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The map label for this gene is gltP [H]

Identifier: 110834339

GI number: 110834339

Start: 1685981

End: 1687285

Strand: Direct

Name: gltP [H]

Synonym: ABO_1478

Alternate gene names: 110834339

Gene position: 1685981-1687285 (Clockwise)

Preceding gene: 110834338

Following gene: 110834340

Centisome position: 54.04

GC content: 55.33

Gene sequence:

>1305_bases
ATGATGAAATTACATCACCAGATATTTTTTGCCATGCTGGCCGGCACTCTGGCCGGCAGTTTTACTGCGGAATCCAGCAC
CCTCTTGGGAATGCCGATTATCAGCGGTTACGATCTGGTGGGCAGCCTGTTCATCAATGCACTGAAGATGGTGGTCATTC
CGTTAATCGTTACCGCCATTATCAACGGCATGGTGGGCGTTGGCGATGACGAAAACCTGGGACGAATGGGTTTGAAAACC
GTCGTCCTATACATGAGCACAACCCTGGTGGCGGTGCTAATCGGGCTGGTCGCAGTGAATCTATTCACTCCCGGAATCAT
CAATGGTCAGCCCGCCCGAGATCTACTGGGCTTGGCCACAGAAACCCAGGACGCCCTAGCTAAAATCGACGGCCGAGGCG
TCGGTGATTTCACCGAGATCCTACTCCAGATGCTTCCCCCCAATCTGATCGCCGCTGCCGCCAACGGGCAAATGCTCGGG
CTGATCGTCTTTTCGCTGCTGTTTGGGTTTTTTCTGCGCACCGAGCGCTCATCGTCTGGCCAGAGTCTGCGCAATATCAT
CGACGGGATCTACCAGGTGGTCATGAAAATCACCATGCTGGTGATCCGTTTTACCCCGCTAGGAATATTCGCTCTTATTG
CCGCCACCGTGACTCGCACTGGCATGGATGCCATCGAACCGCTTGCCTGGTTCTTTCTTACGGTACTGGTAGCCCTGGCT
CTGCATGCTTTCGTGTTCATGCCGCTGCTGATCGTGCTAGCCGCGAAACGCTCCCCTCTTCGCCATATTCAAGCCATGAC
GCCAGCGCTGCTCACGGCATTCTCCTCGGCCAGTTCAGCAGCAACGTTGCCGCTGTCTATGGAATGTGTACAGAAACGCT
CCGGCGTATCAACCCGCACCAGCAGCTTCGTGCTGCCTCTGGGGGCCACCGTCAATATGGATGGCACCGCCCTATATGAA
TGTGTAGCAGCCATGTTTATTGCCCAGGCTTACGGTATGGATCTGTCTCTGGCCACCCAGTTCATGATCGTGATTACCGC
CCTGCTTACATCAATCGGCGTAGCCAGTATTCCAGCTGCCTCCTTAGTGGCCATCACCGTGATCCTTGGCGCTATCGGCC
TGCCAGCCGAAGCCATCGGACTGATTCTGGTAACGGATCGTGTGCTGGATATGTGCCGCACCGCCGTCAACGTCTGGGGA
GATAGTGTGGTAACCGTGGTGCTCGCCCGTAGCGAGGGGGAAGAAACGGTGTTGTCGCTACCGGTTTCCAAGATGGAGAA
GGTAACGACAACAGACGTACATTGA

Upstream 100 bases:

>100_bases
GAAGGGCTGCAGGCACTGATGTAGACTTACTCTCTGTTACACAGCACAGGATCAGGTACTCTCAGAAGTTGAAGAGACCG
AGGTTCGCACCACAGGGGAA

Downstream 100 bases:

>100_bases
ACTGGTGATGCAACTGTTAACGAACACTCTTAGAATGCGTCGGGAGCGCCGCTACTCTCCCAATCGCGCTTAATGGTAAC
GGCTGCGCTGGCGATAACAG

Product: sodium:dicarboxylate symporter family protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MMKLHHQIFFAMLAGTLAGSFTAESSTLLGMPIISGYDLVGSLFINALKMVVIPLIVTAIINGMVGVGDDENLGRMGLKT
VVLYMSTTLVAVLIGLVAVNLFTPGIINGQPARDLLGLATETQDALAKIDGRGVGDFTEILLQMLPPNLIAAAANGQMLG
LIVFSLLFGFFLRTERSSSGQSLRNIIDGIYQVVMKITMLVIRFTPLGIFALIAATVTRTGMDAIEPLAWFFLTVLVALA
LHAFVFMPLLIVLAAKRSPLRHIQAMTPALLTAFSSASSAATLPLSMECVQKRSGVSTRTSSFVLPLGATVNMDGTALYE
CVAAMFIAQAYGMDLSLATQFMIVITALLTSIGVASIPAASLVAITVILGAIGLPAEAIGLILVTDRVLDMCRTAVNVWG
DSVVTVVLARSEGEETVLSLPVSKMEKVTTTDVH

Sequences:

>Translated_434_residues
MMKLHHQIFFAMLAGTLAGSFTAESSTLLGMPIISGYDLVGSLFINALKMVVIPLIVTAIINGMVGVGDDENLGRMGLKT
VVLYMSTTLVAVLIGLVAVNLFTPGIINGQPARDLLGLATETQDALAKIDGRGVGDFTEILLQMLPPNLIAAAANGQMLG
LIVFSLLFGFFLRTERSSSGQSLRNIIDGIYQVVMKITMLVIRFTPLGIFALIAATVTRTGMDAIEPLAWFFLTVLVALA
LHAFVFMPLLIVLAAKRSPLRHIQAMTPALLTAFSSASSAATLPLSMECVQKRSGVSTRTSSFVLPLGATVNMDGTALYE
CVAAMFIAQAYGMDLSLATQFMIVITALLTSIGVASIPAASLVAITVILGAIGLPAEAIGLILVTDRVLDMCRTAVNVWG
DSVVTVVLARSEGEETVLSLPVSKMEKVTTTDVH
>Mature_434_residues
MMKLHHQIFFAMLAGTLAGSFTAESSTLLGMPIISGYDLVGSLFINALKMVVIPLIVTAIINGMVGVGDDENLGRMGLKT
VVLYMSTTLVAVLIGLVAVNLFTPGIINGQPARDLLGLATETQDALAKIDGRGVGDFTEILLQMLPPNLIAAAANGQMLG
LIVFSLLFGFFLRTERSSSGQSLRNIIDGIYQVVMKITMLVIRFTPLGIFALIAATVTRTGMDAIEPLAWFFLTVLVALA
LHAFVFMPLLIVLAAKRSPLRHIQAMTPALLTAFSSASSAATLPLSMECVQKRSGVSTRTSSFVLPLGATVNMDGTALYE
CVAAMFIAQAYGMDLSLATQFMIVITALLTSIGVASIPAASLVAITVILGAIGLPAEAIGLILVTDRVLDMCRTAVNVWG
DSVVTVVLARSEGEETVLSLPVSKMEKVTTTDVH

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI4827012, Length=457, Percent_Identity=34.1356673960613, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI169790839, Length=425, Percent_Identity=34.1176470588235, Blast_Score=216, Evalue=4e-56,
Organism=Homo sapiens, GI66773030, Length=399, Percent_Identity=34.3358395989975, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI40254478, Length=430, Percent_Identity=31.1627906976744, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI194239697, Length=470, Percent_Identity=30.4255319148936, Blast_Score=188, Evalue=9e-48,
Organism=Homo sapiens, GI21314632, Length=434, Percent_Identity=28.8018433179723, Blast_Score=179, Evalue=7e-45,
Organism=Homo sapiens, GI5032093, Length=409, Percent_Identity=31.7848410757946, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI223468566, Length=251, Percent_Identity=36.6533864541833, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI223468564, Length=251, Percent_Identity=36.6533864541833, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI262359914, Length=376, Percent_Identity=31.6489361702128, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI301601644, Length=182, Percent_Identity=39.010989010989, Blast_Score=128, Evalue=9e-30,
Organism=Escherichia coli, GI1790514, Length=415, Percent_Identity=35.1807228915663, Blast_Score=245, Evalue=3e-66,
Organism=Escherichia coli, GI1789947, Length=411, Percent_Identity=28.9537712895377, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1788024, Length=387, Percent_Identity=27.6485788113695, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1789473, Length=392, Percent_Identity=25.5102040816327, Blast_Score=105, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI71996953, Length=414, Percent_Identity=35.7487922705314, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17537407, Length=394, Percent_Identity=34.7715736040609, Blast_Score=207, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI71983106, Length=410, Percent_Identity=34.1463414634146, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI71983099, Length=410, Percent_Identity=34.1463414634146, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI193206505, Length=401, Percent_Identity=34.1645885286783, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI193206654, Length=485, Percent_Identity=29.2783505154639, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17541374, Length=424, Percent_Identity=31.8396226415094, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24583025, Length=400, Percent_Identity=32.75, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI17137668, Length=400, Percent_Identity=32.75, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24583023, Length=400, Percent_Identity=32.75, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI281360481, Length=424, Percent_Identity=30.8962264150943, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI281360483, Length=424, Percent_Identity=30.8962264150943, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI17137666, Length=424, Percent_Identity=30.8962264150943, Blast_Score=142, Evalue=4e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 45864; Mature: 45864

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKLHHQIFFAMLAGTLAGSFTAESSTLLGMPIISGYDLVGSLFINALKMVVIPLIVTAI
CCHHHHHHHHHHHHHHHHCCCCCCCCCEECCCHHCHHHHHHHHHHHHHHHHHHHHHHHHH
INGMVGVGDDENLGRMGLKTVVLYMSTTLVAVLIGLVAVNLFTPGIINGQPARDLLGLAT
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
ETQDALAKIDGRGVGDFTEILLQMLPPNLIAAAANGQMLGLIVFSLLFGFFLRTERSSSG
HHHHHHHHHCCCCCCHHHHHHHHHCCCHHEEECCCCCHHHHHHHHHHHHHHHHHCCCCCH
QSLRNIIDGIYQVVMKITMLVIRFTPLGIFALIAATVTRTGMDAIEPLAWFFLTVLVALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LHAFVFMPLLIVLAAKRSPLRHIQAMTPALLTAFSSASSAATLPLSMECVQKRSGVSTRT
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCC
SSFVLPLGATVNMDGTALYECVAAMFIAQAYGMDLSLATQFMIVITALLTSIGVASIPAA
CCEEEECCCEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHCCHH
SLVAITVILGAIGLPAEAIGLILVTDRVLDMCRTAVNVWGDSVVTVVLARSEGEETVLSL
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHEEEECCCCCHHEEEC
PVSKMEKVTTTDVH
CHHHHHHHHCCCCC
>Mature Secondary Structure
MMKLHHQIFFAMLAGTLAGSFTAESSTLLGMPIISGYDLVGSLFINALKMVVIPLIVTAI
CCHHHHHHHHHHHHHHHHCCCCCCCCCEECCCHHCHHHHHHHHHHHHHHHHHHHHHHHHH
INGMVGVGDDENLGRMGLKTVVLYMSTTLVAVLIGLVAVNLFTPGIINGQPARDLLGLAT
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
ETQDALAKIDGRGVGDFTEILLQMLPPNLIAAAANGQMLGLIVFSLLFGFFLRTERSSSG
HHHHHHHHHCCCCCCHHHHHHHHHCCCHHEEECCCCCHHHHHHHHHHHHHHHHHCCCCCH
QSLRNIIDGIYQVVMKITMLVIRFTPLGIFALIAATVTRTGMDAIEPLAWFFLTVLVALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
LHAFVFMPLLIVLAAKRSPLRHIQAMTPALLTAFSSASSAATLPLSMECVQKRSGVSTRT
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCC
SSFVLPLGATVNMDGTALYECVAAMFIAQAYGMDLSLATQFMIVITALLTSIGVASIPAA
CCEEEECCCEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHCCHH
SLVAITVILGAIGLPAEAIGLILVTDRVLDMCRTAVNVWGDSVVTVVLARSEGEETVLSL
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHEEEECCCCCHHEEEC
PVSKMEKVTTTDVH
CHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]