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The map label for this gene is dhbE [H]

Identifier: 110834667

GI number: 110834667

Start: 2056271

End: 2057890

Strand: Direct

Name: dhbE [H]

Synonym: ABO_1806

Alternate gene names: 110834667

Gene position: 2056271-2057890 (Clockwise)

Preceding gene: 110834651

Following gene: 110834669

Centisome position: 65.9

GC content: 56.85

Gene sequence:

>1620_bases
ATGATTTTGCACAAACCTGAACTGGTTGAGAAATATACGAACATGGGGCACTGGGGGGACAAGACCCTGCTCCAGCGCGC
GGCCGCCAATTGTATCGCCCACCCAGAGCGAGAAGCGGTGGTGGATCCCCCCAACCGGAACGAGCTGGTGGGCACCCCCG
CCCAGCGCCTCACCTGGGCAGAGTTCGGCCAGGCAGTGGATGCTACGGCAGCAGAATTGTCGCGCCGCGGCTTTGGTAAG
GACGACGTATTAGTGGCCCAGTTACCCAACGTGTGGGAGCTGGCCATGTTGTACCTAGCCGCAGCAAAGGCCGGCGGCTT
GCTTTCTGCACTGCCTATGCAATGGCGAAGCAAGGATGTGGGTTATGTGAAAAAAATGACCGAGGCCCGCTTCTACGCGT
CGGCTGAGAGCTTTCACGGCTTTGATTACCAAGCTCTAGGCCAGGAGTTGGGTTTCGAGCACTACATCGGCCTGAAAGAA
CTGACCGATATTGCCCGCAGCAAACCCAGCCAGGGACCTGAGGTGCCAGTAGAAGCCAATGATATTTTTACGCTGTGCTG
GACATCTGGCACTGAGGCAGACCCTAAAGGCTGCCCCATGAGCCACAACAACTGGGAGTACATGATTAACCTCGTGTTCA
CCACCTGTGGCTTGCAGCAGGGCGACCGGATTCTATGCGTGGCGCCCCTGGTAAACATGACAGCGGTGGGGGTGAACTAC
GTACCTTGGCTAGCGACAGCAGGGACCCTAGTGCTGCACCATCCCATCACGCCGGAGATCTTGCTGCGCCAGCTTACCGA
AGAGCGCATTCAATATACCATCCTAGTACCGGCGATGCTGAACATGATCGCCAAACTGCCCAACGTGGACCAGCTCGATC
TGTCCAGCGTGCGGACCATCACCACCGGGTCAGCACCGCCTTCTGCCTGGTCCATGCAGGAGTTCAAGCGCCGCTGGGAT
ATCGACATCGTCAATATCTGGGGCCAGAACGAAGGCTCCTGCCTAGTGGCCGGCCCCGCCGACGTACCGGACCTGGCTAT
GCGGGTGGATCATCTACCCTGGTGGGGCAGAGAAAGCGTCGAATGGCCCTCCGGCATCAATGGCATTGAAGTGAAGATTC
TCGGCGACCAAGATGAAGAGATCACCGAGCCCGGAGGCATCGGAGAGCTTTGCTACCGAAGCCCGGGGGTCTTTGCCGGT
TACTTCCAACGCCCGGACATCACCGAGCAGTCTTTCACCGCTGACGGTTTCTTCCGCACCGGAGACCTGTTCATTGTGCA
AAATGCCAACCACGTAGGCTTTTACGATCGCAAGAAAGACATGGTGATCCGCGGAGGCTTCAACATCTCCAGTGTCGAGG
TGGAAAACGCCGTGCTTGGCTTTGATAAGGTGCAAGACGTTGCCGTCATACCCCACCCGGACGAAATCATGGGGGAGCGT
GTCTGCATTTGCGTGGTGCCTGCGGATGAGAGCCATCCGCCAGCGTTAGAGGAAATCAATGACTACCTGAAGAGTCAGGG
TATGAGTGTTTACAAGCTTCCCGAAAAGATGAGGCTAGTAGATGTCATTCCCCGCAATCCGATAGGTAAGATCATGAAGA
AAGAATTGCGGGCTCAGTAA

Upstream 100 bases:

>100_bases
CGAAGCACTACTGGCAGGAAGTGGTCCCGAGTGTCGACGTCAACCATCATCGCTTCCAATTGGATGGCAACAACAATAAC
CGTCACAGGAGAATTAATTC

Downstream 100 bases:

>100_bases
CGCAAAAGGGCCGGAATCTTGTCTTCCGGCCCTTTTTATTGCACTTCTATATCCATTTTTACAGGCTGTACTCATCGGGG
ACACGCACAAAATCAAGACA

Product: AMP-binding family protein

Products: NA

Alternate protein names: Dihydroxybenzoic acid-activating enzyme [H]

Number of amino acids: Translated: 539; Mature: 539

Protein sequence:

>539_residues
MILHKPELVEKYTNMGHWGDKTLLQRAAANCIAHPEREAVVDPPNRNELVGTPAQRLTWAEFGQAVDATAAELSRRGFGK
DDVLVAQLPNVWELAMLYLAAAKAGGLLSALPMQWRSKDVGYVKKMTEARFYASAESFHGFDYQALGQELGFEHYIGLKE
LTDIARSKPSQGPEVPVEANDIFTLCWTSGTEADPKGCPMSHNNWEYMINLVFTTCGLQQGDRILCVAPLVNMTAVGVNY
VPWLATAGTLVLHHPITPEILLRQLTEERIQYTILVPAMLNMIAKLPNVDQLDLSSVRTITTGSAPPSAWSMQEFKRRWD
IDIVNIWGQNEGSCLVAGPADVPDLAMRVDHLPWWGRESVEWPSGINGIEVKILGDQDEEITEPGGIGELCYRSPGVFAG
YFQRPDITEQSFTADGFFRTGDLFIVQNANHVGFYDRKKDMVIRGGFNISSVEVENAVLGFDKVQDVAVIPHPDEIMGER
VCICVVPADESHPPALEEINDYLKSQGMSVYKLPEKMRLVDVIPRNPIGKIMKKELRAQ

Sequences:

>Translated_539_residues
MILHKPELVEKYTNMGHWGDKTLLQRAAANCIAHPEREAVVDPPNRNELVGTPAQRLTWAEFGQAVDATAAELSRRGFGK
DDVLVAQLPNVWELAMLYLAAAKAGGLLSALPMQWRSKDVGYVKKMTEARFYASAESFHGFDYQALGQELGFEHYIGLKE
LTDIARSKPSQGPEVPVEANDIFTLCWTSGTEADPKGCPMSHNNWEYMINLVFTTCGLQQGDRILCVAPLVNMTAVGVNY
VPWLATAGTLVLHHPITPEILLRQLTEERIQYTILVPAMLNMIAKLPNVDQLDLSSVRTITTGSAPPSAWSMQEFKRRWD
IDIVNIWGQNEGSCLVAGPADVPDLAMRVDHLPWWGRESVEWPSGINGIEVKILGDQDEEITEPGGIGELCYRSPGVFAG
YFQRPDITEQSFTADGFFRTGDLFIVQNANHVGFYDRKKDMVIRGGFNISSVEVENAVLGFDKVQDVAVIPHPDEIMGER
VCICVVPADESHPPALEEINDYLKSQGMSVYKLPEKMRLVDVIPRNPIGKIMKKELRAQ
>Mature_539_residues
MILHKPELVEKYTNMGHWGDKTLLQRAAANCIAHPEREAVVDPPNRNELVGTPAQRLTWAEFGQAVDATAAELSRRGFGK
DDVLVAQLPNVWELAMLYLAAAKAGGLLSALPMQWRSKDVGYVKKMTEARFYASAESFHGFDYQALGQELGFEHYIGLKE
LTDIARSKPSQGPEVPVEANDIFTLCWTSGTEADPKGCPMSHNNWEYMINLVFTTCGLQQGDRILCVAPLVNMTAVGVNY
VPWLATAGTLVLHHPITPEILLRQLTEERIQYTILVPAMLNMIAKLPNVDQLDLSSVRTITTGSAPPSAWSMQEFKRRWD
IDIVNIWGQNEGSCLVAGPADVPDLAMRVDHLPWWGRESVEWPSGINGIEVKILGDQDEEITEPGGIGELCYRSPGVFAG
YFQRPDITEQSFTADGFFRTGDLFIVQNANHVGFYDRKKDMVIRGGFNISSVEVENAVLGFDKVQDVAVIPHPDEIMGER
VCICVVPADESHPPALEEINDYLKSQGMSVYKLPEKMRLVDVIPRNPIGKIMKKELRAQ

Specific function: Activation of the carboxylate group of 2,3-dihydroxy- benzoate (DHB), via ATP-dependent PPi exchange reactions, to the acyladenylate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=566, Percent_Identity=25.4416961130742, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI187761345, Length=400, Percent_Identity=27, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI187761343, Length=400, Percent_Identity=27, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI58082049, Length=493, Percent_Identity=25.5578093306288, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI157311624, Length=493, Percent_Identity=24.7464503042596, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI157311622, Length=493, Percent_Identity=24.7464503042596, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI122937307, Length=513, Percent_Identity=22.4171539961014, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI42544132, Length=514, Percent_Identity=23.3463035019455, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI38505220, Length=487, Percent_Identity=21.5605749486653, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI115511026, Length=499, Percent_Identity=22.6452905811623, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI28416953, Length=405, Percent_Identity=24.9382716049383, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI145693145, Length=546, Percent_Identity=27.2893772893773, Blast_Score=179, Evalue=5e-46,
Organism=Escherichia coli, GI1786810, Length=548, Percent_Identity=24.6350364963504, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI221142682, Length=512, Percent_Identity=25, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1788107, Length=375, Percent_Identity=28.5333333333333, Blast_Score=132, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17559526, Length=534, Percent_Identity=25.6554307116105, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17558820, Length=495, Percent_Identity=24.6464646464646, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI32563687, Length=488, Percent_Identity=24.7950819672131, Blast_Score=135, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17557194, Length=521, Percent_Identity=24.9520153550864, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17538037, Length=526, Percent_Identity=23.9543726235741, Blast_Score=125, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17531443, Length=570, Percent_Identity=22.8070175438596, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71994703, Length=547, Percent_Identity=22.6691042047532, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71994694, Length=547, Percent_Identity=22.6691042047532, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI71994690, Length=547, Percent_Identity=22.6691042047532, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17560308, Length=529, Percent_Identity=24.3856332703214, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71985884, Length=384, Percent_Identity=24.21875, Blast_Score=93, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6319699, Length=360, Percent_Identity=23.8888888888889, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24581924, Length=534, Percent_Identity=23.0337078651685, Blast_Score=116, Evalue=4e-26,
Organism=Drosophila melanogaster, GI18859661, Length=511, Percent_Identity=23.8747553816047, Blast_Score=112, Evalue=8e-25,
Organism=Drosophila melanogaster, GI21355181, Length=495, Percent_Identity=24.040404040404, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21356441, Length=358, Percent_Identity=24.8603351955307, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24653035, Length=385, Percent_Identity=21.8181818181818, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI281365686, Length=344, Percent_Identity=22.9651162790698, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI161076582, Length=393, Percent_Identity=22.1374045801527, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24648253, Length=357, Percent_Identity=22.4089635854342, Blast_Score=76, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24648255, Length=358, Percent_Identity=22.3463687150838, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21358303, Length=483, Percent_Identity=20.2898550724638, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR011963 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: NA

Molecular weight: Translated: 59960; Mature: 59960

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILHKPELVEKYTNMGHWGDKTLLQRAAANCIAHPEREAVVDPPNRNELVGTPAQRLTWA
CCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHH
EFGQAVDATAAELSRRGFGKDDVLVAQLPNVWELAMLYLAAAKAGGLLSALPMQWRSKDV
HHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCH
GYVKKMTEARFYASAESFHGFDYQALGQELGFEHYIGLKELTDIARSKPSQGPEVPVEAN
HHHHHHHHHHHHCCHHHCCCCCHHHHHHHCCHHHHCCHHHHHHHHHCCCCCCCCCCCCCC
DIFTLCWTSGTEADPKGCPMSHNNWEYMINLVFTTCGLQQGDRILCVAPLVNMTAVGVNY
CEEEEEECCCCCCCCCCCCCCCCCHHHEEEEHHHHCCCCCCCEEEEEECCHHHHHCCCCH
VPWLATAGTLVLHHPITPEILLRQLTEERIQYTILVPAMLNMIAKLPNVDQLDLSSVRTI
HHHHHCCCEEEEECCCCHHHHHHHHHHHHHEEEEEHHHHHHHHHHCCCCCCCCCCCCEEE
TTGSAPPSAWSMQEFKRRWDIDIVNIWGQNEGSCLVAGPADVPDLAMRVDHLPWWGRESV
ECCCCCCCCCCHHHHHHHCCCEEEEEECCCCCCEEEECCCCCHHHHHHHHCCCCCCCCCC
EWPSGINGIEVKILGDQDEEITEPGGIGELCYRSPGVFAGYFQRPDITEQSFTADGFFRT
CCCCCCCCEEEEEECCCCHHHCCCCCCCHHHHCCCCCEEEECCCCCCCCCCCCCCCEEEE
GDLFIVQNANHVGFYDRKKDMVIRGGFNISSVEVENAVLGFDKVQDVAVIPHPDEIMGER
CCEEEEECCCCCCEECCCCCEEEECCCCCCEEEHHHHHCCCCCCCCEEECCCCHHHCCCE
VCICVVPADESHPPALEEINDYLKSQGMSVYKLPEKMRLVDVIPRNPIGKIMKKELRAQ
EEEEEEECCCCCCCHHHHHHHHHHHCCCEEEECCCHHEEEEECCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MILHKPELVEKYTNMGHWGDKTLLQRAAANCIAHPEREAVVDPPNRNELVGTPAQRLTWA
CCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHH
EFGQAVDATAAELSRRGFGKDDVLVAQLPNVWELAMLYLAAAKAGGLLSALPMQWRSKDV
HHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCH
GYVKKMTEARFYASAESFHGFDYQALGQELGFEHYIGLKELTDIARSKPSQGPEVPVEAN
HHHHHHHHHHHHCCHHHCCCCCHHHHHHHCCHHHHCCHHHHHHHHHCCCCCCCCCCCCCC
DIFTLCWTSGTEADPKGCPMSHNNWEYMINLVFTTCGLQQGDRILCVAPLVNMTAVGVNY
CEEEEEECCCCCCCCCCCCCCCCCHHHEEEEHHHHCCCCCCCEEEEEECCHHHHHCCCCH
VPWLATAGTLVLHHPITPEILLRQLTEERIQYTILVPAMLNMIAKLPNVDQLDLSSVRTI
HHHHHCCCEEEEECCCCHHHHHHHHHHHHHEEEEEHHHHHHHHHHCCCCCCCCCCCCEEE
TTGSAPPSAWSMQEFKRRWDIDIVNIWGQNEGSCLVAGPADVPDLAMRVDHLPWWGRESV
ECCCCCCCCCCHHHHHHHCCCEEEEEECCCCCCEEEECCCCCHHHHHHHHCCCCCCCCCC
EWPSGINGIEVKILGDQDEEITEPGGIGELCYRSPGVFAGYFQRPDITEQSFTADGFFRT
CCCCCCCCEEEEEECCCCHHHCCCCCCCHHHHCCCCCEEEECCCCCCCCCCCCCCCEEEE
GDLFIVQNANHVGFYDRKKDMVIRGGFNISSVEVENAVLGFDKVQDVAVIPHPDEIMGER
CCEEEEECCCCCCEECCCCCEEEECCCCCCEEEHHHHHCCCCCCCCEEECCCCHHHCCCE
VCICVVPADESHPPALEEINDYLKSQGMSVYKLPEKMRLVDVIPRNPIGKIMKKELRAQ
EEEEEEECCCCCCCHHHHHHHHHHHCCCEEEECCCHHEEEEECCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8921902; 9384377; 8224884; 12221282 [H]