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The map label for this gene is trx-2 [H]

Identifier: 110835323

GI number: 110835323

Start: 2788597

End: 2788923

Strand: Direct

Name: trx-2 [H]

Synonym: ABO_2462

Alternate gene names: 110835323

Gene position: 2788597-2788923 (Clockwise)

Preceding gene: 110835321

Following gene: 110835324

Centisome position: 89.37

GC content: 53.52

Gene sequence:

>327_bases
ATGAGCGGCGAGATTATTAACGTGACCGATGCGGACTTCGAAGCCAAGGTCATCAACGCAGACGGCCCCGTGCTGGTCGA
TTACTGGGCTCCTTGGTGTGGCCCCTGCAAAATGGTCGCGCCGATCCTTGAGCAACTGGCCGGAGAGTACGGCGACAAGC
TGACCATTGCCAAAATCAATATCGATGATAATCCGGAAACACCGAAGAAATACGGCGTTCGAGGCATCCCTACCCTGACT
GTTTTCAAAAATGGCAACGTGGAAGCCACCAAAGTGGGCGCCCTGTCTAAAAGCCAACTGACCGCATTCTTGGACAGCAC
GCTTTAA

Upstream 100 bases:

>100_bases
CGCTTGAAATTCTTCACCCGCAACCTGATATTATTCATCATCACAGAGGCCGGTAAGCAACCGTGACAGGTCTTTGAAAC
CTTTATATCAGGAGAATTCA

Downstream 100 bases:

>100_bases
GCACGGATGTAATAACCTGTTACCCCTTCGTCGCCCGGCGAAGGGGTTTCCTTACCCTGCCACGACCGACGGGCTAGACA
GCCCCAACCATGAGTGATAG

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MSGEIINVTDADFEAKVINADGPVLVDYWAPWCGPCKMVAPILEQLAGEYGDKLTIAKINIDDNPETPKKYGVRGIPTLT
VFKNGNVEATKVGALSKSQLTAFLDSTL

Sequences:

>Translated_108_residues
MSGEIINVTDADFEAKVINADGPVLVDYWAPWCGPCKMVAPILEQLAGEYGDKLTIAKINIDDNPETPKKYGVRGIPTLT
VFKNGNVEATKVGALSKSQLTAFLDSTL
>Mature_107_residues
SGEIINVTDADFEAKVINADGPVLVDYWAPWCGPCKMVAPILEQLAGEYGDKLTIAKINIDDNPETPKKYGVRGIPTLTV
FKNGNVEATKVGALSKSQLTAFLDSTL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=105, Percent_Identity=40, Blast_Score=90, Evalue=5e-19,
Organism=Homo sapiens, GI21361657, Length=84, Percent_Identity=38.0952380952381, Blast_Score=70, Evalue=5e-13,
Organism=Homo sapiens, GI20070125, Length=80, Percent_Identity=36.25, Blast_Score=66, Evalue=6e-12,
Organism=Homo sapiens, GI5031973, Length=81, Percent_Identity=32.0987654320988, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=64.8148148148148, Blast_Score=152, Evalue=6e-39,
Organism=Escherichia coli, GI1788936, Length=108, Percent_Identity=39.8148148148148, Blast_Score=96, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI212646193, Length=97, Percent_Identity=39.1752577319588, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71998175, Length=86, Percent_Identity=40.6976744186046, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17556044, Length=106, Percent_Identity=27.3584905660377, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17507705, Length=66, Percent_Identity=37.8787878787879, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI115532378, Length=79, Percent_Identity=36.7088607594937, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI115532380, Length=104, Percent_Identity=31.7307692307692, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17509965, Length=83, Percent_Identity=37.3493975903614, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17554386, Length=87, Percent_Identity=36.7816091954023, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17569137, Length=84, Percent_Identity=38.0952380952381, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI32566189, Length=84, Percent_Identity=38.0952380952381, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17549970, Length=83, Percent_Identity=33.7349397590361, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193209454, Length=84, Percent_Identity=38.0952380952381, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=82, Percent_Identity=36.5853658536585, Blast_Score=70, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6323072, Length=86, Percent_Identity=39.5348837209302, Blast_Score=69, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28573567, Length=100, Percent_Identity=39, Blast_Score=84, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24639826, Length=86, Percent_Identity=40.6976744186046, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24664269, Length=100, Percent_Identity=37, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21358065, Length=102, Percent_Identity=37.2549019607843, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17648013, Length=76, Percent_Identity=34.2105263157895, Blast_Score=69, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24583090, Length=76, Percent_Identity=34.2105263157895, Blast_Score=69, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24639068, Length=94, Percent_Identity=30.8510638297872, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921434, Length=87, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11613; Mature: 11482

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGEIINVTDADFEAKVINADGPVLVDYWAPWCGPCKMVAPILEQLAGEYGDKLTIAKIN
CCCCEEEEECCCCEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEE
IDDNPETPKKYGVRGIPTLTVFKNGNVEATKVGALSKSQLTAFLDSTL
CCCCCCCCHHCCCCCCCEEEEEECCCEEEEEECCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SGEIINVTDADFEAKVINADGPVLVDYWAPWCGPCKMVAPILEQLAGEYGDKLTIAKIN
CCCEEEEECCCCEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEE
IDDNPETPKKYGVRGIPTLTVFKNGNVEATKVGALSKSQLTAFLDSTL
CCCCCCCCHHCCCCCCCEEEEEECCCEEEEEECCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10224002; 10984043 [H]