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The map label for this gene is holA [H]

Identifier: 110834810

GI number: 110834810

Start: 2228631

End: 2229644

Strand: Direct

Name: holA [H]

Synonym: ABO_1949

Alternate gene names: 110834810

Gene position: 2228631-2229644 (Clockwise)

Preceding gene: 110834809

Following gene: 110834811

Centisome position: 71.43

GC content: 59.96

Gene sequence:

>1014_bases
ATGCGCCTGCGTCCCGAACAACTTGGCAAGCACCTGTCCGCGACGCTGTTGCCCGTTTATCTAGTTGCCGGTGACGAACC
CCTACAGCAAGGCGAACTCATCGACGATTTACGCCGAGCGGCTCGCGACCAAGGCTTTGACGAACGCCAACGCTTTTCCA
GTGATACCGGCATCGACTGGAACGCCCTGCTCAATGAATCACAGAGCATGAGCCTGTTTGGTGGCCGCCGGATTCTTGAA
CTGGTCCTGAACGACAAACGCCCGGATAAAACCGGCAGCCAAATTCTTCGTGATGTTCTCGCCAGCCTGAAAGGCGAAGC
CAGTAGCGACACCCTGTTATTGATTCGTTGCTCGCGACTGGATCGACGCAAGGACTGGAATAGCGCCTGGGTAAAAGCCC
TAGATGAAATGGGCGCAGTGATTGAAGTCTGGCCTGTAGAAGGAAATGGCCTACGCAACTGGCTACAGGAACGCCTAACC
AGCCGCGGGCTGCGCGCCAGTGAAGACGCCCTCGCCCTGCTGATCGAACGCAGTGAAGGTAATCTGCTGGCCGCCGCTCA
AGAAGTGGACAAACTGGCCCTGCTAGTGGAAGACGGCCAAGTCGGGCCGGAAGACGTGCAGCAAGCAGTGGGCGACTCCA
GCCGCTACTCGCCGTTCGATCTCACCGACGCCACCGCCCAAGGTGATAGCCAACGGGTCATGCACATCATCCAGACCCTT
CGCGCTGAAGGCGTAGAACCCCCTGTATTACTGTGGGCCTTGAGCCGCGACATCCGCCTGCTCGATGGCATGCTCGGCGG
CGGACCGCCCCCGCGCCTGCCCCCGCAAAGGGTACGCGCCATGCAGAATCAGGCCCAACGCCTTAACCCCCAGCAATTAC
GCATTGCCCAAGCCTGCGCCATCCGCGCCGACCAATGCGTCAAAGGCATGGCCAAAGGCGACCCTTGGAAACACATCATT
TCTCTGGCTCTGCGCCTAGCCGGCCACCCCCTGCCCCGCAGTATGGAACGGTAA

Upstream 100 bases:

>100_bases
CAGATGAAGAGCAACTGGTGCGCGACGACTTGTACGAAGATATGACCTTCCGGCTGATCAACCAGATCGCTGCGGCCTCT
AAGGGGTGGGAGACCTACTA

Downstream 100 bases:

>100_bases
AGCTCCGATCCGTAGCCGTTCCTTTTGAGGAACAAAATCAAGAACCGACTTTCTGTGAGAGCCTACCTGCAAGCAAAGGC
TGCAACACGACTAAGGCCCG

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MRLRPEQLGKHLSATLLPVYLVAGDEPLQQGELIDDLRRAARDQGFDERQRFSSDTGIDWNALLNESQSMSLFGGRRILE
LVLNDKRPDKTGSQILRDVLASLKGEASSDTLLLIRCSRLDRRKDWNSAWVKALDEMGAVIEVWPVEGNGLRNWLQERLT
SRGLRASEDALALLIERSEGNLLAAAQEVDKLALLVEDGQVGPEDVQQAVGDSSRYSPFDLTDATAQGDSQRVMHIIQTL
RAEGVEPPVLLWALSRDIRLLDGMLGGGPPPRLPPQRVRAMQNQAQRLNPQQLRIAQACAIRADQCVKGMAKGDPWKHII
SLALRLAGHPLPRSMER

Sequences:

>Translated_337_residues
MRLRPEQLGKHLSATLLPVYLVAGDEPLQQGELIDDLRRAARDQGFDERQRFSSDTGIDWNALLNESQSMSLFGGRRILE
LVLNDKRPDKTGSQILRDVLASLKGEASSDTLLLIRCSRLDRRKDWNSAWVKALDEMGAVIEVWPVEGNGLRNWLQERLT
SRGLRASEDALALLIERSEGNLLAAAQEVDKLALLVEDGQVGPEDVQQAVGDSSRYSPFDLTDATAQGDSQRVMHIIQTL
RAEGVEPPVLLWALSRDIRLLDGMLGGGPPPRLPPQRVRAMQNQAQRLNPQQLRIAQACAIRADQCVKGMAKGDPWKHII
SLALRLAGHPLPRSMER
>Mature_337_residues
MRLRPEQLGKHLSATLLPVYLVAGDEPLQQGELIDDLRRAARDQGFDERQRFSSDTGIDWNALLNESQSMSLFGGRRILE
LVLNDKRPDKTGSQILRDVLASLKGEASSDTLLLIRCSRLDRRKDWNSAWVKALDEMGAVIEVWPVEGNGLRNWLQERLT
SRGLRASEDALALLIERSEGNLLAAAQEVDKLALLVEDGQVGPEDVQQAVGDSSRYSPFDLTDATAQGDSQRVMHIIQTL
RAEGVEPPVLLWALSRDIRLLDGMLGGGPPPRLPPQRVRAMQNQAQRLNPQQLRIAQACAIRADQCVKGMAKGDPWKHII
SLALRLAGHPLPRSMER

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=340, Percent_Identity=34.4117647058824, Blast_Score=157, Evalue=8e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 37471; Mature: 37471

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLRPEQLGKHLSATLLPVYLVAGDEPLQQGELIDDLRRAARDQGFDERQRFSSDTGIDW
CCCCHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHCCCCCCCCH
NALLNESQSMSLFGGRRILELVLNDKRPDKTGSQILRDVLASLKGEASSDTLLLIRCSRL
HHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHH
DRRKDWNSAWVKALDEMGAVIEVWPVEGNGLRNWLQERLTSRGLRASEDALALLIERSEG
HCCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCC
NLLAAAQEVDKLALLVEDGQVGPEDVQQAVGDSSRYSPFDLTDATAQGDSQRVMHIIQTL
CEEHHHHHHHHHEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
RAEGVEPPVLLWALSRDIRLLDGMLGGGPPPRLPPQRVRAMQNQAQRLNPQQLRIAQACA
HHCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHH
IRADQCVKGMAKGDPWKHIISLALRLAGHPLPRSMER
HHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MRLRPEQLGKHLSATLLPVYLVAGDEPLQQGELIDDLRRAARDQGFDERQRFSSDTGIDW
CCCCHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHCCCCCCCCH
NALLNESQSMSLFGGRRILELVLNDKRPDKTGSQILRDVLASLKGEASSDTLLLIRCSRL
HHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHH
DRRKDWNSAWVKALDEMGAVIEVWPVEGNGLRNWLQERLTSRGLRASEDALALLIERSEG
HCCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCC
NLLAAAQEVDKLALLVEDGQVGPEDVQQAVGDSSRYSPFDLTDATAQGDSQRVMHIIQTL
CEEHHHHHHHHHEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
RAEGVEPPVLLWALSRDIRLLDGMLGGGPPPRLPPQRVRAMQNQAQRLNPQQLRIAQACA
HHCCCCCCEEEHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHH
IRADQCVKGMAKGDPWKHIISLALRLAGHPLPRSMER
HHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]