Click here to switch to the map view.

The map label for this gene is proA

Identifier: 110834812

GI number: 110834812

Start: 2231409

End: 2232680

Strand: Direct

Name: proA

Synonym: ABO_1951

Alternate gene names: 110834812

Gene position: 2231409-2232680 (Clockwise)

Preceding gene: 110834811

Following gene: 110834813

Centisome position: 71.52

GC content: 58.49

Gene sequence:

>1272_bases
ATGGATATCCAGCAATACATGCAACGCCTGGGAGAACAGGCCCGCCAAGCCTCCCGTGCCATGGCCCGTGCCAGTTCCAG
CGACAAGGACAAGGCCCTAGCGGCCATTGCCGGCGCCTTGCGCAGCCACCGTAACGCGATCCTGCAGGCCAATCAGCAGG
ATCTGGACGCCGGACGTAACAATGGTCTGGACGCTGCCCTGCTAGACCGGCTGGAACTGACTCCCGACCGCTTTGACGGC
ATGGTGGAAGGCTTAGAACAAATTATCGGGCTGGCAGACCCAATCGGTGTAATTACCGACCTGGCTTACCGCCCATCAGG
CATTCAAGTGGGCAAAATGCGTGTGCCCTTGGGGGTTATCGGCATCATTTACGAGTCCCGCCCGAACGTTACCGTTGATG
CCGCCGCTTTATGCCTGAAATCCGGCAACGCGGCGATTTTGCGTGGCGGCTCCGAAGCCATCAACGCTAACCAAGCCATT
GCCGAATGCATACGCGAGGGCCTTCGTGAGGCTGGGCTGCCTGACACCGCCGTACAGGTGGTGGAAACCACCGACCGCGC
CGCCGTAGGCGAGCTGATTAGCCACCCGGAATTCGTGGACGTGATTGTCCCCCGGGGCGGCAAGGGGCTGATCGAGCGCA
TCAGTAATGACGCTCGCGTGCCAGTGATTAAGCATCTGGATGGCAACTGCCACACCTACATTGATGGTCAGGCCAATATC
GCCAAAGCGATCAGCGTGGCCTACAACGCCAAGACCCAGCGTTACGGCACCTGCAATACCACCGAAACGTTACTGGTAGC
CAATGCGATTGCGCCACAGGTGCTGCCAGAGCTAGCGGGCAAGTACCAACAGGCCGGCGTGGAGCTACGCGGTTGTGATA
AGGCCCGTCGGCTCCTGACAGAAGCAGGCATCACCGGCATGGTGGAAGCCTCCAACAGCGACTGGGAAGAGGAATTCCTG
GCGCCGGTGCTCGCGGTAAAAATCGTTGACGGTATTAATGACGCCATCGAACATATCAACCGCTATAGTTCGGGCCATAC
CGAAGCCATCATTACCGAAAACTACACCTTGGCTCGCAGGTTTCTCACCGAAGTGGACTCCAGTTCAGTGATGGTGAATG
CCTCCACCCGTTTTGCTGACGGGTTCGAATACGGGCTGGGTGCCGAGATCGGCATTTCCACCGATAAAATCCATGCCCGC
GGCCCAGTGGGTCTAGAAGGGCTGACCAGCCAGAAATGGGTGGTGTTGGGTGATGGGCATATACGGCTGTAA

Upstream 100 bases:

>100_bases
GGCACCCGGCTCCTCTACCTTATAGGCGGGTTTAGATCCCACAGTAACGTAGCAGCCCGGCACAGCCCGCAAGCCATCAA
CCGATTTAACGCAGAGATTT

Downstream 100 bases:

>100_bases
ACGCCAGATGCAGGATGCCGGATACCTAACGCCAAACACGGAGGCGTGCTTTGCATAACGTCCAACATGCGGCGTCCGGC
GGCCGGCCTTTGGTTCTCTT

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MDIQQYMQRLGEQARQASRAMARASSSDKDKALAAIAGALRSHRNAILQANQQDLDAGRNNGLDAALLDRLELTPDRFDG
MVEGLEQIIGLADPIGVITDLAYRPSGIQVGKMRVPLGVIGIIYESRPNVTVDAAALCLKSGNAAILRGGSEAINANQAI
AECIREGLREAGLPDTAVQVVETTDRAAVGELISHPEFVDVIVPRGGKGLIERISNDARVPVIKHLDGNCHTYIDGQANI
AKAISVAYNAKTQRYGTCNTTETLLVANAIAPQVLPELAGKYQQAGVELRGCDKARRLLTEAGITGMVEASNSDWEEEFL
APVLAVKIVDGINDAIEHINRYSSGHTEAIITENYTLARRFLTEVDSSSVMVNASTRFADGFEYGLGAEIGISTDKIHAR
GPVGLEGLTSQKWVVLGDGHIRL

Sequences:

>Translated_423_residues
MDIQQYMQRLGEQARQASRAMARASSSDKDKALAAIAGALRSHRNAILQANQQDLDAGRNNGLDAALLDRLELTPDRFDG
MVEGLEQIIGLADPIGVITDLAYRPSGIQVGKMRVPLGVIGIIYESRPNVTVDAAALCLKSGNAAILRGGSEAINANQAI
AECIREGLREAGLPDTAVQVVETTDRAAVGELISHPEFVDVIVPRGGKGLIERISNDARVPVIKHLDGNCHTYIDGQANI
AKAISVAYNAKTQRYGTCNTTETLLVANAIAPQVLPELAGKYQQAGVELRGCDKARRLLTEAGITGMVEASNSDWEEEFL
APVLAVKIVDGINDAIEHINRYSSGHTEAIITENYTLARRFLTEVDSSSVMVNASTRFADGFEYGLGAEIGISTDKIHAR
GPVGLEGLTSQKWVVLGDGHIRL
>Mature_423_residues
MDIQQYMQRLGEQARQASRAMARASSSDKDKALAAIAGALRSHRNAILQANQQDLDAGRNNGLDAALLDRLELTPDRFDG
MVEGLEQIIGLADPIGVITDLAYRPSGIQVGKMRVPLGVIGIIYESRPNVTVDAAALCLKSGNAAILRGGSEAINANQAI
AECIREGLREAGLPDTAVQVVETTDRAAVGELISHPEFVDVIVPRGGKGLIERISNDARVPVIKHLDGNCHTYIDGQANI
AKAISVAYNAKTQRYGTCNTTETLLVANAIAPQVLPELAGKYQQAGVELRGCDKARRLLTEAGITGMVEASNSDWEEEFL
APVLAVKIVDGINDAIEHINRYSSGHTEAIITENYTLARRFLTEVDSSSVMVNASTRFADGFEYGLGAEIGISTDKIHAR
GPVGLEGLTSQKWVVLGDGHIRL

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI21361368, Length=418, Percent_Identity=34.688995215311, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI62912457, Length=418, Percent_Identity=34.688995215311, Blast_Score=249, Evalue=3e-66,
Organism=Escherichia coli, GI1786438, Length=416, Percent_Identity=46.875, Blast_Score=374, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17569967, Length=420, Percent_Identity=36.6666666666667, Blast_Score=262, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI17569969, Length=420, Percent_Identity=36.6666666666667, Blast_Score=262, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6324899, Length=429, Percent_Identity=40.0932400932401, Blast_Score=301, Evalue=9e-83,
Organism=Drosophila melanogaster, GI21357643, Length=414, Percent_Identity=35.9903381642512, Blast_Score=263, Evalue=2e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_ALCBS (Q0VN49)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_693671.1
- ProteinModelPortal:   Q0VN49
- SMR:   Q0VN49
- STRING:   Q0VN49
- GeneID:   4211219
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_1951
- NMPDR:   fig|393595.12.peg.1952
- eggNOG:   COG0014
- HOGENOM:   HBG318080
- OMA:   QYPAACN
- PhylomeDB:   Q0VN49
- BioCyc:   ABOR393595:ABO_1951-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 45300; Mature: 45300

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIQQYMQRLGEQARQASRAMARASSSDKDKALAAIAGALRSHRNAILQANQQDLDAGRN
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCC
NGLDAALLDRLELTPDRFDGMVEGLEQIIGLADPIGVITDLAYRPSGIQVGKMRVPLGVI
CCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEECEEECCEEEE
GIIYESRPNVTVDAAALCLKSGNAAILRGGSEAINANQAIAECIREGLREAGLPDTAVQV
EEEEECCCCEEHHHHHHHHHCCCEEEEECCCHHCCHHHHHHHHHHHHHHHCCCCHHHHHH
VETTDRAAVGELISHPEFVDVIVPRGGKGLIERISNDARVPVIKHLDGNCHTYIDGQANI
HHHCCHHHHHHHHCCCCEEEEEECCCCHHHHHHCCCCCCCCEEEECCCCEEEEECCCHHH
AKAISVAYNAKTQRYGTCNTTETLLVANAIAPQVLPELAGKYQQAGVELRGCDKARRLLT
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHH
EAGITGMVEASNSDWEEEFLAPVLAVKIVDGINDAIEHINRYSSGHTEAIITENYTLARR
HCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHH
FLTEVDSSSVMVNASTRFADGFEYGLGAEIGISTDKIHARGPVGLEGLTSQKWVVLGDGH
HHHHCCCCCEEEECCCCCCCCCCCCCCCEECCCCCCEECCCCCCCCCCCCCCEEEECCCC
IRL
EEC
>Mature Secondary Structure
MDIQQYMQRLGEQARQASRAMARASSSDKDKALAAIAGALRSHRNAILQANQQDLDAGRN
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCC
NGLDAALLDRLELTPDRFDGMVEGLEQIIGLADPIGVITDLAYRPSGIQVGKMRVPLGVI
CCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCEECEEECCEEEE
GIIYESRPNVTVDAAALCLKSGNAAILRGGSEAINANQAIAECIREGLREAGLPDTAVQV
EEEEECCCCEEHHHHHHHHHCCCEEEEECCCHHCCHHHHHHHHHHHHHHHCCCCHHHHHH
VETTDRAAVGELISHPEFVDVIVPRGGKGLIERISNDARVPVIKHLDGNCHTYIDGQANI
HHHCCHHHHHHHHCCCCEEEEEECCCCHHHHHHCCCCCCCCEEEECCCCEEEEECCCHHH
AKAISVAYNAKTQRYGTCNTTETLLVANAIAPQVLPELAGKYQQAGVELRGCDKARRLLT
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHH
EAGITGMVEASNSDWEEEFLAPVLAVKIVDGINDAIEHINRYSSGHTEAIITENYTLARR
HCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHH
FLTEVDSSSVMVNASTRFADGFEYGLGAEIGISTDKIHARGPVGLEGLTSQKWVVLGDGH
HHHHCCCCCEEEECCCCCCCCCCCCCCCEECCCCCCEECCCCCCCCCCCCCCEEEECCCC
IRL
EEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA