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The map label for this gene is crp [H]

Identifier: 110834884

GI number: 110834884

Start: 2312039

End: 2312668

Strand: Direct

Name: crp [H]

Synonym: ABO_2023

Alternate gene names: 110834884

Gene position: 2312039-2312668 (Clockwise)

Preceding gene: 110834881

Following gene: 110834889

Centisome position: 74.1

GC content: 52.22

Gene sequence:

>630_bases
ATGATGAACGGCAACAAAATCATCCCAAATCTGGACCACTTTTTGGCCCAGTGCCACCGCCGCAAGTACCCGGCGAAGAG
CACCATCATCTATGCTGGTGATGAATCGGATGCGCTGTATTACATCCTCAAAGGCTCTGTGACGGTAATGATCGAGGACG
ACGATGGTCGCGAGATGATCATGGCATACCTTAATGAAGGGGATTTCTTCGGTGAAATGGGTCTATTTGAAAACGACCCC
TCCCGCTCTGCTTGGGTAAAAGCCAAGACAGAATGTGAAGTTGCCGAAGTTAGTTACCCAAAATTTCGGCAGTTGGCACG
TGAAGACGCAGATATCCTGTTCACCGTATCCGCCCAAATTGCGGGCCGCCTACGCGCCACCACTCGCAAAGTGGGCGATC
TGGCATTTCTGGATGTCACCGGCCGTGTCGCGGGCACCCTGCTAGACCTATGTAAACAACCCGATGCAATGACACACCCA
GACGGCATGCAGATCAAAATCACTCGCCAGGAAATCGGTCGCATCGTCGGTTGCTCCCGGGAAATGGTAGGCCGGGTACT
CAAAAACCTAGAAGAACAGGGCTTGGTCTCCGTAAAAGGCAAAACCATGGTGGTGTACGGTACTAGGTAA

Upstream 100 bases:

>100_bases
CACGATAAAGAACCTGTCCTCTTGGCATAACTCATAAAAACAGGCAGTATCCATAGGCTTATAACTAAGACATTTTTCTG
GTTTCAAAGACTGAGCTCCC

Downstream 100 bases:

>100_bases
GCTACACGTTCAAACGCGAATGAATGTTCTGCCAATTCACCGCAAAGAGGCCGCGCCCAACCATTAGCGCGGCCTCTTTC
GTTTCCATCTCTTGCCTGTT

Product: cAMP-regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MMNGNKIIPNLDHFLAQCHRRKYPAKSTIIYAGDESDALYYILKGSVTVMIEDDDGREMIMAYLNEGDFFGEMGLFENDP
SRSAWVKAKTECEVAEVSYPKFRQLAREDADILFTVSAQIAGRLRATTRKVGDLAFLDVTGRVAGTLLDLCKQPDAMTHP
DGMQIKITRQEIGRIVGCSREMVGRVLKNLEEQGLVSVKGKTMVVYGTR

Sequences:

>Translated_209_residues
MMNGNKIIPNLDHFLAQCHRRKYPAKSTIIYAGDESDALYYILKGSVTVMIEDDDGREMIMAYLNEGDFFGEMGLFENDP
SRSAWVKAKTECEVAEVSYPKFRQLAREDADILFTVSAQIAGRLRATTRKVGDLAFLDVTGRVAGTLLDLCKQPDAMTHP
DGMQIKITRQEIGRIVGCSREMVGRVLKNLEEQGLVSVKGKTMVVYGTR
>Mature_209_residues
MMNGNKIIPNLDHFLAQCHRRKYPAKSTIIYAGDESDALYYILKGSVTVMIEDDDGREMIMAYLNEGDFFGEMGLFENDP
SRSAWVKAKTECEVAEVSYPKFRQLAREDADILFTVSAQIAGRLRATTRKVGDLAFLDVTGRVAGTLLDLCKQPDAMTHP
DGMQIKITRQEIGRIVGCSREMVGRVLKNLEEQGLVSVKGKTMVVYGTR

Specific function: Can bind cyclic AMP. Is a global regulator of virulence factor expression and is required for exotoxin A and protease production [H]

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789756, Length=201, Percent_Identity=67.6616915422886, Blast_Score=300, Evalue=6e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR018488
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 23362; Mature: 23362

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00889 CNMP_BINDING_2 ; PS50042 CNMP_BINDING_3 ; PS00042 HTH_CRP_1 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNGNKIIPNLDHFLAQCHRRKYPAKSTIIYAGDESDALYYILKGSVTVMIEDDDGREMI
CCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEEECCEEEEEECCCCCEEH
MAYLNEGDFFGEMGLFENDPSRSAWVKAKTECEVAEVSYPKFRQLAREDADILFTVSAQI
HEECCCCCCEECCCCCCCCCCCCEEEEECCCCEEECCCCHHHHHHHHCCCCEEEEEEHHH
AGRLRATTRKVGDLAFLDVTGRVAGTLLDLCKQPDAMTHPDGMQIKITRQEIGRIVGCSR
HHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHCCCH
EMVGRVLKNLEEQGLVSVKGKTMVVYGTR
HHHHHHHHHHHHCCEEEECCCEEEEEECC
>Mature Secondary Structure
MMNGNKIIPNLDHFLAQCHRRKYPAKSTIIYAGDESDALYYILKGSVTVMIEDDDGREMI
CCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEEECCEEEEEECCCCCEEH
MAYLNEGDFFGEMGLFENDPSRSAWVKAKTECEVAEVSYPKFRQLAREDADILFTVSAQI
HEECCCCCCEECCCCCCCCCCCCEEEEECCCCEEECCCCHHHHHHHHCCCCEEEEEEHHH
AGRLRATTRKVGDLAFLDVTGRVAGTLLDLCKQPDAMTHPDGMQIKITRQEIGRIVGCSR
HHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHCCCH
EMVGRVLKNLEEQGLVSVKGKTMVVYGTR
HHHHHHHHHHHHCCEEEECCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8002577; 10984043 [H]