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The map label for this gene is hemB [H]

Identifier: 110835320

GI number: 110835320

Start: 2783307

End: 2784317

Strand: Direct

Name: hemB [H]

Synonym: ABO_2459

Alternate gene names: 110835320

Gene position: 2783307-2784317 (Clockwise)

Preceding gene: 110835316

Following gene: 110835321

Centisome position: 89.2

GC content: 58.85

Gene sequence:

>1011_bases
ATGTCTGTCACCCGTGCTTCCTGGCCCGCCACACGTATGCGCCGCATGCGCCGCGATGATTTTTCCCGCCGCCTGATGCG
CGAGCACACCCTCACCGTTGACGACCTGATTTACCCGGTGTTTGTACTGGAAGGCAGCAATCAAATCGAAGCCGTTCCCT
CCATGCCCGGTGTGGAACGTAAAAGCATTGATCTGCTGGTGGAAGAAGCCCGTGAGCTGGCCGATCTAGGCGTTCCCGCC
ATGGCCTTGTTTCCAGTCACCCCAGGCGATATAAAAACCCTCGATGGCCGTGAAGCCTGGAACCCTGAGGGGCTAGCCCA
GCGTGCCGTGCGCGCGATCAAGGCAGCCGTTCCCGAGATGGGAGTCATCACTGACGGCGCCTTGGATCCGTTCACTACCC
ACGGCCAGGACGGCATCATTGATGACAACGGCTATGTACTCAACGACGTGACCGTGGATGCACTGGTCAAGCAGGCCCTA
TCCCATGCCGACGCCGGCGCCGACATGGTTGCCCCTTCAGACATGATGGATGGCCGCATCGGGGCCATTCGCGATGCCCT
GGAAGCCCACGGCCATATCCACACCCGTATCATGGCCTACTCTGCCAAGTACGCCAGCGCCTACTATGGCCCTTTCCGCG
ATGCGGTCGGCTCCGCCGGCAATCTCGGCAAGGCGGACAAGACCACCTATCAAATGGACCCAGCCAATTCCGATGAGGCG
CTGCATGAGATCGCCTTAGACCTGGCGGAAGGCGCCGACGTGGTAATGGTGAAACCGGGCATGCCTTACTTGGACGTGGT
CCGCCGAGTGAAAGACGAATTCAAAGTCCCTGTGTACGCCTATCAAGTGAGTGGCGAATACGCCATGCACATGGCCGCTT
TTCAAAACGGCTGGCTGGACCAAGACAAAGTGATGATGGAATCCTTGCTGGCATTCAAACGCGCCGGCGCCGATGGCATC
CTCACCTACTTTGCCAAAACGGCAGCGCAAGCACTGAAAAAACAGCGTTAA

Upstream 100 bases:

>100_bases
GCCCAGAAAGCTAAGATGGCATTGGCATGCTTCGCGTTTTAACGTTGAACTAGCTTACCCCAGCACCAGGCGCGCCCATA
CTACTAGAGGAACCCTGCGC

Downstream 100 bases:

>100_bases
CCGAAGGCGACACGCGCTTCAATGTAAGCAAAACAGGAACGACCCGTGCTTGCCGTTCCTGTTCTGCCTGCCTTTTTAAC
ACCCTGTGGCCTGCCTATTG

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MSVTRASWPATRMRRMRRDDFSRRLMREHTLTVDDLIYPVFVLEGSNQIEAVPSMPGVERKSIDLLVEEARELADLGVPA
MALFPVTPGDIKTLDGREAWNPEGLAQRAVRAIKAAVPEMGVITDGALDPFTTHGQDGIIDDNGYVLNDVTVDALVKQAL
SHADAGADMVAPSDMMDGRIGAIRDALEAHGHIHTRIMAYSAKYASAYYGPFRDAVGSAGNLGKADKTTYQMDPANSDEA
LHEIALDLAEGADVVMVKPGMPYLDVVRRVKDEFKVPVYAYQVSGEYAMHMAAFQNGWLDQDKVMMESLLAFKRAGADGI
LTYFAKTAAQALKKQR

Sequences:

>Translated_336_residues
MSVTRASWPATRMRRMRRDDFSRRLMREHTLTVDDLIYPVFVLEGSNQIEAVPSMPGVERKSIDLLVEEARELADLGVPA
MALFPVTPGDIKTLDGREAWNPEGLAQRAVRAIKAAVPEMGVITDGALDPFTTHGQDGIIDDNGYVLNDVTVDALVKQAL
SHADAGADMVAPSDMMDGRIGAIRDALEAHGHIHTRIMAYSAKYASAYYGPFRDAVGSAGNLGKADKTTYQMDPANSDEA
LHEIALDLAEGADVVMVKPGMPYLDVVRRVKDEFKVPVYAYQVSGEYAMHMAAFQNGWLDQDKVMMESLLAFKRAGADGI
LTYFAKTAAQALKKQR
>Mature_335_residues
SVTRASWPATRMRRMRRDDFSRRLMREHTLTVDDLIYPVFVLEGSNQIEAVPSMPGVERKSIDLLVEEARELADLGVPAM
ALFPVTPGDIKTLDGREAWNPEGLAQRAVRAIKAAVPEMGVITDGALDPFTTHGQDGIIDDNGYVLNDVTVDALVKQALS
HADAGADMVAPSDMMDGRIGAIRDALEAHGHIHTRIMAYSAKYASAYYGPFRDAVGSAGNLGKADKTTYQMDPANSDEAL
HEIALDLAEGADVVMVKPGMPYLDVVRRVKDEFKVPVYAYQVSGEYAMHMAAFQNGWLDQDKVMMESLLAFKRAGADGIL
TYFAKTAAQALKKQR

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=308, Percent_Identity=41.5584415584416, Blast_Score=231, Evalue=8e-61,
Organism=Escherichia coli, GI87081728, Length=314, Percent_Identity=45.5414012738853, Blast_Score=253, Evalue=9e-69,
Organism=Saccharomyces cerevisiae, GI6321398, Length=307, Percent_Identity=37.1335504885993, Blast_Score=189, Evalue=7e-49,
Organism=Drosophila melanogaster, GI21358291, Length=291, Percent_Identity=37.1134020618557, Blast_Score=203, Evalue=1e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 36807; Mature: 36676

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVTRASWPATRMRRMRRDDFSRRLMREHTLTVDDLIYPVFVLEGSNQIEAVPSMPGVER
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEEEEEECCCCEEECCCCCCCCH
KSIDLLVEEARELADLGVPAMALFPVTPGDIKTLDGREAWNPEGLAQRAVRAIKAAVPEM
HHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHCCCC
GVITDGALDPFTTHGQDGIIDDNGYVLNDVTVDALVKQALSHADAGADMVAPSDMMDGRI
CCEECCCCCCCCCCCCCCEECCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCHH
GAIRDALEAHGHIHTRIMAYSAKYASAYYGPFRDAVGSAGNLGKADKTTYQMDPANSDEA
HHHHHHHHHCCCHHHHHEEHHHHHHHHHCCHHHHHHCCCCCCCCCCCCEEEECCCCCHHH
LHEIALDLAEGADVVMVKPGMPYLDVVRRVKDEFKVPVYAYQVSGEYAMHMAAFQNGWLD
HHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCC
QDKVMMESLLAFKRAGADGILTYFAKTAAQALKKQR
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SVTRASWPATRMRRMRRDDFSRRLMREHTLTVDDLIYPVFVLEGSNQIEAVPSMPGVER
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEEEEEECCCCEEECCCCCCCCH
KSIDLLVEEARELADLGVPAMALFPVTPGDIKTLDGREAWNPEGLAQRAVRAIKAAVPEM
HHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHCCCC
GVITDGALDPFTTHGQDGIIDDNGYVLNDVTVDALVKQALSHADAGADMVAPSDMMDGRI
CCEECCCCCCCCCCCCCCEECCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCHH
GAIRDALEAHGHIHTRIMAYSAKYASAYYGPFRDAVGSAGNLGKADKTTYQMDPANSDEA
HHHHHHHHHCCCHHHHHEEHHHHHHHHHCCHHHHHHCCCCCCCCCCCCEEEECCCCCHHH
LHEIALDLAEGADVVMVKPGMPYLDVVRRVKDEFKVPVYAYQVSGEYAMHMAAFQNGWLD
HHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCC
QDKVMMESLLAFKRAGADGILTYFAKTAAQALKKQR
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9529530; 10984043; 10356331; 12079382 [H]