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The map label for this gene is accC [H]

Identifier: 110834871

GI number: 110834871

Start: 2295648

End: 2296994

Strand: Direct

Name: accC [H]

Synonym: ABO_2010

Alternate gene names: 110834871

Gene position: 2295648-2296994 (Clockwise)

Preceding gene: 110834870

Following gene: 110834872

Centisome position: 73.58

GC content: 55.61

Gene sequence:

>1347_bases
ATGCTGGAAAAGGTCGTCATTGCCAACCGCGGCGAGATTGCTCTACGGATTCTGCGCGCCTGCAAAGAGCTAGGCATTCG
TACCGTAGCGGTTTACTCGAAACCGGACCGGGATCTAATGCATGTTCGTCTTGCTGACGAAGCCGTGTGCATTGGTCCCG
CTTCATCCGCCGATTCATACTTGAACATTCCCGCGCTGATCAGCGCCGCCGAAGTGACCGATGCCGACGCCATTCACCCA
GGCTATGGCTTTCTGGCGGAAAATGCAGACTTTGCTGAAAGCGTAGAACGCTCCGGCTTCACCTTTATCGGCCCCAAGGC
AGACACTATTCGCCTGATGGGCAATAAGGTAGCCGCCATTGAAGCCATGAAAAAAGCGGGTGTGCCCACCGTACCGGGCT
CCAACGGCCCCATCGGCGACGATGATGAAGCCTCACTGGCCATGGCCGAACAAATCGGCTACCCGGTGATCATCAAGGCC
GCAGCAGGCGGCGGCGGGCGCGGCATGCGTGTGGTTGATGAAGCAAAACAGCTGCTAAACGCCATCACCCTGACCCGCTC
CGAAGCGAAAAATGCCTTTGGCGACGCCACCGTCTACATGGAGAAATTCCTGCAGCAACCACGCCACGTGGAAGTGCAAG
TGCTGGCCGATGGTGCCGGCCATGCAATTCACTTAGGCGACCGTGATTGCTCCTTGCAGCGCCGTCACCAGAAGGTGGTG
GAAGAAGCTCCGGCACCCGGAATCCCTCAGCATCTAAAAGAAGAAGTCGCCGAGCGCTGCGTTAACGCCTGTAAAGAAAT
CAATTACCGGGGTGCGGGCACCTTCGAATTTCTCTACGAGAATGAAGGCTTCTACTTCATCGAAATGAATACCCGTGTAC
AGGTAGAACACCCCGTCACCGAAATGGTTACCGGGGTGGATATTGTCAAGGAACAATTGCGTATCGCCGGCGGTGAAGGC
CTGCAAATCCAGCAGTCCGATGTACAATTCCAGGGCCATGCCATTGAGGTTCGCGTCAACGCAGAAGACCCGGTACGGTT
TACCCCCTGCCCGGGCAAAGTCACCTACTTCCACGCCCCCGGTGGCAATGGCGTACGAGTCGATTCCCACATCTACAGTG
GTTACACTGTTCCGCCATACTACGACTCCCTGATCGGCAAGCTGATCACTTGGGGGGAAAATCGCGAGACCGCCTTCTCC
CGTATGAAAAATGCGCTGGACGAAATTGTCGTGGAAGGCATCAAAACCAATATTGCCCTGCACCGCGACAAAATCTTCAA
GGACGAGGCTTTCATTAAAGGCGGCGTGGACATTCACCACCTAGAAAAGAAACTCGGGACACACTAA

Upstream 100 bases:

>100_bases
GGCGGACAAGTCCGGCACTCTGGATGCCATTTTGGTTGAAGACGGCGAGCCGGTTGAATTCGACCAGCCTCTGTTCTCCA
TCGTTTAACGGAGGCTTCCC

Downstream 100 bases:

>100_bases
AAGCCGTTGATAGTGAATTGATCGCTATTATCGTTAACGGTTACCATCCCCCTGATGGCCGCGCCCAGCGTTTGGGCGCG
GCCTCTTGCGTTACAGACAC

Product: acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MLEKVVIANRGEIALRILRACKELGIRTVAVYSKPDRDLMHVRLADEAVCIGPASSADSYLNIPALISAAEVTDADAIHP
GYGFLAENADFAESVERSGFTFIGPKADTIRLMGNKVAAIEAMKKAGVPTVPGSNGPIGDDDEASLAMAEQIGYPVIIKA
AAGGGGRGMRVVDEAKQLLNAITLTRSEAKNAFGDATVYMEKFLQQPRHVEVQVLADGAGHAIHLGDRDCSLQRRHQKVV
EEAPAPGIPQHLKEEVAERCVNACKEINYRGAGTFEFLYENEGFYFIEMNTRVQVEHPVTEMVTGVDIVKEQLRIAGGEG
LQIQQSDVQFQGHAIEVRVNAEDPVRFTPCPGKVTYFHAPGGNGVRVDSHIYSGYTVPPYYDSLIGKLITWGENRETAFS
RMKNALDEIVVEGIKTNIALHRDKIFKDEAFIKGGVDIHHLEKKLGTH

Sequences:

>Translated_448_residues
MLEKVVIANRGEIALRILRACKELGIRTVAVYSKPDRDLMHVRLADEAVCIGPASSADSYLNIPALISAAEVTDADAIHP
GYGFLAENADFAESVERSGFTFIGPKADTIRLMGNKVAAIEAMKKAGVPTVPGSNGPIGDDDEASLAMAEQIGYPVIIKA
AAGGGGRGMRVVDEAKQLLNAITLTRSEAKNAFGDATVYMEKFLQQPRHVEVQVLADGAGHAIHLGDRDCSLQRRHQKVV
EEAPAPGIPQHLKEEVAERCVNACKEINYRGAGTFEFLYENEGFYFIEMNTRVQVEHPVTEMVTGVDIVKEQLRIAGGEG
LQIQQSDVQFQGHAIEVRVNAEDPVRFTPCPGKVTYFHAPGGNGVRVDSHIYSGYTVPPYYDSLIGKLITWGENRETAFS
RMKNALDEIVVEGIKTNIALHRDKIFKDEAFIKGGVDIHHLEKKLGTH
>Mature_448_residues
MLEKVVIANRGEIALRILRACKELGIRTVAVYSKPDRDLMHVRLADEAVCIGPASSADSYLNIPALISAAEVTDADAIHP
GYGFLAENADFAESVERSGFTFIGPKADTIRLMGNKVAAIEAMKKAGVPTVPGSNGPIGDDDEASLAMAEQIGYPVIIKA
AAGGGGRGMRVVDEAKQLLNAITLTRSEAKNAFGDATVYMEKFLQQPRHVEVQVLADGAGHAIHLGDRDCSLQRRHQKVV
EEAPAPGIPQHLKEEVAERCVNACKEINYRGAGTFEFLYENEGFYFIEMNTRVQVEHPVTEMVTGVDIVKEQLRIAGGEG
LQIQQSDVQFQGHAIEVRVNAEDPVRFTPCPGKVTYFHAPGGNGVRVDSHIYSGYTVPPYYDSLIGKLITWGENRETAFS
RMKNALDEIVVEGIKTNIALHRDKIFKDEAFIKGGVDIHHLEKKLGTH

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=420, Percent_Identity=47.3809523809524, Blast_Score=403, Evalue=1e-112,
Organism=Homo sapiens, GI65506442, Length=444, Percent_Identity=45.945945945946, Blast_Score=397, Evalue=1e-111,
Organism=Homo sapiens, GI189095269, Length=444, Percent_Identity=45.945945945946, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI295821183, Length=444, Percent_Identity=45.945945945946, Blast_Score=397, Evalue=1e-110,
Organism=Homo sapiens, GI106049528, Length=449, Percent_Identity=45.43429844098, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI106049295, Length=449, Percent_Identity=45.43429844098, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI106049292, Length=449, Percent_Identity=45.43429844098, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI38679960, Length=515, Percent_Identity=31.4563106796116, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI38679977, Length=515, Percent_Identity=31.4563106796116, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI38679967, Length=515, Percent_Identity=31.4563106796116, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI38679974, Length=515, Percent_Identity=31.4563106796116, Blast_Score=239, Evalue=6e-63,
Organism=Homo sapiens, GI38679971, Length=515, Percent_Identity=31.4563106796116, Blast_Score=239, Evalue=6e-63,
Organism=Homo sapiens, GI134142062, Length=505, Percent_Identity=30.0990099009901, Blast_Score=229, Evalue=4e-60,
Organism=Escherichia coli, GI1789654, Length=446, Percent_Identity=70.4035874439462, Blast_Score=635, Evalue=0.0,
Organism=Escherichia coli, GI1786216, Length=198, Percent_Identity=26.2626262626263, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17567343, Length=444, Percent_Identity=45.945945945946, Blast_Score=389, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI71987519, Length=439, Percent_Identity=44.6469248291572, Blast_Score=371, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17562816, Length=449, Percent_Identity=44.3207126948775, Blast_Score=366, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI133931226, Length=495, Percent_Identity=27.6767676767677, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI71997168, Length=509, Percent_Identity=27.3084479371316, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI71997163, Length=509, Percent_Identity=27.3084479371316, Blast_Score=189, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6319685, Length=444, Percent_Identity=42.5675675675676, Blast_Score=362, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6319695, Length=440, Percent_Identity=45.4545454545455, Blast_Score=350, Evalue=2e-97,
Organism=Saccharomyces cerevisiae, GI6321376, Length=440, Percent_Identity=46.1363636363636, Blast_Score=344, Evalue=2e-95,
Organism=Saccharomyces cerevisiae, GI6324343, Length=510, Percent_Identity=29.2156862745098, Blast_Score=213, Evalue=5e-56,
Organism=Saccharomyces cerevisiae, GI6323863, Length=451, Percent_Identity=31.0421286031042, Blast_Score=203, Evalue=5e-53,
Organism=Drosophila melanogaster, GI24651757, Length=423, Percent_Identity=47.2813238770686, Blast_Score=404, Evalue=1e-113,
Organism=Drosophila melanogaster, GI281363050, Length=449, Percent_Identity=45.6570155902004, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652224, Length=449, Percent_Identity=45.6570155902004, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652222, Length=449, Percent_Identity=45.6570155902004, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652220, Length=449, Percent_Identity=45.6570155902004, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652218, Length=449, Percent_Identity=45.6570155902004, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652212, Length=449, Percent_Identity=45.6570155902004, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652210, Length=449, Percent_Identity=45.6570155902004, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652214, Length=449, Percent_Identity=45.6570155902004, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI19921944, Length=449, Percent_Identity=45.6570155902004, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24652216, Length=449, Percent_Identity=45.6570155902004, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24651759, Length=385, Percent_Identity=46.7532467532467, Blast_Score=359, Evalue=3e-99,
Organism=Drosophila melanogaster, GI161076409, Length=497, Percent_Identity=29.5774647887324, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI161076407, Length=497, Percent_Identity=29.5774647887324, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24586460, Length=497, Percent_Identity=29.5774647887324, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI24586458, Length=497, Percent_Identity=29.5774647887324, Blast_Score=219, Evalue=3e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48885; Mature: 48885

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEKVVIANRGEIALRILRACKELGIRTVAVYSKPDRDLMHVRLADEAVCIGPASSADSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCEEEECCCCCCCCC
LNIPALISAAEVTDADAIHPGYGFLAENADFAESVERSGFTFIGPKADTIRLMGNKVAAI
CCCHHHHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHCCCEEECCCCCEEEECCCHHHHH
EAMKKAGVPTVPGSNGPIGDDDEASLAMAEQIGYPVIIKAAAGGGGRGMRVVDEAKQLLN
HHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHH
AITLTRSEAKNAFGDATVYMEKFLQQPRHVEVQVLADGAGHAIHLGDRDCSLQRRHQKVV
HHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHH
EEAPAPGIPQHLKEEVAERCVNACKEINYRGAGTFEFLYENEGFYFIEMNTRVQVEHPVT
HHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
EMVTGVDIVKEQLRIAGGEGLQIQQSDVQFQGHAIEVRVNAEDPVRFTPCPGKVTYFHAP
HHHHHHHHHHHHHHHCCCCCCEEECCCCEECCEEEEEEECCCCCEEEECCCCCEEEEECC
GGNGVRVDSHIYSGYTVPPYYDSLIGKLITWGENRETAFSRMKNALDEIVVEGIKTNIAL
CCCCEEECCEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEE
HRDKIFKDEAFIKGGVDIHHLEKKLGTH
HHHHHHCCCHHEECCCHHHHHHHHHCCC
>Mature Secondary Structure
MLEKVVIANRGEIALRILRACKELGIRTVAVYSKPDRDLMHVRLADEAVCIGPASSADSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCEEEECCCCCCCCC
LNIPALISAAEVTDADAIHPGYGFLAENADFAESVERSGFTFIGPKADTIRLMGNKVAAI
CCCHHHHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHCCCEEECCCCCEEEECCCHHHHH
EAMKKAGVPTVPGSNGPIGDDDEASLAMAEQIGYPVIIKAAAGGGGRGMRVVDEAKQLLN
HHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHH
AITLTRSEAKNAFGDATVYMEKFLQQPRHVEVQVLADGAGHAIHLGDRDCSLQRRHQKVV
HHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHH
EEAPAPGIPQHLKEEVAERCVNACKEINYRGAGTFEFLYENEGFYFIEMNTRVQVEHPVT
HHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
EMVTGVDIVKEQLRIAGGEGLQIQQSDVQFQGHAIEVRVNAEDPVRFTPCPGKVTYFHAP
HHHHHHHHHHHHHHHCCCCCCEEECCCCEECCEEEEEEECCCCCEEEECCCCCEEEEECC
GGNGVRVDSHIYSGYTVPPYYDSLIGKLITWGENRETAFSRMKNALDEIVVEGIKTNIAL
CCCCEEECCEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEE
HRDKIFKDEAFIKGGVDIHHLEKKLGTH
HHHHHHCCCHHEECCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7693652; 10984043 [H]