Click here to switch to the map view.

The map label for this gene is gltA [H]

Identifier: 110834362

GI number: 110834362

Start: 1713356

End: 1714639

Strand: Direct

Name: gltA [H]

Synonym: ABO_1501

Alternate gene names: 110834362

Gene position: 1713356-1714639 (Clockwise)

Preceding gene: 110834352

Following gene: 110834363

Centisome position: 54.91

GC content: 53.89

Gene sequence:

>1284_bases
ATGACCGAGAAGAAAGCCACTCTCAAGGTAGAGGGTCAGGACCTGGACCTGCCGATCTACACCCCTACTCTGGGCCGCGA
CGTTATCGACGTGTCCAAACTGGTAGCCAACGGCGTCTTTACTTTCGACCCGGGTTTCACCTCTACCGCTTCCTGTGAAT
CCAAAATCACCTTTATCGATGGTGAAGTGGGTAAACTTCTGCACCGCGGCTACTCTATCGAGGAGCTAGCAGGTCAGTCT
GAATATCTGGAAGTGTGCTACACCCTGCTGTACGGCGAACTGCCCACCGCAGAACAGAAAGAAAAGTTTGTCAGCACGGT
GAAAAACCACACCATGGTGCACGAGCAGATTCGTAATTTCTTCAACGGTTTCCGCCGTGATGCGCACCCCATGGCCATCA
TGTGTGGCGTAGTGGGCGCCCTGTCCGCCTTCTACCACGACTCTCTGGACATCAACAATCCTGAGCACCGTGAAATCACT
GCGTACCGTCTGATCGCCAAGATGCCTACCATCGCGGCCATGTGCTATAAGTACGCTTTGGGCCAGCCTTTCATGTACCC
ACGCAACGACTTGGGTTATGCGGAAAACTTTCTGCATATGATGTTCGGCAACCCCTGTGAAGAATCCAAGATCAGCCCGA
CCCTGGCCAAGGCCATGGACCGTATTTTTATCCTGCACGCTGATCACGAGCAGAACGCCTCCACCTCCACCGTACGCTTG
GCTGGTTCCTCTGGCGCCAACCCGTTCGCCTGTATTGCTGCGGGCATTTCTGCCCTGTGGGGCCCGGCACACGGCGGCGC
TAACGAAGCCGTACTGAACATGCTTGATGAAATCGGCTCACTGGATAACATCGACGCCTACATCGCCAAAGCAAAAGACA
AGAACGACCCGTTCAAGCTGATGGGCTTCGGCCATCGCGTTTACAAAAATTATGACCCCCGTGCCACCGTGATGCGCGAA
TCTTGCCACGAAGTATTGGCCGAACTGGGCGTAAATGATCCGCAGCTGGCGCTGGCCATGAAGCTGGAAGAGATCGCCCT
AAATGACCCCTACTTTAAAGAGAAAAAGTTGTTCCCCAACGTGGACTTCTACTCCGGCATCATCTTGAAAGCGATTGGAA
TTCCCACTTCCATGTTCACCGTAATCTTTGCCCTGTCTCGCACCGTTGGCTGGATTGCACACTGGAACGAAATGATCTCC
AACCCGTACAAGATTGGTCGTCCGCGTCAGCTGTACACCGGCGAAGCCGAACGTTCATTCGTTCCGGTCAACGAGCGCAA
ATAA

Upstream 100 bases:

>100_bases
GCGTTGACAAAGGTGTGTCAAAACCTTACCTTCCCCCGCGTTTTGGAGGACCTTCCTTACCTTGAGGAACGTTCCCTCGT
CCGCCAATGGAGAGATTCCC

Downstream 100 bases:

>100_bases
GCGCTTCGTTATCGCCCGACAAAAAAACCGCCTTCCGGCGGTTTTTTTGTGCCTGCAGATACATCAACCTGAAAAATATT
CTTCCAAAGTTCACTAAAAA

Product: type II citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MTEKKATLKVEGQDLDLPIYTPTLGRDVIDVSKLVANGVFTFDPGFTSTASCESKITFIDGEVGKLLHRGYSIEELAGQS
EYLEVCYTLLYGELPTAEQKEKFVSTVKNHTMVHEQIRNFFNGFRRDAHPMAIMCGVVGALSAFYHDSLDINNPEHREIT
AYRLIAKMPTIAAMCYKYALGQPFMYPRNDLGYAENFLHMMFGNPCEESKISPTLAKAMDRIFILHADHEQNASTSTVRL
AGSSGANPFACIAAGISALWGPAHGGANEAVLNMLDEIGSLDNIDAYIAKAKDKNDPFKLMGFGHRVYKNYDPRATVMRE
SCHEVLAELGVNDPQLALAMKLEEIALNDPYFKEKKLFPNVDFYSGIILKAIGIPTSMFTVIFALSRTVGWIAHWNEMIS
NPYKIGRPRQLYTGEAERSFVPVNERK

Sequences:

>Translated_427_residues
MTEKKATLKVEGQDLDLPIYTPTLGRDVIDVSKLVANGVFTFDPGFTSTASCESKITFIDGEVGKLLHRGYSIEELAGQS
EYLEVCYTLLYGELPTAEQKEKFVSTVKNHTMVHEQIRNFFNGFRRDAHPMAIMCGVVGALSAFYHDSLDINNPEHREIT
AYRLIAKMPTIAAMCYKYALGQPFMYPRNDLGYAENFLHMMFGNPCEESKISPTLAKAMDRIFILHADHEQNASTSTVRL
AGSSGANPFACIAAGISALWGPAHGGANEAVLNMLDEIGSLDNIDAYIAKAKDKNDPFKLMGFGHRVYKNYDPRATVMRE
SCHEVLAELGVNDPQLALAMKLEEIALNDPYFKEKKLFPNVDFYSGIILKAIGIPTSMFTVIFALSRTVGWIAHWNEMIS
NPYKIGRPRQLYTGEAERSFVPVNERK
>Mature_426_residues
TEKKATLKVEGQDLDLPIYTPTLGRDVIDVSKLVANGVFTFDPGFTSTASCESKITFIDGEVGKLLHRGYSIEELAGQSE
YLEVCYTLLYGELPTAEQKEKFVSTVKNHTMVHEQIRNFFNGFRRDAHPMAIMCGVVGALSAFYHDSLDINNPEHREITA
YRLIAKMPTIAAMCYKYALGQPFMYPRNDLGYAENFLHMMFGNPCEESKISPTLAKAMDRIFILHADHEQNASTSTVRLA
GSSGANPFACIAAGISALWGPAHGGANEAVLNMLDEIGSLDNIDAYIAKAKDKNDPFKLMGFGHRVYKNYDPRATVMRES
CHEVLAELGVNDPQLALAMKLEEIALNDPYFKEKKLFPNVDFYSGIILKAIGIPTSMFTVIFALSRTVGWIAHWNEMISN
PYKIGRPRQLYTGEAERSFVPVNERK

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=388, Percent_Identity=27.5773195876289, Blast_Score=115, Evalue=5e-26,
Organism=Escherichia coli, GI1786939, Length=421, Percent_Identity=70.5463182897862, Blast_Score=643, Evalue=0.0,
Organism=Escherichia coli, GI1786527, Length=371, Percent_Identity=32.3450134770889, Blast_Score=169, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17555174, Length=398, Percent_Identity=26.8844221105528, Blast_Score=106, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6319850, Length=364, Percent_Identity=28.021978021978, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6324328, Length=387, Percent_Identity=26.8733850129199, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6325257, Length=370, Percent_Identity=27.027027027027, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24640126, Length=405, Percent_Identity=27.6543209876543, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24640124, Length=405, Percent_Identity=27.6543209876543, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21356863, Length=367, Percent_Identity=26.4305177111717, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 47638; Mature: 47507

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKKATLKVEGQDLDLPIYTPTLGRDVIDVSKLVANGVFTFDPGFTSTASCESKITFID
CCCCCCEEEECCCCCCCEEECCCCCCHHHHHHHHHHCCCEEECCCCCCCCCCCCEEEEEC
GEVGKLLHRGYSIEELAGQSEYLEVCYTLLYGELPTAEQKEKFVSTVKNHTMVHEQIRNF
CHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FNGFRRDAHPMAIMCGVVGALSAFYHDSLDINNPEHREITAYRLIAKMPTIAAMCYKYAL
HHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GQPFMYPRNDLGYAENFLHMMFGNPCEESKISPTLAKAMDRIFILHADHEQNASTSTVRL
CCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHCEEEEEECCCCCCCCCCEEEE
AGSSGANPFACIAAGISALWGPAHGGANEAVLNMLDEIGSLDNIDAYIAKAKDKNDPFKL
ECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCEEE
MGFGHRVYKNYDPRATVMRESCHEVLAELGVNDPQLALAMKLEEIALNDPYFKEKKLFPN
EECCHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
VDFYSGIILKAIGIPTSMFTVIFALSRTVGWIAHWNEMISNPYKIGRPRQLYTGEAERSF
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCC
VPVNERK
CCCCCCC
>Mature Secondary Structure 
TEKKATLKVEGQDLDLPIYTPTLGRDVIDVSKLVANGVFTFDPGFTSTASCESKITFID
CCCCCEEEECCCCCCCEEECCCCCCHHHHHHHHHHCCCEEECCCCCCCCCCCCEEEEEC
GEVGKLLHRGYSIEELAGQSEYLEVCYTLLYGELPTAEQKEKFVSTVKNHTMVHEQIRNF
CHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FNGFRRDAHPMAIMCGVVGALSAFYHDSLDINNPEHREITAYRLIAKMPTIAAMCYKYAL
HHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GQPFMYPRNDLGYAENFLHMMFGNPCEESKISPTLAKAMDRIFILHADHEQNASTSTVRL
CCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHCEEEEEECCCCCCCCCCEEEE
AGSSGANPFACIAAGISALWGPAHGGANEAVLNMLDEIGSLDNIDAYIAKAKDKNDPFKL
ECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCEEE
MGFGHRVYKNYDPRATVMRESCHEVLAELGVNDPQLALAMKLEEIALNDPYFKEKKLFPN
EECCHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
VDFYSGIILKAIGIPTSMFTVIFALSRTVGWIAHWNEMISNPYKIGRPRQLYTGEAERSF
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCC
VPVNERK
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2507528; 10984043 [H]