLGGRILGWIESQEKQGKTACIG
HHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHCCCCCCCC
>Mature Secondary Structure 
TVGQRAWKRHARLAVCSTRSLRCTSATLMAHLQPPFGTTVFTMTDQAIINEVGLRDGLQ
CCCHHHHHHHCEEEEECCCCCCHHHHHHHHCCCCCCCCEEEEECHHHHHHHHHHHCCCC
NQPVTVDTATKAKLAQLLVDAGMRYLEPVSFVSPKAIPQMADAAALTPLLPQGNDLHYTA
CCCEEEECHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHCCCCCCCCCEEEEE
LIPNLKGYQLARDAGYPTVGLVLSTTDSFNERNLRMSLEQAAQSCEAIIAAAKADGIATR
ECCCCCCCEEHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEH
TYISGAFACPYDGPVPVTLPQKLSERMFAAGSDEVAIADTIGAGNPQQMKDIMAPLIQEF
HHHCCEEECCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHH
GAEKFYVHLHDTRGLAAAMAWAAADLGVRRFDASIGGLGGCPFAPGATGNMATEDLVYLL
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
ESAGLKTGIDVQGLREAVALAAEATQRPLGGRILGWIESQEKQGKTACIG
HHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]