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The map label for this gene is mrdA [H]

Identifier: 110834816

GI number: 110834816

Start: 2234508

End: 2236424

Strand: Direct

Name: mrdA [H]

Synonym: ABO_1955

Alternate gene names: 110834816

Gene position: 2234508-2236424 (Clockwise)

Preceding gene: 110834815

Following gene: 110834817

Centisome position: 71.62

GC content: 56.86

Gene sequence:

>1917_bases
ATGCGCCGACCATTAACGCTGAAGGATCATCATCACGAGCAGCGCATTTTCAGCGTTCGTCTTGTCGTGAGTGTTTTCCT
GGTGTTACTGCTCACCTGTGTGTTGATCGGGCGCATGATCTGGTTACAGATCATCGAACACAATCGTTACACCACCCTCA
GTGACAACAACCGGGTTCAGACACAAGCTGTGGCCCCACCGCGCGGGCTAATTACCGACCGCAATGGCGAAATTCTTGCC
GATAACCGCCCTGATTTTTCGCTGGAAATCATCATCGAGCAAGCAGCTGATCTGGATCAGCTGCTCACCGAGCTGGGCAA
TCTTATCGAGCTCGATGAGGGGGACCGGGAACGTTTCGAGAAACGCCGCCATACCGCTCGCCGCCCCTGGGAACCTGTGC
CACTACGTGGCCGGCTCACCGAAGAAGAAATTGCCCGGCTGGTGGTGAACCAGCACCGGCTCGCGGGTATCAGGATCTCC
GCCGACCCGATTCGCCACTACCCTCACGGCATTCTGTTTTCCCATGTTTTGGGCTACGTAAACCGGATCAATGTCCAAGA
TTTGGACGCGATGACTCTAGACCAACAACGCAACTACGCGGGCACCCATTTTTACGGGCGCAGTGGCATCGAACGGTTTT
ATGAAGATACCCTGCACGGTGAAGTTGGCTACCGCCAAGTAGAAACCAATGCTCGAGGCCGAATCTTAAGGGTGCTAGAA
GAGCAAGCGCCGGTGCCGGGTAAGCCCCTGCGACTTCGCCTTTCCATGCGAGTGCAAAAAGCAGCTTATGATGCTTTGGG
CGAACGCCGTGGCGCCGTGGTCGCCATTGATCCTCGCGATGGCAGTGTGCTGGCATTCGTTAGCCGGCCAGGCTTTAACC
CCAACCTGTTCGTCACCGGCATTTCCTATAAAGATTATTCCGCCTATCGCAACGACCACGACAACCCCCTGTTCAACCGT
GCACTGCAAGGGCGCTACCCACCAGGTTCCACCATCAAGCCCATGTATGGCCTGGCCGGGCTCGATGCCGGGGTAACCAC
CTGGGAGCGGACCATTTTTGATCCCGGATACTATCAGCTAGAAAACGACCCTCACCGCTACCGAGACTGGAAACGCTGGG
GCCATGGTCGCGTCAATCTGCGCGATGCAGTGGTGCAGTCCTGCGACACCTATTTTTACGACATGGGCTTTAAACTGGGC
ATTGAACGCCTACACCGCTACATGACCCAGTTTTCCCTAGGTCAGCCTACCGGTATCGACCTGCACAACGAATCCAGCGG
CATTATGCCGTCCAAACAGTGGAAAAAGGCCGCACGCGGCCGCCCCTGGTTCCACGGTGACACCATCAACGCCAGCATTG
GCCAGGGGTTTGTACTTGCCACACCACTGCAACTAGCCAATGCCACAGCGATCATGGCCAACCACGGCAAACAGGTGGTC
CCCACTCTCGCCGGAGACACTAAACCAGTAGAACGTACCGATATCGTGCTTAATGATCAGAGCAACTGGGAAAAAATGGC
CGACGCCATGGTTGGTGTAACCCAGCTCGGCGGCACGGCGCGGGCCATGGCCGTGAAAGCCAAATATGACATCGCTGCTA
AATCCGGCACTGCTCAGGTTTTCTCGGTGGGCCAGGACGAAACCTATAATGAAGAAGAATTGACGGAACGACTACTGGAC
CACGCCCTACTGGTATCCTTTGCCCCCGCCGACAAGCCAGCGATTGCCGTGGCGGTGCTGGTGGAAAATGGCCGCCACGG
CGGCTCTACCGCGGGGCCGGTTGCCCGCGAAGTCATGGATGCGTGGCTACTGGATGAACAGGGGGAGCTGAAAGTACCGC
CGGTGTTTGCCGAAACCCCGCCCCATCCACCGTCCAATACCACCATCAATAATGCCGGTAACGAGAACCGCCCATGA

Upstream 100 bases:

>100_bases
TATAGCTTGTGGCTTTGAGTGATCCCCCGACACAACGTTATTTTGCTACTATCACGCGTTCCTTTATTCGCCCTAAGTAA
CCCCGGACTCTAACGCCAAC

Downstream 100 bases:

>100_bases
GCCAGCGCGAATTTACCCGCCAAATGCCAGGCCAAACCGGCGCTAGCCTATCACCCGGGCTGGCGGTACGCCTGCACCTG
GATCCACCATTACTGGTGGG

Product: penicillin-binding protein 2

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 638; Mature: 638

Protein sequence:

>638_residues
MRRPLTLKDHHHEQRIFSVRLVVSVFLVLLLTCVLIGRMIWLQIIEHNRYTTLSDNNRVQTQAVAPPRGLITDRNGEILA
DNRPDFSLEIIIEQAADLDQLLTELGNLIELDEGDRERFEKRRHTARRPWEPVPLRGRLTEEEIARLVVNQHRLAGIRIS
ADPIRHYPHGILFSHVLGYVNRINVQDLDAMTLDQQRNYAGTHFYGRSGIERFYEDTLHGEVGYRQVETNARGRILRVLE
EQAPVPGKPLRLRLSMRVQKAAYDALGERRGAVVAIDPRDGSVLAFVSRPGFNPNLFVTGISYKDYSAYRNDHDNPLFNR
ALQGRYPPGSTIKPMYGLAGLDAGVTTWERTIFDPGYYQLENDPHRYRDWKRWGHGRVNLRDAVVQSCDTYFYDMGFKLG
IERLHRYMTQFSLGQPTGIDLHNESSGIMPSKQWKKAARGRPWFHGDTINASIGQGFVLATPLQLANATAIMANHGKQVV
PTLAGDTKPVERTDIVLNDQSNWEKMADAMVGVTQLGGTARAMAVKAKYDIAAKSGTAQVFSVGQDETYNEEELTERLLD
HALLVSFAPADKPAIAVAVLVENGRHGGSTAGPVAREVMDAWLLDEQGELKVPPVFAETPPHPPSNTTINNAGNENRP

Sequences:

>Translated_638_residues
MRRPLTLKDHHHEQRIFSVRLVVSVFLVLLLTCVLIGRMIWLQIIEHNRYTTLSDNNRVQTQAVAPPRGLITDRNGEILA
DNRPDFSLEIIIEQAADLDQLLTELGNLIELDEGDRERFEKRRHTARRPWEPVPLRGRLTEEEIARLVVNQHRLAGIRIS
ADPIRHYPHGILFSHVLGYVNRINVQDLDAMTLDQQRNYAGTHFYGRSGIERFYEDTLHGEVGYRQVETNARGRILRVLE
EQAPVPGKPLRLRLSMRVQKAAYDALGERRGAVVAIDPRDGSVLAFVSRPGFNPNLFVTGISYKDYSAYRNDHDNPLFNR
ALQGRYPPGSTIKPMYGLAGLDAGVTTWERTIFDPGYYQLENDPHRYRDWKRWGHGRVNLRDAVVQSCDTYFYDMGFKLG
IERLHRYMTQFSLGQPTGIDLHNESSGIMPSKQWKKAARGRPWFHGDTINASIGQGFVLATPLQLANATAIMANHGKQVV
PTLAGDTKPVERTDIVLNDQSNWEKMADAMVGVTQLGGTARAMAVKAKYDIAAKSGTAQVFSVGQDETYNEEELTERLLD
HALLVSFAPADKPAIAVAVLVENGRHGGSTAGPVAREVMDAWLLDEQGELKVPPVFAETPPHPPSNTTINNAGNENRP
>Mature_638_residues
MRRPLTLKDHHHEQRIFSVRLVVSVFLVLLLTCVLIGRMIWLQIIEHNRYTTLSDNNRVQTQAVAPPRGLITDRNGEILA
DNRPDFSLEIIIEQAADLDQLLTELGNLIELDEGDRERFEKRRHTARRPWEPVPLRGRLTEEEIARLVVNQHRLAGIRIS
ADPIRHYPHGILFSHVLGYVNRINVQDLDAMTLDQQRNYAGTHFYGRSGIERFYEDTLHGEVGYRQVETNARGRILRVLE
EQAPVPGKPLRLRLSMRVQKAAYDALGERRGAVVAIDPRDGSVLAFVSRPGFNPNLFVTGISYKDYSAYRNDHDNPLFNR
ALQGRYPPGSTIKPMYGLAGLDAGVTTWERTIFDPGYYQLENDPHRYRDWKRWGHGRVNLRDAVVQSCDTYFYDMGFKLG
IERLHRYMTQFSLGQPTGIDLHNESSGIMPSKQWKKAARGRPWFHGDTINASIGQGFVLATPLQLANATAIMANHGKQVV
PTLAGDTKPVERTDIVLNDQSNWEKMADAMVGVTQLGGTARAMAVKAKYDIAAKSGTAQVFSVGQDETYNEEELTERLLD
HALLVSFAPADKPAIAVAVLVENGRHGGSTAGPVAREVMDAWLLDEQGELKVPPVFAETPPHPPSNTTINNAGNENRP

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=617, Percent_Identity=42.7876823338736, Blast_Score=505, Evalue=1e-144,
Organism=Escherichia coli, GI1786272, Length=621, Percent_Identity=25.2818035426731, Blast_Score=138, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 71714; Mature: 71714

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRPLTLKDHHHEQRIFSVRLVVSVFLVLLLTCVLIGRMIWLQIIEHNRYTTLSDNNRVQ
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEE
TQAVAPPRGLITDRNGEILADNRPDFSLEIIIEQAADLDQLLTELGNLIELDEGDRERFE
EEECCCCCCCEECCCCCEEECCCCCCEEEEEEHHHCCHHHHHHHHCCEEECCCCHHHHHH
KRRHTARRPWEPVPLRGRLTEEEIARLVVNQHRLAGIRISADPIRHYPHGILFSHVLGYV
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEEECCHHHHCCCHHHHHHHHHHH
NRINVQDLDAMTLDQQRNYAGTHFYGRSGIERFYEDTLHGEVGYRQVETNARGRILRVLE
HCCCCCCCCHHHHHHCCCCCCCEEECHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHH
EQAPVPGKPLRLRLSMRVQKAAYDALGERRGAVVAIDPRDGSVLAFVSRPGFNPNLFVTG
HCCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEECCCCCCCEEEEE
ISYKDYSAYRNDHDNPLFNRALQGRYPPGSTIKPMYGLAGLDAGVTTWERTIFDPGYYQL
ECCCCHHHHCCCCCCHHHHHHHCCCCCCCCCCCCHHCCCCCCCCCHHHHHHHCCCCCEEE
ENDPHRYRDWKRWGHGRVNLRDAVVQSCDTYFYDMGFKLGIERLHRYMTQFSLGQPTGID
CCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCE
LHNESSGIMPSKQWKKAARGRPWFHGDTINASIGQGFVLATPLQLANATAIMANHGKQVV
ECCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCHHHHCCEEEEECCCCEEE
PTLAGDTKPVERTDIVLNDQSNWEKMADAMVGVTQLGGTARAMAVKAKYDIAAKSGTAQV
EECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEEEECCCCCEEE
FSVGQDETYNEEELTERLLDHALLVSFAPADKPAIAVAVLVENGRHGGSTAGPVAREVMD
EECCCCCCCCHHHHHHHHHHHHHHEEECCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHH
AWLLDEQGELKVPPVFAETPPHPPSNTTINNAGNENRP
HHHCCCCCCEECCCEECCCCCCCCCCCEECCCCCCCCC
>Mature Secondary Structure
MRRPLTLKDHHHEQRIFSVRLVVSVFLVLLLTCVLIGRMIWLQIIEHNRYTTLSDNNRVQ
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEE
TQAVAPPRGLITDRNGEILADNRPDFSLEIIIEQAADLDQLLTELGNLIELDEGDRERFE
EEECCCCCCCEECCCCCEEECCCCCCEEEEEEHHHCCHHHHHHHHCCEEECCCCHHHHHH
KRRHTARRPWEPVPLRGRLTEEEIARLVVNQHRLAGIRISADPIRHYPHGILFSHVLGYV
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEEECCHHHHCCCHHHHHHHHHHH
NRINVQDLDAMTLDQQRNYAGTHFYGRSGIERFYEDTLHGEVGYRQVETNARGRILRVLE
HCCCCCCCCHHHHHHCCCCCCCEEECHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHH
EQAPVPGKPLRLRLSMRVQKAAYDALGERRGAVVAIDPRDGSVLAFVSRPGFNPNLFVTG
HCCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEECCCCCCCEEEEE
ISYKDYSAYRNDHDNPLFNRALQGRYPPGSTIKPMYGLAGLDAGVTTWERTIFDPGYYQL
ECCCCHHHHCCCCCCHHHHHHHCCCCCCCCCCCCHHCCCCCCCCCHHHHHHHCCCCCEEE
ENDPHRYRDWKRWGHGRVNLRDAVVQSCDTYFYDMGFKLGIERLHRYMTQFSLGQPTGID
CCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCE
LHNESSGIMPSKQWKKAARGRPWFHGDTINASIGQGFVLATPLQLANATAIMANHGKQVV
ECCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCHHHHCCEEEEECCCCEEE
PTLAGDTKPVERTDIVLNDQSNWEKMADAMVGVTQLGGTARAMAVKAKYDIAAKSGTAQV
EECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEEEECCCCCEEE
FSVGQDETYNEEELTERLLDHALLVSFAPADKPAIAVAVLVENGRHGGSTAGPVAREVMD
EECCCCCCCCHHHHHHHHHHHHHHEEECCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHH
AWLLDEQGELKVPPVFAETPPHPPSNTTINNAGNENRP
HHHCCCCCCEECCCEECCCCCCCCCCCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]