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The map label for this gene is purH

Identifier: 110834876

GI number: 110834876

Start: 2300994

End: 2302571

Strand: Direct

Name: purH

Synonym: ABO_2015

Alternate gene names: 110834876

Gene position: 2300994-2302571 (Clockwise)

Preceding gene: 110834875

Following gene: 110834877

Centisome position: 73.75

GC content: 57.73

Gene sequence:

>1578_bases
ATGAGCAATGTTGAACGTGCACTGATCAGTGTTTCCGATAAAACCGGTATCGTCGAATTCGCCCAGGCCCTAGCTGACAA
GGGCGTGGAACTGCTGTCCACAGGCGGGACCTTCAAGAAACTGCAGGAGGCCGGCATCGCCGTACGCGAAGTCTCCGACT
ACACCGGTTTCCCGGAAATGATGGCCGGCCGGGTAAAAACCCTGCACCCTAAAGTGCACGGCGGCATCCTTGGCCGTCGC
GGCCAGGACGAACAGGTCATGGCCGACAACGACATCAGCCCCATTGATCTGGTGGTGGTCAACCTTTACCCCTTCGAGGC
CACCGTGGCCAACCCGGATTGCTCTCTGGAGGACGCCATCGAGAACATCGACATTGGCGGTCCGACCATGGTTCGTTCTG
CCGCCAAGAACAATGCCAGCGTTGGCATTGTGACTGATGCCGCCGACTACCAGCGCGTACTCGACGACATGGCCGCCAAC
AACGGCGCGCTGTCTGATGACTTGCGTTTTGACCTGGCCATCAAAGCGTTCGAGCACACCGCCGCCTATGACAGTGCCAT
TGCCAACTACTTTGGCAAGAAAGTCGAAGGACAGGATGGTATGAGCAATCTGGACTTCCCGCGCACCATTAACCTGAACT
TCGAAAAAACCCAGAACATGCGTTATGGCGAGAACCCGCACCAGAAAGCGGCCTTCTACACCGAGCGCAACCCGGCCCCG
GCATCCATCGCCACCGCGAAACAGCTGCAGGGCAAAGAACTAAGCTACAACAACATCGCTGATACCGACGCCGCACTGGA
ATGCGTAAAAGGCTTCACCAAGCCGGCCTGTGTAATCGTCAAGCACGCCAACCCCTGTGGGGTGGCGGTGAGCCTAGATG
GCATTACCACAGCTTATGATCTGGCCTTCGCCACCGATACCGAATCCGCCTTCGGCGGCATCATCGCCTTCAACCGCAAG
CTGGATGCCGCCACCGCCCAGGCCATCGTTGATCGCCAGTTTGTCGAAGTGATTATCGCCCCCAGCGCCACAGAAGAAGC
CCTGGCCATCACCGCCGCCAAAAAGAATGTGCGAGTACTGGTGTGTGGTGAAATGGAGGGTGTAGCGGCTTCTGGCCTGG
ACTACAAACGCGTCAACGGCGGGCTACTGGTGCAAGATCGCGATCTCGGCATGATCACCGAAGGTGAATTGAAGGTGGTC
ACCAAGCGCGCGCCCACTGAAGCCGAAATGCACGACCTGATCTTCGCTTGGAAAGTGGCTAAGTTCGTCAAATCCAATGC
CATTGTTTACGCCAAAGATCGTCAAACCGTAGGCGTGGGCGCCGGCCAGATGAGCCGGGTCAACTCTGCGCGCATTGCGG
CTATCAAAGCAGAACATGCTGGCCTGCAAGTGAAAGGCTCCGTAATGGCCTCCGATGCTTTCTTCCCGTTCCGCGATGGC
ATCGACAACGCGGCTAAGGTAGGAATCAGCTGCGTAATCCAGCCCGGCGGCTCGATTCGCGATGAAGAAGTTATTGCCGC
CGCCGACGAAGCCGGCATGGCCATGGTCTTCACCGGCATGCGCCATTTCAGGCATTAA

Upstream 100 bases:

>100_bases
TTGTAATACAGACCCGTAACACCAAGGGCAGTGACCACACTGCCCTTTTTTTGTTTCTAGCCCTCGTATTAATTAAGACT
TCGCAACTTGGTGAAACCCC

Downstream 100 bases:

>100_bases
CGCTGGCCGCCAGACGTCCAACGCATGAAGCGACCCTCCGGTCCCGCGTTGGACCTCTGGCGTCAAGCTCGTCGCCGATC
ACGACACGCGATCAGGATTA

Product: phosphoribosylaminoimidazolecarboxamide formyltransferase

Products: NA

Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MSNVERALISVSDKTGIVEFAQALADKGVELLSTGGTFKKLQEAGIAVREVSDYTGFPEMMAGRVKTLHPKVHGGILGRR
GQDEQVMADNDISPIDLVVVNLYPFEATVANPDCSLEDAIENIDIGGPTMVRSAAKNNASVGIVTDAADYQRVLDDMAAN
NGALSDDLRFDLAIKAFEHTAAYDSAIANYFGKKVEGQDGMSNLDFPRTINLNFEKTQNMRYGENPHQKAAFYTERNPAP
ASIATAKQLQGKELSYNNIADTDAALECVKGFTKPACVIVKHANPCGVAVSLDGITTAYDLAFATDTESAFGGIIAFNRK
LDAATAQAIVDRQFVEVIIAPSATEEALAITAAKKNVRVLVCGEMEGVAASGLDYKRVNGGLLVQDRDLGMITEGELKVV
TKRAPTEAEMHDLIFAWKVAKFVKSNAIVYAKDRQTVGVGAGQMSRVNSARIAAIKAEHAGLQVKGSVMASDAFFPFRDG
IDNAAKVGISCVIQPGGSIRDEEVIAAADEAGMAMVFTGMRHFRH

Sequences:

>Translated_525_residues
MSNVERALISVSDKTGIVEFAQALADKGVELLSTGGTFKKLQEAGIAVREVSDYTGFPEMMAGRVKTLHPKVHGGILGRR
GQDEQVMADNDISPIDLVVVNLYPFEATVANPDCSLEDAIENIDIGGPTMVRSAAKNNASVGIVTDAADYQRVLDDMAAN
NGALSDDLRFDLAIKAFEHTAAYDSAIANYFGKKVEGQDGMSNLDFPRTINLNFEKTQNMRYGENPHQKAAFYTERNPAP
ASIATAKQLQGKELSYNNIADTDAALECVKGFTKPACVIVKHANPCGVAVSLDGITTAYDLAFATDTESAFGGIIAFNRK
LDAATAQAIVDRQFVEVIIAPSATEEALAITAAKKNVRVLVCGEMEGVAASGLDYKRVNGGLLVQDRDLGMITEGELKVV
TKRAPTEAEMHDLIFAWKVAKFVKSNAIVYAKDRQTVGVGAGQMSRVNSARIAAIKAEHAGLQVKGSVMASDAFFPFRDG
IDNAAKVGISCVIQPGGSIRDEEVIAAADEAGMAMVFTGMRHFRH
>Mature_524_residues
SNVERALISVSDKTGIVEFAQALADKGVELLSTGGTFKKLQEAGIAVREVSDYTGFPEMMAGRVKTLHPKVHGGILGRRG
QDEQVMADNDISPIDLVVVNLYPFEATVANPDCSLEDAIENIDIGGPTMVRSAAKNNASVGIVTDAADYQRVLDDMAANN
GALSDDLRFDLAIKAFEHTAAYDSAIANYFGKKVEGQDGMSNLDFPRTINLNFEKTQNMRYGENPHQKAAFYTERNPAPA
SIATAKQLQGKELSYNNIADTDAALECVKGFTKPACVIVKHANPCGVAVSLDGITTAYDLAFATDTESAFGGIIAFNRKL
DAATAQAIVDRQFVEVIIAPSATEEALAITAAKKNVRVLVCGEMEGVAASGLDYKRVNGGLLVQDRDLGMITEGELKVVT
KRAPTEAEMHDLIFAWKVAKFVKSNAIVYAKDRQTVGVGAGQMSRVNSARIAAIKAEHAGLQVKGSVMASDAFFPFRDGI
DNAAKVGISCVIQPGGSIRDEEVIAAADEAGMAMVFTGMRHFRH

Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]

COG id: COG0138

COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purH family

Homologues:

Organism=Homo sapiens, GI20127454, Length=512, Percent_Identity=38.0859375, Blast_Score=288, Evalue=8e-78,
Organism=Escherichia coli, GI1790439, Length=525, Percent_Identity=71.6190476190476, Blast_Score=754, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71985564, Length=510, Percent_Identity=34.7058823529412, Blast_Score=270, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI71985574, Length=341, Percent_Identity=28.1524926686217, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI71985556, Length=63, Percent_Identity=50.7936507936508, Blast_Score=77, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323768, Length=500, Percent_Identity=36.2, Blast_Score=278, Evalue=1e-75,
Organism=Saccharomyces cerevisiae, GI6323056, Length=492, Percent_Identity=36.5853658536585, Blast_Score=275, Evalue=1e-74,
Organism=Drosophila melanogaster, GI24649832, Length=511, Percent_Identity=38.5518590998043, Blast_Score=291, Evalue=8e-79,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR9_ALCBS (Q0VMY5)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_693735.1
- ProteinModelPortal:   Q0VMY5
- SMR:   Q0VMY5
- STRING:   Q0VMY5
- GeneID:   4211146
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_2015
- NMPDR:   fig|393595.12.peg.2017
- eggNOG:   COG0138
- HOGENOM:   HBG498048
- OMA:   ASDGFFP
- PhylomeDB:   Q0VMY5
- BioCyc:   ABOR393595:ABO_2015-MONOMER
- HAMAP:   MF_00139
- InterPro:   IPR002695
- InterPro:   IPR013982
- InterPro:   IPR016193
- InterPro:   IPR011607
- Gene3D:   G3DSA:3.40.50.1380
- PANTHER:   PTHR11692
- PIRSF:   PIRSF000414
- SMART:   SM00798
- SMART:   SM00851
- TIGRFAMs:   TIGR00355

Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS; SSF53927 Cytidine_deaminase-like; SSF52335 MGS-like_dom

EC number: =2.1.2.3; =3.5.4.10

Molecular weight: Translated: 56122; Mature: 55991

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNVERALISVSDKTGIVEFAQALADKGVELLSTGGTFKKLQEAGIAVREVSDYTGFPEM
CCCHHHHHEEECCCCCHHHHHHHHHHCCCEEEECCCHHHHHHHCCCEEEECCCCCCCHHH
MAGRVKTLHPKVHGGILGRRGQDEQVMADNDISPIDLVVVNLYPFEATVANPDCSLEDAI
HHCCHHCCCCHHHCCCCCCCCCCCCEECCCCCCCEEEEEEEEECCEEEECCCCCCHHHHH
ENIDIGGPTMVRSAAKNNASVGIVTDAADYQRVLDDMAANNGALSDDLRFDLAIKAFEHT
HHCCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCEEEEEEEHHHHH
AAYDSAIANYFGKKVEGQDGMSNLDFPRTINLNFEKTQNMRYGENPHQKAAFYTERNPAP
HHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCHHHCCCCCCCCCCCCCCEEEECCCCCC
ASIATAKQLQGKELSYNNIADTDAALECVKGFTKPACVIVKHANPCGVAVSLDGITTAYD
CHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCEEEEECCCCEEEE
LAFATDTESAFGGIIAFNRKLDAATAQAIVDRQFVEVIIAPSATEEALAITAAKKNVRVL
EEEECCCCHHCCCEEEECCCCCHHHHHHHHHHHEEEEEECCCCCCCCEEEEEECCCEEEE
VCGEMEGVAASGLDYKRVNGGLLVQDRDLGMITEGELKVVTKRAPTEAEMHDLIFAWKVA
EECCCCCCCCCCCCEEECCCCEEEEECCCCEEECCCEEEEEECCCCHHHHHHHHHHHHHH
KFVKSNAIVYAKDRQTVGVGAGQMSRVNSARIAAIKAEHAGLQVKGSVMASDAFFPFRDG
HHHHCCCEEEEECCCEEECCCCHHHHCCCCEEEEEEECCCCEEEECCEEECCCCCCHHCC
IDNAAKVGISCVIQPGGSIRDEEVIAAADEAGMAMVFTGMRHFRH
CCHHHCCCEEEEECCCCCCCCCCEEEECCCCCEEHHHHHHHHHCC
>Mature Secondary Structure 
SNVERALISVSDKTGIVEFAQALADKGVELLSTGGTFKKLQEAGIAVREVSDYTGFPEM
CCHHHHHEEECCCCCHHHHHHHHHHCCCEEEECCCHHHHHHHCCCEEEECCCCCCCHHH
MAGRVKTLHPKVHGGILGRRGQDEQVMADNDISPIDLVVVNLYPFEATVANPDCSLEDAI
HHCCHHCCCCHHHCCCCCCCCCCCCEECCCCCCCEEEEEEEEECCEEEECCCCCCHHHHH
ENIDIGGPTMVRSAAKNNASVGIVTDAADYQRVLDDMAANNGALSDDLRFDLAIKAFEHT
HHCCCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCEEEEEEEHHHHH
AAYDSAIANYFGKKVEGQDGMSNLDFPRTINLNFEKTQNMRYGENPHQKAAFYTERNPAP
HHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCHHHCCCCCCCCCCCCCCEEEECCCCCC
ASIATAKQLQGKELSYNNIADTDAALECVKGFTKPACVIVKHANPCGVAVSLDGITTAYD
CHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCEEEEECCCCEEEE
LAFATDTESAFGGIIAFNRKLDAATAQAIVDRQFVEVIIAPSATEEALAITAAKKNVRVL
EEEECCCCHHCCCEEEECCCCCHHHHHHHHHHHEEEEEECCCCCCCCEEEEEECCCEEEE
VCGEMEGVAASGLDYKRVNGGLLVQDRDLGMITEGELKVVTKRAPTEAEMHDLIFAWKVA
EECCCCCCCCCCCCEEECCCCEEEEECCCCEEECCCEEEEEECCCCHHHHHHHHHHHHHH
KFVKSNAIVYAKDRQTVGVGAGQMSRVNSARIAAIKAEHAGLQVKGSVMASDAFFPFRDG
HHHHCCCEEEEECCCEEECCCCHHHHCCCCEEEEEEECCCCEEEECCEEECCCCCCHHCC
IDNAAKVGISCVIQPGGSIRDEEVIAAADEAGMAMVFTGMRHFRH
CCHHHCCCEEEEECCCCCCCCCCEEEECCCCCEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA